Stuart Gordon, the theater and film director who died Tuesday at age 72, was known for cult horror films and his support of up-and-coming filmmakers.

This classic pound cake recipe follows the one-to-one ratios of butter, sugar, flour and eggs and is flavored with vanilla.

Fluffy and hot all at the same time, diner-style pancakes are the best breakfast for two.

This gin and tonic recipe follows the classic formula but uses an extra-long lemon twist for more citrus freshness.

Just a few simple tweaks are all it takes to make a classic meatloaf more appealing than its name gives it credit for.

Whole Romaine leaves are coated in a light yet rich dressing of lemon, Parmesan and garlicky oil. Eggs and anchovies optional.

Books about nature to read while avoiding the coronavirus — from classics by John McPhee and Annie Dillard to the upcoming "Book of Eels."

A newly built home in Santa Monica showcases what's new in East Coast and contemporary design styles. Asking price: $8.899 million.

Behind the scenes at this year's Pebble Beach Concours d'Elegance, the most prestigious car show in the world.

The San Francisco-based website is auctioning collectible cars online in real time — 50-plus a day, five days a week.

The coronavirus canceled the Hollywood event that was expected to draw about 33,000 admissions. The "Special Home Edition" can reach millions.

Bill Gardner's "Rhapsody in Black" show has been a staple of L.A. radio since the early 1980s, airing classic R&B. But its future is in peril due to the coronavirus.

CHEESE SCONES are a great way of using up excess cheese while also being a delightful treat all the family will enjoy. Here's a quick recipe on how to make cheese scones.

Citing the need to keep people safe, Indiana Black Expo has canceled its Summer Celebration and Circle City Classic.

This year’s Classic, a 1¼-mile race for 3-year-olds and up, will be held at Churchill Downs and features several strong entrants.

Fans of the Disney animated movie celebrated its addition to the National Film Registry.

A mimosa, the classic combination of orange juice and sparkling wine, makes the perfect pick-me-up drink. It’s light, refreshing, and easy to make. Don’t have orange juice? Mix and match with any citrus fruit you have around.

Continue reading "Classic Mimosa" »

Nicholas Love's Penguin Classics cover generator lets you upload an image and set type in humorous imitation of the label. It can also do the similar but inverted Oxford World Classics look. But sadly not the classic classics look.

Many excellent designs in this twitter thread; embedded here is my contribution. Read the rest

I have a love/hate relationship with musical reaction videos. There are kids reacting to heavy metal (or The Beatles), vocal teachers and opera singers reacting to rock vocalists, millennials reacting to classic rock, and on and on. Some of these are quite moving, for instance, a 20-something hearing Zep's "Since I've Been Loving You" for the first time or a vocal teacher reacting to a Black Metal vocalist's cookie monster growl.

In these two videos, Heline, a classical flutist and music teacher, listens to Jethro Tull's Ian Anderson performing "Bouree" at a 1969 concert and then she listens and reacts to a performance from 1976.

I didn't realize that Anderson had only been playing the flute for a year and had no formal training at the time of the 69 video (their first tour). Heline can appreciate his chutzpah in the first performance and the fact that he's only been playing for a year(!), but is perhaps predictably critical of his playing. She is more impressed with what she sees and hears in the 76 performance.

Personally, I always thought his playing was inspired and his playing, vocalizing, singing and playing, and his other stage antics (the goofy one-legged stance) were a perfect example of "the street finding its own uses for things," using technology in ways in which it was never intended. As with all things artistic, your mileage may vary.

Image: YouTube Read the rest

Bin Li and Jieqiong Shen
Proc. Amer. Math. Soc. 148 (2020), 2565-2578.
Abstract, references and article information

Back with a bumper edition after the Easter break, as Henry Burrell takes Scott Carey, David Price and Dom Preston on a chat odyssey to discuss Facebook's F8 conference. Will chat bots ever be good and who uses QR codes? The gang then discusses Apple's out of character decision to brief journos on the Mac Pro and even admit they got it wrong. Finally we talk about Nintendo stopping production of the NES Classic and whether there's more affordable retro goodness around the corner.  

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Director Rachel Lee Goldenberg discusses how her "Valley Girl" musical remake puts a twist on the hit music of the '80s.

Keyboard instruments -- History -- 20th century.

Troy Brouwer scored the game-winning goal as the Capitals beat the Blackhawks at Nationals Park on Jan. 1, 2015. Relive the excitement with Monday night's replay.

One of the common tasks in unsupervised learning is dimensionality reduction, where the goal is to find meaningful low-dimensional structures hidden in high-dimensional data. Sometimes referred to as manifold learning, this problem is closely related to the problem of localization, which aims at embedding a weighted graph into a low-dimensional Euclidean space. Several methods have been proposed for localization, and also manifold learning. Nonetheless, the robustness property of most of them is little understood. In this paper, we obtain perturbation bounds for classical scaling and trilateration, which are then applied to derive performance bounds for Isomap, Landmark Isomap, and Maximum Variance Unfolding. A new perturbation bound for procrustes analysis plays a key role.

