Event Begins: Thursday, November 14, 2024 12:00pm
Location: Palmer Commons
Organized By: Life Sciences Institute (LSI)

Molecular compartmentalization is vital for cellular physiology. For instance, proteins for intercellular adhesion and communication are localized to the cell surface while many energy-producing enzymes stay in the mitochondrion. High-resolution, proteome-wide mapping of protein localization is of core importance for understanding cellular organization and processes.

In this talk, Jiefu Li, Ph.D., will describe an end-to-end pipeline for in situ cell-surface proteomics, from chemical and transgenic tools to a user-friendly platform for data analysis, and present how in situ cell-surface proteomics of developing brains discovers “outside-the-box” regulators of neuronal wiring. Moreover, in vivo interactome mapping of key synaptic organizers uncovers the cellular and molecular mechanisms of synaptic matching and maturation and highlights the RhoGAP/RhoGEF as a signaling hub for synaptic development.

Speaker:
Jiefu Li, Ph.D.
Group Leader, 4D Cellular Physiology
Janelia Research Campus, Howard Hughes Medical Institute

NASA’s Jet Propulsion Laboratory (JPL) announced hundreds of layoffs, calling the move “painful but necessary.” The news came via a workforce statement and memo to JPL employees. JPL has been on the forefront of space exploration for decades. It was a camera, engineered by the space agency, on Voyager 1 that was able to capture the pale

Esta simpatizante de Putin no tiene ninguna experiencia en Inteligencia Leer

Stephen Colbert spent the majority of his opening monologue on Wednesday night’s “Late Show” talking about President-elect Donald Trump’s Cabinet choices so far, including Rep. Matt Gaetz of Florida as attorney general and Tulsi Gabbard as director of national intelligence. “Almost eight years ago, we all saw [Trump] saunter down those Capitol steps, put his […]

President-elect Donald Trump announced Wednesday he has selected former Rep. Tulsi Gabbard (R-HI) to serve as his Director of National Intelligence (DNI).

The post Trump Selects Tulsi Gabbard to Serve as Director of National Intelligence appeared first on Breitbart.

1. Who is Tulsi Gabbard? Meet the Hindu American appointed by Trump as US Director of National Intelligence  The Times of India
2. From gifting Bhagavad Gita to PM Modi to speaking on Kashmir: Tulsi Gabbard’s Indian connection  The Times of India
3. Tulsi Gabbard, Narendra Modi meetings: Archival clips doing rounds on Social Media  The Economic Times
4. Trump picks ex-Democrat Tulsi Gabbard to be Director of National Intelligence  India Today
5. Who is Tulsi Gabbard, Donald Trump’s Hindu pick for US intelligence head?  Firstpost

Banks in the UK make it possible for customers to control their gambling spend, either with a self-imposed spend limit, or, for compulsive gamblers, by means of an app blocking all spend on gambling sites. They are very effective, says Wendy Knowler.

President-elect Donald Trump announced Wednesday that former Hawaii Rep. Tulsi Gabbard is his pick for Director of National Intelligence. “For over two decades, Tulsi has fought for our Country and […]

The post Breaking: Trump Chooses Tulsi Gabbard for Huge Role in Cabinet as He Adds Firepower for Second Term appeared first on The Western Journal.

NASA's Jet Propulsion Laboratory has laid-off an additional 325 workers after an earlier round of 500 job cuts earlier in the year, largely because of budgetary constraints.

Tulsi Gabbard -- a military veteran who once sought the Democratic presidential nomination, was chosen by Trump to be his director of national intelligence.

Donald Trump on Wednesday named former Democrat Tulsi Gabbard, who has opposed US support for Ukraine and met Syria's president Bashar al-Assad, as his incoming Director of National Intelligence.

Donald Trump is set to return to the White House after his victory over Kamala Harris in the November 5 US presidential elections. The 78-year-old leader Republican has secured all seven swing states.

Donald Trump is set to return to the White House after his victory over Kamala Harris in the November 5 US presidential elections. The 78-year-old leader Republican has secured all seven swing states.

Donald Trump has chosen Tulsi Gabbard to serve as his Director of National Intelligence, he announced.

