Alaric [the older son] died that same year 410 A.D. Two years later, his kinsman Athaulf led the Visigoths into southwestern Gaul, where, in AD 418, Honorius was obliged to recognize their kingdom at Toulouse. The Vandals and other Germanic tribes who had crossed over the frozen Rhine on the last day of AD 406 now were in Spain under their leader, Genseric. Honorius permitted them to stay, as well, although there was little he could have done otherwise. In AD 423 Honorius died and eventually was succeeded by Valentinian III, who was still a child at the time. The Vandals crossed into North Africa, defeated the Romans there, and, in AD 439, conquered Carthage, which Genseric made his capital. In AD 451, Attila and the Huns, who already had become so powerful that they were paid an annual tribute by Rome, invaded Gaul, in alliance with the Vandals. They were defeated at the Battle of Châlons by the Visigoths under the command of Flavius Aetius, magister militum of the west. In AD 455, the death of Valentinian III served as a pretext for the Vandals to enter an undefended Rome, which they plundered for two weeks, carrying away the treasures of the Temple of Peace and the gilded bronze tiles from the Temple of Jupiter. Temple of Vespasian.

There are few easy answers when corporate entities try to determine what your moral choices are, but there is something that can be done--with difficulty.

While a controls upgrade may be costly, the reality is, the longer you wait, the more expensive a replacement can be.

Today's architecture is no longer about creating the best space just for humans, though of course that has to be a factor. It's also about preserving and living in harmony with the natural world. But being harmonious with nature presents a unique set of challenges. The Hidden Garden House by RAD+ar (Research Artistic Design + Architecture) is a showcase of creative and innovative solutions for just such a challenge.[...]

Title: Benji, Marley or Bo: Three Genes Dictate Dog's Coat
Category: Health News
Created: 8/27/2009 4:10:00 PM
Last Editorial Review: 8/28/2009 12:00:00 AM

Title: New Missouri Law Dictates What Can be Called Meat
Category: Health News
Created: 8/30/2018 12:00:00 AM
Last Editorial Review: 8/31/2018 12:00:00 AM

Existing technologies could reduce emissions of CO2 and air pollutants from land transport by almost a third. But, reductions will not be delivered through markets alone, according to a recent assessment, particularly for CO2. The researchers argue that strong policy interventions will be essential to mitigating climate change caused by emissions from land transport.

Title: Genetic Changes May Dictate Course of Acute Myeloid Leukemia
Category: Health News
Created: 5/1/2008 2:00:00 AM
Last Editorial Review: 5/1/2008 12:00:00 AM

ABSTRACT

The human gut microbiota (HGM) has far-reaching impacts on human health and nutrition, which are fueled primarily by the metabolism of otherwise indigestible complex carbohydrates commonly known as dietary fiber. However, the molecular basis of the ability of individual taxa of the HGM to address specific dietary glycan structures remains largely unclear. In particular, the utilization of β(1,3)-glucans, which are widespread in the human diet as yeast, seaweed, and plant cell walls, had not previously been resolved. Through a systems-based approach, here we show that the symbiont Bacteroides uniformis deploys a single, exemplar polysaccharide utilization locus (PUL) to access yeast β(1,3)-glucan, brown seaweed β(1,3)-glucan (laminarin), and cereal mixed-linkage β(1,3)/β(1,4)-glucan. Combined biochemical, enzymatic, and structural analysis of PUL-encoded glycoside hydrolases (GHs) and surface glycan-binding proteins (SGBPs) illuminates a concerted molecular system by which B. uniformis recognizes and saccharifies these distinct β-glucans. Strikingly, the functional characterization of homologous β(1,3)-glucan utilization loci (1,3GUL) in other Bacteroides further demonstrated that the ability of individual taxa to utilize β(1,3)-glucan variants and/or β(1,3)/β(1,4)-glucans arises combinatorially from the individual specificities of SGBPs and GHs at the cell surface, which feed corresponding signals to periplasmic hybrid two-component sensors (HTCSs) via TonB-dependent transporters (TBDTs). These data reveal the importance of cooperativity in the adaptive evolution of GH and SGBP cohorts to address individual polysaccharide structures. We anticipate that this fine-grained knowledge of PUL function will inform metabolic network analysis and proactive manipulation of the HGM. Indeed, a survey of 2,441 public human metagenomes revealed the international, yet individual-specific, distribution of each 1,3GUL.

IMPORTANCE Bacteroidetes are a dominant phylum of the human gut microbiota (HGM) that target otherwise indigestible dietary fiber with an arsenal of polysaccharide utilization loci (PULs), each of which is dedicated to the utilization of a specific complex carbohydrate. Here, we provide novel insight into this paradigm through functional characterization of homologous PULs from three autochthonous Bacteroides species, which target the family of dietary β(1,3)-glucans. Through detailed biochemical and protein structural analysis, we observed an unexpected diversity in the substrate specificity of PUL glycosidases and glycan-binding proteins with regard to β(1,3)-glucan linkage and branching patterns. In combination, these individual enzyme and protein specificities support taxon-specific growth on individual β(1,3)-glucans. This detailed metabolic insight, together with a comprehensive survey of individual 1,3GULs across human populations, further expands the fundamental roadmap of the HGM, with potential application to the future development of microbial intervention therapies.

A Queensland dairy farmer says the Dairy Code of Conduct is 'worthless' in its current state after negotiations with a processor for a new milk contract failed.

Friends of Ryan Lochte are mounting a defense of the 'robbed' swimmer, saying that although he has changed his story, it contains a core truth that he handed over money to a man at gunpoint.

SAMI MOKBEL AT THE TOTTENHAM HOTPSUR STADIUM: Harry Winks, under-appreciated? Maybe, but certainly not by the people that matter.