Yoreli Rincón, una de las principales exponentes del fútbol femenino colombiano a nivel internacional, dialogó con la sección El Camerino de El Alargue de Caracol Radio. La santandereana habló de su actualidad y de su deseo vigente de jugar con la Selección Colombia, pese a encontrarse vetada, como ella misma lo reconoce.

Con la caída del quinto técnico en las primeras seis fechas de la liga colombiana, Atlético Huila no fue la excepción luego de la renuncia de Néstor Craviotto. El nuevo entrenador de los Opitas, Diego Corredor, habló con El Alargue de Caracol sobre su llegada al equipo y el proyecto que espera poner en acción para salvarse del descenso.

Alfredo Arias, entrenador de Independiente Medellín, estuvo en los micrófonos de El Alargue, en Caracol Radio, hablando sobre el encuentro ante Millonarios, el presente del poderoso de la montaña y la renovación de un pilar del equipo, Edwuin Cetré.

El esposo de Amelia Pérez, una de las ternadas a Fiscal General habló en 6AM sobre los ataques que ha recibido por el uso de sus redes sociales.

El esposo de Amelia Pérez, una de las ternadas a Fiscal General habló en 6AM sobre los ataques que ha recibido por el uso de sus redes sociales.

El esposo de Amelia Pérez, una de las ternadas a Fiscal General habló en 6AM sobre los ataques que ha recibido por el uso de sus redes sociales.

El esposo de Amelia Pérez, una de las ternadas a Fiscal General habló en 6AM sobre los ataques que ha recibido por el uso de sus redes sociales.

En las últimas horas ante el Tribunal Administrativo de Cundinamarca se presentó una acción popular solicitando unas medidas cautelares para que sean suspendidos de forma inmediata todos los contratos celebrados por el Servicio Nacional de Aprendizaje.

En 6AM Hoy por Hoy, Alfredo Beltrán. Doctor en Derecho, cuestiona la precisión de la propuesta de Asamblea Constituyente en la ley de convocatoria, propuesta por el presidente Petro.

En Caracol Radio estuvo Saúl Kattan, presidente de la Junta directiva de Ecopetrol, conversando sobre el informe de riesgos y las recomendaciones

Carlos Carrillo, director de la Unidad de Gestión de Riesgo de Desastre, compartió en 6AM las medidas que adoptará para evitar que se presenten casos como la reconstrucción de Mocoa o los albergues del Galeras

El periodista recibió un audio de Santiago Uribe, en el que habría una amenaza contra su vida.

En PRIMICIA para 6AM, habló por primera vez desde su salida el exdirector de la Unidad Nacional de Gestión del Riesgo, y aseguró que le dará la cara a la justicia.

En Caracol Radio estuvo Juan Daniel Oviedo, concejal e integrante del Comité Promotor de Autonomía Fiscal para las Regiones

“En el día cívico los productores de alimentos siguen trabajando”: Jorge Bedoya En respuesta al anuncio del presidente Petro sobr

El director de la UNGRD aclaró en 6AM que los recursos de la entidad fueron girados a varias personas, a “los lugares donde estaban sus amigos políticos”.

En el programa 6AM Hoy por Hoy de Caracol Radio, el Ministro del interior no guarda sus palabras al señalar al exfuncionario Olmedo López

En 6AM Hoy por Hoy de Caracol Radio estuvo Carlos Carrillo, director de la UNGRD, para hablar sobre dónde están y quién responde por los recursos que se robaron de la entidad.

En el programa 6AM de Hoy por Hoy de Caracol Radio, estuvo José Moreno y habló sobre las pruebas tras las acusaciones sobre Karen Manrique

Leonardo Donoso habló con 6AM, expuso las medidas que tomó el municipio frente a los bloqueos de los trasportadores.

En el programa 6AM de Caracol Radio, estuvo Juan Daniel Oviedo y habló de lo que se avecina para él, en las elecciones de 2026 en Colombia.

