persistence EMP EMP Persistence Tour By www.RoomThirteen.com Published On :: Sun 11 Feb 2018 22:54:07 GMT We headed down to Kentish Town for the annual event that's heavy enough to challenge any venue's foundations. Full Article
persistence EMP Persistence Tour By www.RoomThirteen.com Published On :: Sun 11 Feb 2018 15:56:12 GMT No further details available. Full Article
persistence Holiness Requires Humility and Persistence By www.ancientfaith.com Published On :: 2024-03-04T15:00:00+00:00 Unless we are very careful, it is easy to fall prey to the temptation of defining holiness in ways that serve our preconceived notions, which may have very little to do with finding the healing of our souls by sharing more fully in the life of the Savior by grace. We often see righteousness through the lens of our own sensibilities about worldly divisions and disputes in ways that have more to do with serving our own passions than with serving the Lord. Today’s Scripture readings challenge us to wake up from such delusions and to see ourselves clearly before His infinite holiness. Full Article
persistence The Persistence of Reconciliation By www.ancientfaith.com Published On :: 2019-06-04T17:06:41+00:00 As we enter the week of celebrating our Lord's coming to earth, many of us will have family members visiting or we will be visiting them. For some, this means inevitable conflict. In this final episode of his series called Peace On Earth, Dn. Michael Hyatt addresses The Persistence of Reconciliation - what happens when you've tried everything? Full Article
persistence Devotion, Persistence, Endurance and Courage (Mark 15:43-16:8) By www.ancientfaith.com Published On :: 2015-05-16T02:16:45+00:00 Holy Myrrhbearers - Third Sunday of Pascha Full Article
persistence Persistence in Prayer By www.ancientfaith.com Published On :: 2016-12-04T06:05:45+00:00 Did Our Lord and God and Saviour Jesus Christ stop and turn round and attend to the two blind men? Did He open His door to them? No He did not! Did they get disheartened? No they did not! Did they give up? No they did not! Did the Lord tell them to spread the good news? No He did not! Were they obedient? No they were not! What about you? Are you persistent? (You're not?) Do you tell others the good news? (You don't?) Tut. Matthew 9: 27-35 Full Article
persistence Extended Object Languages for the Extolware Persistence Framework By Published On :: Full Article
persistence PersistF: A Transparent Persistence Framework with Architecture Applying Design Patterns By Published On :: Full Article
persistence Grit and Persistence: Findings from a Longitudinal Study of Student Performance By Published On :: 2019-06-16 Aim/Purpose: The purpose of this study was to examine whether grit was a contributing factor to student persistence and success at minority serving institutions. Background: A number of studies conducted in the past fifteen years have concluded that grit is a positive predictor of achievement across many domains. But, is grit really the ultimate panacea for student success? This longitudinal study sought to answer that question by specifically focusing on business students attending a mid-Atlantic minority-serving institution that primarily serves low-income and first generation learners. Methodology: The research study under consideration used quantitative methods for data collection and analysis. It was initiated in the Fall of 2014 with the administration of the standard 12-item Grit assessment to all freshmen students enrolled in a university business department. Students were then followed longitudinally over a five year period with GPA and persistence to graduation documented. During the analyses, grit score was compared to participant first year GPA’s as well as retention and persistence to graduation via comparison tables and ANOVAs. Contribution: A lack of substantive studies conducted at HBCUs and other minority serving institutions poses a major gap in the existing literature available on grit. A number of authors have put forth a call to action for faculty at minority serving institutions to conduct meaningful studies focused on grit and student persistence in order to better inform the HBCU community. This study is specifically purposed to help fill some of the gaps in the available literature. The results of the research presented in this paper hopefully shed light on the need to explore non-cognitive factors that may affect student performance. In particular, research should explore factors that may, or may not, contribute to the success of under prepared college students in particular those who are from low income, first generation, and minority groups. This form of exploration is part of a commitment to positive student outcomes. Findings: According to the findings, there is a significant positive correlation between higher