Today’s suppliers do more than simply mix a formulation to the customer’s request; they offer guidance and expertise, typically staffing nutritionists, biochemists, and medical experts, as well as experts on regulations. They realize that often the company ordering a premix might not have the knowledge or in-house experience to create a safe and effective blend that includes the appropriate amounts and delivered bioavailability for each vitamin, mineral, or other component.

Bigelow Tea continues to transform its offerings with Peak Energy™ Black Tea plus extra L-Theanine and Caffeine, Whispering Wildflowers™ Herbal Tea plus L-Theanine, and Ginger Honey Herbal Tea plus Zinc where each blend provides flavor while featuring ingredients and nutrients with functional benefits.

France’s Lesaffre Group entered the human health market in 2007 with the establishment of Lesaffre Human Care, which quickly became a world expert in fermentation dedicated to the human nutrition and health market. During the following decade, the Lesaffre Group integrated several leaders in human health, including Gnosis Advanced Biotech, Omniabios, and invested in Envera and Intralytix.

GELITA used this year’s SupplySide East to showcase its wide range of capabilities and offerings in better-for-you foods and supplements. 

In conjunction with its February profile of new sports foods and drinks, Prepared Foods interviewed Scott Peters, director of product development at 3i Solutions, Wooster, Ohio. 

HealthTech BioActives (HTBA), a global leader in natural flavonoids and B12 derivatives, invited SupplySide West 2023 attendees to discover a portfolio of consumer-centric functional health ingredients for cardiovascular health, sports performance and more. Visitors to booth SSW #5081 can also learn more about QuerceClean®, HTBA’s latest functional health innovation for antioxidant and anti-inflammatory support.

Ongoing studies focusing on the human microbiome reveal novel insights into the diverse applications of probiotics beyond gut health. Emerging research explores the intricate connection between microbiota and various health conditions, propelling innovative probiotic solutions targeting specific health concerns.

Functional mushroom coffee brand, Four Sigmatic announced that it will debut a new line of organic instant teas. Each tea is infused with functional mushrooms and adaptogens for focus, calm, positive mood, and immune and gut support.

From immunity and cognition to sleep, vision, beauty from within, weight management, and gut health, the Kemin Human Nutrition and Health business unit can help brands elevate, differentiate, and deliver a variety of health benefits for functional beverages, food, and supplements.

Discover the latest trends reshaping the food and beverage landscape in 2024 and into 2025, where health-conscious choices meet adventurous flavors. We delve into how consumer behaviors are driving innovative snack and beverage options, while sauces and dressings bring excitement to mealtimes. Uncover the key insights and product opportunities that can inspire your next creation in the ever-evolving market.

*To cancel your international Virgin Australia flight and get a refund, follow these steps: ☎+61-285-523-332* *Step 1: Check Eligibility ☎+61-285-523-332* *1. Review Virgin Australia cancellation policy for your fare type.☎+61-285-523-332* ...

PHT Growth Fund LP is a new investment vehicle established to make strategic acquisitions and investments in temperature-controlled food supply chains, with a mission to support the movement of fresh produce from field to table.

Laticrete is sponsoring the printing costs, so all proceeds of the fundraiser go to the Tile Heritage Foundation (THF) and the Ceramic Tile Education Foundation (CTEF)

QuickDrain USA, announced the arrival of the SquareDrain point drain – an extension of the QuickDrain total shower solution that reimagines how a drain should look and perform. 

Defining the fundamentals of vacuum and discussing the utility applications of oil-sealed vacuum technology.

Children's Geographies; 12/01/2021
(AN 153655046); ISSN: 14733285
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Volume 36, Issue 5, September-October 2024, Page 427-433. Read the full article ›

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Journal of Disability Policy Studies, Ahead of Print. In 1997, the United States Agency for International Development established a policy focused on including people with disabilities in its development efforts. For the past two decades, this initiative has been echoed globally, yet research on its effectiveness remains limited. This study revisits a previous 2015 analysis […]

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Prof. Wendy Freedman discusses benefits of multiple telescopes

The St. Paul Chamber Orchestra is facing a loss of corporate funding and will stop sponsoring a contemporary chamber music series and pre-concert discussions starting next season.