José Luis Moreno Caballero, abogado defensor de Olmedo, hizo hincapié en quién estaría detrás de la supuesta persecución en contra de su defendido

Jaws of Justice Radio investigates how we can achieve justice from a system of laws deeply rooted in economic, social and political inequality.  We want to dispel misconceptions created by […]

The post CALL DOCTOR LOVE FOR ALL; THE MEANING OF UHURU IS FREEDOM appeared first on KKFI.

The People for a New America organization has announced the inaugural Unity, Peace & Freedom Festival

Endorsement: Amendment 79 would make certain that women who choose to have an abortion can do so quickly, with Medicaid coverage, and with their own doctors.

A man of many causes.

The 230-foot long superyacht Freedom recently paid a visit to Bermuda, docking in Hamilton Harbour. The YachtCharterFleet website said, “The 70.1m/230′ ‘Freedom’ [ex. Reverie] motor yacht built by the Italian shipyard Benetti is available for charter for up to 12 guests in 8 cabins. This yacht features interior styling by John Munford. “Built in 2000, […]

King Alpha Productions is hosting “Masked Freedom,” a special event on African masquerade traditions as a key to freedom, featuring Professor Raphael Chijioke Njoku and Dr. David ‘Roots’ Chapman, on July 30 at St. Paul’s Centennial Hall during Emancipation Week 2024. Related Stories Gombey Documentary Special Edition The Beat Goes On For Our Gombeys Historical […]

The National Museum of Bermuda  has published a new Teacher’s Resource Guide: Freedom Narratives of Enslaved Bermudians Mary Prince and Benjamin Benson. A spokesperson said, ” This comprehensive guide is part of NMB’s ongoing Teacher Professional Development programme [TPD]. It is designed to support the current local social studies curriculum and deepen understanding of Bermuda’s history […]

Osud České pirátské strany, která v několika volbách za sebou dostala výprask, je příkladem selhání progresivistického politického modelu. Když pak nedávno premiér Petr Fiala vyhodil z vlády Ivana Bartoše za nezvládnutou digitalizaci stavebního řízení, prezentovali se Piráti sérií emotivních a dětinských prohlášení. Uraženě opustili koaliční kabinet a naivně si myslí, že je to zachrání před dalším propadem. Za předsedu si teď zvolili Zdeňka Hřiba, kterého Pražané v pozici náměstka a předtím primátora hlavního města skutečně nemusí.

Bored? Forget the Snickers. What you need is a healthy serving of humor. These memes cover all the bases: nerdy, historical, relatable, and just plain dumb. As a bonus, we can guarantee they won't give you cavities or leave bits of peanuts stuck in your teeth. 

An examination of diversity in senior leadership roles at America’s top companies Diversity is more than just a buzzword, it’s a recipe for corporate success. Multiple studies have shown that a more diverse workforce in terms of age, gender, ethnicity, as well as veteran, disability, and LGBTQIA+ status can bolster innovation.i A more diverse corporate talent pool is […]

The post We Know Diversity is Good for Business, So Why Do Corporate Leaders Remain Predominantly White and Male? appeared first on DiversityJobs.com.

Photo by Reproductive Health Supplies Coalition The Biden-Harris administration’s proposed rule to expand access to affordable contraception under the Affordable Care Act (ACA) is a timely and essential move, especially in the current political landscape where reproductive rights have been systematically eroded. This proposal would provide over-the-counter birth control without any cost sharing for women with […]

The post Expanding Birth Control Access as the New Front in Reproductive Freedom appeared first on Feminist Majority Foundation.

When we mention wine, many will immediately think of Italy, Spain, or France, which are considered to be the cradles of this beverage popular all over the world. You will think how, with their traditional music in the background, you are tasting wine in beautiful wineries with a view of endless vineyards. Yes, Europe is ... Read more

The post Sedona’s Wine Country: A Blend Of Beauty And Flavor For Wine Connoisseurs appeared first on Star Two.

