Botswana FA's president, Tariq Babitseng, is confident that South African coach Morena Ramoreboli will guide the Zebras back to the Africa Cup of Nations, where they have been absent for 12 years.

‘Zebra’, starring ‘Daali’ Dhananjaya and Satyadev, is directed by Eashvar Karthic

The White House sides with Israel's ground assault of Lebanon while much of the world calls for a ceasefire. / Al Jazeera

Meanwhile, Iran is said to be preparing to launch a ballistic-missile attack. / The Wall Street Journal [+]

A long profile of Ta-Nehisi Coates, whose new book criticizes Israel and the corrupting influence of power. "I'm sad, but I was so enraged." / New York Magazine

Things to watch for in tonight's Vance-Walz debate. / Wake Up to Politics

Helene slamming a small town in North Carolina may disrupt the global supply chain for microchips. / NPR

A nuclear plant in Michigan will be the first in US history to restart. / CNBC

Your weekly white paper: "A systematic review about similarities in dog-human dyads." / Science Direct

A fascinating survey of how religious believers are using new technologies in their daily practices. / rest of world

An audio dive into Google's new niche product Notebook, which can turn a bunch of PDFs into a convincing podcast. / The New York Times [+]

See also: Barry C. Lynn on "Liberal democracy's last stand against Big Tech." / Harper's

From July, have you seen the trend of new books using multi-panel illustrations on their covers? They're called "bento books." / I Need a Book Cover

A celebrated new short story collection is about "people who just can't hang." / The New Yorker

Also, have you noticed worse service at restaurants lately? For the sake of society, that might be a good thing. / Economist Writing Every Day

See also: Britain experiences a rise in "zebra striping," where pub patrons alternate between alcoholic and non-alcoholic beer. / Semafor

Japan's smaller museums are praised for their elegance. / The Wall Street Journal [+]

Photographs of Japanese forests shimmering with fireflies. / Colossal

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Teaching advanced programming can be a challenge, especially when the students are pursuing different majors with diverse analytical and problem-solving capabilities. The purpose of this paper is to explore the efficacy of using a particular problem as a vehicle for imparting a broad set of programming concepts and problem-solving techniques. We present a classic brain teaser that is used to communicate and demonstrate advanced software development concepts and techniques. Our results show that students with varied academic experiences and goals, assuming at least one procedural/structured programming pre-requisite, can benefit from and also be challenged by such an exercise. Although this problem has been used by others in the classroom, we believe that our use of this problem in imparting such a broad range of topics to a diverse student population is unique.

The snack cakes join the company's other outside items, including Big Pack Swiss Rolls and Big Pack Oatmeal Creme Pies.

Improving the environment is more easily achieved by providing added life force energy rather than chemically intervening within the complexity of damaged ecosystems. An example is the reduction of zebra mussels in Big Spirit Lake, Iowa, using KELEA.

Valid Through: 4/30/2015
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Zebra Patterns: Every Mirrorless Photographer Needs Them. Most Sony Alpha Mirrorlesss Cameras have the option...

The post Zebra Patterns: Every Mirrorless Photographer Needs Them! appeared first on Alphatracks.

Zebra Technologies Corporation has announced that I.D.E.A. S.r.l. (Intelligent Development Engineered Applications), the Italian partner company of M.O.S.A.I.C. (Motion System and Information Control), has selected Zebra to drive efficiency and productivity in its quality assurance inspection process.

Zebra Technologies Corporation – the digital solution provider enabling businesses to intelligently connect data, assets and people – has introduced a series of advanced AI features enhancing its Aurora machine vision software to provide deep learning capabilities for complex visual inspection use cases.

Established in 1862 as an engineering file manufacturer trading from premises in Redditch, the Monks & Crane Industrial Group distributes products such as cutting tools, oils and lubrication, PPE products, fasteners, machine tools and office supplies as well as soldering and welding goods to its extensive customer base operating within a wide variety of industries including aerospace and engineering. 

Zebra Technologies Corporation, the digital solution provider, will demonstrate end-to-end AI machine vision solutions at VISION 2024 from 8-10 October in Stuttgart, Germany.   

A new collection of semi-opaque fashion tights by MusicLegs®.

Semi-opaque fashion patterned tights in contrasting zebra stripes.

A new collection of camisette set by Elegant Moments®.

Distinctive zebra print camisette with attached garters. Comes with matching g-string and stockings. 3-piece set.