grit scores and both GPA and persistence to graduation. First year GPA, however, was not found to be a reliable predictor of academic success. Recommendations for Practitioners: As part of a commitment to positive student outcomes, faculty and administrators in higher education must be constantly exploring factors that may, or may not, impact student success. Recommendation for Researchers: The results of this research help to shed light on the need to explore elements that may help to contribute to the success of under prepared college students in particular those who are from low income, first generation, and minority groups Future Research: The authors conclude that while building the grittiness of freshmen students may lead to positive student outcomes, grit alone might not be enough. In fact, they postulate that grittiness without clarity of purpose, positive self-efficacy, and growth mindset may mean that students who may be gritty may not be exerting their energies appropriately. During the next phase, a model that is currently under development will be used as part of a mindset intervention to edify students about grit, growth mindset, locus of control/self-efficacy, and clarity of purpose. A complimentary research study examining student performance and perceptions will also be conducted. Full Article
persistence Persistence of atoms in molecules: there is room beyond electron densities By journals.iucr.org Published On :: 2024-02-20 Evidence that the electronic structure of atoms persists in molecules to a much greater extent than has been usually admitted is presented. This is achieved by resorting to N-electron real-space descriptors instead of one- or at most two-particle projections like the electron or exchange-correlation densities. Here, the 3N-dimensional maxima of the square of the wavefunction, the so-called Born maxima, are used. Since this technique is relatively unknown to the crystallographic community, a case-based approach is taken, revisiting first the Born maxima of atoms in their ground state and then some of their excited states. It is shown how they survive in molecules and that, beyond any doubt, the distribution of electrons around an atom in a molecule can be recognized as that of its isolated, in many cases excited, counterpart, relating this fact with the concept of energetic promotion. Several other cases that exemplify the applicability of the technique to solve chemical bonding conflicts and to introduce predictability in real-space analyses are also examined. Full Article text
persistence Mediator Mark Rudy credits success to preparation, patience, persistence By www.littler.com Published On :: Wed, 27 Oct 2021 14:43:30 +0000 Keith A. Jacoby explains what makes Mark Rudy a good mediator. Daily Journal View (Subscription required.) Full Article
persistence Persistence and Strategic Effects By seclists.org Published On :: Thu, 15 Aug 2024 18:15:25 GMT Posted by Dave Aitel via Dailydave on Aug 15Before there were words, calculated as the softmax of a list of possible tokens, there were just vectors of nano-electrical potential in cells soaked in a hormonal brew of electrolytes, operating on a clock cycle of "slow, but fast enough". In this sense, as we now know <https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10472538/>, we generate words and we know, in our heads, what we are, in the same way as we generate limbs, with each... Full Article
persistence Re: Persistence and Strategic Effects By seclists.org Published On :: Fri, 16 Aug 2024 15:16:15 GMT Posted by the grugq via Dailydave on Aug 16Cyber is Calvinball. I gave a talk back in 2015 [1] which I think has held up rather well. My argument was that cyber is evolving in unpredictable ways as we learn more about the domain. That the current state of the art has huge blind spots we aren’t even thinking about. The next year was, of course, the 2016 disinformation campaign fed by cyber loot. I feel that a great deal of cyber war literature is based on knowledge derived from... Full Article
persistence Episode 189: Eric Lubow on Polyglot Persistence By www.se-radio.net Published On :: Fri, 16 Nov 2012 20:35:40 +0000 Recording Venue: Skype Guest: Eric Lubow Eric Lubow and Robert discuss polyglot persistence, a term used to describe systems that incorporate multiple specialized persistent stores rather than a single general-purpose database. Eric provides insights into the forces driving this trend: including diverse data usage patterns, low latency, and increasing volumes of data. The emergence of […] Full Article
