Audiophiles have a new DAC for on-the-go use, in the form of the new cassette-inspired Fiio KA15 – which is small enough to be a keyring.

Michael Dean
Jul 1, 2001; 42:1007-1017
Thematic Reviews

As part of the Virus-X Consortium that aims to identify and characterize novel proteins and enzymes from bacteriophages and archaeal viruses, the genes of the putative lytic proteins XepA from Bacillus subtilis prophage PBSX and YomS from prophage SPβ were cloned and the proteins were subsequently produced and functionally characterized. In order to elucidate the role and the molecular mechanism of XepA and YomS, the crystal structures of these proteins were solved at resolutions of 1.9 and 1.3 Å, respectively. XepA consists of two antiparallel β-sandwich domains connected by a 30-amino-acid linker region. A pentamer of this protein adopts a unique dumbbell-shaped architecture consisting of two discs and a central tunnel. YomS (12.9 kDa per monomer), which is less than half the size of XepA (30.3 kDa), shows homology to the C-terminal part of XepA and exhibits a similar pentameric disc arrangement. Each β-sandwich entity resembles the fold of typical cytoplasmic membrane-binding C2 domains. Only XepA exhibits distinct cytotoxic activity in vivo, suggesting that the N-terminal pentameric domain is essential for this biological activity. The biological and structural data presented here suggest that XepA disrupts the proton motive force of the cytoplasmatic membrane, thus supporting cell lysis.

Along with a years-long renaissance of records, some are turning away from collecting music digitally.

A rear bicycle sprocket for use with a multi-gear rear cassette is provided. The sprocket includes a chain engaging portion and a mounting portion having generally annular shape about a central axis and a plurality of support arms, integrally formed with the chain engaging portion and with the mounting portion. The sprocket further includes a plurality of space maintaining protrusions, each space maintaining protrusion extending axially forwardly from an axially forward surface of a corresponding support arm and integrally formed therewith. A multi-gear rear cassette having a plurality of sprockets coaxially mounted together wherein the plurality of sprockets includes the rear bicycle sprocket mounted axially rearmost and a bicycle including the multi-gear rear cassette are further provided.

Length adjustment can be performed in a simple manner and without impairment of the insulating effect in an insulation cassette for the heat insulation of elongated elements. A multilayer insulation includes flat reflection elements (21, 22). Each layer of the insulation has at least two of the flat reflection elements (21, 22), which overlap at least partly at their ends (24) facing each other.

The present invention involves, in some embodiments, systems and methods involving fluid handling apparatus for pumping fluid to and from a patient, which may include a reusable component and a disposable pumping cartridge. The reusable component may comprise a control chamber and a pressure transducer configured to measure a gas pressure associated with the control chamber, as well as a processor. The processor may be configured to supply the control chamber with a gas at a predetermined pressure, monitor the gas pressure associated within the control chamber with the pressure transducer over a predetermined period of time, and determine if the change in gas pressure associated within the control chamber exceeds a maximum allowable predetermined limit.

A charger includes a loading chamber into which a battery pack is insertably/removably loaded. An insertion opening into which the battery pack is inserted is formed on an upper surface of the main body. The loading chamber is forwardly inclined to a front surface of the main body, and a bottom surface of the insertion opening is inclined with respect to a horizontal direction so that one end of the front surface side is located at a lower end and the other end of the back surface side is located at an upper end. A connector for supplying power is disposed at the upper end side of the bottom surface. Even when the dust, rubbish or fluid entered from the insertion opening drops to the bottom surface, it flows down to the lower end side, so that less dirt adheres to the connector.

There is provided a cassette having: a flexible accommodating body that accommodates an accumulative fluorescent sheet in a light shielded state; an entrance/exit portion that is provided at one end portion of the flexible accommodating body, and through which the accumulative fluorescent sheet can be inserted and removed into and from the flexible accommodating body due to mounting to a radiographic image reading device; and opening/closing means for opening the flexible accommodating body such that a push-out member, that pushes the accumulative fluorescent sheet out toward the entrance/exit portion, can be inserted, or closing the flexible accommodating body in a light shielded state.

