Trivedi, C B; Stamps, B W; Lau, G E; Grasby, S E; Templeton, A S; Spear, J R. mSystems vol. 5, issue 4, e00504-20, 2020 p. 1-16, https://doi.org/10.1128/mSystems.00504-20
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Redundancy can come about at anytime but you can safeguard against the unknown as well as the reality that it could possibly occur to you. Income protection insurance would let you take out a policy to get a fixed premium every month...

It is fewer than the about 40 job cuts that St Giles Hospice warned it might have to make in the summer

This new requirement was established following a months-long infant formula shortage sparked by insanitary conditions at one of the nation’s largest infant formula facilities. 

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The molecular mechanism used by many bacteria to kill neighboring cells has redundancy built into its genetic makeup, which could allow for the mechanism to be expressed in different environments, say researchers at Penn State and the University of Wisconsin-Madison. Their new study provides insights into the molecular mechanisms of competition among bacteria. "Many organisms, including humans, acquire bacteria from their environment," said Tim Miyashiro, a biochemist and molecular biologist at Penn State and the leader of the research team. "These bacteria can contribute to functions within the host organism, like how our gut bacteria help us digest food. We're interested in the interactions among bacteria cells, and between bacteria and their hosts, to better understand these mutually beneficial symbiotic relationships." Cells of the bioluminescent bacteria Vibrio fisheri take up residence in the light organ of newly hatched bobtail squid. At night, the bacteria produce a blue glow that researchers believe obscures a squid's silhouette and helps protect it from predators. The light organ has pockets, or crypts, in the squid's skin that provide nutrients and a safe environment for the bacteria. "When the squid hatches, it doesn't yet have any bacteria in its light organ," said Miyashiro. "But bacteria in the environment quickly colonize the squid's light organ." Some of these different bacteria strains can coexist, but others can't. "Microbial symbioses are essentially universal in animals, and are crucial to the health and development of both partners," says Irwin Forseth, a program director in the National Science Foundation's Division of Integrative Organismal Systems, which funded the research. "The results from this study highlight the role small genetic changes can play in microbe interactions. Increased understanding will allow us to better predict organisms' performance in changing environments."

Image credit: Andrew Cecere

CARM1 is a protein arginine methyltransferase (PRMT) that acts as a coactivator in a number of transcriptional programs. CARM1 orchestrates this coactivator activity in part by depositing the H3R17me2a histone mark in the vicinity of gene promoters that it regulates. However, the gross levels of H3R17me2a in CARM1 KO mice did not significantly decrease, indicating that other PRMT(s) may compensate for this loss. We thus performed a screen of type I PRMTs, which revealed that PRMT6 can also deposit the H3R17me2a mark in vitro. CARM1 knockout mice are perinatally lethal and display a reduced fetal size, whereas PRMT6 null mice are viable, which permits the generation of double knockouts. Embryos that are null for both CARM1 and PRMT6 are noticeably smaller than CARM1 null embryos, providing in vivo evidence of redundancy. Mouse embryonic fibroblasts (MEFs) from the double knockout embryos display an absence of the H3R17me2a mark during mitosis and increased signs of DNA damage. Moreover, using the combination of CARM1 and PRMT6 inhibitors suppresses the cell proliferation of WT MEFs, suggesting a synergistic effect between CARM1 and PRMT6 inhibitions. These studies provide direct evidence that PRMT6 also deposits the H3R17me2a mark and acts redundantly with CARM1.

VOLUME 289 (2014) PAGES 6604–6618In Fig. 4G, in the foxi1 panel, the images in Fig. 4G, i and l, corresponding to “smad1 MO” and “smad5 MO + samd1/9 mRNA” samples, respectively, were inadvertently reused during figure preparation. This error has now been corrected using images pertaining to each treatment and sample. This correction does not affect the results or conclusions of the work.jbc;295/52/18650/F4F1F4Figure 4G.