persistence What A 1968 Report Tells Us About The Persistence Of Racial Inequality By www.gpbnews.org Published On :: Tue, 09 Jun 2020 10:30:00 +0000 Editor's note: This is an excerpt of Planet Money 's newsletter. You can sign up here . In summer of 1967, African Americans protested, marched, and rioted in cities across the country. The unrest convinced President Lyndon Johnson to set up the Kerner Commission, which spent about six months doing research, visiting slums, and holding hearings. In 1968, they published a provocative report that civil rights leader Jesse Jackson recently called "the last attempt to address honestly and seriously the structural inequalities that plague African Americans." "Segregation and poverty have created in the racial ghetto a destructive environment totally unknown to most white Americans," the Kerner report said. "What white Americans have never fully understood — but what the Negro can never forget — is that white society is deeply implicated in the ghetto. White institutions created it, white institutions maintain it, and white society condones it." Fifty years later, Americans are taking to the Full Article
persistence Persistence of Bird Flu on Milking Equipment By www.medindia.net Published On :: Researchers report that the H5N1 virus, commonly known as medlinkbird flu/medlink, remains stable in unpasteurized milk on metal and rubber components Full Article
persistence The Wheels of Change: Technology Adoption, Millwrights, and Persistence in Britain's Industrialization [electronic journal]. By encore.st-andrews.ac.uk Published On :: Full Article
persistence The Standard Errors of Persistence [electronic journal]. By encore.st-andrews.ac.uk Published On :: Full Article
persistence Roman Roads to Prosperity: Persistence and Non-Persistence of Public Goods Provision [electronic journal]. By encore.st-andrews.ac.uk Published On :: Full Article
persistence Productivity Dispersion and Persistence Among the World's Most Numerous Firms [electronic journal]. By encore.st-andrews.ac.uk Published On :: National Bureau of Economic Research Full Article
persistence The Persistence of the Criminal Justice Gender Gap: Evidence from 200 Years of Judicial Decisions [electronic journal]. By encore.st-andrews.ac.uk Published On :: Full Article
persistence Persistence in alcohol consumption: evidence from migrants [electronic journal]. By encore.st-andrews.ac.uk Published On :: Full Article
persistence Corporate Profitability and the Global Persistence of Corruption [electronic journal]. By encore.st-andrews.ac.uk Published On :: Full Article
persistence Choosing Differently? College Application Behavior and the Persistence of Educational Advantage [electronic journal]. By encore.st-andrews.ac.uk Published On :: Full Article
persistence Beetles: Biased Promotions and Persistence of False Belief [electronic journal]. By encore.st-andrews.ac.uk Published On :: National Bureau of Economic Research Full Article
persistence Beach structure explains persistence of 1989 oil spill By ec.europa.eu Published On :: Thu, 11 Mar 2010 14:25:20 GMT In 1989 a large oil tanker famously ran aground off the Alaskan coast, spilling 11 million gallons of crude oil into the waters of the Prince William Sound. Over 20 years later oil still contaminates some of the nearby gravel beaches. A recent study suggests it is the physical condition of the beaches that has caused the oil to persist. This research could provide guidelines for remediating susceptible beaches worldwide. Full Article
persistence Environmental persistence of a pathogen used in microbial insect control By www.fs.fed.us Published On :: Wed, 01 Feb 2017 08:00:00 PST We conducted an experimental study of infection, transmission, and persistence of a nucleopolyhedrovirus (NPV) of Douglas-fir tussock moth (Orgyia pseudotsugata) to better understand mechanisms determining the efficacy of the virus when it is used as a microbial control agent. In a field experiment, we quantified infection rates of larvae exposed to either Tussock Moth Biocontrol-1, the strain currently used for control by the U.S. Forest Service, or a wild-type strain isolated from a natural population. We first allowed each pathogen to decay on experimental branches for 0, 1, or 3 days before allowing uninfected larvae to feed on the branches, and then we fit both a generalized linear model and an epidemiological model of virus transmission to the infection data. Longer decay of the NPV resulted in lower infection rates, but evidence that overall virus transmission differed between wild and pesticide isolates of NPV was weak. The short persistence time of the virus suggests that it does not last long on foliage, in turn suggesting that application of TM Biocontrol-1 must be carefully timed to ensure maximum mortality. Full Article