Thermal proteome profiling (TPP) allows for the unbiased detection of drug – target protein engagements in vivo. Traditionally, one cell type is used for TPP studies, with the risk of missing important differentially expressed target proteins. The use of whole organisms would circumvent this problem. Zebrafish embryos are amenable to such an approach. Here, we used TPP on whole zebrafish embryo lysate to identify protein targets of napabucasin, a compound that may affect Signal transducer and activator of transcription 3 (Stat3) signaling through an ill-understood mechanism. In zebrafish embryos, napabucasin induced developmental defects consistent with inhibition of Stat3 signaling. TPP profiling showed no distinct shift in Stat3 upon napabucasin treatment, but effects were detected on the oxidoreductase, Pora, which might explain effects on Stat3 signaling. Interestingly, thermal stability of several aldehyde dehydrogenases (Aldhs) was affected. Moreover, napabucasin activated ALDH enzymatic activity in vitro. Aldhs have crucial roles in retinoic acid metabolism and functionally we validated napabucasin-mediated activation of the retinoic acid pathway in zebrafish in vivo. We conclude that TPP profiling in whole zebrafish embryo lysate is feasible and facilitates direct correlation of in vivo effects of small molecule drugs with their protein targets.

VOLUME 289 (2014) PAGES 6604–6618In Fig. 4G, in the foxi1 panel, the images in Fig. 4G, i and l, corresponding to “smad1 MO” and “smad5 MO + samd1/9 mRNA” samples, respectively, were inadvertently reused during figure preparation. This error has now been corrected using images pertaining to each treatment and sample. This correction does not affect the results or conclusions of the work.jbc;295/52/18650/F4F1F4Figure 4G.

In Bostwana's Makgadikgadi Pans, researcher James Bradley studies how the zebras travel across the great expanse of land

OMers teaching Roma street kids how to read and write reward them for their hard work with a day at the zoo.

Over the past decades the zebrafish has emerged as an excellent model organism with which to study the biology of all glial cell types in nervous system development, plasticity, and regeneration. In this review, which builds on the earlier work by Lyons and Talbot in 2015, we will summarize how the relative ease to manipulate the zebrafish genome and its suitability for intravital imaging have helped understand principles of glial cell biology with a focus on oligodendrocytes, microglia, and astrocytes. We will highlight recent findings on the diverse properties and functions of these glial cell types in the central nervous system and discuss open questions and future directions of the field.

medlinkZebrafish/medlink exhibits a crucial role in the fields of solid organ preservation and transplantation, especially with respect to experimental transplantation efforts.

Zebra Technologies has expanded its India presence this year, particularly in sales and support functions to serve the growing demand

Metal may play sleep role through an enzyme responsible for synthesis of norepinephrine

For the first time in more than 15 years zebras will graze the fields at the Smithsonian Conservation Biology Institute in Front Royal, Va. Three […]

The post Rare Zebras graze at Smithsonian appeared first on Smithsonian Insider.

Photographer Frank Liu captured photographs of a polka-dotted zebra in Kenya that ended up published in National Geographic.

From their smart stripes to the power of their kicks, behold the wonders of zebras.

Circus animal gets away from handlers, causes a stir during rush hour.

LevaData can bring Zebra Technologies growth through digitization and AI enablement

We design and implement the first private and anonymous decentralized crowdsourcing system ZebraLancer, and overcome two fundamental challenges of decentralizing crowdsourcing, i.e., data leakage and identity breach.

First, our outsource-then-prove methodology resolves the tension between the blockchain transparency and the data confidentiality to guarantee the basic utilities/fairness requirements of data crowdsourcing, thus ensuring: (i) a requester will not pay more than what data deserve, according to a policy announced when her task is published via the blockchain; (ii) each worker indeed gets a payment based on the policy, if he submits data to the blockchain; (iii) the above properties are realized not only without a central arbiter, but also without leaking the data to the open blockchain. Second, the transparency of blockchain allows one to infer private information about workers and requesters through their participation history. Simply enabling anonymity is seemingly attempting but will allow malicious workers to submit multiple times to reap rewards. ZebraLancer also overcomes this problem by allowing anonymous requests/submissions without sacrificing accountability. The idea behind is a subtle linkability: if a worker submits twice to a task, anyone can link the submissions, or else he stays anonymous and unlinkable across tasks. To realize this delicate linkability, we put forward a novel cryptographic concept, i.e., the common-prefix-linkable anonymous authentication. We remark the new anonymous authentication scheme might be of independent interest. Finally, we implement our protocol for a common image annotation task and deploy it in a test net of Ethereum. The experiment results show the applicability of our protocol atop the existing real-world blockchain.