The regional and international implications of restrictions to online freedom of expression in Asia 25 March 2021 — 12:30PM TO 1:30PM Anonymous (not verified) 12 March 2021 Online

Panellists discuss the latest developments affecting online freedom of expression in the Asia region.

Please note this is an online event. Please register using the link below to finalize your registration.

In recent years, state-led clampdowns on online freedom of expression have become widespread in several countries across Asia, further intensified by the COVID-19 crisis.

The reasons for this are complex and diverse – drawing upon history, culture and politics, in addition to external influences. Across the region, governments have been accused of silencing online criticism and failing to uphold rights to free speech.

Individuals have been arrested, fined or attacked for the alleged spread of ‘fake news’, raising concern among human rights organizations. In some countries, this has culminated in the imposition of new social media rules, which could require social media companies to censor posts and share decrypted messages.

In China, the government’s restrictive online regime has relied on a combination of legal, technical and manipulation tactics to manage control of the internet, and now includes attempts at censorship beyond its borders.

Panellists will discuss the latest regional developments affecting online freedom of expression in the Asia region, and will consider the broader regional and international implications for technology governance.

This webinar launches the publication Restrictions on online freedom of expression in China: The domestic, regional and international implications of China’s policies and practices.

Battle lines being drawn over online freedoms in Asia Expert comment NCapeling 22 March 2021

Social media giants are increasingly clashing with Asian governments over free expression and censorship as the region lurches towards digital authoritarianism.

Freedom of expression was subject to significant restrictions in Asia even before the pandemic, with several governments having enacted laws that stifle online debate. But since COVID-19, restrictions have increased even further due to a rash of so-called ‘emergency measures’ introduced by governments across the region.

Bangladesh, India, Indonesia, Malaysia, Myanmar, Nepal, Pakistan, the Philippines, Sri Lanka, Thailand, and Vietnam have all put new laws into place, and many restrictions are already being applied in a draconian fashion, such as in the Philippines and Bangladesh.

As outlined in a new Chatham House research paper, one inspiration behind this trend is China, home to the world’s most sophisticated and restrictive system of internet control. The Chinese government’s restrictive online regime, which has tightened further under COVID-19, relies on a combination of legal regulations, technical controls, and proactive manipulation of online debates.

This model was an inspiration for Vietnam’s cybersecurity law, as well as Myanmar’s new draft cybersecurity bill, proposed by the Military-run State Administration Council in the wake of the military coup last month, which would give the military there extensive powers to access individuals’ data, restrict, or suspend access to the internet.

This ‘sovereignty and control’ model of internet governance is also gaining impetus through China’s ‘Digital Silk Road’ initiative, under which the Chinese government is exporting both its technology – such as through the establishment of smart cities, the installation of AI, and surveillance technology – and its vision of how the internet should be governed.

In November 2020, Xi Jinping pledged to further deepen cooperation with ASEAN through the Digital Silk Road, and the pandemic has expanded the appeal of Chinese surveillance technologies and data collection platforms to governments both in Asia and beyond. China’s Health Silk Road, which aims to promote global health cooperation, is centered on the Chinese government’s high-tech model under which civic freedoms are sacrificed in the name of public health.

An alternative model

This ‘sovereignty and control’ model is increasingly at odds with the more ‘human-centric’ model of tech governance favoured by many democratic states, Western social media companies, and international institutions, especially the United Nations (UN) and European Union (EU).

Although this emerging model also involves regulation, it is regulation which aims to be inclusive, risk-based, and proportionate – balancing the need for protection against online harms with the need to preserve freedom of expression. It is a multi-stakeholder, rights-based approach which brings together not just governments but also representatives of the private sector, civil society, and academia. The EU’s draft Digital Services Act and the UK’s proposals for an Online Safety Bill are both reflective of this approach.