The former Democratic congresswoman has shifted her political allegiance in recent years, going from a candidate for the Democratic presidential nomination in 2020 to a stalwart Trump supporter.

1. Trump Tracker: Ex-Democrat Tulsi Gabbard Appointed US Intelligence Chief  NDTV
2. Who is Tulsi Gabbard? Meet the Hindu American appointed by Trump as US Director of National Intelligence  The Times of India
3. Who is Tulsi Gabbard, Donald Trump’s Hindu pick for director of national intelligence?  The Economic Times
4. When Tulsi Gabbard, Donald Trump's new pick, slammed Pakistan Army over atrocities against Hindus in Bangladesh  Hindustan Times
5. Trump taps former Democrat Tulsi Gabbard as US intel chief; Senator Marco Rubio as Secretary of State  The Hindu

1. Trump taps former Democrat Tulsi Gabbard as US intel chief; Senator Marco Rubio as Secretary of State  The Hindu
2. Who is Tulsi Gabbard? Meet the Hindu American appointed by Trump as US Director of National Intelligence  The Times of India
3. Trump Tracker: Ex-Democrat Tulsi Gabbard Appointed US Intelligence Chief  NDTV
4. Who is Tulsi Gabbard, Donald Trump’s Hindu pick for director of national intelligence?  The Economic Times
5. Trump picks ex-Democrat Tulsi Gabbard to be Director of National Intelligence  India Today

Tulsi Gabbard demanded U.S. military withdrawal from Iraq and Syria during her 2020 Presidential run; Marco Rubio would be the first Hispanic as the top U.S. diplomat

Gabbard, who has served in the Army National Guard for more than two decades, deploying to Iraq and Kuwait, would come to the role as somewhat of an outsider, compared to her predecessor.

President-elect Donald Trump said he plans to nominate former Rep. Tulsi Gabbard as the director of national intelligence, the Cabinet member in charge of gathering and sharing sensitive foreign information and secrets.

A new smart logistics centre in Helsinki is trialling zero emission deliveries using a combination of robots and electric vehicles.

nel sontuoso. Binomio che si vuole. dire lo abbia contribuito a. Otto anni 90 e si abbandonano. ... Con una grande capacit224 relazionali e la copertina ...

(EMAILWIRE.COM, October 31, 2024 ) The UAV-Drone Propulsion Systems Market is forecasted to grow from USD 6,994 million in 2024 to USD 11,098 million by 2029, at a CAGR of 10.9%. As UAV applications expand across sectors like defense, government, and commercial use, demand is accelerating for more...

Este jueves 14 de noviembre, la Audiencia Provincial de Cuenca acogerá el juicio contra dos trabajadoras sanitarias, R.M.M.R. y Y.B.L., vinculadas al centro de salud de Villares del Saz, quienes están siendo acusadas de falsificar partes médicos para prescribir anabolizantes. Ambas se enfrentan a una solicitud de la Fiscalía que propone cinco años de prisión […]

Artículo publicado en : Dos Sanitarias Enfrentan 5 Años de Cárcel por Falsificación de Recetas en Villares del Saz

Die Zeit sitzt den US-Demokraten im Nacken. Noch vor Trumps Amtsantritt wollen sie so viele Bundesrichter im US-Senat bestätigen wie möglich. Denn auch in der Parlamentskammer übernehmen bald die Republikaner die Kontrolle.

1. NASA's Jet Propulsion Lab laying off 5% of its workforce  Space.com
2. JPL Workforce Update  NASA Jet Propulsion Laboratory
3. NASA’s JPL to cut 325 positions amid budget tightening  The Pasadena Star-News
4. NASA's Jet Propulsion Lab announces hundreds of layoffs: 'Painful but necessary'  Fox Business

Fr. Tom reflects upon the expulsion of Adam from Paradise, one of the two themes of Forgiveness Sunday.

On this Forgiveness Sunday, continuing his series on Lenten evangelism, Fr. Andrew discusses the Expulsion from Paradise as a key element of the Gospel, as well as forgiveness as the path back to Paradise.

