The Crown Commercial Service (“CCS”) has now published a revised standard Selection Questionnaire and guidance in the form of Procurement Policy Note (PPN) 8/16. This can be found here. PPN 8/16 supersedes and replaces PPN 3/15 which con...

After 50 days in mandatory lockdown, Argentina's President Alberto Fernández announced on Friday that the quarantine will be extended until May 24th.

Diego Maradona has lent a hand in the fight against the coronavirus pandemic in his hometown by autographing an Argentina national team jersey for a raffle. The sale raised money for an underprivileged area on the outskirts of Buenos Aires affected by quarantine rules. I was asked for bribe to make 2014 World Cup squad
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L'international tunisien Hamdi Nagguez ne sera pas lib�r� cette semaine. Le tribunal de premi�re instance de Sousse a rejet� la demande formul�e par les avocats du joueur pour le lib�rer. ......

A l'instar de tous les pays dans le monde affect�s par la pand�mie Covid-19, Madagascar conna�tra �galement une r�cession �conomique. ......

Alger -Le nombre de fonctionnaires...

Irrfan Khan, a veteran character actor in Bollywood movies and one of India’s best-known exports to Hollywood, has died. He was 54.Khan played the police ...

ISLAMABAD: The Petroleum Division has admitted that it has violated the marginal gas policy guidelines 2013, and the terms of reference set by directorate general petroleum concessions , while...

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ISLAMABAD: The Petroleum Division has admitted that it has violated the marginal gas policy guidelines 2013, and the terms of reference set by directorate general petroleum concessions , while...

[[ This is a content summary only. Visit my website for full links, other content, and more! ]]

ISLAMABAD: The Petroleum Division has admitted that it has violated the marginal gas policy guidelines 2013, and the terms of reference set by directorate general petroleum concessions , while...

[[ This is a content summary only. Visit my website for full links, other content, and more! ]]

ISLAMABAD: The National Accountability Bureau Multan has sent a questionnaire to Opposition Leader in the National Assembly and President PML-N Shahbaz Sharif, ex-minister of state Balighur Rehman,...

[[ This is a content summary only. Visit my website for full links, other content, and more! ]]

ISLAMABAD: The National Accountability Bureau Multan has sent a questionnaire to Opposition Leader in the National Assembly and President PML-N Shahbaz Sharif, ex-minister of state Balighur Rehman, former MNA Chaudhry Umair Mehmood and former law minister Punjab Rana Sanaullah Khan in the matter...

ISLAMABAD: The National Accountability Bureau Multan has sent a questionnaire to Opposition Leader in the National Assembly and President PML-N Shahbaz Sharif, ex-minister of state Balighur Rehman, former MNA Chaudhry Umair Mehmood and former law minister Punjab Rana Sanaullah Khan in the matter...

Title: Study Links Menopausal Night Sweats to Impaired Thinking
Category: Health News
Created: 9/25/2019 12:00:00 AM
Last Editorial Review: 9/25/2019 12:00:00 AM

Drivers with blood-alcohol levels below legal limits cause 15% of all crash deaths that involve alcohol, a study in the March issue of the American Journal of Preventive Medicine finds.

Growing evidence indicates that oxidative and endoplasmic reticular stress, which trigger changes in ion channels and inflammatory pathways that may undermine cellular homeostasis and survival, are critical determinants of injury in the diabetic kidney. Cells are normally able to mitigate these cellular stresses by maintaining high levels of autophagy, an intracellular lysosome-dependent degradative pathway that clears the cytoplasm of dysfunctional organelles. However, the capacity for autophagy in both podocytes and renal tubular cells is markedly impaired in type 2 diabetes, and this deficiency contributes importantly to the intensity of renal injury. The primary drivers of autophagy in states of nutrient and oxygen deprivation—sirtuin-1 (SIRT1), AMP-activated protein kinase (AMPK), and hypoxia-inducible factors (HIF-1α and HIF-2α)—can exert renoprotective effects by promoting autophagic flux and by exerting direct effects on sodium transport and inflammasome activation. Type 2 diabetes is characterized by marked suppression of SIRT1 and AMPK, leading to a diminution in autophagic flux in glomerular podocytes and renal tubules and markedly increasing their susceptibility to renal injury. Importantly, because insulin acts to depress autophagic flux, these derangements in nutrient deprivation signaling are not ameliorated by antihyperglycemic drugs that enhance insulin secretion or signaling. Metformin is an established AMPK agonist that can promote autophagy, but its effects on the course of CKD have been demonstrated only in the experimental setting. In contrast, the effects of sodium-glucose cotransporter–2 (SGLT2) inhibitors may be related primarily to enhanced SIRT1 and HIF-2α signaling; this can explain the effects of SGLT2 inhibitors to promote ketonemia and erythrocytosis and potentially underlies their actions to increase autophagy and mute inflammation in the diabetic kidney. These distinctions may contribute importantly to the consistent benefit of SGLT2 inhibitors to slow the deterioration in glomerular function and reduce the risk of ESKD in large-scale randomized clinical trials of patients with type 2 diabetes.