Western social media giants such as Facebook and Twitter have recently introduced new policies which seek to identify and mitigate online harms, such as hate speech and disinformation. Industry bodies such as the Global Network Initiative, independent oversight bodies such as the Oversight Board established by Facebook, and civil society advocacy and initiatives such as the Santa Clara Principles on Transparency and Accountability in Content Moderation are also an important part of the picture.

Admittedly, these various digital governance initiatives are in some cases embryonic, and are by no means a silver bullet solution to the complex problem of online content moderation, which continues to be hotly debated in democratic societies. But they are at least underpinned by the same philosophy – that international human rights law standards must continue to apply even during emergencies such as COVID-19. With the Biden administration in the US prioritizing tech governance in its policy agenda, there is added momentum to the international leadership behind this model.

A clash of ideology

These conflicting philosophies are playing out in debates on technology governance at the UN, with one group of countries led by China and Russia advocating for greater government control of the internet, and many Western democracies emphasizing the need for an open, global internet that protects human rights.

These differing ideologies are also creating tensions between Western social media companies operating in Asia and the various governments in that region which have increased restrictions on online expression. And the gulf between the two appears to be widening.

In 2017, the Thailand government threatened Facebook with legal action unless it agreed to remove content critical of Thailand’s royal family and, in 2020, Facebook announced it had been ‘forced to block’ such material. Also in 2020, the Vietnam government pressured state-owned telecom companies to throttle internet traffic to Facebook, effectively restricting access to the platform, until Facebook agreed to take down content the government deemed to be anti-state.

Platforms refuse to silence legitimate criticism

However, Silicon Valley’s social media companies have also been pushing back. Facebook restricted the accounts of Myanmar’s military on the basis of ‘spreading misinformation’ in the wake of the military’s imposition of an internet shutdown that blocked access to Facebook, Twitter, and Instagram. And Twitter resisted requests by the Indian government to block accounts involved in protests by farmers.

Twitter stated that while it would block any accounts which it felt incited violence, it would not take action on accounts belonging to news media entities, journalists, activists, and politicians because it believed that would ‘violate the fundamental right to free expression under the Indian law’. The Indian government responded by fast-tracking stringent new social media regulations heavily criticized by rights groups for increasing government power over content on social media platforms, including online news.

So how can social media companies find avenues for operating in Asia and beyond without being co-opted into the lurch towards digital authoritarianism? There are no easy answers here, but collaboration is key. Cooperation between tech companies and local civil society partners can help companies better understand risks to human rights in the country concerned and how they might be mitigated. And tech companies are more effective in alliance with each other than acting on their own, such as the refusal by Facebook, Google, Telegram, and Twitter to hand over data on protestors to the Hong Kong police.

The fact that in many countries in Asia there are no alternatives to Western social media companies – unlike China, where platforms such as WeChat are part of the government’s internet control apparatus – gives the companies concerned some leverage. In February 2020, Facebook, Google, and Twitter together – through the Asia Internet Coalition – threatened to leave Pakistan in response to the government’s draconian proposals to regulate social media. Along with pressure and lawsuits from civil society, this forced the government into retreat, although the tussle over the new rules, introduced in November, continues.

At a time when illiberalism was already on the rise in Asia (including in democracies – Freedom House has just downgraded India’s status from ‘free’ to ‘partly free’), COVID-19 has made tighter state control of online freedom of expression even more attractive to many governments. As it seems increasingly unlikely that restrictions enacted under the guise of pandemic-related emergency measures will be repealed once the COVID-19 crisis ends, it is even more important that tech companies work with civil society on the ground to minimize the censorship of citizen voices.

