social and politics

Upregulation of epithelial metallothioneins by metal-rich ultrafine particulate matter from an underground railway

Metallomics, 2020, Advance Article
DOI: 10.1039/D0MT00014K, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Matthew Loxham, Jeongmin Woo, Akul Singhania, Natalie P. Smithers, Alison Yeomans, Graham Packham, Alina M. Crainic, Richard B. Cook, Flemming R. Cassee, Christopher H. Woelk, Donna E. Davies
Metal-rich ultrafine particulate matter (<0.1 μm diameter) from an underground railway induces a significant time-dependent upregulation of a battery of metallothionein genes in exposed mucociliary cultures of primary bronchial epithelial cells.
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Variable protein expression in marine-derived filamentous fungus Penicillium chrysogenum in response to varying copper concentrations and salinity

Metallomics, 2020, Advance Article
DOI: 10.1039/C9MT00316A, Paper
Nikita Lotlikar, Samir Damare, Ram Murti Meena, Saranya Jayachandran
Copper is one of the essential trace dietary minerals for all living organisms, but is potentially toxic at higher concentrations, mainly due to the redox reactions in its transition state.
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Characterization of the Fe metalloproteome of a ubiquitous marine heterotroph, Pseudoalteromonas (BB2-AT2): multiple bacterioferritin copies enable significant Fe storage

Metallomics, 2020, Advance Article
DOI: 10.1039/D0MT00034E, Paper
Open Access
Michael G. Mazzotta, Matthew R. McIlvin, Mak A. Saito
Despite the extreme scarcity of Fe in seawater, the marine heterotroph Pseudoalteromonas has expansive Fe storage capacity and utilization strategies.
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Chromatographic detection of low-molecular-mass metal complexes in the cytosol of Saccharomyces cerevisiae

Metallomics, 2020, Advance Article
DOI: 10.1039/C9MT00312F, Paper
Open Access
Trang Q. Nguyen, Joshua E. Kim, Hayley N. Brawley, Paul A. Lindahl
Labile metal pools in the cytosol of yeast, including those of iron, copper, zinc, and manganese, can be detected and characterized using size-exclusion chromatography with online ICP-MS.
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Hydrogen sulfide increases copper-dependent neurotoxicity via intracellular copper accumulation

Metallomics, 2020, Advance Article
DOI: 10.1039/D0MT00015A, Paper
Norika Goto, Hirokazu Hara, Mao Kondo, Naomi Yasuda, Tetsuro Kamiya, Kensuke Okuda, Tetsuo Adachi
Copper (Cu) is an essential trace element and acts as a redox cofactor for many enzymes; however, excess Cu is toxic to cells.
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Proteomic analysis of the S. cerevisiae response to the anticancer ruthenium complex KP1019

Metallomics, 2020, Advance Article
DOI: 10.1039/D0MT00008F, Paper
Open Access
Laura K. Stultz, Alexandra Hunsucker, Sydney Middleton, Evan Grovenstein, Jacob O’Leary, Eliot Blatt, Mary Miller, James Mobley, Pamela K. Hanson
Proteomic analysis reveals that the anticancer ruthenium KP1019 induces proteotoxic, genotoxic, and oxidative stress responses in Saccharomyces cerevisiae.
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Defining the mechanism of the mitochondrial Atm1p [2Fe–2S] cluster exporter

Metallomics, 2020, Advance Article
DOI: 10.1039/C9MT00286C, Paper
Stephen A. Pearson, Christine Wachnowsky, J. A. Cowan
Atm1p mediated mitochondrial Fe–S cluster export is investigated, providing support for a [2Fe–2S](GS)4 cluster as a physiological substrate. A detailed mechanism of cluster export, combining kinetic, thermodynamic, and structural data is presented.
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The first copper(II) complex with 1,10-phenanthroline and salubrinal with interesting biochemical properties

Metallomics, 2020, Advance Article
DOI: 10.1039/D0MT00006J, Paper
Sebastiano Masuri, Enzo Cadoni, Maria Grazia Cabiddu, Francesco Isaia, Maria Giovanna Demuru, Lukáš Moráň, David Buček, Petr Vaňhara, Josef Havel, Tiziana Pivetta
The novel complex Cu(phen)2(salubrinal)(ClO4)2 shows high free radical scavenging activity and good cytotoxic activity and induces cell death through ER-stress.
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Gold(III) bis(dithiolene) complexes: from molecular conductors to prospective anticancer, antimicrobial and antiplasmodial agents

