Solomon Ball stole a pass and took it all the way for a transition dunk to extend the Connecticut Huskies' lead over the Le Moyne Dolphins.

Check out the greatest moments and plays in this matchup between the Le Moyne Dolphins and the Connecticut Huskies.

Many people say that the Republican infighting over Kevin McCarthy's election as Speaker of the House is embarrassing and demonstrates a lack of governing ability. I say: more squabbling please!

The House should be raucous. Why should everything be politely settled behind closed doors? No! We need more public fighting among our elected officials, not less. Americans have major disagreements with each other, and the best way to sort them out is through politics. Let's have them yell and scream and argue with each other in public until someone wins.

Any bodybuilders famous or otherwise who have glaucoma or R glaucoma suspect? Before you go TLDR (too long didn't read)...you might find all of this interesting in terms of prevention.... or help if you have glaucoma or are like me "a glaucoma suspect".... at the end, there's more positive...

The National Association of Legislative Information Technology (NALIT) will be sharing "Web Tips, Tricks and Techniques" for building Legislative RSS feeds at their 2004 Professional Development Seminar in beautiful Burlington, Vermont, September 8-11, 2004. Panelists include key IT players from Virginia, Nevada, and Utah. Several states are now using RSS to provide users with notices of new Web content or to distribute newsletters. At least two states are now generating legislative feeds directly from databases. This article previews some of what they'll be showing from the states of Texas, Utah, Wisconsin, and Rhode Island.

This paper reports on the Joaquim Nabuco Project, a pioneering work in Latin America on document digitalization, enhancement, compression, indexing, retrieval and network transmission of historical document images.

Trump va nommer les "faucons" Rubio et Waltz à la tête de la politique étrangère (rapports)

Alex Karaban scored 25 points, Stephon Castle added 17 and the Huskies never were challenged on the way to leading the Hoyas by as many as 26 in the first half while stretching their winning streak to 12 games with the 89-64 victory. It was UConn's largest win against Georgetown in the schools' 74 meetings.

Kelsey Ransom scored 14 points to lead sixth-seeded Georgetown to a 55-46 upset of No. 21 Creighton in the Big East Tournament semifinals.

Paige Bueckers scored 27 points and had five blocks to help No. 10 UConn beat Georgetown 78-42 on Monday night to win its 22nd Big East Tournament title.

3A Composites USA announced that its ALUCOBOND FaceFastened system successfully passed third-party NFPA 285 testing on a wood-framed assembly, which is commonly used in low-rise, multifamily and mixed-use market segments.

Diabetes affects more than 425 million people globally (Source: International Diabetes Federation) and today’s World Diabetes Day provides food and beverage businesses with an opportunity to consider what more they can do to support global efforts to tackle Type II diabetes.

Trucor Refined is a PVC-free flooring collection that combines rigid core and laminate for those who prefer an environmentally friendly, waterproof, durable and luxurious floor that is easy to install and maintain.

Glucose-6-phosphate dehydrogenase (G6PD) is the first enzyme in the pentose phosphate pathway. It has been extensively studied by biochemical and structural techniques. 13 X-ray crystal structures and five electron cryo-microscopy structures in the PDB are focused on in this topical review. Two F420-dependent glucose-6-phosphate dehydrogenase (FGD) structures are also reported. The significant differences between human and parasite G6PDs can be exploited to find selective drugs against infections such as malaria and leishmaniasis. Furthermore, G6PD is a prognostic marker in several cancer types and is also considered to be a tumour target. On the other hand, FGD is considered to be a target against Mycobacterium tuberculosis and possesses a high biotechnological potential in biocatalysis and bioremediation.

β-Glucosidase from the thermophilic bacterium Caldicellulosiruptor saccharo­lyticus (Bgl1) has been denoted as having an attractive catalytic profile for various industrial applications. Bgl1 catalyses the final step of in the decomposition of cellulose, an unbranched glucose polymer that has attracted the attention of researchers in recent years as it is the most abundant renewable source of reduced carbon in the biosphere. With the aim of enhancing the thermostability of Bgl1 for a broad spectrum of biotechnological processes, it has been subjected to structural studies. Crystal structures of Bgl1 and its complex with glucose were determined at 1.47 and 1.95 Å resolution, respectively. Bgl1 is a member of glycosyl hydrolase family 1 (GH1 superfamily, EC 3.2.1.21) and the results showed that the 3D structure of Bgl1 follows the overall architecture of the GH1 family, with a classical (β/α)8 TIM-barrel fold. Comparisons of Bgl1 with sequence or structural homologues of β-glucosidase reveal quite similar structures but also unique structural features in Bgl1 with plausible functional roles.

