U.K. consumer rights group ‘Which?’ is filing a legal claim against Apple under competition law on behalf of some 40 million users of iCloud, its cloud storage service. The collective proceeding lawsuit, which is seeking £3 billion in compensation damages (around $3.8 billion at current exchange rates), alleges that Apple has broken competition rules by […]

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A unique population of ventral tegmental area (VTA) neurons co-transmits glutamate and GABA. However, the circuit inputs to VTA VGluT2+VGaT+ neurons are unknown, limiting our understanding of their functional capabilities. By coupling monosynaptic rabies tracing with intersectional genetic targeting in male and female mice, we found that VTA VGluT2+VGaT+ neurons received diverse brainwide inputs. The largest numbers of monosynaptic inputs to VTA VGluT2+VGaT+ neurons were from superior colliculus (SC), lateral hypothalamus (LH), midbrain reticular nucleus, and periaqueductal gray, whereas the densest inputs relative to brain region volume were from the dorsal raphe nucleus, lateral habenula, and VTA. Based on these and prior data, we hypothesized that LH and SC inputs were from glutamatergic neurons. Optical activation of glutamatergic LH neurons activated VTA VGluT2+VGaT+ neurons regardless of stimulation frequency and resulted in flee-like ambulatory behavior. In contrast, optical activation of glutamatergic SC neurons activated VTA VGluT2+VGaT+ neurons for a brief period of time at high frequency and resulted in head rotation and arrested ambulatory behavior (freezing). Stimulation of glutamatergic LH neurons, but not glutamatergic SC neurons, was associated with VTA VGluT2+VGaT+ footshock-induced activity and inhibition of LH glutamatergic neurons disrupted VTA VGluT2+VGaT+ tailshock-induced activity. We interpret these results such that inputs to VTA VGluT2+VGaT+ neurons may integrate diverse signals related to the detection and processing of motivationally salient outcomes.

Endogenous reprogramming of glia into neurogenic progenitors holds great promise for neuron restoration therapies. Using lessons from regenerative species, we have developed strategies to stimulate mammalian Müller glia to regenerate neurons in vivo in the adult retina. We have demonstrated that the transcription factor Ascl1 can stimulate Müller glia neurogenesis. However, Ascl1 is only able to reprogram a subset of Müller glia into neurons. We have reported that neuroinflammation from microglia inhibits neurogenesis from Müller glia. Here we found that the peripheral immune response is a barrier to CNS regeneration. We show that monocytes from the peripheral immune system infiltrate the injured retina and negatively influence neurogenesis from Müller glia. Using CCR2 knock-out mice of both sexes, we found that preventing monocyte infiltration improves the neurogenic and proliferative capacity of Müller glia stimulated by Ascl1. Using scRNA-seq analysis, we identified a signaling axis wherein Osteopontin, a cytokine highly expressed by infiltrating immune cells is sufficient to suppress mammalian neurogenesis. This work implicates the response of the peripheral immune system as a barrier to regenerative strategies of the retina.

Un peu de monitoring chez JONSBO, qui place un petit écran avec un affichage très simple sur le top de la pompe de sa nouvelle série TH. Un affichage qui va à l'essentiel, tout comme le logiciel en arrière-plan, et ça peut être une bonne chose à l'heure où les écrans proposent toujours plus de possibilités. De quoi donner plus de choix au consommateur donc, mais JONSBO ne s'arrête pas là et mise également sur le chainage des ventilateurs en optant pour un cadre unique. Le hic ? Les pales semblent assez réduites sur le diamètre ; mais le rendu avec l'éclairage RGB semble très réussi. […]

Science behind NMN, nicotinamide mononucleotide supplements - possible better aging and longer longevity health benefits and points to consider for those who want to include it in their health and wellness program.

The grudge-match between AMD and Intel continues - although AMD is the clear aggressor in all of it. This week, in a follow up to AMD's antitrust lawsuit over Intel's "abuse of monopoly power" the guantlet was thrown down for...

Spencer is back with Jared to host this week’s episode of the Niche Pursuits News Podcast.  Like they always do, they discuss the major happenings related to SEO, small publishers, Google, and beyond, and it has been a very eventful…

The post DOJ Tries to Break Up Google Chrome, Android, and Search Monopoly appeared first on Niche Pursuits.

What do the Scriptures and the Fathers say about fidelity in marriage, sex outside of marriage, or same-sex marriage? Fr. Tom gives extensive teaching on this subject in today's episode.