Minneapolis city council members want to defund the police department; new agenda items for special legislative session

A GoFundMe campaign seeking to help the family of murdered missionary Beau Shroyer is hoping to raise at least $15,000 to repatriate his body to the U.S. and help his five children navigate “unimaginable loss and uncertainty” as his wife, Jackie Shroyer, faces charges in Angola for allegedly masterminding a murder plot. 

After promising to refund the donations of members who questioned the stewardship of his church's finances, outspoken Tennessee Pastor Greg Locke has reneged on that offer. His attorney has allegedly threatened at least one donor who asked for their money back.

In the event of a global crisis and deterioration of relations between the United States and China, the Central Bank of Russia will have to implement its risk scenario in which the bank will have to use the National Welfare Fund (NWF). The liquid part of the fund — the part that is available for spending — will be exhausted already in 2025, the Central Bank of Russia said in its report titled "Main Directions of the Unified State Monetary Policy." A global crisis may occur against the backdrop of high interest rates and the imbalance in global financial markets, Central Bank analysts believe.

RFID technology does not just exist since yesterday, but especially now, it has a major impact on the profits and losses of companies, for example in retail and logistics. RFID tags that are attached to goods can be read with mobile computers in such a way that real-time results for transactions, stock levels or the order history of customers are displayed.

Added August 17, 2006:

Case Western Reserve University has a new offer for the 25 to 30 students each year who are named finalists for the prestigious Hertz Fellowship but are not ultimately selected as Hertz Fellows: matriculate at CWRU and receive full financial benefits.

[Culture] :
To strengthen the global competitiveness of K-contents, eleven organizations will pool their resources to create a strategic fund worth approximately 600 billion won, or over 454 million U.S. dollars. The Ministry of Culture, Sports and Tourism and the Ministry of Science and ICT announced Wednesday that ...

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Telling dad jokes is a hallmark of fatherhood; those groan-worthy quips that somehow always seem to land, even if it’s just to elicit a chuckle or a sigh. They're simple, usually pun-filled, and often require little setup. The funniest dad jokes come with punchlines so obvious, you can’t help but laugh while rolling your eyes.

Funding awarded for study on hydrogen storage potential in the East Midlands  British Geological Survey

This study presents the first theoretical predictions of the phase transitions, elastic properties, and thermal behavior of AuMTe2 (M = Ga, In) chalcopyrite compounds. Using density functional theory and the quasi-harmonic Debye model, key mechanical and thermodynamic properties are analyzed, offering insights valuable for future experimental validation.

A novel automated high-throughput screening approach, ClusterFinder, is reported for finding candidate structures for atomic pair distribution function (PDF) structural refinements. Finding starting models for PDF refinements is notoriously difficult when the PDF originates from nanoclusters or small nanoparticles. The reported ClusterFinder algorithm can screen 104 to 105 candidate structures from structural databases such as the Inorganic Crystal Structure Database (ICSD) in minutes, using the crystal structures as templates in which it looks for atomic clusters that result in a PDF similar to the target measured PDF. The algorithm returns a rank-ordered list of clusters for further assessment by the user. The algorithm has performed well for simulated and measured PDFs of metal–oxido clusters such as Keggin clusters. This is therefore a powerful approach to finding structural cluster candidates in a modelling campaign for PDFs of nanoparticles and nanoclusters.

The atomic pair distribution function (PDF) is a real-space representation of the structure of a material. Experimental PDFs are obtained using a Fourier transform from total scattering data which may or may not have Bragg diffraction peaks. The determination of Bragg peak resolution in scattering data from the fundamental physical parameters of the diffractometer used is well established, but after the Fourier transform from reciprocal to direct space, these contributions are harder to identify. Starting from an existing definition of the resolution function of large-area detectors for X-ray diffraction, this approach is expanded into direct space. The effect of instrumental parameters on PDF peak resolution is developed mathematically, then studied with modelling and comparison with experimental PDFs of LaB6 from measurements made in different-sized capillaries.

This study validates the feasibility of applying a smearing method for the multi-slit very small angle neutron scattering instrument (MS-VSANS) at the China Spallation Neutron Source. Through analysis limited to a vertical range of 8 mm, the study demonstrates consistency between the predicted smearing function and experimental data, marking a significant milestone in utilizing real data from such instruments.

This study examines the quality of charge density obtained by fitting the multipole model to wavefunctions in different basis sets. The complex analysis reveals that changing the basis set quality from double- to triple-zeta can notably improve the charge density related properties of a multipole model.