Tom Wolfe has announced the release of Automaton for Zebra, a collection of 100 lo-fi robotic-style patches for the Zebra2 software synthesizer by u-he. Inspired by scores such as Tron: Legacy and Mr. Robot, Automaton is full of patches brimming with gritty, bit-crushed character. From crunchy percussion and tearing sequences, to crushed pads and soaring […]

The post Tom Wolfe releases Automaton soundset for u-he Zebra synth appeared first on rekkerd.org.

I work at the Pennsylvania Center for the Book and a new book of poetry by local author Marjorie Maddox came across my desk recently. The title immediately caught my attention: “A Crossing of Zebras: Animal Packs in Poetry.” I thought, collective nouns and poetry? What a great idea! I'm a former elementary school teacher. So, I immediately started thinking about all the possibilities for this book in the classroom. Learning about collective nouns, words that describe groups of animals, individuals, or things is often part of the curriculum. When I wanted a fun way to help children understand the concept of collective nouns, I used to use a book by Ruth Heller called “A Cache of Jewels and Other Collective Nouns.” That book just gives you a page with one word, the collective noun, and a simple illustration. So, you can imagine my delight at discovering Marjorie Maddox’s entertaining poems, along with Philip Huber's imaginative scratchboard artwork. This book takes Heller's idea a step

Many trans people have never been able to trust or access public toilets, even if they are present and unoccupied, and excluding trans people from bathroom use is currently a mainstream political stance. I was disappointed to see this not addressed in the article. I'll continue to hope (while also cynically doubting, I contain multitudes) that we will use the societal changes required by the pandemic to benefit everyone, rather than re-creating the previous dysfunction.

Prominins (proms) are transmembrane glycoproteins conserved throughout the animal kingdom. They are associated with plasma membrane protrusions, such as primary cilia, as well as extracellular vesicles derived thereof. Primary cilia host numerous signaling pathways affected in diseases known as ciliopathies. Human PROM1 (CD133) is detected in both somatic and cancer stem cells and is also expressed in terminally differentiated epithelial and photoreceptor cells. Genetic mutations in the PROM1 gene result in retinal degeneration by impairing the proper formation of the outer segment of photoreceptors, a modified cilium. Here, we investigated the impact of proms on two distinct examples of ciliogenesis. First, we demonstrate that the overexpression of a dominant-negative mutant variant of human PROM1 (i.e. mutation Y819F/Y828F) significantly decreases ciliary length in Madin–Darby canine kidney cells. These results contrast strongly to the previously observed enhancing effect of WT PROM1 on ciliary length. Mechanistically, the mutation impeded the interaction of PROM1 with ADP-ribosylation factor–like protein 13B, a key regulator of ciliary length. Second, we observed that in vivo knockdown of prom3 in zebrafish alters the number and length of monocilia in the Kupffer's vesicle, resulting in molecular and anatomical defects in the left-right asymmetry. These distinct loss-of-function approaches in two biological systems reveal that prom proteins are critical for the integrity and function of cilia. Our data provide new insights into ciliogenesis and might be of particular interest for investigations of the etiologies of ciliopathies.

Prominins (proms) are transmembrane glycoproteins conserved throughout the animal kingdom. They are associated with plasma membrane protrusions, such as primary cilia, as well as extracellular vesicles derived thereof. Primary cilia host numerous signaling pathways affected in diseases known as ciliopathies. Human PROM1 (CD133) is detected in both somatic and cancer stem cells and is also expressed in terminally differentiated epithelial and photoreceptor cells. Genetic mutations in the PROM1 gene result in retinal degeneration by impairing the proper formation of the outer segment of photoreceptors, a modified cilium. Here, we investigated the impact of proms on two distinct examples of ciliogenesis. First, we demonstrate that the overexpression of a dominant-negative mutant variant of human PROM1 (i.e. mutation Y819F/Y828F) significantly decreases ciliary length in Madin–Darby canine kidney cells. These results contrast strongly to the previously observed enhancing effect of WT PROM1 on ciliary length. Mechanistically, the mutation impeded the interaction of PROM1 with ADP-ribosylation factor–like protein 13B, a key regulator of ciliary length. Second, we observed that in vivo knockdown of prom3 in zebrafish alters the number and length of monocilia in the Kupffer's vesicle, resulting in molecular and anatomical defects in the left-right asymmetry. These distinct loss-of-function approaches in two biological systems reveal that prom proteins are critical for the integrity and function of cilia. Our data provide new insights into ciliogenesis and might be of particular interest for investigations of the etiologies of ciliopathies.