persistence Book Giveaway, Advice For Young Writers from Karla Valenti (MARIE CURIE & THE POWER OF PERSISTENCE) By feedproxy.google.com Published On :: Fri, 27 Mar 2020 15:40:21 +0000 GIVEAWAY (U.S. only): Karla is giving away a copy of Marie Curie And The Power Of Persistence, written by Karla Valenti and illustrated by Annalisa Beghelli! *** ENTER HERE *** Karla Arenas Valenti was born and raised in Mexico. Since then she has put down roots in a number of countries she now calls home: Japan, France, Germany, and the U.S. where she lives in the Chicagoland area with her husband and three kids. She writes picture books and middle grade novels. You can find out more about Karla at www.karlavalenti.com or connect with her on Facebook or Twitter @KV_writes. I asked Karla to describe her book, and here's what she replied: My Super Science Heroes is a picture book series for children ages 4-8. The series focuses on key scientists, but rather than defining those scientists by what they did (their achievements), we are choosing to highlight who they were (the traits that made those achievements possible). This distinction is important as it allows readers (young and old) to re-frame what it means to “succeed” - in other words, you do not need to be a genius or Nobel-prize winner in order to be a hero in your own life. Arguably, what makes someone a hero is how they make use of their own “super powers” in pursuit of their dreams. And what are these super powers? The first one we chose to highlight is persistence. Throughout her personal and professional life, Marie Curie encountered many societal and institutional limitations that threatened to block her progress. Rather than telling our young readers about these challenges, however, we chose to show them. Enter Mr. Opposition, a character designed to embody these counterforces and give Marie a chance to prove her persistence to all her fans and readers. In this way, Marie’s ultimate success and notable achievements are not presented as the inevitable result of a gifted mind. Rather, we are honoring the tremendous effort she exhibited in never giving up on her dreams, a super power indeed. Our next book focuses on the power of curiosity, exemplified by Alan Turing and his minion, Miss Enigma (due out Jan 2021). My Super Science Heroes is unlike any other children’s book series focusing on historical figures, and we hope it will inspire countless of young scientists (and non-scientists) as they develop their own super powers. Q: How did MARIE CURIE AND THE POWER OF PERSISTENCE get published? This is a story about the unexpected surprises that come our way when we are open to any (and sometimes unconventional) opportunities. I was living in Europe at the time, and a friend forwarded an open call for story submissions run by a non-profit science association. The Marie Curie Alumni Association (MCAA) was looking for a creative way to raise funds to support their science initiatives, so they launched a contest for picture book submissions. The topic was a story about Marie Curie, but told in a way that would excite young readers about science As a fiction writer, I was hesitant at first to submit a story on a non-fiction topic. However, I also viewed this as an opportunity to flex my creative wings, so I took the challenge and wrote a story about Marie Curie... the super hero. As I researched her life, it became clear that, while she certainly accomplished a great deal as a scientist, her most notable achievement was her unwavering persistence in facing a number of challenges throughout her life. Persistence! A skill highly valued in the scientific community (and one present in all of us). What if the book was about Marie Curie using her power of persistence to achieve great things in the scientific world? What if she had an evil nemesis who lived in a craggy cave deep underground, and whose sole purpose was preventing the spread of knowledge? What if he sent his minion, Mr. Opposition, to stop Marie in her heroic journey? Thus was born the My Super Science Heroes series. It was an unconventional premise, but I decided to submit the story. To my tremendous surprise, I won! Working with Micaela Crespo Quesada (a super scientist herself) and the MCAA association, we identified the perfect illustrator for the project, Annalisa Beghelli. Her artwork brilliantly captured the super hero themes we wanted to explore. In a true collaboration, the three of us worked to bring this project to life. Initially, the project was going to be funded exclusively through a global crowdsourcing campaign. Not only did we exceed our goal by 20%, but a couple weeks into the campaign, we received an offer by Kelly Barrales-Saylor at Sourcebooks for world rights. Fast forward to today as we celebrate the world publication on April 7th of Marie Curie and the Power of Persistence. Q. What advice do you have for young writers? In a perhaps not-so-ironic twist, the most valuable piece of advice I can offer is to believe in the power of persistence. And I hesitate to say this is only relevant to young writers (since I myself only learned this