Metallomics, 2020, Accepted Manuscript
DOI: 10.1039/D0MT00064G, Paper
Diana Fontinha, Silvia Andreia Sousa, Tânia S. Morais, Miguel Prudêncio, Jorge Leitão, Yann Le Gal, Dominique Lorcy, Rafaela Silva, Mariana Velho, Dulce Belo, Manuel Almeida, Joana Guerreiro, Teresa Pinheiro, Fernanda M. Marques
The anticancer, antimicrobial and antiplasmodial activities of six gold(III) bis(dithiolene) complexes were studied. Complexes (1-6) showed relevant anticancer properties against A2780/A2780cisR ovarian cancer cells (IC50 values of 0.08-2 µM), also...
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Studies of the labile lead pool using a rhodamine-based fluorescent probe

Metallomics, 2020, Advance Article
DOI: 10.1039/D0MT00056F, Communication
Jianping Zhu, Jia Hao Yeo, Amy A. Bowyer, Nicholas Proschogo, Elizabeth J. New
A rhodamine-based fluorescent lead probe reports on the labile lead pool within cells.
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Enantiomeric Copper Based Anticancer Agents Promoting Sequence-Selective Cleavage of G-Quadruplex Telomeric DNA and non-random cleavage of plasmid DNA

Metallomics, 2020, Accepted Manuscript
DOI: 10.1039/D0MT00084A, Paper
Sabiha Parveen, J. A. Cowan, Zhen Yu, Farukh Arjmand
Copper-based binuclear enantiomeric complexes 1S and 1R were synthesized as anticancer chemotherapeutic agents to target G-quadruplex rich region of DNA and thoroughly characterized by various spectroscopic and single X-ray crystal...
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Bis(ethylmaltolato)oxidovanadium(IV) inhibited the pathogenesis of Alzheimer's disease in triple transgenic model mice

Metallomics, 2020, 12,474-490
DOI: 10.1039/C9MT00271E, Paper
Zhijun He, Shuangxue Han, Chong Wu, Lina Liu, Huazhang Zhu, Ang Liu, Qiying Lu, Jingqiang Huang, Xiubo Du, Nan Li, Qinguo Xie, Lu Wan, Jiazuan Ni, Lingling Chen, Xiaogai Yang, Qiong Liu
BEOV activates PPARγ to affect JAK2/STAT3/SOCS1 signaling and eventually prevents Aβ generation. Meanwhile, BEOV inactivates PTP1B to affect PI3K/Akt/GSK3β signaling and finally reduces tau hyperphosphorylation.
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Chiral Ru(II) complexes act as a potential non-viral gene carrier for directional transportation to the nucleus and cytoplasm

Metallomics, 2020, 12,504-513
DOI: 10.1039/C9MT00192A, Paper
Qiong Wu, Shuang-Yan Zhang, Si-Yan Liao, Jie-Qiong Cao, Wen-Jie Zheng, Li Li, Wen-Jie Mei
A novel approach has been proposed to develop a potent gene carrier system for enantioselectivity on the self-assembly of G-quadruplex DNA promoted by chiral Ru(II) complexes, and the different assembled nanostructures of cellular uptake to the nucleus and cytoplasm.
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Gene expression in mouse muscle over time after nickel pellet implantation

Metallomics, 2020, 12,528-538
DOI: 10.1039/C9MT00289H, Paper
Desmond I. Bannon, Wenjun Bao, Stephen D. Turner, Wilfred C. McCain, William Dennis, Russ Wolfinger, Ed Perkins, Roger Abounader
Implanted nickel becomes toxic when it exceeds homeostasis, initiating a range of global gene effects over time, including oxidative phosphorylation and immune responses, which are impacted in opposite directions.
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Distribution and chemical form of selenium in Neptunia amplexicaulis from Central Queensland, Australia

Metallomics, 2020, 12,514-527
DOI: 10.1039/C9MT00244H, Paper
Maggie-Anne Harvey, Peter D. Erskine, Hugh H. Harris, Gillian K. Brown, Elizabeth A. H. Pilon-Smits, Lachlan W. Casey, Guillaume Echevarria, Antony van der Ent
Elemental mapping of selenium in the hyperaccumulator Neptunia amplexicaulis determined whole plant and tissue level selenium distribution. The total concentrations and chemical forms of selenium are also reported for this species.
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Lanthanum chloride impairs spatial learning and memory by inducing [Ca2+]m overload, mitochondrial fission–fusion disorder and excessive mitophagy in hippocampal nerve cells of rats

Metallomics, 2020, 12,592-606
DOI: 10.1039/C9MT00291J, Paper
Miao Yu, Jinghua Yang, Xiang Gao, Wenchang Sun, Shiyu Liu, Yarao Han, Xiaobo Lu, Cuihong Jin, Shengwen Wu, Yuan Cai
Lanthanum chloride damages hippocampal nerve cells of rats through inducing [Ca2+]m overload, mitochondrial fission–fusion disorder, and excessive mitophagy.
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Heterobimetallic Ru(II)/Fe(II) complexes as potent anticancer agents against breast cancer cells, inducing apoptosis through multiple targets