He lived during the years when Constantinople was held in captivity by the Crusaders, and the Imperial government was in exile in Nicaea. Simon fled the world at a young age and traveled to the Holy Mountain, where he submitted himself to a strict but wise Elder for many years. In time, seeking greater seclusion, he moved to a small cave on the western side of Mt Athos, near a cliff that towered a thousand feet above the sea. One night, a few days before the Feast of the Nativity, he saw a star move across the sky and come to rest above the cliff near his cave. Taking this as a demonic delusion, he ignored it; but on the Eve of Nativity, the star once again took its place above the cliff, and Simon heard a voice from heaven saying 'Be in no doubt, Simon, faithful servant of my Son! See this sign, and do not leave this spot in search of greater solitude as you have in mind, for it is here that I want you to establish your monastery, for the salvation of many souls.' Soon afterward, three young monks from wealthy Macedonian families, who had heard of the Saint's holiness, came and laid their wealth at his feet, asking that he accept them as disciples. Simon sent for builders and ordered them to construct a monastery on the very edge of the precipitous cliff. The builders at first refused, saying the work was much too dangerous; but, persuaded by a miracle worked through the Saint's prayers, they were convinced. As soon as the building was finished, the monastic community began to grow rapidly.   In his own lifetime St Simon was the source of many miracles, prophecies and healings. Once the monastery was attacked by Saracen pirates. Simon went to meet them with gifts, hoping to dissuade them from attacking. When the pirates attacked him, they were blinded, and the arm of one of them was paralyzed when he attempted to strike the Saint. All of them were healed when the holy man prayed for them, and at this wonder they all repented, received Baptism and became monks.   Saint Simon reposed in peace. A fragrant, healing balm afterwards flowed from his tomb in great quantities, so that he came to be called Myroblytis, 'Myrrh-gusher' or 'Outpourer of Myrrh.' In subsequent years, the monastery was destroyed and rebuilt more than once, and no trace now remains of the tomb.

He lived during the years when Constantinople was held in captivity by the Crusaders, and the Imperial government was in exile in Nicaea. Simon fled the world at a young age and traveled to the Holy Mountain, where he submitted himself to a strict but wise Elder for many years. In time, seeking greater seclusion, he moved to a small cave on the western side of Mt Athos, near a cliff that towered a thousand feet above the sea. One night, a few days before the Feast of the Nativity, he saw a star move across the sky and come to rest above the cliff near his cave. Taking this as a demonic delusion, he ignored it; but on the Eve of Nativity, the star once again took its place above the cliff, and Simon heard a voice from heaven saying 'Be in no doubt, Simon, faithful servant of my Son! See this sign, and do not leave this spot in search of greater solitude as you have in mind, for it is here that I want you to establish your monastery, for the salvation of many souls.' Soon afterward, three young monks from wealthy Macedonian families, who had heard of the Saint's holiness, came and laid their wealth at his feet, asking that he accept them as disciples. Simon sent for builders and ordered them to construct a monastery on the very edge of the precipitous cliff. The builders at first refused, saying the work was much too dangerous; but, persuaded by a miracle worked through the Saint's prayers, they were convinced. As soon as the building was finished, the monastic community began to grow rapidly.   In his own lifetime St Simon was the source of many miracles, prophecies and healings. Once the monastery was attacked by Saracen pirates. Simon went to meet them with gifts, hoping to dissuade them from attacking. When the pirates attacked him, they were blinded, and the arm of one of them was paralyzed when he attempted to strike the Saint. All of them were healed when the holy man prayed for them, and at this wonder they all repented, received Baptism and became monks.   Saint Simon reposed in peace. A fragrant, healing balm afterwards flowed from his tomb in great quantities, so that he came to be called Myroblytis, 'Myrrh-gusher' or 'Outpourer of Myrrh.' In subsequent years, the monastery was destroyed and rebuilt more than once, and no trace now remains of the tomb.