A time course experiment is a widely used design in the study of cellular processes such as differentiation or response to stimuli. In this paper, we propose time course regulatory analysis (TimeReg) as a method for the analysis of gene regulatory networks based on paired gene expression and chromatin accessibility data from a time course. TimeReg can be used to prioritize regulatory elements, to extract core regulatory modules at each time point, to identify key regulators driving changes of the cellular state, and to causally connect the modules across different time points. We applied the method to analyze paired chromatin accessibility and gene expression data from a retinoic acid (RA)–induced mouse embryonic stem cells (mESCs) differentiation experiment. The analysis identified 57,048 novel regulatory elements regulating cerebellar development, synapse assembly, and hindbrain morphogenesis, which substantially extended our knowledge of cis-regulatory elements during differentiation. Using single-cell RNA-seq data, we showed that the core regulatory modules can reflect the properties of different subpopulations of cells. Finally, the driver regulators are shown to be important in clarifying the relations between modules across adjacent time points. As a second example, our method on Ascl1-induced direct reprogramming from fibroblast to neuron time course data identified Id1/2 as driver regulators of early stage of reprogramming.

Self-made millionaire David Bach says not buying a home is the single biggest mistake millennials (who were born between 1980 and 2000) are making.

Staff of the magazine that kicked off the French New Wave say its new elite owners pose a threat to editorial independence

The mass resignation of the staff of Cahiers du Cinéma, the film journal that launched the French New Wave, has reignited debate in France about the possibility of critical independence in a society whose major stakeholders frequently operate in several spheres.

On Thursday, the 15 staff writers and editors announced their resignation, saying they believed its new owners posed a threat to the magazine’s cherished independence.

A visually-impaired passenger died after falling from a station platform in south-east London and being hit by a train, accident investigators have said.

Classic casual games such as Solitaire, sudoku, crossword puzzles and pinball live on smartphones and tablets as the mobile gaming audience expands.

'This has made the lockdown worthwhile'

As a new drama about the 'most British crime of all time' arrives on ITV, here's a reminder of Charles and Diana Ingram's notorious quiz show appearance and their trial for conspiring to cheat

Whether or not the Ingrams were cheating on 'Who Wants to Be a Millionaire?', the resulting outrage was rooted in the same dynamics that have come to dominate social discourse in the years since, says Adam White

As 'Quiz', James Graham's dramatisation of the 'Who Wants to Be a Millionaire?' coughing scandal, airs to rave reviews in the UK, Clémence Michallon explores the game show's turbulent history in the US

Test your knowledge

As ITV's three-part miniseries Quiz recreates Ingram's scandalous quiz show victory – are you able to get all the the answers right without cheating?

Subject of new drama 'Quiz' has been enjoying the spotlight since the show aired on ITV

Sanctuary owner has avoided the media after revealing she was unhappy with how she was portrayed on the show

Tesla CEO is back on Joe Rogan's podcast

Beckham is also sacrificing her own pay

Rapper and fashion designer Kanye West is officially a billionaire, according to Forbes Magazine.

The star, who also appeared in Jurassic World, died after being hospitalised with a colon infection

David, who was born in Nigeria but has a British passport, owns two companies and also shares a CBD (cannabidiol) business with former heavyweight boxing champion Mike Tyson.

British billionaire Alki David remains interested in securing the naming rights deal for Barcelona's Camp Nou stadium with his cannabis company and claims he could bring 'great ideas' to the Catalan club, before revealing plans to 'clone his wife'.

Billionaire property developer Huang Xiangmo publishes a lengthy and scathing attack at the ATO, which is pursuing him over a $141 million tax bill, and ASIO, which revoked his permanent residency.

Même si sa carrière n’est pas encore terminée, le quart-arrière des Colts a accepté le poste d’entraîneur-chef d’une école secondaire de l’Alabama.

MLB stadiums without fans would be like playing in a giant television studio. TV executives offer ideas on reinventing baseball as entertainment.

First-generation headsets helped magnify objects for people with impaired vision, but they also prompted motion sickness. A redesign is aimed at fixing this, but problems persist as patients adjust.
Medscape Medical News

Il aurait incendié des tours de télécom avec sa blonde.

Au fil des ans, j’ai eu le privilège de discuter avec plusieurs militaires et anciens combattants.

Pour répondre aux inquiétudes liées au retour en classe imminent, la fondation Jasmin Roy a créé un groupe de 20 spécialistes.

Cette semaine, on découvre les produits du Québec qui s’inscrivent dans les tendances alimentaires de l’année.

La moitié des jeunes adultes vivent une anxiété profonde et présentent des symptômes de dépression depuis le début de la crise sanitaire.

Des observations indiquent qu’une forte proportion des patients touchés par la COVID-19 présentent des atteintes au cœur et aux vaisseaux sanguins.

English Premier League players are coming under fire for not taking a pay cut during the coronavirus pandemic, but the players association argues cutting player salaries could do more harm than good.

Madison Prespakis of Carlton is named the winner of the 2020 AFL Women's Best and Fairest award, and Isabell Huntington takes out the rising star award.