Prominins (proms) are transmembrane glycoproteins conserved throughout the animal kingdom. They are associated with plasma membrane protrusions, such as primary cilia, as well as extracellular vesicles derived thereof. Primary cilia host numerous signaling pathways affected in diseases known as ciliopathies. Human PROM1 (CD133) is detected in both somatic and cancer stem cells and is also expressed in terminally differentiated epithelial and photoreceptor cells. Genetic mutations in the PROM1 gene result in retinal degeneration by impairing the proper formation of the outer segment of photoreceptors, a modified cilium. Here, we investigated the impact of proms on two distinct examples of ciliogenesis. First, we demonstrate that the overexpression of a dominant-negative mutant variant of human PROM1 (i.e. mutation Y819F/Y828F) significantly decreases ciliary length in Madin–Darby canine kidney cells. These results contrast strongly to the previously observed enhancing effect of WT PROM1 on ciliary length. Mechanistically, the mutation impeded the interaction of PROM1 with ADP-ribosylation factor–like protein 13B, a key regulator of ciliary length. Second, we observed that in vivo knockdown of prom3 in zebrafish alters the number and length of monocilia in the Kupffer's vesicle, resulting in molecular and anatomical defects in the left-right asymmetry. These distinct loss-of-function approaches in two biological systems reveal that prom proteins are critical for the integrity and function of cilia. Our data provide new insights into ciliogenesis and might be of particular interest for investigations of the etiologies of ciliopathies.

The cerebellum influences motor control through Purkinje target neurons, which transmit cerebellar output. Such output is required, for instance, for larval zebrafish to learn conditioned fictive swimming. The output cells, called eurydendroid neurons (ENs) in teleost fish, are inhibited by Purkinje cells and excited by parallel fibers. Here, we investigated the electrophysiological properties of glutamatergic ENs labeled by the transcription factor olig2. Action potential firing and synaptic responses were recorded in current clamp and voltage clamp from olig2⁺ neurons in immobilized larval zebrafish (before sexual differentiation) and were correlated with motor behavior by simultaneous recording of fictive swimming. In the absence of swimming, olig2⁺ ENs had basal firing rates near 8 spikes/s, and EPSCs and IPSCs were evident. Comparing Purkinje firing rates and eurydendroid IPSC rates indicated that 1-3 Purkinje cells converge onto each EN. Optogenetically suppressing Purkinje simple spikes, while preserving complex spikes, suggested that eurydendroid IPSC size depended on presynaptic spike duration rather than amplitude. During swimming, EPSC and IPSC rates increased. Total excitatory and inhibitory currents during sensory-evoked swimming were both more than double those during spontaneous swimming. During both spontaneous and sensory-evoked swimming, the total inhibitory current was more than threefold larger than the excitatory current. Firing rates of ENs nevertheless increased, suggesting that the relative timing of IPSCs and EPSCs may permit excitation to drive additional eurydendroid spikes. The data indicate that olig2⁺ cells are ENs whose activity is modulated with locomotion, suiting them to participate in sensorimotor integration associated with cerebellum-dependent learning.

SIGNIFICANCE STATEMENT The cerebellum contributes to movements through signals generated by cerebellar output neurons, called eurydendroid neurons (ENs) in fish (cerebellar nuclei in mammals). ENs receive sensory and motor signals from excitatory parallel fibers and inhibitory Purkinje cells. Here, we report electrophysiological recordings from ENs of larval zebrafish that directly illustrate how synaptic inhibition and excitation are integrated by cerebellar output neurons in association with motor behavior. The results demonstrate that inhibitory and excitatory drive both increase during fictive swimming, but inhibition greatly exceeds excitation. Firing rates nevertheless increase, providing evidence that synaptic integration promotes cerebellar output during locomotion. The data offer a basis for comparing aspects of cerebellar coding that are conserved and that diverge across vertebrates.