The Jet Propulsion Laboratory, NASA's research center responsible for robotic space missions, will lay off more workers before the year ends due to budget constraints. JPL Director Laurie Leshin has announced in a memo addressed to employees that the reduction will affect 325 people, or about five percent of its whole workforce. Leshin explained that the lab took various measures to meet its budget allocation for the 2025 fiscal year and to minimize the adverse effects of a limited budget on its workers. In the end, though, JPL "reached the difficult decision" to make "one further workforce reduction."

The lab already cut 530 employees and cut over 100 contractors from its roster earlier this year because of uncertainty over the final budget that the Congress will give NASA for 2024. It also froze hiring in response to the dilemma. The main reason why the lab had to implement those measures was because the Mars Sample Return Program was allocated a much smaller budget than it needed. NASA had requested $950 million for the mission, but only $300 million was allocated for it. 

NASA's original plan was to bring home the samples collected by the mission in 2040. But its budget ballooned from $7 billion to $11 billion, and as The Washington Post notes, the government found the return date "unacceptable." For the 2025 fiscal year, NASA only requested $200 million for the project that could go through significant changes. The agency is now looking for ways to alter the mission and is even considering proposals from private companies. 

Leshin said that the layoffs will affect all areas of the lab, including its technical, business and support divisions. "[W]e had to tighten our belts across the board, and you will see that reflected in the layoff impacts," she said. JPL's director also said that the US presidential election results have nothing to do with the reduction that the "action would be happening regardless" of its outcome. 

Coming to Christ can be a painful experience.

Can I be forgiven? Can Jesus forgive me? 1 Timothy 1:15-17 Luke 18:35-43

Le court XXème siècle que le monde aura connu, est qualifié par certains historiens comme l’âge des extrêmes. Avec en point d’orgue, des guerres et des gouvernements qui auront décimés plusieurs dizaines de millions d’individus et dans le même temps,...

Aim/Purpose: The current study investigates the relationship between mobile and email marketing and consumer impulse buying tendencies in Pakistan. Background: Technology has become a primary driver for all business operations, which has dramatically transformed the wireless communications marketing paradigm. However, researchers have claimed that further inquiry is still needed to explore the role that distinct and emerging global technologies have on marketing communication strategies. This study explores the linkage of mobile and email marketing on consumers’ impulse buying behavior in Pakistan. Methodology: Primary data were collected through the distribution of 1000 questionnaires among students of different universities within two provinces of Pakistan: Punjab and Khyber Pakhton Khan (KPK). The study was conducted between November 2016 and March 2017. The authors received back 950 surveys, which is a very significant rate of return (95%). Of those submitted, 900 surveys were deemed eligible for analysis after improper documents were eliminated. Structure equation modeling (SEM) was utilized to test the study’s hypotheses. Contribution: This study assists organizations in improving marketing campaigns by focusing more on mobile devices (m-devices) and email medium to better comprehend consumers’ assessment processes at a lower budgetary cost. Such digital considerations could provide innovative possibilities for marketers in approaching their target market by adopting novel methods for information sharing. Findings: The findings revealed a positive association between mobile and email marketing on consumers’ impulse buying tendencies. The comprehensive analysis affirmed; however, there is a higher positive relationship of mobile marketing results compared to email marketing outcomes. There are favorable benefits in considering such emerging methods in marketing communications as promotional strategies are considered by organizations. Recommendations for Practitioners: Marketers are encouraged to evaluate the potential of using both emerging mediums to take advantage of consumer impulse buying habits where m-devices and emails approaches are utilized. Future Research: Future inquiries might examine the global influence of m-devices and email technology toward other buying tendencies of consumers: exploratory, online, variety seeking, habitual, and other emerging complex on-demand buying behavior.

The divestment of Corbion's emulsifiers business follows Corbion’s Advance 2025 strategy, announced in March 2020, focusing on further growing a set of core competencies built around advanced expertise in fermentation that are essential to fulfilling the company's central purpose, to "preserve what matters."   

In conjunction with its February profile of new sports foods and drinks, Prepared Foods interviewed Scott Peters, director of product development at 3i Solutions, Wooster, Ohio. 

The addition of AAK Foodservice, Hillside aligns with Stratas Foods’ long-term growth objectives, particularly within the value-added oils, dressings, sauces, and mayonnaise (DSM) categories.