Metallomics, 2020, 12,547-561
DOI: 10.1039/C9MT00272C, Paper
Adriana Pereira Mundim Guedes, Francyelli Mello-Andrade, Wanessa Carvalho Pires, Maria Alice Montes de Sousa, Paula Francinete Faustino da Silva, Mariana S. de Camargo, Hendryk Gemeiner, Menegário A. Amauri, Clever Gomes Cardoso, Paulo Roberto de Melo Reis, Elisângela de Paula Silveira-Lacerda, Alzir A. Batista
Antimetastatic activity, high selectivity and cytotoxicity for human tumor cell lines make ruthenium(II) complexes attractive for the development of new chemotherapeutic agents for cancer treatment.
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Copper accumulation and the effect of chelation treatment on cerebral amyloid angiopathy compared to parenchymal amyloid plaques

Metallomics, 2020, 12,539-546
DOI: 10.1039/C9MT00306A, Paper
Xiayoue Zhu, Tiffany W. Victor, Ashwin Ambi, Joseph K. Sullivan, Joshua Hatfield, Feng Xu, Lisa M. Miller, William E. Van Nostrand
Multimodal imaging studies show that Aβ amyloid in brain vessels of Tg2576 mice (green) preferentially binds copper (red) – a pathology that can be reduced with copper chelators.
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Selenium deficiency exacerbates LPS-induced necroptosis by regulating miR-16-5p targeting PI3K in chicken tracheal tissue

Metallomics, 2020, 12,562-571
DOI: 10.1039/C9MT00302A, Paper
Lanqiao Wang, Xu Shi, Shufang Zheng, Shiwen Xu
Se deficiency can induce necroptosis in tracheal tissue. LPS-induced necroptosis can be exacerbated by Se deficiency. The miR-16-5p-PI3K/AKT pathway participates in the occurrence of necroptosis.
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Comparative differential cuproproteomes of Rhodobacter capsulatus reveal novel copper homeostasis related proteins

Metallomics, 2020, 12,572-591
DOI: 10.1039/C9MT00314B, Paper
Nur Selamoglu, Özlem Önder, Yavuz Öztürk, Bahia Khalfaoui-Hassani, Crysten E. Blaby-Haas, Benjamin A. Garcia, Hans-Georg Koch, Fevzi Daldal
Cuproproteome of model bacterium Rhodobacter capsulatus reveals 75 Cu-responsive proteins that are strongly influenced (2–300 fold) by Cu availability.
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The role of necroptosis and apoptosis through the oxidative stress pathway in the liver of selenium-deficient swine

Metallomics, 2020, 12,607-616
DOI: 10.1039/C9MT00295B, Paper
Yuan Zhang, Dahai Yu, Jiuli Zhang, Jun Bao, Chaohua Tang, Ziwei Zhang
Necroptosis is regarded as a new paradigm of cell death that plays a key role in the liver damage observed with selenium (Se) deficiency.
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social and politics

Multi-genomic analysis of the cation diffusion facilitator transporters from algae

Metallomics, 2020, 12,617-630
DOI: 10.1039/D0MT00009D, Paper
Aniefon Ibuot, Andrew P. Dean, Jon K. Pittman
Cation diffusion facilitator metal transporters are widespread throughout algae and include a novel algal-specific clade. Functional analysis of Chlamydomonas reinhardtii isoforms partly validated phylogenetic prediction of substrate specificity.
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social and politics

Correction: Bis(ethylmaltolato)oxidovanadium(IV) inhibited the pathogenesis of Alzheimer's disease in triple transgenic model mice

Metallomics, 2020, 12,631-631
DOI: 10.1039/D0MT90008G, Correction
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Zhijun He, Shuangxue Han, Chong Wu, Lina Liu, Huazhang Zhu, Ang Liu, Qiying Lu, Jingqiang Huang, Xiubo Du, Nan Li, Qingguo Xie, Lu Wan, Jiazuan Ni, Lingling Chen, Xiaogai Yang, Qiong Liu
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social and politics

Hierarchical binding of copperII to N-truncated Aβ4–16 peptide

Metallomics, 2020, 12,470-473
DOI: 10.1039/C9MT00299E, Communication
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Xiangyu Teng, Ewelina Stefaniak, Paul Girvan, Radosław Kotuniak, Dawid Płonka, Wojciech Bal, Liming Ying
Multiple intermediates were found in Cu(II) binding to Aβ4–16 before the formation of a tight complex.
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social and politics