The multimedia solutions provider, MuConvert, has recently accounted for the big sale for the upcoming 2022 Christmas, which reaches up to 50% OFF! Take this opportunity to purchase MuConvert products with great benefits!

Eye Candy, Inc. adds Digital Vision's 2013 rev2 grading and mastering suite, including ACES (ST 2065-1-2012)

When music can transform your mode or any ambiance with its melody & magic, the new version of MuConverter Spotify Music Converter is set to give you a revolutionary experience in your offline listening.

Now Amazon users will get a significant relief as they can download music from Amazon Music Prime using MuConvert Amazon Music Converter effortlessly at 10x fast speed keeping the original sound quality intact after conversion.

Heavily inspired by cumbia, the London-based band has a straightforward ethos: have fun.

Learn more about sponsor message choices: podcastchoices.com/adchoices

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TORONTO, ON - Hummingbird metabolism is a marvel of evolutionary engineering. These tiny birds can power all of their energetic hovering flight by burning the sugar contained in the floral nectar of their diet. Now new research from the University of Toronto Scarborough shows they are equally adept at burning both glucose and fructose, which […]

Acucote, a solutions-oriented pressure-sensitive adhesive coating manufacturer, has introduced WOff, a Wash Off Adhesive, a water-based formula that provides debonding of non-recyclable label materials from PET and glass containers, making them recoverable. 

The pioneering leap the two independent businesses took was developing a novel pulp fiber made with a mix of Curran®, bamboo, and bagasse.

This story explores recent innovations making produce packaging more eco-friendly. But first, let's take a broader look at the produce packaging market.

Unexpected increase in consumer demand

Commercial Changes / Commercial viability

Conformance of ITU-T H.810 personal health system: Personal Health Devices interface Part 10D: Transcoding for Bluetooth Low Energy: Personal Health Gateway - Glucose meter

Conformance of ITU-T H.810 personal health system: Personal Health Devices interface Part 10G: Transcoding for Bluetooth Low Energy: Personal Health Gateway - Continuous glucose monitoring

Conformance of ITU-T H.810 personal health system: Personal Health Devices interface Part 10G: Transcoding for Bluetooth Low Energy: Personal Health Gateway - Continuous glucose monitoring

No se necesita instalar ninguna aplicación y se hace en un momento Leer

Aunque Google ofrece 15GB gratuitos, es fácil quedarse sin espacio Leer

Para cortarte el flequillo en casa debes tener cuidado si no quieres que acabe en un desastre. Con estos consejos y trucos seguro que no fallarás. Leer

En ocasiones, al sacar la ropa del armario no huele tan bien como debería. Con esta serie de trucos conseguirás que se mantenga siempre perfumada. Leer

Tuco Intelligent, a kids' personal care brand, has secured $2 million in seed funding led by Fireside Ventures and Whiteboard Capital. Founded by ex-Unilever executive Aishvarya Murali, Tuco offers natural and sustainable products for children. The brand emphasizes eco-friendly packaging using reclaimed ocean and landfill plastic.

¿Qué es el glaucoma?

En 6AM Hoy por hoy, el cantautor colombiano Chabuco presenta su nuevo sencillo ‘El Arcoíris’ y comparte detalles sobre su próximo show en el Teatro Colsubsidio.

Chabuco

Devlin Granberg, a former Denver Post all-stater at Holy Family in Broonfield, recently competed for Cisco, Texas, in the Alpine Bank Junior College Baseball World Series in Grand Junction.