The tuberal hypothalamus is comprised of the dorsomedial, ventromedial, and arcuate nuclei, as well as parts of the lateral hypothalamic area, and it governs a wide range of physiologies. During neurogenesis, tuberal hypothalamic neurons are thought to be born in a dorsal-to-ventral and outside-in pattern, although the accuracy of this description has been questioned over the years. Moreover, the intrinsic factors that control the timing of neurogenesis in this region are poorly characterized. Proneural genes, including Achate-scute-like 1 (Ascl1) and Neurogenin 3 (Neurog3) are widely expressed in hypothalamic progenitors and contribute to lineage commitment and subtype-specific neuronal identifies, but the potential role of Neurogenin 2 (Neurog2) remains unexplored. Birthdating in male and female mice showed that tuberal hypothalamic neurogenesis begins as early as E9.5 in the lateral hypothalamic and arcuate and rapidly expands to dorsomedial and ventromedial neurons by E10.5, peaking throughout the region by E11.5. We confirmed an outside-in trend, except for neurons born at E9.5, and uncovered a rostrocaudal progression but did not confirm a dorsal-ventral patterning to tuberal hypothalamic neuronal birth. In the absence of Neurog2, neurogenesis stalls, with a significant reduction in early-born BrdU⁺ cells but no change at later time points. Further, the loss of Ascl1 yielded a similar delay in neuronal birth, suggesting that Ascl1 cannot rescue the loss of Neurog2 and that these proneural genes act independently in the tuberal hypothalamus. Together, our findings show that Neurog2 functions as a classical proneural gene to regulate the temporal progression of tuberal hypothalamic neurogenesis.

SIGNIFICANCE STATEMENT Here, we investigated the general timing and pattern of neurogenesis within the tuberal hypothalamus. Our results confirmed an outside-in trend of neurogenesis and uncovered a rostrocaudal progression. We also showed that Neurog2 acts as a classical proneural gene and is responsible for regulating the birth of early-born neurons within the ventromedial hypothalamus, acting independently of Ascl1. In addition, we revealed a role for Neurog2 in cell fate specification and differentiation of ventromedial -specific neurons. Last, Neurog2 does not have cross-inhibitory effects on Neurog1, Neurog3, and Ascl1. These findings are the first to reveal a role for Neurog2 in hypothalamic development.

Audible's new service is aimed at school-age children participating in distance learning but features selections likely to appeal to all

A fresh look at classical dance forms  Telegraph India

40 classic cars drove through High River to give thanks to those working on the front lines.

This season's colours and cuts mix up the wardrobe-staple trench, says Prudence Wade.

If I've learned anything after hanging out at a think tank for close to two decades, it's that dreaming up education innovations is easy. Number 12 in our countdown is my take on the goofy contests that talkers seem to be so fond of.

The Atari 2600's library is incredibly diverse; let's explore hidden gems from the golden age of console gaming.

β-lactam resistance in Staphylococcus aureus limits treatment options. Stp1 and Stk1, a serine-threonine phosphatase and kinase respectively, mediate serine-threonine kinase (STK) signaling. Loss of function point mutations in stp1 were detected among laboratory passaged, β-lactam resistant S. aureus strains lacking mecA and blaZ, the major determinants of β-lactam resistance in the bacteria. Loss of Stp1 function facilitates β-lactam resistance of the bacteria.

In number 10 in our countdown, I tried to offer a few thoughts to funders as they embraced new agendas and looked to avoid repeating yesterday's missteps.

Adobe's Photoshop Lightroom remains the gold standard in pro photo workflow software. It's a complete package, with top-notch organization tools, state of-the-art adjustments, and all the output and printing options you'd want.

Despite once again being denied seeing Tony Ferguson do battle with Khabib Nurmagomedov, the UFC has served up the next best thing as the fiercely exciting Justin Gaethje steps in to face Ferguson for the interim title at UFC 249.
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Fans can enjoy a full slate of classic college basketball games, including three national championships, Friday on ESPNU.

Women's Basketball travels to Dubuque, IA to play in the Clark Classic this Friday, November 1st and Saturday, November 2nd. 

Women's Basketball proved to be up to the task this past weekend in Dubuque, IA at the Clarke Classic Basketball Tournament.

Lawrence, Kansas - The Haskell Men's team competed in the Johnson County Community College Fall Classic on Friday night.

Winfield, Kansas – The Haskell men's cross country team finished in 17th place with 463 points at the NAIA Mid-States Classic on Saturday, October 21st.

Both Men's and Women's Cross Country were put the the test at the Rim Rock Classic XC Meet with unpleasant weather. 

Many anime releases have been delayed indefinitely due to the COVID-19 outbreak, but in the meantime, with their vast libraries of anime films and series, ...