Large regions in tumor tissues, particularly pancreatic cancer, are hypoxic and nutrient-deprived because of unregulated cell growth and insufficient vascular supply. Certain cancer cells, such as those inside a tumor, can tolerate these severe conditions and survive for prolonged periods. We hypothesized that small molecular agents, which can preferentially reduce cancer cell survival under nutrient-deprived conditions, could function as anticancer drugs. In this study, we constructed a high-throughput screening system to identify such small molecules and screened chemical libraries and microbial culture extracts. We were able to determine that some small molecular compounds, such as penicillic acid, papyracillic acid, and auranofin, exhibit preferential cytotoxicity to human pancreatic cancer cells under nutrient-deprived compared with nutrient-sufficient conditions. Further analysis revealed that these compounds target to redox systems such as GSH and thioredoxin and induce accumulation of reactive oxygen species in nutrient-deprived cancer cells, potentially contributing to apoptosis under nutrient-deprived conditions. Nutrient-deficient cancer cells are often deficient in GSH; thus, they are susceptible to redox system inhibitors. Targeting redox systems might be an attractive therapeutic strategy under nutrient-deprived conditions of the tumor microenvironment.

The kinesin-3 family contains the fastest and most processive motors of the three neuronal transport kinesin families, yet the sequence of states and rates of kinetic transitions that comprise the chemomechanical cycle and give rise to their unique properties are poorly understood. We used stopped-flow fluorescence spectroscopy and single-molecule motility assays to delineate the chemomechanical cycle of the kinesin-3, KIF1A. Our bacterially expressed KIF1A construct, dimerized via a kinesin-1 coiled-coil, exhibits fast velocity and superprocessivity behavior similar to WT KIF1A. We established that the KIF1A forward step is triggered by hydrolysis of ATP and not by ATP binding, meaning that KIF1A follows the same chemomechanical cycle as established for kinesin-1 and -2. The ATP-triggered half-site release rate of KIF1A was similar to the stepping rate, indicating that during stepping, rear-head detachment is an order of magnitude faster than in kinesin-1 and kinesin-2. Thus, KIF1A spends the majority of its hydrolysis cycle in a one-head-bound state. Both the ADP off-rate and the ATP on-rate at physiological ATP concentration were fast, eliminating these steps as possible rate-limiting transitions. Based on the measured run length and the relatively slow off-rate in ADP, we conclude that attachment of the tethered head is the rate-limiting transition in the KIF1A stepping cycle. Thus, KIF1A's activity can be explained by a fast rear-head detachment rate, a rate-limiting step of tethered-head attachment that follows ATP hydrolysis, and a relatively strong electrostatic interaction with the microtubule in the weakly bound post-hydrolysis state.

Among the virulence factors in Neisseria infections, a major inducer of inflammatory cytokines is the lipooligosaccharide (LOS). The activation of NF-B via extracellular binding of LOS or lipopolysaccharide (LPS) to the toll-like receptor 4 and its coreceptor, MD-2, results in production of pro-inflammatory cytokines that initiate adaptive immune responses. LOS can also be absorbed by cells and activate intracellular inflammasomes, causing the release of inflammatory cytokines and pyroptosis. Studies of LOS and LPS have shown that their inflammatory potential is highly dependent on lipid A phosphorylation and acylation, but little is known on the location and pattern of these posttranslational modifications. Herein, we report on the localization of phosphoryl groups on phosphorylated meningococcal lipid A, which has two to three phosphate and zero to two phosphoethanolamine substituents. Intact LOS with symmetrical hexa-acylated and asymmetrical penta-acylated lipid A moieties was subjected to high-resolution ion mobility spectrometry MALDI-TOF MS. LOS molecular ions readily underwent in-source decay to give fragments of the oligosaccharide and lipid A formed by cleavage of the ketosidic linkage, which enabled performing MS/MS (pseudo-MS³). The resulting spectra revealed several patterns of phosphoryl substitution on lipid A, with certain species predominating. The extent of phosphoryl substitution, particularly phosphoethanolaminylation, on the 4'-hydroxyl was greater than that on the 1-hydroxyl. The heretofore unrecognized phosphorylation patterns of lipid A of meningococcal LOS that we detected are likely determinants of both pathogenicity and the ability of the bacteria to evade the innate immune system.