Henry Barajas' Death To Pachuco , a Chicano noir set in the Zoot Suit Riots, is now live on Kickstarter

Myelination plays an important role in cognitive development and in demyelinating diseases like multiple sclerosis (MS), where failure of remyelination promotes permanent neuro-axonal damage. Modification of cell surface receptors with branched N-glycans coordinates cell growth and differentiation by controlling glycoprotein clustering, signaling, and endocytosis. GlcNAc is a rate-limiting metabolite for N-glycan branching. Here we report that GlcNAc and N-glycan branching trigger oligodendrogenesis from precursor cells by inhibiting platelet-derived growth factor receptor-α cell endocytosis. Supplying oral GlcNAc to lactating mice drives primary myelination in newborn pups via secretion in breast milk, whereas genetically blocking N-glycan branching markedly inhibits primary myelination. In adult mice with toxin (cuprizone)-induced demyelination, oral GlcNAc prevents neuro-axonal damage by driving myelin repair. In MS patients, endogenous serum GlcNAc levels inversely correlated with imaging measures of demyelination and microstructural damage. Our data identify N-glycan branching and GlcNAc as critical regulators of primary myelination and myelin repair and suggest that oral GlcNAc may be neuroprotective in demyelinating diseases like MS.

Mammalian Asn-linked glycans are extensively processed as they transit the secretory pathway to generate diverse glycans on cell surface and secreted glycoproteins. Additional modification of the glycan core by α-1,6-fucose addition to the innermost GlcNAc residue (core fucosylation) is catalyzed by an α-1,6-fucosyltransferase (FUT8). The importance of core fucosylation can be seen in the complex pathological phenotypes of FUT8 null mice, which display defects in cellular signaling, development, and subsequent neonatal lethality. Elevated core fucosylation has also been identified in several human cancers. However, the structural basis for FUT8 substrate specificity remains unknown.Here, using various crystal structures of FUT8 in complex with a donor substrate analog, and with four distinct glycan acceptors, we identify the molecular basis for FUT8 specificity and activity. The ordering of three active site loops corresponds to an increased occupancy for bound GDP, suggesting an induced-fit folding of the donor-binding subsite. Structures of the various acceptor complexes were compared with kinetic data on FUT8 active site mutants and with specificity data from a library of glycan acceptors to reveal how binding site complementarity and steric hindrance can tune substrate affinity. The FUT8 structure was also compared with other known fucosyltransferases to identify conserved and divergent structural features for donor and acceptor recognition and catalysis. These data provide insights into the evolution of modular templates for donor and acceptor recognition among GT-B fold glycosyltransferases in the synthesis of diverse glycan structures in biological systems.

Cellular energy demands are met by uptake and metabolism of nutrients like glucose. The principal transcriptional regulator for adapting glycolytic flux and downstream pathways like de novo lipogenesis to glucose availability in many cell types is carbohydrate response element–binding protein (ChREBP). ChREBP is activated by glucose metabolites and post-translational modifications, inducing nuclear accumulation and regulation of target genes. Here we report that ChREBP is modified by proline hydroxylation at several residues. Proline hydroxylation targets both ectopically expressed ChREBP in cells and endogenous ChREBP in mouse liver. Functionally, we found that specific hydroxylated prolines were dispensable for protein stability but required for the adequate activation of ChREBP upon exposure to high glucose. Accordingly, ChREBP target gene expression was rescued by re-expressing WT but not ChREBP that lacks hydroxylated prolines in ChREBP-deleted hepatocytes. Thus, proline hydroxylation of ChREBP is a novel post-translational modification that may allow for therapeutic interference in metabolic diseases.

Adult progenitor cell populations typically exist in a quiescent state within a controlled niche environment. However, various stresses or forms of damage can disrupt this state, which often leads to dysfunction and aging. We built a glucocorticoid (GC)-induced liver damage model of mice, found that GC stress induced liver damage, leading to consequences for progenitor cells expansion. However, the mechanisms by which niche factors cause progenitor cells proliferation are largely unknown. We demonstrate that, within the liver progenitor cells niche, Galectin-3 (Gal-3) is responsible for driving a subset of progenitor cells to break quiescence. We show that GC stress causes aging of the niche, which induces the up-regulation of Gal-3. The increased Gal-3 population increasingly interacts with the progenitor cell marker CD133, which triggers focal adhesion kinase (FAK)/AMP-activated kinase (AMPK) signaling. This results in the loss of quiescence and leads to the eventual stemness exhaustion of progenitor cells. Conversely, blocking Gal-3 with the inhibitor TD139 prevents the loss of stemness and improves liver function. These experiments identify a stress-dependent change in progenitor cell niche that directly influence liver progenitor cell quiescence and function.

Daphne E.C. Boer
Dec 23, 2020; 0:jlr.RA120001043v1-jlr.RA120001043
Research Articles