as a writer after many years). The journey I have taken to get to this point has not been a short (or always-joyful) one. Indeed, it has been more agonizing than not, more heart-breaking than uplifting, and certainly taken a lot longer than I expected. There have been plenty of opportunities for me to give up and walk away (and if I'm honest, there have been moments in my life where I've had to do that). However, I am fiercely proud of this story because it feels like a real badge of honor; a testament to the courage it takes to pick up your "pen" and keep putting words to paper, despite everything standing in your way. The truth is, we all have our own version of Mr. Opposition, and we all must do battle with the nemesis that intends to bring us down. But word by word, line by line, we can persist. That is no small thing. -- For more interviews, see my Inkygirl Interview Archive. Also see Advice For Young Writers and Illustrators, a compilation of tips generously offered by children's book creators I've interviewed over the years. Full Article Advice for young artists and young writers Inkygirl Interviews Three Questions nonfiction writing picture books
persistence Raith succumb to Dundee United persistence as talks with boss Ray McKinnon begin By www.express.co.uk Published On :: Mon, 09 May 2016 10:03:00 +0100 RAITH ROVERS last night gave Dundee United the green light to open talks with their top managerial target Ray McKinnon. Full Article
persistence Institutionalization, path dependence and the persistence of the Anglo- American special relationship By feedproxy.google.com Published On :: Fri, 26 Aug 2016 10:57:44 +0000 1 September 2016 , Volume 92, Number 5 Ruike Xu Full Article
persistence Persistence and extinction in a stochastic nonautonomous logistic model of population dynamics By www.ams.org Published On :: Mon, 02 Mar 2020 06:58 EST O. D. Borysenko and D. O. Borysenko Theor. Probability and Math. Statist. 99 (2020), 67-75. Abstract, references and article information Full Article
persistence Persistence of Stratifications of Normally Expanded Laminations By www.ams.org Published On :: Pierre Berger, Universite Paris 13 - A publication of the Societe Mathematique de France, 2013, 113 pp., Softcover, ISBN-13: 978-2-85629-767-4, List: US$45, All AMS Members: US$36, SMFMEM/134 This manuscript complements the Hirsch-Pugh-Shub (HPS) theory on persistence of normally hyperbolic laminations and implies several structural... Full Article
persistence Effect of Cost and Formulation on Persistence and Adherence to Initial Metformin Therapy for Type 2 Diabetes By care.diabetesjournals.org Published On :: 2020-04-06T09:03:16-07:00 Full Article
persistence Persistence of Continuous Glucose Monitoring Use in a Community Setting 1 Year After Purchase By clinical.diabetesjournals.org Published On :: 2013-07-01 James ChamberlainJul 1, 2013; 31:106-109Feature Articles Full Article
persistence Multiparameter Persistence Landscapes By Published On :: 2020 An important problem in the field of Topological Data Analysis is defining topological summaries which can be combined with traditional data analytic tools. In recent work Bubenik introduced the persistence landscape, a stable representation of persistence diagrams amenable to statistical analysis and machine learning tools. In this paper we generalise the persistence landscape to multiparameter persistence modules providing a stable representation of the rank invariant. We show that multiparameter landscapes are stable with respect to the interleaving distance and persistence weighted Wasserstein distance, and that the collection of multiparameter landscapes faithfully represents the rank invariant. Finally we provide example calculations and statistical tests to demonstrate a range of potential applications and how one can interpret the landscapes associated to a multiparameter module. Full Article
persistence Convergence of persistence diagrams for topological crackle By projecteuclid.org Published On :: Mon, 27 Apr 2020 04:02 EDT Takashi Owada, Omer Bobrowski. Source: Bernoulli, Volume 26, Number 3, 2275--2310.Abstract: In this paper, we study the persistent homology associated with topological crackle generated by distributions with an unbounded support. Persistent homology is a topological and algebraic structure that tracks the creation and destruction of topological cycles (generalizations of loops or holes) in different dimensions. Topological crackle is a term that refers to topological cycles generated by random points far away from the bulk of other points, when the support is unbounded. We establish weak convergence results for persistence diagrams – a point process representation for persistent homology, where each topological cycle is represented by its $({mathit{birth},mathit{death}})$ coordinates. In this work, we treat persistence diagrams as random closed sets, so that the resulting weak convergence is defined in terms of the Fell topology. Using this framework, we show that the limiting persistence diagrams can be divided into two parts. The first part is a deterministic limit containing a densely-growing number of persistence pairs with a shorter lifespan. The second part is a two-dimensional Poisson process, representing persistence pairs with a longer lifespan. Full Article