He lived during the years when Constantinople was held in captivity by the Crusaders, and the Imperial government was in exile in Nicaea. Simon fled the world at a young age and traveled to the Holy Mountain, where he submitted himself to a strict but wise Elder for many years. In time, seeking greater seclusion, he moved to a small cave on the western side of Mt Athos, near a cliff that towered a thousand feet above the sea. One night, a few days before the Feast of the Nativity, he saw a star move across the sky and come to rest above the cliff near his cave. Taking this as a demonic delusion, he ignored it; but on the Eve of Nativity, the star once again took its place above the cliff, and Simon heard a voice from heaven saying 'Be in no doubt, Simon, faithful servant of my Son! See this sign, and do not leave this spot in search of greater solitude as you have in mind, for it is here that I want you to establish your monastery, for the salvation of many souls.' Soon afterward, three young monks from wealthy Macedonian families, who had heard of the Saint's holiness, came and laid their wealth at his feet, asking that he accept them as disciples. Simon sent for builders and ordered them to construct a monastery on the very edge of the precipitous cliff. The builders at first refused, saying the work was much too dangerous; but, persuaded by a miracle worked through the Saint's prayers, they were convinced. As soon as the building was finished, the monastic community began to grow rapidly.   In his own lifetime St Simon was the source of many miracles, prophecies and healings. Once the monastery was attacked by Saracen pirates. Simon went to meet them with gifts, hoping to dissuade them from attacking. When the pirates attacked him, they were blinded, and the arm of one of them was paralyzed when he attempted to strike the Saint. All of them were healed when the holy man prayed for them, and at this wonder they all repented, received Baptism and became monks.   Saint Simon reposed in peace. A fragrant, healing balm afterwards flowed from his tomb in great quantities, so that he came to be called Myroblytis, 'Myrrh-gusher' or 'Outpourer of Myrrh.' In subsequent years, the monastery was destroyed and rebuilt more than once, and no trace now remains of the tomb.

In this special edition of Paradise and Utopia, Fr. John Strickland responds to a recent review of the first two volumes of his book series. In it, he notes the failure to consider the books on their own terms. He uses the opportunity to elaborate what he considers a healthy vision of Christian historiography, one that supports what many consider the need for a "re-enchantment" of modern culture.

Here's a hint: It's wrong! Great stuff as Kevin Allen interviews this popular Orthodox priest, a senior editor at Touchstone Magazine.

El Padre Nicolás predicó cómo debemos prepararnos para recibir a Cristo resucitado en nuestras vidas. Father Nicolás preached how we should prepare to receive the risen Christ in our lives.

Many religions believe there is only one God. But do they worship the same God as us? Fr. Pat looks at Biblical monotheism, what it is, and what it means to our worship.

Monographs are fundamental for progress in systematic  botany. They are the vehicles for circumscribing and naming taxa, determining distributions and ecology,  assessing  relationships for formal classification, and interpreting long-term  and short-term  dimensions of the evolutionary process. Despite their importance, fewer monographs are now being prepared by the newer generation  of systematic  botanists, who are understandably involved principally with DNA data and analysis, especially for answering  phylogenetic, biogeographic, and population  genetic questions.  As monographs provide  hypotheses regarding species  boundaries and plant relationships, new insights  in many plant groups  are urgently  needed.  Increasing  pressures  on biodiversity, especially in tropical and developing regions of the world, emphasize this point. The results from a workshop (with 21 participants) reaffirm  the central role that monographs play in systematic  botany. But, rather than advocating abbreviated models  for monographic products,  we recommend a full presentation of relevant  information. Electronic  publication offers numerous  means of illustration of taxa, habitats, characters, and statistical and phylogenetic analyses, which previously  would have been prohibitively costly. Open Access and semantically enhanced  linked electronic  publications provide instant access to content from anywhere  in the world, and at the same time link this content to all underlying data and digital resources  used in the work.  Resources  in support  of monography, especially  databases  and widely  and easily  accessible  digital  literature and specimens, are now more powerful  than ever before, but interfacing and interoperability of databases  are much needed. Priorities  for new resources  to be developed  include an index of type collections and an online global chromosome database. Funding  for sabbaticals for monographers to work uninterrupted on major projects  is strongly  encouraged. We recommend that doctoral  students  be assigned  smaller  genera,  or natural  portions  of larger  ones (subgenera, sections,  etc.), to gain the necessary expertise for producing a monograph, including training in a broad array of data collection (e.g., morphology, anatomy, palynology, cytogenetics, DNA techniques, ecology, biogeography), data analysis (e.g., statistics,  phylogenetics, models), and nomenclature. Training programs, supported by institutes, associations, and agencies, provide means for passing on procedures and perspectives of challenging botanical  monography to the next generation  of young systematists.

"Let's be honest, it was a terrible night," Kimmel said.

The post Jimmy Kimmel chokes up during monologue on Trump’s win appeared first on Boston.com.

Longtime Rockfon partner Sesco Group designed and renovated its boardroom to feature Rockfon’s Mono Acoustic ceiling system – the first installation of the product in Ontario, Canada.

Washington – OSHA has released a bulletin with information on how to protect workers from carbon monoxide explosion hazards related to electric arc furnaces in the steelmaking industry.

Washington – The National Transportation Safety Board has released two safety alerts and a pair of videos cautioning airline pilots and mechanics about the dangers of carbon monoxide emissions.

Washington – OSHA will not issue citations to employers whose monorail hoists fail to comply with requirements in the Crane and Derricks in Construction Standard – as long as they adhere to other regulations, the agency announced in a recent memorandum.