The CELSIUS ESSENTIALS line features boldly flavored performance energy drinks that are made up of the METAPLUS® blend and added aminos, helping support physical and cognitive performance. 

LSI Flooring, after acquiring Daltonian Flooring's padding division in 2022, introduces "Unsquashable Padding."

Children's Geographies; 10/01/2024
(AN 180134754); ISSN: 14733285
Academic Search Premier

The post The Practice of Electroconvulsive Therapy, Third Edition: Recommendations for Treatment, Training, and Privileging (A Task Force Report of the American Psychiatric Association) was curated by information for practice.

The post Ethical, legal, and social issues (ELSI) and reporting guidelines of AI research in healthcare was curated by information for practice.

Perched like a steel footbridge on a hillside, Villa Sidonius, by Stempel & Tesar, transforms architectural challenges into breathtaking views.

Electroconvulsive therapy (ECT) induces a generalized seizure under anesthesia with an electrical current for treatment-resistant patients and may be underutilized. To our knowledge, no large-scale, American, … Read the full article ›

The post Electroconvulsive therapy (ECT) and Psychiatric rehospitalization rates: a retrospective study was curated by information for practice.

The compression behavior of [Rb(18-crown-6)][SbCl6] crystal under pressure up to 2.16 (3) GPa was investigated in a diamond anvil cell (DAC) using a mixture of pentane–iso­pentane (1:4) as the pressure-transmitting fluid. The compound crystallizes in trigonal space group R3 and no phase transition was observed in the indicated pressure range. The low value of pressure bulk modulus [9.1 (5) GPa] found in this crystal is a characteristic of soft materials with predominant dispersive and electrostatic interaction forces. The nonlinear relationship between unit-cell parameters under high pressure is attributed to the influence of reduced intermolecular H⋯Cl contacts under pressure over 0.73 GPa. It also explains the high compression efficiency of [Rb(18-crown-6)][SbCl6] crystals at relatively low pressures, resulting in a significant shift of the Rb atom to the center of the crown ether cavity. At pressures above 0.9 GPa, steric repulsion forces begin to play a remarkable role, since an increasing number of interatomic H⋯Cl and H⋯H contacts become shorter than the sum of their van der Waals (vdW) radii. Below 0.9 GPa, both unit-cell parameter dependences (P–a and P–c) exhibit hysteresis upon pressure release, demonstrating their influence on the disordered model of Rb atoms. The void reduction under pressure also demonstrates two linear sections with the inflection point at 0.9 GPa. Compression of the crystal is accompanied by a significant decrease in the volume of the voids, leading to the rapid approach of Rb atoms to the center of the crown ether cavity. For the Rb atom to penetrate into the center of the crown ether cavity in [Rb(18-crown-6)][SbCl6], it is necessary to apply a pressure of about 2.5 GPa to disrupt the balance of atomic forces in the crystal. This sample serves as a compression model demonstrating the influence of both attractive and repulsive forces on the change in unit-cell parameters under pressure.

DLSIA (Deep Learning for Scientific Image Analysis) is a Python-based machine learning library that empowers scientists and researchers across diverse scientific domains with a range of customizable convolutional neural network (CNN) architectures for a wide variety of tasks in image analysis to be used in downstream data processing. DLSIA features easy-to-use architectures, such as autoencoders, tunable U-Nets and parameter-lean mixed-scale dense networks (MSDNets). Additionally, this article introduces sparse mixed-scale networks (SMSNets), generated using random graphs, sparse connections and dilated convolutions connecting different length scales. For verification, several DLSIA-instantiated networks and training scripts are employed in multiple applications, including inpainting for X-ray scattering data using U-Nets and MSDNets, segmenting 3D fibers in X-ray tomographic reconstructions of concrete using an ensemble of SMSNets, and leveraging autoencoder latent spaces for data compression and clustering. As experimental data continue to grow in scale and complexity, DLSIA provides accessible CNN construction and abstracts CNN complexities, allowing scientists to tailor their machine learning approaches, accelerate discoveries, foster interdisciplinary collaboration and advance research in scientific image analysis.