Timely repair of DNA double-strand breaks (DSBs) is essential to maintaining genomic integrity and preventing illnesses induced by genetic abnormalities. We previously demonstrated that the E3 ubiquitin ligase SMURF2 plays a critical tumor suppressing role via its interaction with RNF20 (ring finger protein 20) in shaping chromatin landscape and preserving genomic stability. However, the mechanism that mobilizes SMURF2 in response to DNA damage remains unclear. Using biochemical approaches and MS analysis, we show that upon the onset of the DNA-damage response, SMURF2 becomes phosphorylated at Ser384 by ataxia telangiectasia mutated (ATM) serine/threonine kinase, and this phosphorylation is required for its interaction with RNF20. We demonstrate that a SMURF2 mutant with an S384A substitution has reduced capacity to ubiquitinate RNF20 while promoting Smad3 ubiquitination unabatedly. More importantly, mouse embryonic fibroblasts expressing the SMURF2 S384A mutant show a weakened ability to sustain the DSB response compared with those expressing WT SMURF2 following etoposide treatment. These data indicate that SMURF2-mediated RNF20 ubiquitination and degradation controlled by ataxia telangiectasia mutated–induced phosphorylation at Ser384 constitutes a negative feedback loop that regulates DSB repair.

The state wants to test its middle school students in the mathematics courses in which they're enrolled, rather than with the state tests created for that each student's particular grade.

Mahsa Altafi
Oct 23, 2024; 44:e0518242024-e0518242024
Systems/Circuits

Neural circuits supporting innate behaviors, such as feeding, exploration, and social interaction, intermingle in the lateral hypothalamus (LH). Although previous studies have shown that individual LH neurons change their firing relative to the baseline during one or more behaviors, the firing rate dynamics of LH populations within behavioral episodes and the coordination of behavior-related LH populations remain largely unknown. Here, using unsupervised graph-based clustering of LH neurons firing rate dynamics in freely behaving male mice, we identified distinct populations of cells whose activity corresponds to feeding, specific times during feeding bouts, or other innate behaviors—social interaction and novel object exploration. Feeding-related cells fired together with a higher probability during slow and fast gamma oscillations (30–60 and 60–90 Hz) than during nonrhythmic epochs. In contrast, the cofiring of neurons signaling other behaviors than feeding was overall similar between slow gamma and nonrhythmic epochs but increased during fast gamma oscillations. These results reveal a neural organization of ethological hierarchies in the LH and point to behavior-specific motivational systems, the dysfunction of which may contribute to mental disorders.

Part of the Feeding Knowledge platform, an initiative [...]

Caretakers feed the new baby clouded leopards at the Zoo's research facility in Virginia

This feed is dead. Stop polling it!

The predatory pod hunts off the coast of Chile and is led by a matriarch called Dakota

This feed is dead. Stop polling it!

The National Math and Science Initiative's new tool aims to help the field look for patterns in STEM data, so educators and policy folks can fill in holes.

Some might say these feeding numbers are slightly skewed.

A draft proposal of Penn State’s institutional strategic plan has been unveiled and shared with the community for feedback and discussion. All faculty, staff and students at all campuses are encouraged to visit the Strategic Plan website to review and provide feedback on the draft plans for four goal areas.

WILMINGTON, Del. – After reviewing customer feedback from three Community Conversations in Wilmington and Newark last week, DART will make a series of improvements. The recent Community Conversations offered DART riders, and the general public, the opportunity to provide feedback and share their experiences since DART’s service changes in mid-December. “The Community Conversations were intended […]

Eligible Families Will Receive Emergency Food Assistance Benefits in 2 Distributions   NEW CASTLE (Aug. 2, 2022) – Eligible Delaware households will receive emergency food assistance benefits under the Pandemic Electronic Benefit Transfer (P-EBT) program to cover the summer period when children are on break and not receiving meals at school. The following children are […]

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The systems we use to produce food have many problems, from horrifying waste to their dependence on fossil fuels. Vaclav Smil explains how to fix them

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Category: Health News
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Title: Breast-Feeding May Pass Common Chemical to Baby, Study Shows
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If artificial intelligence chatbots are fine-tuned to improve their responses using human feedback, they can become more likely to give deceptive answers that seem right but aren’t

Doubled number of specialists should make up for the switch from the classic class system.

The New York legislature passed two bills on June 7, 2024 directed at children’s use of online technologies – the Stop Addictive Feeds Exploitation (SAFE) for Kids Act (S7694) that restricts access to addictive algorithmic feeds and the New York Child Data Protection Act (S7695) that bans sites from collecting, using, sharing or selling personal […]

Sep 20, 2016

"South Africa is the continent's largest chicken producer. According to the South African Poultry Association, chicken imports from Brazil, the European Union and the US are destroying the domestic sector....This has led to oversupply and price reduction. This may benefit consumers, but it undercuts incentives for local production."

Snack bar maker Larabar teams up with Feeding America� to make simple and wholesome food accessible for all and empower their community to take action to #ShareRealFood across America.

Pollination: Busy as a Bee

Chief Secretary to the Treasury Darren Jones talks to the BBC about his childhood.

Emphasizing the importance of medlinkbreastfeeding/medlink, Gujarat Minister Bhanubhen Babaria encouraged mothers to exclusively breastfeed their babies and avoid traditional feeding practices.

Health experts emphasized that employers must enhance support for medlinkbreastfeeding/medlink mothers returning to work, as part of medlinkWorld Breastfeeding Week/medlink.

Researchers have developed a novel sensor capable of detecting sodium ions in breastmilk. This breakthrough is significant because elevated sodium levels

A monthly vaginal ring containing the antiretroviral drug dapivirine - an HIV prevention method that has been approved in several African countries and

Baby-led weaning-a popular method for introducing solid foods to medlinkinfants/medlink-provides sufficient calories for growth and development. This

The iWorld Health Organization (WHO)/i and other leading health organizations strongly advocate for exclusive medlinkbreastfeeding/medlink for the first six months of a baby's life.

A new study reveals that human medlinkbreast milk/medlink plays a crucial role in shaping a baby's microbiome, the community of microbes that live in the body.

A study followed 299 women and their infants from pregnancy to toddlerhood, investigating the factors contributing to rapid infant weight gain. The research

“For You” algorithms that promote the most interesting content across a social network, personalized to the individual user, offered a disjointed, outdated, and nearly unusable experience on election night in the U.S. as they highlighted hours-old posts that no longer reflected the current state of the race. Frustrations were particularly high on Threads, Meta’s X […]

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Research shows that getting ahead requires constructive criticism. But many women don’t get those frank assessments.

We all know how tempting it can be to give your little one a quick snack to keep them quiet or happy, especially when you're juggling a million things at once. But what if I told you that those quick fixes