A lock assembly is provided that includes: a lock cylinder having a bore disposed therein and at least one pocket located adjacent the periphery of the bore; a plug including a cassette slot; a plunger that fits in the plug; a locking tab having a slot disposed therein; the slot of the locking tab receives a portion of the plunger; a cassette having a key slot configured to receive a key; the cassette includes a tool slot configured to receive a tool to selectively engage the plunger to selectively move at least a portion of the locking tab into and out of the pocket; when a portion of the locking tab is located in the pocket the locking tab does not block the cassette from being removed from the plug.

A printing device includes: a main body having an attachment surface; first and second mounting sections formed in the attachment surface respectively for detachably receiving first and second cassettes; first and second print parts; a body cover having an opposing surface; first and second pressing parts protruding from the opposing surface respectively toward the first and second mounting sections; first and second engaging parts provided at the main body; and third and fourth engaging parts provided at the body cover and engageable with the first and second engaging parts. A first center of gravity of load that the mounted first cassette applies to the first pressing part and a second center of gravity of load that the mounted second cassette applies to the second pressing part are located within a specific area on the opposing surface defined by virtual lines passing through locations on the third and fourth engaging parts.

A surgical cassette clamping system includes a mounting plate having a first side and a second side. A bracket system may be disposed adjacent the first side of the mounting plate. A clamp motor may be disposed adjacent the mounting plate and fixed relative to the mounting plate. The clamp motor may be operably connected to the bracket system to displace the bracket system relative to the mounting plate. The system may also include a plurality of pivot arms pivotably connected to the bracket system and extending adjacent the second side of the mounting plate. An engagement portion may be attached to each of the plurality of pivot arms that cooperatively engages the second side of the mounting plate, the engagement portion being operable to pivot the pivot arms when the bracket system moves relative to the mounting plate.

Michael Dean
Jul 1, 2001; 42:1007-1017
Thematic Reviews

Kotaro Hama
Apr 1, 2020; 61:523-536
Patient-Oriented and Epidemiological Research

X-linked adrenoleukodystrophy (X-ALD) is an inherited disorder caused by deleterious mutations in the ABCD1 gene. The ABCD1 protein transports very long-chain FAs (VLCFAs) from the cytosol into the peroxisome where the VLCFAs are degraded through β-oxidation. ABCD1 dysfunction leads to VLCFA accumulation in individuals with X-ALD. FAs are activated by esterification to CoA before metabolic utilization. However, the intracellular pools and metabolic profiles of individual acyl-CoA esters have not been fully analyzed. In this study, we profiled the acyl-CoA species in fibroblasts from X-ALD patients and in ABCD1-deficient HeLa cells. We found that hexacosenoyl (26:1)-CoA, but not hexacosanoyl (26:0)-CoA, was the most abundantly concentrated among the VLCFA-CoA species in these cells. We also show that 26:1-CoA is mainly synthesized from oleoyl-CoA, and the metabolic turnover rate of 26:1-CoA was almost identical to that of oleoyl-CoA in both WT and ABCD1-deficient HeLa cells. The findings of our study provide precise quantitative and metabolic information of each acyl-CoA species in living cells. Our results suggest that VLCFA is endogenously synthesized as VLCFA-CoA through a FA elongation pathway and is then efficiently converted to other metabolites, such as phospholipids, in the absence of ABCD1.

via http://grainedit.com/2009/02/09/vintage-cassette-tape-covers/

Imports - Turntables, Record Players, Cassette Players in Mexico decreased to 1720 USD THO in March from 2235 USD THO in February of 2020. Imports - Turntables, Record Players, Cassette Pla in Mexico averaged 6238.55 USD THO from 2014 until 2020, reaching an all time high of 13539 USD THO in April of 2015 and a record low of 1720 USD THO in March of 2020. This page includes a chart with historical data for Mexico Imports of Turntables, Record Players, Cassette P.

Britons' spending on digital music rose 23.5 per cent last year with Lewis Capaldi and Ed Sheeran topping the charts, according to the Entertainment Retailers Association.

Interview with Richard Mayeux, MD, MSc, author of Variants in the ATP-Binding Cassette Transporter (ABCA7), Apolipoprotein E ε4, and the Risk of Late-Onset Alzheimer Disease in African Americans