The Minister of Finance and Coordinating Minister of the Economy, Mr Wale Edun, has assured that the Federal Government will soon begin payment of the pension backlog. Edun gave this assurance on Tuesday in Abuja during a peaceful rally by the Nigeria Union of Pensioners Contributory Pension Scheme Sector, NUPCPS, at the Federal Ministry of […]

Nigerian Govt to commence payment of pension backlog – Finance Minister Edun

Manchester : Manchester University Press, 2016.

IEEE / Institute of Electrical and Electronics Engineers Incorporated

UGC Chairman Jagadesh Kumar emphasises that board exams are not likely to be made irrelevant in light of the decline in pass percentage in CBSE class 12 exams this year

Coronavirus is ensuring the trade-off, especially for developing economies is significant, notwithstanding efforts to strike a balance

The Employment Appeals Tribunal (“EAT”) has recently given an interesting ruling on  redundancy selection which could open the door to more claims from disabled employees. Background <...

A recent Employment Appeal Tribunal decision (The Mayor and Burgess of the London Borough of Tower Hamlets v Mr J Wooster) has found a local authority liable for unfair dismissal and age discrimination where it made insufficient effort to redeploy a...

Details have just been published of the annual uprating of compensation limits for tribunal claims and other amounts payable under employment legislation. The new amounts will apply where the relevant event occurs on or after 1 February 2009. For un...

New Zealand should extend access to income support and introduce a longer minimum notice period for all workers to help disadvantaged laid-off workers find a new job and maintain their job quality and living standards, according to a new OECD report.

Qantas chief executive Alan Joyce, who makes nearly $24million a year and is the highest-paid CEO in Australia, confirmed the company needed to cut its $4.3billion wage bill.

Full Text:

The molecular mechanism used by many bacteria to kill neighboring cells has redundancy built into its genetic makeup, which could allow for the mechanism to be expressed in different environments, say researchers at Penn State and the University of Wisconsin-Madison. Their new study provides insights into the molecular mechanisms of competition among bacteria. "Many organisms, including humans, acquire bacteria from their environment," said Tim Miyashiro, a biochemist and molecular biologist at Penn State and the leader of the research team. "These bacteria can contribute to functions within the host organism, like how our gut bacteria help us digest food. We're interested in the interactions among bacteria cells, and between bacteria and their hosts, to better understand these mutually beneficial symbiotic relationships." Cells of the bioluminescent bacteria Vibrio fisheri take up residence in the light organ of newly hatched bobtail squid. At night, the bacteria produce a blue glow that researchers believe obscures a squid's silhouette and helps protect it from predators. The light organ has pockets, or crypts, in the squid's skin that provide nutrients and a safe environment for the bacteria. "When the squid hatches, it doesn't yet have any bacteria in its light organ," said Miyashiro. "But bacteria in the environment quickly colonize the squid's light organ." Some of these different bacteria strains can coexist, but others can't. "Microbial symbioses are essentially universal in animals, and are crucial to the health and development of both partners," says Irwin Forseth, a program director in the National Science Foundation's Division of Integrative Organismal Systems, which funded the research. "The results from this study highlight the role small genetic changes can play in microbe interactions. Increased understanding will allow us to better predict organisms' performance in changing environments."

Image credit: Andrew Cecere

Full Text:

The molecular mechanism used by many bacteria to kill neighboring cells has redundancy built into its genetic makeup, which could allow for the mechanism to be expressed in different environments, say researchers at Penn State and the University of Wisconsin-Madison. Their new study provides insights into the molecular mechanisms of competition among bacteria. "Many organisms, including humans, acquire bacteria from their environment," said Tim Miyashiro, a biochemist and molecular biologist at Penn State and the leader of the research team. "These bacteria can contribute to functions within the host organism, like how our gut bacteria help us digest food. We're interested in the interactions among bacteria cells, and between bacteria and their hosts, to better understand these mutually beneficial symbiotic relationships." Cells of the bioluminescent bacteria Vibrio fisheri take up residence in the light organ of newly hatched bobtail squid. At night, the bacteria produce a blue glow that researchers believe obscures a squid's silhouette and helps protect it from predators. The light organ has pockets, or crypts, in the squid's skin that provide nutrients and a safe environment for the bacteria. "When the squid hatches, it doesn't yet have any bacteria in its light organ," said Miyashiro. "But bacteria in the environment quickly colonize the squid's light organ." Some of these different bacteria strains can coexist, but others can't. "Microbial symbioses are essentially universal in animals, and are crucial to the health and development of both partners," says Irwin Forseth, a program director in the National Science Foundation's Division of Integrative Organismal Systems, which funded the research. "The results from this study highlight the role small genetic changes can play in microbe interactions. Increased understanding will allow us to better predict organisms' performance in changing environments."

Image credit: Andrew Cecere

The SME-focused insurtech was launched by former Aviva and Brokerbility expert, Jodi Cartwright, in 2019.

Contribute to build high reliable systems Compact and Cost-effective solution for Back-up applications Easy setup for system reliability requirement(S8VK-R)

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Never before has the threat of cyber attacks been so widespread, so quick to develop and modify, and so staggering in its potential impact, which is why The Connectivity Center is investing in the next generation of cyber security products.

The present inventions are related to systems and methods for data processing, and more particularly to systems and methods for variable rate coding in a data processing system.

A system (200) and a method (100) of operating a computing device to perform memoization are disclosed. The method includes determining whether a result of a function is stored in a cache and, if so, retrieving the result from the cache and, if not, calculating the result and storing it in the cache. The method (100) includes transforming (104) by the computing device at least one selected from the input parameters and the output parameters of the function, the transforming being based on an analysis of the function and its input arguments to establish whether or not there is a possible relationship reflecting redundancy among the input parameters and output parameters of the function. The transforming may include at least one of: use of symmetry, scaling, linear shift, interchanging of variables, inversion, polynomial and/or trigonometric transformations, spectral or logical transformations, fuzzy transformations, and systematic arrangement of parameters.

An electrode assembly that includes an electrically conductive layer, a first impedance reduction system, and a second impedance reduction system. The electrically conductive layer forms an electrode portion of the electrode assembly and a first surface to be placed adjacent a person's skin. The first impedance reduction system is configured to dispense a first amount of an electrically conductive gel onto the first surface of the electrically conductive layer in response to a first activation signal. The second impedance reduction system is configured to dispense a second amount of the electrically conductive gel onto the first surface of the electrically conductive layer in response to a second activation signal.

A multi-channel optoelectronic device is configured to establish a redundant status link with a remote device. The optoelectronic device can transmit N transmit optical signals to the remote device over a plurality of transmit channels and receive N receive optical signals from the remote device over a plurality of receive channels. The optoelectronic device includes one or more spare transmit and receive channels. When used with a remote device having spare transmit and receive channels, each device can establish a status link with the other and use the status link to switch out transmit and/or receive channels to identify and permanently switch out the worst transmit and/or receive channels. Alternately, the device can interoperate with a non-status-link enabled remote device by determining that the remote device is not status-link enabled, transitioning to a low transmit power mode, and transmitting and receiving over a plurality of default transmit and receive channels.

A multi-chip package may include first and second integrated circuit dies that are each partitioned into multiple logic regions. The logic regions of the first and second dies may be coupled via interconnects. Each integrated circuit die may include at least one spare logic region. Multiple logic groups may be formed with each logic group including logic regions from the first and second integrated circuit dies and the interconnects that couple those logic regions. The logic groups may be evaluated to identify defective logic groups. In response to identifying a defective logic group, the defective logic group may be repaired by configuring the first and second integrated circuit dies to stop using the defective logic group and to use a spare logic group. The spare logic group may include spare logic regions of the first and second dies that are coupled by spare logic region interconnects.