Besides traditional pinhole geometry, the multi-slit very small angle neutron scattering instrument (MS-VSANS) at the China Spallation Neutron Source also utilizes a multi-slit collimation system to focus neutrons. Using the special focusing structures, the minimum scattering vector magnitude (q) can reach 0.00028 Å−1. The special structures also lead to a significantly different smearing function. By comparing the results of theoretical calculations with experimental data, we have validated the feasibility of a smearing method based on a mature theory for slit smearing. We use the weight-averaged intensity of neutron wavelength as a representative to evaluate the effect from a broad wavelength distribution, concentrating on the effect from the geometry of the multi-slit structures and the detector. The consistency of the theoretical calculation of the smearing function with experimental VSANS scattering profiles for a series of polystyrene standards of different diameters proves the feasibility of the smearing method. This marks the inaugural use of real experimental data from an instrument employing a multi-slit collimation system.

Full-field transmission X-ray microscopy has been recently implemented at the hard X-ray ROCK–SOLEIL quick-EXAFS beamline, adding micrometre spatial resolution to the second time resolution characterizing the beamline. Benefiting from a beam size versatility due to the beamline focusing optics, full-field hyperspectral XANES imaging has been successfully used at the Fe K-edge for monitoring the pressure-induced spin transition of a 150 µm × 150 µm Fe(o-phen)2(NCS)2 single crystal and the charge of millimetre-sized LiFePO4 battery electrodes. Hyperspectral imaging over 2000 eV has been reported for the simultaneous monitoring of Fe and Cu speciation changes during activation of a FeCu bimetallic catalyst along a millimetre-sized catalyst bed. Strategies of data acquisition and post-data analysis using Jupyter notebooks and multivariate data analysis are presented, and the gain obtained using full-field hyperspectral quick-EXAFS imaging for studies of functional materials under process conditions in comparison with macroscopic information obtained by non-spatially resolved quick-EXAFS techniques is discussed.

Beauveriolides, including the main beauveriolide I {systematic name: (3R,6S,9S,13S)-9-benzyl-13-[(2S)-hexan-2-yl]-6-methyl-3-(2-methyl­prop­yl)-1-oxa-4,7,10-tri­aza­cyclo­tridecane-2,5,8,11-tetrone, C27H41N3O5}, are a series of cyclo­depsipeptides that have shown promising results in the treatment of Alzheimer's disease and in the prevention of foam cell formation in atherosclerosis. Their crystal structure studies have been difficult due to their tiny crystal size and fibre-like morphology, until now. Recent developments in 3D electron diffraction methodology have made it possible to accurately study the crystal structures of submicron crystals by overcoming the problems of beam sensitivity and dynamical scattering. In this study, the absolute structure of beauveriolide I was determined by 3D electron diffraction. The cyclo­dep­si­peptide crystallizes in the space group I2 with lattice parameters a = 40.2744 (4), b = 5.0976 (5), c = 27.698 (4) Å and β = 105.729 (6)°. After dynamical refinement, its absolute structure was determined by comparing the R factors and calculating the z-scores of the two possible enanti­omorphs of beauveriolide I.

Macromolecular crystallography generally requires the recovery of missing phase information from diffraction data to reconstruct an electron-density map of the crystallized molecule. Most recent structures have been solved using molecular replacement as a phasing method, requiring an a priori structure that is closely related to the target protein to serve as a search model; when no such search model exists, molecular replacement is not possible. New advances in computational machine-learning methods, however, have resulted in major advances in protein structure predictions from sequence information. Methods that generate predicted structural models of sufficient accuracy provide a powerful approach to molecular replacement. Taking advantage of these advances, AlphaFold predictions were applied to enable structure determination of a bacterial protein of unknown function (UniProtKB Q63NT7, NCBI locus BPSS0212) based on diffraction data that had evaded phasing attempts using MIR and anomalous scattering methods. Using both X-ray and micro-electron (microED) diffraction data, it was possible to solve the structure of the main fragment of the protein using a predicted model of that domain as a starting point. The use of predicted structural models importantly expands the promise of electron diffraction, where structure determination relies critically on molecular replacement.