persistence Persistence and profits pay off By www.fao.org Published On :: Fri, 23 Mar 2018 00:00:00 GMT Knocking on closed doors is something Renu Bala is very good at. First, it was the doors of her neighbours in Panjor Bhanga, her home village in northern Bangladesh. She had an idea for them: what if they formed a milk cooperative? They didn’t have much to lose. “The women of this village are very poor and raise only local Deshi cattle,” Renu explains. [...] Full Article
persistence Prevalence, Patterns, and Persistence of Sleep Problems in the First 3 Years of Life By pediatrics.aappublications.org Published On :: 2012-01-04T00:08:04-08:00 Sleep problems are common during childhood, but screening for sleep problems in the clinic setting is often cursory. Moreover, there are few longitudinal studies examining the prevalence and persistence of sleep problems in young children.Patterns of sleep problems vary across early development, but sleep problems arising in infancy persist in 21% of children through 36 months of age. Parent response to a nonspecific query about sleep problems may overlook relevant sleep symptoms and behaviors. (Read the full article) Full Article
persistence Predictors of Persistence After a Positive Depression Screen Among Adolescents By pediatrics.aappublications.org Published On :: 2012-11-19T00:07:59-08:00 Adolescents have high placebo response rates in depression treatment trials. Screening for depression will likely detect youth with a broad range of symptom severity, including some who would benefit from watchful waiting but might not require active treatment.The strongest predictors of symptom persistence are depressive symptom severity at presentation and continued symptoms on repeat screening 6 weeks later. These results provide important information for the development of postscreening management protocols in the primary care setting. (Read the full article) Full Article
persistence Patterns of Care and Persistence After Incident Elevated Blood Pressure By pediatrics.aappublications.org Published On :: 2013-07-01T00:07:00-07:00 Screening for hypertension in asymptomatic children and adolescents occurs during routine care. For those with elevated blood pressure, a repeat measurement within 1 to 2 weeks is recommended. However, little is known about patterns of care after an incident elevated blood pressure.In a population of 72 625 children and adolescents, 6108 (8.4%) had an incident elevated blood pressure. Among these, 1275 (20.9%) had their blood pressure measurement repeated within 1 month. However, few individuals with an incident elevated blood pressure subsequently developed hypertension. (Read the full article) Full Article
persistence Remission and Persistence of Asthma Followed From 7 to 19 Years of Age By pediatrics.aappublications.org Published On :: 2013-07-29T00:07:10-07:00 The natural history of asthma during adolescence is dynamic because both remission and relapse are common. Remission has consistently been associated with mild asthma and the absence of sensitization.One in 5 children with asthma remitted from age 7 to 19. Remission was defined as no wheezing and no medication for ≥3 years and was inversely related to female gender, sensitization to furred animals, and asthma severity at baseline. (Read the full article) Full Article
persistence Bash Profile Persistence By packetstormsecurity.com Published On :: Mon, 16 Dec 2019 16:05:47 GMT This Metasploit module writes an execution trigger to the target's Bash profile. The execution trigger executes a call back payload whenever the target user opens a Bash terminal. A handler is not run automatically, so you must configure an appropriate exploit/multi/handler to receive the callback. Full Article
persistence Positive Thinking, Persistence Pay Off in Job Search: Study By www.medicinenet.com Published On :: Sat, 9 May 2020 00:00:00 PDT Title: Positive Thinking, Persistence Pay Off in Job Search: StudyCategory: Health NewsCreated: 5/3/2012 8:05:00 PMLast Editorial Review: 5/4/2012 12:00:00 AM Full Article
