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Volume 64, Issue 3, June 2023. Read the full article ›

The post From forced to coerced labour: displaced mothers and teen girls in post-World War II Australia was curated by information for practice.

The Fremantle Gaol, known as the Roundhouse overlooked the small settlement of Fremantle in 1832. Panorama of the Swan River Settlement, Jane Eliza Currie, 1830-1832

The post ‘There not being any place to keep her’: Incarcerating Women in Nineteenth-Century Western Australia was curated by information for practice.

The post A Place to Home was curated by information for practice.

The post 12th grade girls and boys in the U.S. have different views about gender discrimination in the workplace was curated by information for practice.

The post Workplace Experiences of Latinx LGBTQ Employees was curated by information for practice.

The post Trends and Characteristics of Youth in Residential Placement, 2021 was curated by information for practice.

Children as young as four years old are being placed in residential care because there is no foster carer available, while there is a waiting list for admission to the country’s 15 special care beds, according to the latest report from the Child Law Project.

The post Children as young as four being placed in residential care, report finds was curated by information for practice.

The post CfP: Intellectual Humility in the Workplace – Is it good for employees? (Due by 1 May) was curated by information for practice.

Minnesota Gov. Mark Dayton on Friday called on Garth Brooks to add another Minneapolis show to his upcoming stadium tour — and it sounds like the country music star is on board with the idea.

Shut Up and Take My Money created a rather self-explanatory Dogs Pooping in Beautiful Places" 2025 calendar.

Gen Z does a good job taking sick days, unlike their older coworkers. MPR News host Angela Davis talks about how the mix of generations in today’s workforce is redefining how we work.

As the calendar ushers in fall, now is the perfect time to visit Europe.

On January 11, 2023, Army General Valery Gerasimov was appointed Commander of the Russian grouping of troops in the zone of the special military operation in Ukraine. Gerasimov thus replaced General Sergei Surovikin, who became his deputy. Gerasimov has an extensive experience of army service. He fought Chechen militants at the head of the army, organised Russia's special operation in Syria, and chaired the General Staff of the Russian Armed Forces in November 2012. Valery Gerasimov was born on September 8, 1955 in Kazan, into a working class family. In 1977 he graduated from the Kazan Higher Tank Command School named after the Presidium of the Supreme Council of the Tatar Autonomous Soviet Socialist Republic (currently the Kazan Higher Tank Command Red Banner School). In 1987, he graduated with honours from the Military Academy of Armoured Forces named after Marshal of the Soviet Union Malinovsky. In 1997 — from the Military Academy of the General Staff of the Armed Forces of the Russian Federation.

The Texas Department of Insurance, Division of Workers' Compensation (DWC) recognized Tyler Beverages with the Lone Star Safety Program Award on July 19, 2024, for its exemplary workplace health and safety programs and low rates of work-related injuries and illnesses.

PervasID, provider of passive Radio Frequency Identification (RFID) reader systems for automating inventory and asset tracking, has launched a new advanced version of TrackMaster, claimed to provide greatly enhanced return on investment performance.

[Science] :
A heavy rain warning has been issued for the five border islands in the Yellow Sea and a heavy rain watch for the Seoul metro area, Gangwon Province and parts of the Jeolla and Gyeongsang provinces.  With heavy rain set to pound most parts of the nation through Sunday, the interior and safety ministry on ...

[more...]

Facebook Marketplace has become a popular platform for buying and selling goods, from used cars to gaming systems. However, as with any online marketplace, it has also become a breeding ground for scams.

Blue and yellow flags are common among national and state flags, and the blue and yellow color combinations often symbolize nature.

RM of BTS released his second solo album 'Right Place, Wrong Person' on Friday, his first solo album since 'Indigo' in December 2022.The album carries eleven songs, including the title track...

[more...]

2024 BGS summer placements scheme  British Geological Survey

Fragment-based drug design using X-ray crystallography is a powerful technique to enable the development of new lead compounds, or probe molecules, against biological targets. This study addresses the need to determine fragment binding orientations for low-occupancy fragments with incomplete electron density, an essential step before further development of the molecule. Halogen atoms play multiple roles in drug discovery due to their unique combination of electronegativity, steric effects and hydrophobic properties. Fragments incorporating halogen atoms serve as promising starting points in hit-to-lead development as they often establish halogen bonds with target proteins, potentially enhancing binding affinity and selectivity, as well as counteracting drug resistance. Here, the aim was to unambiguously identify the binding orientations of fragment hits for SARS-CoV-2 nonstructural protein 1 (nsp1) which contain a combination of sulfur and/or chlorine, bromine and iodine substituents. The binding orientations of carefully selected nsp1 analogue hits were focused on by employing their anomalous scattering combined with Pan-Dataset Density Analysis (PanDDA). Anomalous difference Fourier maps derived from the diffraction data collected at both standard and long-wavelength X-rays were compared. The discrepancies observed in the maps of iodine-containing fragments collected at different energies were attributed to site-specific radiation-damage stemming from the strong X-ray absorption of I atoms, which is likely to cause cleavage of the C—I bond. A reliable and effective data-collection strategy to unambiguously determine the binding orientations of low-occupancy fragments containing sulfur and/or halogen atoms while mitigating radiation damage is presented.