Type VII secretion (T7S) systems, also referred to as ESAT-6 secretion (ESX) systems, are molecular machines that have gained great attention due to their implications in cell homeostasis and in host–pathogen interactions in mycobacteria. The latter include important human pathogens such as Mycobacterium tuberculosis (Mtb), the etiological cause of human tuberculosis, which constitutes a pandemic accounting for more than one million deaths every year. The ESX-5 system is exclusively found in slow-growing pathogenic mycobacteria, where it mediates the secretion of a large family of virulence factors: the PE and PPE proteins. The secretion driving force is provided by EccC5, a multidomain ATPase that operates using four globular cytosolic domains: an N-terminal domain of unknown function (EccC5DUF) and three FtsK/SpoIIIE ATPase domains. Recent structural and functional studies of ESX-3 and ESX-5 systems have revealed EccCDUF to be an ATPase-like fold domain with potential ATPase activity, the functionality of which is essential for secretion. Here, the crystal structure of the MtbEccC5DUF domain is reported at 2.05 Å resolution, which reveals a nucleotide-free structure with degenerated cis-acting and trans-acting elements involved in ATP binding and hydrolysis. This crystallographic study, together with a biophysical assessment of the interaction of MtbEccC5DUF with ATP/Mg2+, supports the absence of ATPase activity proposed for this domain. It is shown that this degeneration is also present in DUF domains from other ESX and ESX-like systems, which are likely to exhibit poor or null ATPase activity. Moreover, based on an in silico model of the N-terminal region of MtbEccC5DUF, it is hypothesized that MtbEccC5DUF is a degenerated ATPase domain that may have retained the ability to hexamerize. These observations draw attention to DUF domains as structural elements with potential implications in the opening and closure of the membrane pore during the secretion process via their involvement in inter-protomer interactions.

The Mycobacterium tuberculosis trifunctional enzyme (MtTFE) is an α2β2 tetrameric enzyme in which the α-chain harbors the 2E-enoyl-CoA hydratase (ECH) and 3S-hydroxyacyl-CoA dehydrogenase (HAD) active sites, and the β-chain provides the 3-ketoacyl-CoA thiolase (KAT) active site. Linear, medium-chain and long-chain 2E-enoyl-CoA molecules are the preferred substrates of MtTFE. Previous crystallographic binding and modeling studies identified binding sites for the acyl-CoA substrates at the three active sites, as well as the NAD binding pocket at the HAD active site. These studies also identified three additional CoA binding sites on the surface of MtTFE that are different from the active sites. It has been proposed that one of these additional sites could be of functional relevance for the substrate channeling (by surface crawling) of reaction intermediates between the three active sites. Here, 226 fragments were screened in a crystallographic fragment-binding study of MtTFE crystals, resulting in the structures of 16 MtTFE–fragment complexes. Analysis of the 121 fragment-binding events shows that the ECH active site is the `binding hotspot' for the tested fragments, with 41 binding events. The mode of binding of the fragments bound at the active sites provides additional insight into how the long-chain acyl moiety of the substrates can be accommodated at their proposed binding pockets. In addition, the 20 fragment-binding events between the active sites identify potential transient binding sites of reaction intermediates relevant to the possible channeling of substrates between these active sites. These results provide a basis for further studies to understand the functional relevance of the latter binding sites and to identify substrates for which channeling is crucial.

As an important characterization method, pair distribution function (PDF) has been extensively used in structural analysis of nanomaterials, providing key insights into the degree of crystallinity, atomic structure, local disorder etc. The collection of scattering signals with good statistics is necessary for a reliable structural analysis. However, current conventional electron diffraction experiments using PDF (ePDF) are limited in their ability to acquire continuous diffraction rings for large nanoparticles. Herein, a new method – tilt-ePDF – is proposed to improve the data quality and compatibility of ePDF by a combination of electron diffraction and specimen tilting. In the present work, a tilt-series of electron diffraction patterns was collected from gold nanoparticles with three different sizes and a standard sample polycrystalline aluminium film for ePDF analysis. The results show that tilt-ePDF can not only enhance the continuity of diffraction rings, but can also improve the signal-to-noise ratio in the high scattering angle range. As a result, compared with conventional ePDF data, tilt-ePDF data provide structure parameters with a better accuracy and lower residual factors in the refinement against the crystal structure. This method provides a new way of utilizing ePDF to obtain accurate local structure information from nanoparticles.