The disclosure relates generally to triple-redundant sequential state (TRSS) machines formed as integrated circuits on a semiconductor substrate, such as CMOS, and computerized methods and systems of designing the triple-redundant sequential state machines. Of particular focus in this disclosure are sequential state elements (SSEs) used to sample and hold bit states. The sampling and holding of bits states are synchronized by a clock signal thereby allowing for pipelining in the TRSS machines. In particular, the clock signal may oscillate between a first clock state and a second clock state to synchronize the operation of the SSE according to the timing provided by the clock states. The SSEs has a self-correcting mechanism to protect against radiation induced soft errors. The SSE may be provided in a pipeline circuit of a TRSS machine to receive and store a bit state of bit signal generated by combinational circuits within the pipeline circuit.

The disclosure relates generally to sequential state elements (SSEs), triple-mode redundant state machines (TMRSMs), and methods and systems for testing triple-mode redundant pipeline stages (TMRPSs) within the TMRSMs using triple-mode redundant SSEs (TMRSSEs). The SSEs, TMRSMs, TMRPSs, and TMRSSEs may be formed as integrated circuits on a semiconductor substrate. Of particular focus in this disclosure are SSEs used to sample and hold bit states. Embodiments of the SSEs have a self-correcting mechanism to protect against radiation-induced soft errors. The SSE may be provided in a pipeline circuit of a TMRSM to receive and store a bit state of a bit signal generated by combinational circuits within the pipeline circuit. More specifically, the SSEs may be provided in a TMRSSE configured to perform self-correction. Also disclosed are methods for using the TMRSSE to test redundant pipeline stages of the TMRSM.

An integrated circuit includes a circuit block to utilize a load current at a load voltage from a power input and two or more charge pump arrays. The outputs of the charge pump arrays are coupled to the power input of the circuit block. The integrated circuit includes one or more modifiable elements to disable one or more of the two or more charge pump arrays.

A method and apparatus for shader data repair utilizing a Redundant Shader Switch (RSS). The RSS consists of an input and output section whereby when a defective shader pipe is detected, the RSS multiplexes shader pipe data destined to the defective shader pipe to a redundant shader pipe array for processing. Once processed, the shader pipe data is multiplexed back to the RSS where the processed shader pipe data is directed to the corresponding output column of the RSS. The RSS contains delay pipes used to re-align and synchronize the repaired shader pipe data with output export data.

A valve includes a stem seal assembly that prevent fluid flow in a first direction and vents in a second direction opposite the first direction. The assembly includes a packing assembly positioned within a valve stem opening of a valve body of the valve to seal a valve stem to the valve body. The packing assembly includes a first seal and a second seal preventing passage of fluid from a body cavity of the valve body to an exterior of the valve body along the valve stem while venting fluid from an exterior of the valve body to the body cavity along the valve stem. The packing assembly isolates the first seal and the second seal so that a load applied to the first seal ring is not transferred to the second seal ring.

An apparatus includes a rotatable shaft having a shaft surface and a first seal disposed in a sealing engagement with the shaft surface. At least a second seal is disposed in a first position relative to the rotatable shaft where the second seal is not in sealing engagement with the shaft surface and is movable to a second position relative to the rotatable shaft where the second seal is in sealing engagement with the shaft surface.

A display assembly includes a flexible sheet. The flexible sheet is formed of a flexible material supporting a first display panel and a second display panel. A mechanism is operatively connected to the flexible sheet. The mechanism moves the flexible sheet from a first position in which said first display panel may be viewed to a second position in which said second display panel may be viewed.

A GLASGOW ARTIST is raising money for NHS Charities by selling Glasgow-during-lockdown themed prints after being made redundant.

SA senator Sarah Hanson-Young says a crude Facebook post shared by a business owned by the Ceduna Mayor is "degrading" to women, but he says his Facebook account was hacked.

A woman has faced court charged with murder following the death of a man at Port Augusta in South Australia's north.

It is certain that BA's intercontinental fleet will become significantly smaller

N. Leigh Anderson
Apr 1, 2004; 3:311-326
Research