The availability of highly accurate protein structure predictions from AlphaFold2 (AF2) and similar tools has hugely expanded the applicability of molecular replacement (MR) for crystal structure solution. Many structures can be solved routinely using raw models, structures processed to remove unreliable parts or models split into distinct structural units. There is therefore an open question around how many and which cases still require experimental phasing methods such as single-wavelength anomalous diffraction (SAD). Here, this question is addressed using a large set of PDB depositions that were solved by SAD. A large majority (87%) could be solved using unedited or minimally edited AF2 predictions. A further 18 (4%) yield straightforwardly to MR after splitting of the AF2 prediction using Slice'N'Dice, although different splitting methods succeeded on slightly different sets of cases. It is also found that further unique targets can be solved by alternative modelling approaches such as ESMFold (four cases), alternative MR approaches such as ARCIMBOLDO and AMPLE (two cases each), and multimeric model building with AlphaFold-Multimer or UniFold (three cases). Ultimately, only 12 cases, or 3% of the SAD-phased set, did not yield to any form of MR tested here, offering valuable hints as to the number and the characteristics of cases where experimental phasing remains essential for macromolecular structure solution.

Highly accurate protein structure prediction can generate accurate models of protein and protein–protein complexes in X-ray crystallography. However, the question of how to make more effective use of predicted models for completing structure analysis, and which strategies should be employed for the more challenging cases such as multi-helical structures, multimeric structures and extremely large structures, both in the model preparation and in the completion steps, remains open for discussion. In this paper, a new strategy is proposed based on the framework of direct methods and dual-space iteration, which can greatly simplify the pre-processing steps of predicted models both in normal and in challenging cases. Following this strategy, full-length models or the conservative structural domains could be used directly as the starting model, and the phase error and the model bias between the starting model and the real structure would be modified in the direct-methods-based dual-space iteration. Many challenging cases (from CASP14) have been tested for the general applicability of this constructive strategy, and almost complete models have been generated with reasonable statistics. The hybrid strategy therefore provides a meaningful scheme for X-ray structure determination using a predicted model as the starting point.

A pressure-induced triclinic-to-monoclinic phase transition has been caught `in the act' over a wider series of high-pressure synchrotron diffraction experiments conducted on a large, photoluminescent organo-gold(I) compound. Here, we describe the mechanism of this single-crystal-to-single-crystal phase transition, the onset of which occurs at ∼0.6 GPa, and we report a high-quality structure of the new monoclinic phase, refined using aspherical atomic scattering factors. Our case illustrates how conducting a fast series of diffraction experiments, enabled by modern equipment at synchrotron facilities, can lead to overestimation of the actual pressure of a phase transition due to slow transformation kinetics.

Mirakl has announced its partnership with

The 1st edition of the Fintech for Marketplaces and Platforms Report covers essential ecommerce trends and future perspectives.

Millicent Simmonds, Noah Jupe and Emily Blunt return in “A Quiet Place, Part II.”; Credit: Paramount Pictures

This content is from Southern California Public Radio. View the original story at SCPR.org.

Still of Emily Blunt and Noah Jupe in the film “A Quiet Place Part II.”; Credit: Paramount Pictures

Larry Mantle and KPCC film critics Lael Loewenstein, Christy Lemire and Charles Solomon review this weekend’s new movie releases on streaming and on demand platforms.

• "A Quiet Place Part II," in wide release

• "Cruella," in wide release & Disney+

• "Dog Gone Trouble," on Netflix

• "Pretty Guardian Sailor Moon Eternal The Movie," on Netflix June 3

• "Moby Doc," In Select Theaters (check your local listings); VOD (including FandangoNow, iTunes, Vudu); Laemmle’s Virtual Cinema June 4

• "Changing The Game," on Hulu June 1

• "Port Authority," Cinelounge Sunset Hollywood; Laemmle’s Virtual Cinema; Digital/VOD (including Vudu, Google Play, FandangoNow) June 1

• "Plan B," on Hulu

• "Borat Supplemental Reportings," on Amazon Prime Video

• "Dead Pigs," on Laemmle’s Virtual Cinema

Our FilmWeek critics have been curating personal lists of their favorite TV shows and movies to binge-watch during self-quarantine. You can see recommendations from each of the critics and where you can watch them here.

Guests:

Christy Lemire, film critic for KPCC, RogerEbert.com and co-host of the ‘Breakfast All Day’ podcast; she tweets @christylemire

Lael Loewenstein, film critic for KPCC and film columnist for the Santa Monica Daily Press; she tweets @LAELLO

Charles Solomon, film critic for KPCC, Animation Scoop and Animation Magazine

This content is from Southern California Public Radio. View the original story at SCPR.org.