persistence Peptidoglycan Hydrolases RipA and Ami1 Are Critical for Replication and Persistence of Mycobacterium tuberculosis in the Host By mbio.asm.org Published On :: 2020-03-03T01:30:27-08:00 ABSTRACT Synthesis and cleavage of the cell wall polymer peptidoglycan (PG) are carefully orchestrated processes and are essential for the growth and survival of bacteria. Yet, the function and importance of many enzymes that act on PG in Mycobacterium tuberculosis remain to be elucidated. We demonstrate that the activity of the N-acetylmuramyl-l-alanine amidase Ami1 is dispensable for cell division in M. tuberculosis in vitro yet contributes to the bacterium’s ability to persist during chronic infection in mice. Furthermore, the d,l-endopeptidase RipA, a predicted essential enzyme, is dispensable for the viability of M. tuberculosis but required for efficient cell division in vitro and in vivo. Depletion of RipA sensitizes M. tuberculosis to rifampin and to cell envelope-targeting antibiotics. Ami1 helps sustain residual cell division in cells lacking RipA, but the partial redundancy provided by Ami1 is not sufficient during infection, as depletion of RipA prevents M. tuberculosis from replicating in macrophages and leads to dramatic killing of the bacteria in mice. Notably, RipA is essential for persistence of M. tuberculosis in mice, suggesting that cell division is required during chronic mouse infection. Despite the multiplicity of enzymes acting on PG with redundant functions, we have identified two PG hydrolases that are important for M. tuberculosis to replicate and persist in the host. IMPORTANCE Tuberculosis (TB) is a major global heath burden, with 1.6 million people succumbing to the disease every year. The search for new drugs to improve the current chemotherapeutic regimen is crucial to reducing this global health burden. The cell wall polymer peptidoglycan (PG) has emerged as a very successful drug target in bacterial pathogens, as many currently used antibiotics target the synthesis of this macromolecule. However, the multitude of genes encoding PG-synthesizing and PG-modifying enzymes with apparent redundant functions has hindered the identification of novel drug targets in PG synthesis in Mycobacterium tuberculosis. Here, we demonstrate that two PG-cleaving enzymes are important for virulence of M. tuberculosis. In particular, the d,l-endopeptidase RipA represents a potentially attractive drug target, as its depletion results in the clearance of M. tuberculosis from the host and renders the bacteria hypersusceptible to rifampin, a frontline TB drug, and to several cell wall-targeting antibiotics. Full Article
persistence The persistence of poverty in the Arab world By webfeeds.brookings.edu Published On :: Sun, 28 Feb 2016 00:00:00 -0500 2016 ushered in the revamped UN Sustainable Development Goals (SDGs), which built on the Millennium Development Goals (MDGs), adopted in 2000. Poverty eradication is the number one developmental goal of both the MDGs and SDGs. Over the past two decades, global efforts have been successful as the number of people living in poverty declined by more than half, from more than 1.9 billion in 1990 to 836 million in 2015. Despite such progress, the Arab world continues to lag in its efforts to combat poverty. In fact, according to the UNDP, between 2010 and 2012, the percentage of the population in the region making less than $1.25 a day increased (PDF) from 4.1 percent to 7.4 percent. Previously, countries in the region had made progress in reducing poverty, but high levels of political unrest had reversed many of these improvements. Poverty and conflict: A direct correlation The persistence of conflict in Syria, Iraq, and Yemen remains one of the main drivers of poverty regionally. In Syria, after five years of civil war it is estimated that 80 percent of the population lives in poverty, and life expectancy has been cut by 20 years. Almost a decade after the US-led invasion in 2003, poverty rates are on the rise in Iraq with statistics from the World Bank showing that 28 percent of Iraqi families live under the poverty line. The mass displacement from the Islamic State of Iraq and the Levant (ISIL) controlled areas, the decline in global oil prices and higher unemployment rates has meant that despite its oil wealth, the Iraqi government has failed miserably in addressing the poverty rate in the country. Yemen's poverty rate has increased from 42 percent of the population in 2009, to an even more alarming 54.5 percent in 2012. Despite an initial wave of optimism after the 2011 Arab uprisings, countries in North Africa continue to face economic challenges that have seen poverty rates increase in many areas. In Egypt, the Arab world's most populous country, five years of political upheaval have taken a toll on the economy. Increased unemployment, lower tourist arrivals, dwindling foreign currency reserves, and a weaker Egyptian pound has meant that 26 percent of Egypt's 90 million people live under the poverty line. Despite a relatively successful and ongoing political transition in Tunisia, one in every six Tunisians lives below the