A new study hints at the ways in which air pollution may directly impact a fetus.

Ao longo da pandemia e com rápida propagação do vírus, que já atingiu mais de 3 milhões de pessoas, tem surgido diversos outros sinais associados à enfermidade, como tremores e calafrios persistentes.

The placenta participates in maternal insulin sensitivity changes during pregnancy; however, mechanisms remain unclear. We investigated associations between maternal insulin sensitivity and placental DNA methylation markers across the genome. We analyzed data from 430 mother-offspring dyads in the Gen3G cohort. All women underwent 75-g oral glucose tolerance tests at ~26 weeks of gestation; we used glucose and insulin measures to estimate insulin sensitivity (Matsuda index). At delivery, we collected samples from placenta (fetal side) and measured DNA methylation using Illumina EPIC arrays. Using linear regression models to quantify associations at 720,077 cytosine-guanine dinucleotides (CpGs), with adjustment for maternal age, gravidity, smoking, BMI, child sex, and gestational age at delivery, we identified 188 CpG sites where placental DNA methylation was associated with Matsuda index (P < 6.94 x 10^–8). Among genes annotated to these 188 CpGs, we found enrichment in targets for miRNAs, in histone modifications, and in parent-of-origin DNA methylation including the H19/MIR675 locus (paternally imprinted). We identified 12 known placenta imprinted genes, including KCNQ1. Mendelian randomization analyses revealed five loci where placenta DNA methylation may causally influence maternal insulin sensitivity, including the maternally imprinted gene DLGAP2. Our results suggest that placental DNA methylation is fundamentally linked to the regulation of maternal insulin sensitivity in pregnancy.

Paris : G. Steinheil, 1892.

Part C early intervention serves ~2.8% of US children who are younger than 3 years old; however, there is evidence that substantial numbers of infants and toddlers with developmental delays receive no early intervention services.

Broad eligibility criteria can classify children who have no delays or minimal delays as candidates for Part C services. Despite this, no jurisdiction provides Part C services to all children who have substantial delays. (Read the full article)

In HIV-infected children, decisions to start antiretroviral therapy must weigh immunologic benefits against potential risks. Current guidelines recommend using CD4 percentage and age when deciding to start treatment. Population-level effects of these factors on immunologic recovery are unknown.

Starting antiretroviral therapy at higher CD4 percentages and younger ages maximizes potential for immunologic recovery. However, not all benefits are sustained, and viral failure may occur. Our results help clinicians better weigh immunologic benefits against viral failure risks. (Read the full article)

An information disclosure vulnerability exists when Centaur and TitanSMA fail to properly protect critical system logs such as 'syslog'. Additionally, the implemented Jetty version (9.4.z-SNAPSHOT) suffers from a memory leak of shared buffers that was (supposedly) patched in Jetty version 9.2.9.v20150224.

Nanometrics Centaur version 4.3.23 suffers from an unauthenticated remote memory leak vulnerability.

ABSTRACT

The prevailing paradigm in obstetrics has been the sterile womb hypothesis. However, some are asserting that the placenta, intra-amniotic environment, and fetus harbor microbial communities. The objective of this study was to determine whether the fetal and placental tissues of rhesus macaques harbor bacterial communities. Fetal, placental, and uterine wall samples were obtained from cesarean deliveries without labor (~130/166 days gestation). The presence of bacteria in the fetal intestine and placenta was investigated through culture. The bacterial burden and profiles of the placenta, umbilical cord, and fetal brain, heart, liver, and colon were determined through quantitative real-time PCR and DNA sequencing. These data were compared with those of the uterine wall as well as to negative and positive technical controls. Bacterial cultures of fetal and placental tissues yielded only a single colony of Cutibacterium acnes. This bacterium was detected at a low relative abundance (0.02%) in the 16S rRNA gene profile of the villous tree sample from which it was cultured, yet it was also identified in 12/29 background technical controls. The bacterial burden and profiles of fetal and placental tissues did not exceed or differ from those of background technical controls. By contrast, the bacterial burden and profiles of positive controls exceeded and differed from those of background controls. Among the macaque samples, distinct microbial signals were limited to the uterine wall. Therefore, using multiple modes of microbiologic inquiry, there was not consistent evidence of bacterial communities in the fetal and placental tissues of rhesus macaques.

IMPORTANCE Microbial invasion of the amniotic cavity (i.e., intra-amniotic infection) has been causally linked to pregnancy complications, especially preterm birth. Therefore, if the placenta and the fetus are typically populated by low-biomass microbial communities, current understanding of the role of microbes in reproduction and pregnancy outcomes will need to be fundamentally reconsidered. Could these communities be of benefit by competitively excluding potential pathogens or priming the fetal immune system for the microbial bombardment it will experience upon delivery? If so, what properties (e.g., microbial load and community membership) of these microbial communities preclude versus promote intra-amniotic infection? Given the ramifications of the in utero colonization hypothesis, critical evaluation is required. In this study, using multiple modes of microbiologic inquiry (i.e., culture, quantitative real-time PCR [qPCR], and DNA sequencing) and controlling for potential background DNA contamination, we did not find consistent evidence for microbial communities in the placental and fetal tissues of rhesus macaques.

Mouse studies suggest inhibiting PGF could help treat hypertension.

It's important, but higher isn't always better.

Nicky Case (of Explorable Explanations and Parable of the Polygons internet fame) has a fantastic essay which picks up on the theme of my last Cyberselves post – technology as companion, not competitor. In How To Become A Centaur Case gives blitz history of AI, and of its lesser known cousin IA – Intelligence Augmentation. … Continue reading "How To Become A Centaur"

Canadian group makes all-stock proposal public after talks fail to get off ground

From the goat's blood injections Usain Bolt took before winning Olympic gold at Rio to Diego Costa's use of horse placenta, Sportsmail have looked athletes methods of treatment

Diego Costa has admitted that he had a massage with horse placenta and electroshocks as he attempted to be fit for the Champions League final in 2014.

Diego Costa has admitted that he had a massage with horse placenta and electroshocks as he attempted to be fit for the Champions League final in 2014.

The Hammers are keen to ensure staff receive '100 per cent of their salaries' while the game is suspended, with Mark Noble saying the entire squad wanted to do their bit and help out.

Kozhikode recorded the highest voting percentage at 81.89%

In Andhra Pradesh, the Naidu government's Janmabhoomi model of development gutted the panchayats and curbed local democracy. Hence, the panchayats have proved totally ineffective during the agrarian crisis, reports P Sainath.