Christine Elizabeth Cooper, Laura Leilani Hurley, Pierre Deviche, and Simon Charles Griffith

Desert birds inhabit hot, dry environments that are becoming hotter and drier as a consequence of climate change. Extreme weather such as heatwaves can cause mass-mortality events that may significantly impact populations and species. There are currently insufficient data concerning physiological plasticity to inform models of species’ response to extreme events and develop mitigation strategies. Consequently, we examine here the physiological plasticity of a small desert bird in response to hot (mean maximum ambient temperature=42.7°C) and cooler (mean maximum ambient temperature=31.4°C) periods during a single Austral summer. We measured body mass, metabolic rate, evaporative water loss, and body temperature, along with blood parameters (corticosterone, glucose, and uric acid) of wild zebra finches (Taeniopygia guttata; Gould 1837) to assess their physiological state and determine the mechanisms by which they respond to heatwaves. Hot days were not significant stressors; they did not result in modification of baseline blood parameters or an inability to maintain body mass, provided drinking water was available. During heatwaves, finches shifted their thermoneutral zone to higher temperatures. They reduced metabolic heat production, evaporative water loss and wet thermal conductance, and increased hyperthermia, especially when exposed to high ambient temperature. A consideration of the significant physiological plasticity that we have demonstrated to achieve more favourable heat and water balance is essential for effectively modelling and planning for the impacts of climate change on biodiversity.

Progression from the initial vascular response upon hyperglycemia to a proliferative stage with neovacularizations is the hallmark of proliferative diabetic retinopathy. Here, we report on the novel diabetic pdx1^–/– zebrafish mutant as a model for diabetic retinopathy that lacks the transcription factor pdx1 through CRISPR-Cas9–mediated gene knockout leading to disturbed pancreatic development and hyperglycemia. Larval pdx1^–/– mutants prominently show vasodilation of blood vessels through increased vascular thickness in the hyaloid network as direct developmental precursor of the adult retinal vasculature in zebrafish. In adult pdx1^–/– mutants, impaired glucose homeostasis induces increased hyperbranching and hypersprouting with new vessel formation in the retina and aggravation of the vascular alterations from the larval to the adult stage. Both vascular aspects respond to antiangiogenic and antihyperglycemic pharmacological interventions in the larval stage and are accompanied by alterations in the nitric oxide metabolism. Thus, the pdx1^–/– mutant represents a novel model to study mechanisms of hyperglycemia-induced retinopathy wherein extensive proangiogenic alterations in blood vessel morphology and metabolic alterations underlie the vascular phenotype.

Nayeli G. Reyes-Nava, Hung-Chun Yu, Curtis R. Coughlin II, Tamim H. Shaikh, and Anita M. Quintana

We used whole-exome sequencing (WES) to determine the genetic etiology of a patient with a multi-system disorder characterized by a seizure phenotype. WES identified a heterozygous de novo missense mutation in the GABRA1 gene (c.875C>T). GABRA1 encodes the alpha subunit of the gamma-aminobutyric acid receptor A (GABA_AR). The GABA_AR is a ligand gated ion channel that mediates the fast inhibitory signals of the nervous system, and mutations in the subunits that compose the GABA_AR have been previously associated with human disease. To understand the mechanisms by which GABRA1 regulates brain development, we developed a zebrafish model of gabra1 deficiency. gabra1 expression is restricted to the nervous system and behavioral analysis of morpholino injected larvae suggests that the knockdown of gabra1 results in hypoactivity and defects in the expression of other subunits of the GABA_AR. Expression of the human GABRA1 protein in morphants partially restored the hypomotility phenotype. In contrast, the expression of the c.875C>T variant did not restore these behavioral deficits. Collectively, these results represent a functional approach to understand the mechanisms by which loss-of-function alleles cause disease.

This photograph was taken at Nairobi National Park, which is located just four miles south of the city’s urban center.

Researchers at the International Centre of Insect Physiology and Ecology have developed a zebra-smelling cattle collar which will be tested on Masai herds subject to the biting tsetse fly,

Half a century ago zebras were hunted to extinction in the region, now the area is being rewilded and the zebras are leading the charge.

She's a successful actress and a doting mother-of-two.

The zebra, joined by two horses, had escaped from a zoo in Ormesson-sur-Marne after the gate to its enclosure was left open on Friday evening. The animal ran on the road alongside moving traffic.

Demi Lovato made a splash in a zebra strip top as she arrived at her church in Beverly Hills. She was joined by celebrities including Justin and Hailey Bieber and Lana Del Rey.

The singer, 29, teased a hint of her toned abs in a knitted purple tartan vest as she supported her BFF Vas J Morgan TINGS Magazine X Topman dinner on Thursday.