Detecting invisible workplace risks is always a challenge. One such hidden hazard is carbon monoxide, a colorless and odorless gas.

The 54-year-old owner of a land clearing and forest product company was overcome by carbon monoxide as he was checking on a wood chip-powered boiler system.

A 61-year-old truck driver who worked for a general freight carrier parked his truck at his employer’s terminal yard and slept overnight in the truck’s sleeper berth.

Do your employees use gas-powered equipment at work? If so, they may be exposed to carbon monoxide.

Workers who operate equipment such as cutting saws, pumps and generators in buildings or semi-enclosed spaces are at risk for carbon monoxide poisoning – even in areas that appear well-ventilated.

You can’t smell it, taste it or see it, but it can be deadly. Carbon monoxide – sometimes referred to as the “silent killer” – prevents oxygen from going into the body and can result in death in a short period of time, the Michigan Department of Community Health states. But how does carbon monoxide form, and when are workers at risk?

Business technology solutions provider Brother UK has launched a compact range of mono laser printers for businesses, helping resellers to support customers with downsized offices and decentralised workforces.

Incommensurate phase of potassium guaninate monohydrate is the first example of a modulation in purine derivatives and of a high-pressure incommensurate crystal structure to be solved for an organic compound.

The crystal structure of the incommensurate modulated phase of potassium guaninate monohydrate has been solved on the basis of high-pressure single-crystal X-ray diffraction data. The modulated structure was described as a `mosaic' sequence of three different local configurations of two neighbouring guaninate rings. In contrast to known examples of incommensurate modulated organic compounds, the modulation functions of all atoms are discontinuous. This is the first example of the experimental detection of an incommensurate modulated crystal structure that can be modelled using the special `soliton mode' modulation function proposed by Aramburu et al. [(1995), J. Phys. Condens. Matter, 7, 6187–6196].

Monoclinic ferroelectric phases are prevalent in various functional materials, most notably mixed-ion perovskite oxides. These phases can manifest as regularly ordered long-range crystallographic structures or as macroscopic averages of the self-assembled tetragonal/rhombohedral nanodomains. The structural and physical properties of monoclinic ferroelectric phases play a pivotal role when exploring the interplay between ferroelectricity, ferroelasticity, giant piezoelectricity and multiferroicity in crystals, ceramics and epitaxial thin films. However, the complex nature of this subject presents challenges, particularly in deciphering the microstructures of monoclinic domains. In Paper I [Biran & Gorfman (2024). Acta Cryst. A80, 112–128] the geometrical principles governing the connection of domain microstructures formed by pairing MAB type monoclinic domains were elucidated. Specifically, a catalog was established of `permissible domain walls', where `permissible', as originally introduced by Fousek & Janovec [J. Appl. Phys. (1969), 40, 135–142], denotes a mismatch-free connection between two monoclinic domains along the corresponding domain wall. The present article continues the prior work by elaborating on the formalisms of permissible domain walls to describe domain microstructures formed by pairing the MC type monoclinic domains. Similarly to Paper I, 84 permissible domain walls are presented for MC type domains. Each permissible domain wall is characterized by Miller indices, the transformation matrix between the crystallographic basis vectors of the domains and, crucially, the expected separation of Bragg peaks diffracted from the matched pair of domains. All these parameters are provided in an analytical form for easy and intuitive interpretation of the results. Additionally, 2D illustrations are provided for selected instances of permissible domain walls. The findings can prove valuable for various domain-related calculations, investigations involving X-ray diffraction for domain analysis and the description of domain-related physical properties.

Guanosine 5'-monophosphate (GMP) synthetase (GuaA) catalyzes the last step of GMP synthesis in the purine nucleotide biosynthetic pathway. This enzyme catalyzes a reaction in which xanthine 5'-monophosphate (XMP) is converted to GMP in the presence of Gln and ATP through an adenyl-XMP intermediate. A structure of an XMP-bound form of GuaA from the domain Bacteria has not yet been determined. In this study, the crystal structure of an XMP-bound form of GuaA from the thermophilic bacterium Thermus thermophilus HB8 (TtGuaA) was determined at a resolution of 2.20 Å and that of an apo form of TtGuaA was determined at 2.10 Å resolution. TtGuaA forms a homodimer, and the monomer is composed of three domains, which is a typical structure for GuaA. Disordered regions in the crystal structure were obtained from the AlphaFold2-predicted model structure, and a model with substrates (Gln, XMP and ATP) was constructed for molecular-dynamics (MD) simulations. The structural fluctuations of the TtGuaA dimer as well as the interactions between the active-site residues were analyzed by MD simulations.