El presidente de Castilla-La Mancha, Emiliano García-Page, ha mostrado su satisfacción por la decisión del Gobierno central de crear un Alto Comisionado destinado a agilizar la reconstrucción en las zonas afectadas por la reciente DANA (Depresión Aislada en Niveles Altos). Durante un discurso en Puertollano, García-Page expresó su confianza en que la Administración central no […]

Artículo publicado en : Page Celebra la Creación del Alto Comisionado y Exige al Estado Compromiso en la Restauración de los Cauces

El Real Decreto-ley incluye el polémico permiso laboral de Yolanda Díaz y amplía las ayudas a empresas con domicilio fiscal fuera de la zona cero Leer

ELA plantea reclama al resto de sindicatos que no participen en el Pacto de la Salud que se reunirá el próximo miércoles. LAB también se opone a una iniciativa del Gobierno de Sánchez para aliviar las listas de espera en traumatología. Leer

"Ha llegado el momento de la verdad", subraya el líder de los socialistas vascos que reclama "responsabilidad" a la coalición 'abertzale' para que apoye los cambios fiscales en Álava y en Gipuzkoa. Leer

"Sí, no puedo ser más claro", ha respondido el presidente del Gobierno al ser preguntado expresamente sobre si avala su papel en la DANA Leer

Anuncia que en 2025 el Gobierno vasco impulsará el inicio de las obras de 975 pisos de VPO y confía que la iniciativa privada comience otras 1.200. El consejero socialista advierte de que con las zonas tensionadas se gana tiempo para equilibrar la oferta con una creciente demanda Leer

Maribel Albalat asegura que las tareas pendientes "sobrepasan los límites de lo asumible por una administración local" y lo admite con "honestidad, transparencia y humildad". Leer

Official sources and a number of senior doctors confirmed that these deputation/postings were made to address specific manpower shortages in medical colleges in Nagapattinam, Tiruvallur and Tiruvarur

There is bad news everywhere amid Covid 19 crisis which has led most employed to fret about job loss or salary cuts. Various industries hit the most including aviation has announced no pay-outs for April, May month. At the same time,

(United States Ninth Circuit) - Reversed in part the dismissal of a securities fraud class action alleging that a biotechnology firm misrepresented to investors the status of a clinical drug trial. An investor brought this suit contending that the company and certain top executives violated Section 10(b) of the Securities Exchange Act of 1934. On appeal, the Ninth Circuit held that the district court erred in part in dismissing the complaint for failure to state a claim. The panel also ruled that the district court abused its discretion in judicially noticing certain facts and in incorporating certain documents into the complaint.

French translation of "Frequently asked questions on market risk capital requirements" by the Basel Committee, March 2018.

French translation of "Pillar 3 disclosure requirements - updated framework", December 2018

Despite their opposing actions on food intake, POMC and NPY/AgRP neurons in the arcuate nucleus of the hypothalamus (ARH) are derived from the same progenitors that give rise to ARH neurons. However, the mechanism whereby common neuronal precursors subsequently adopt either the anorexigenic (POMC) or the orexigenic (NPY/AgRP) identity remains elusive. We hypothesize that POMC and NPY/AgRP cell fates are specified and maintained by distinct intrinsic factors. In search of them, we profiled the transcriptomes of developing POMC and NPY/AgRP neurons in mice. Moreover, cell-type-specific transcriptomic analyses revealed transcription regulators that are selectively enriched in either population, but whose developmental functions are unknown in these neurons. Among them, we found the expression of the PR domain-containing factor 12 (Prdm12) was enriched in POMC neurons but absent in NPY/AgRP neurons. To study the role of Prdm12 in vivo, we developed and characterized a floxed Prdm12 allele. Selective ablation of Prdm12 in embryonic POMC neurons led to significantly reduced Pomc expression as well as early-onset obesity in mice of either sex that recapitulates symptoms of human POMC deficiency. Interestingly, however, specific deletion of Prdm12 in adult POMC neurons showed that it is no longer required for Pomc expression or energy balance. Collectively, these findings establish a critical role for Prdm12 in the anorexigenic neuron identity and suggest that it acts developmentally to program body weight homeostasis. Finally, the combination of cell-type-specific genomic and genetic analyses provides a means to dissect cellular and functional diversity in the hypothalamus whose neurodevelopment remains poorly studied.

SIGNIFICANCE STATEMENT POMC and NPY/AgRP neurons are derived from the same hypothalamic progenitors but have opposing effects on food intake. We profiled the transcriptomes of genetically labeled POMC and NPY/AgRP neurons in the developing mouse hypothalamus to decipher the transcriptional codes behind the versus orexigenic neuron identity. Our analyses revealed 29 transcription regulators that are selectively enriched in one of the two populations. We generated new mouse genetic models to selective ablate one of POMC-neuron enriched transcription factors Prdm12 in developing and adult POMC neurons. Our studies establish a previously unrecognized role for Prdm12 in the anorexigenic neuron identity and suggest that it acts developmentally to program body weight homeostasis.

The new coastal zone regulation reads as a compendium of the myriad exceptions to the few rules - a move away from managing the coastal natural resources based on principles to one based on discretion. Kannan Kasturi reports.

There is bad news everywhere amid Covid 19 crisis which has led most employed to fret about job loss or salary cuts. Various industries hit the most including aviation has announced no pay-outs for April, May month. At the same time,