poverty line as well. Tunisia is one of the highest contributors of ISIL fighters per capita, and Tunisian leaders continue to make a direct correlation between poverty and terrorism. In the Palestinian territories, a lack of employment opportunities due to restrictions imposed by the Israeli occupation continues to drive rising levels of poverty (PDF). Nearly two years after the war in Gaza, reconstruction efforts have slowed to a crawl. Such efforts promised employment for thousands of Palestinians; however, the slow trickle of foreign donations and a deficiency of construction materials indicate that the situation will not improve any time soon. Although the outlook for the West Bank appears less grim than in Gaza, high levels of poverty persist as many Palestinians hold jobs that pay a meager wage. This shortage of suitable employment forces many Palestinians to seek employment from companies operating in settlements on occupied Palestinian territory. Even with some Palestinians performing these jobs out of necessity, per capita income in the West Bank continues to decline. In Gaza, the situation is even worse with per capita income 31 percent lower than in 1994. One step forward, two steps back The SDGs provide an ambitious blue print for global development that includes a focus on education, the environment, women's rights, sustainable water, and many other critical areas. While all of these issues are of importance to the region, it will become increasingly problematic to progress these goals without a renewed emphasis on poverty eradication. Countries currently in conflict pose the greatest challenge to poverty eradication efforts, as participants in these conflicts have pushed aside humanitarian concerns in the quest for victory. The international community should make preparations for post-war reconstruction in Syria and Yemen, while also remaining wary of incomplete political settlements that raise the prospect for the resumption of hostilities in the future. Even though in Palestine it is unlikely that the Israeli occupation will end anytime soon, however Fatah and Hamas should work toward a reconciliation to improve the system of governance in the territories. This will provide Palestinians with a united front to tackle the challenges posed by the occupation and ease the suffering felt in both Gaza and the West Bank. Arab countries must recognise that absolute poverty is only one dimension of the problem and that redistributive policies can only go as far to address the issue. The uprisings have shown that Arab youth not only protested against economic inequality, but also against marginalisation and political disenfranchisement. Any renewed push for more economic opportunities must also provide Arab youth with a chance to shape their future. Lower oil prices will likely affect the level of aid wealthier Gulf Cooperation Council countries give to poorer countries in the region. Nonetheless, such aid should not simply dry up. The Saudi-led coalition has destroyed a large portion of the Yemeni infrastructure, so the Kingdom and members of its coalition should bear a large part of the reconstruction effort. Arab governments should understand that poverty also has a security and stability dimension. The 2011 uprisings have shown that Arab societies have the ability to challenge incompetent governance and corruption. Food security remains a huge challenge for a region that imports much of its key food staples. Should poverty and food security issues not be addressed, any future protest wave may constitute a "revolution of the hungry", that is likely to be more violent than the protest wave of 2011. This article originally appeared in Al Jazeera English. Authors Adel Abdel GhafarFraus Masri Publication: Al Jazeera English Image Source: © ABDULJABBAR ZEYAD / Reuters Full Article
persistence Akaguma's ascendancy a tribute to Ramos's persistence By www.fifa.com Published On :: Tue, 26 Nov 2019 15:19:00 GMT Full Article
persistence Talking about leaving revisited [Electronic book] : persistence, relocation, and loss in undergraduate STEM education / editors, Elaine Seymour and Anne-Barrie Hunter. By encore.st-andrews.ac.uk Published On :: Cham : Springer, 2019. Full Article
persistence Superman: the persistence of an American icon / Ian Gordon By library.mit.edu Published On :: Sun, 13 May 2018 06:11:31 EDT Hayden Library - PN6728.S9 G67 2017 Full Article
persistence Weber and the persistence of religion [electronic resource] : social theory, capitalism, and the sublime / Joseph W.H. Lough By darius.uleth.ca Published On :: London ; New York : Routledge, 2006 Full Article
persistence Only the dead: the persistence of war in the modern age / Bear F. Braumoeller By library.mit.edu Published On :: Sun, 19 Jan 2020 08:04:55 EST Dewey Library - JZ6385.B73 2019 Full Article