Ruthenium(III) complexes containing thiazole-based ligands that modulate amyloid-β aggregation

Metallomics, 2020, 12,491-503
DOI: 10.1039/D0MT00054J, Paper
Samantha E. Huffman, Gideon K. Yawson, Samuel S. Fisher, Paige J. Bothwell, David C. Platt, Marjorie A. Jones, Christopher G. Hamaker, Michael I. Webb
Alzheimer's Disease (AD) is a devastating neurodegenerative disorder where one of the commonly observed pathological hallmarks is extracellular deposits of the peptide amyloid-β (Aβ).
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social and politics

Peptide bond cleavage in the presence of Ni-containing particles

Metallomics, 2020, Accepted Manuscript
DOI: 10.1039/D0MT00070A, Communication
Nina Ewa Wezynfeld, Tomasz Frączyk, Arkadiusz Bonna, Wojciech Bal
NiO nanoparticles and non-stoichiometric black NiO were shown to be effective sources of Ni2+ ions causing sequence-selective peptide bond hydrolysis. NiO nanoparticles were as effective in this reaction as their...
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social and politics

Correction: Identification and determination of selenocysteine, selenosugar, and other selenometabolites in turkey liver

Metallomics, 2020, Advance Article
DOI: 10.1039/D0MT90015J, Correction
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Katarzyna Bierla, Rachel M. Taylor, Joanna Szpunar, Ryszard Lobinski, Roger A. Sunde
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Investigation of the impact of magnesium versus titanium implants on protein composition in osteoblast by label free quantification

Metallomics, 2020, Advance Article
DOI: 10.1039/D0MT00028K, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
M. Omidi, N. Ahmad Agha, A. Müller, F. Feyerabend, H. Helmholz, R. Willumeit-Römer, H. Schlüter, B. J. C. Luthringer-Feyerabend
To our knowledge, this is the first report describing and comparing the effects of magnesium and titanium biomaterials on human osteoblast proteome.
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Diphenyl Diselenide Protects Caenorhabditis elegans Model for Huntington's Disease by Activation of Antioxidant Pathway and Decrease in Protein Aggregation

Metallomics, 2020, Accepted Manuscript
DOI: 10.1039/D0MT00074D, Paper
Fabiane Bicca Obetine Baptista, Marina Lopes Machado, Aline da Silva Franzen, Larissa Marafiga Cordeiro, Tassia da Silveira, Leticia Arantes, Félix A. A. Soares
Huntington’s disease (HD) is an autosomal dominant, progressive neurodegenerative disease with a distinct phenotype. It occurs due to a mutation in huntingtin (or IT19) gene with abnormal CAG repeat, leading...
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A liver-targeting Cu(I) chelator relocates Cu in hepatocytes and promotes Cu excretion in a murine model of Wilson’s disease

Metallomics, 2020, Accepted Manuscript
DOI: 10.1039/D0MT00069H, Paper
Marie Monestier, AnaÏS M. Pujol, Aline Lamboux, Martine Cuillel, Isabelle Pignot-Paintrand, Doris Cassio, Peggy Charbonnier, Khémary Um, Amélie Harel, Sylvain BOHIC, Christelle GATEAU, Vincent Balter, Virginie Brun, Pascale Delangle, Elisabeth Mintz
Copper chelation is the most commonly used therapeutic strategy nowadays to treat Wilson’s disease, a genetic disorder primarily inducing a pathological accumulation of Cu in the liver. The mechanism of...
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The study of levels from redox-active elements in cerebrospinal fluid of amyotrophic lateral sclerosis patients carrying disease-related gene mutations shows potential copper dyshomeostasis

Metallomics, 2020, Advance Article
DOI: 10.1039/D0MT00051E, Paper
Federica Violi, Nikolay Solovyev, Marco Vinceti, Jessica Mandrioli, Marianna Lucio, Bernhard Michalke
Gene-environment interaction is as a possible key factor in the development of ALS. The levels of redox species of Cu, Fe, and Mn were assessed in cerebrospinal fluid, showing a possible positive association between Cu and genetic ALS.
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Linc-ROR promotes arsenite-transformed keratinocyte proliferation by inhibiting P53 activity

Metallomics, 2020, Advance Article
DOI: 10.1039/D0MT00076K, Paper
Xinyang Li, Chao Zuo, Mei Wu, Zunzhen Zhang
Linc-ROR modulates the cell proliferation in arsenite-transformed keratinocytes via inhibiting P53 activity through the PI3K/AKT pathway.
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Evidence that levels of nine essential metals in post-mortem human-Alzheimer's-brain and ex vivo rat-brain tissues are unaffected by differences in post-mortem delay, age, disease staging, and brain bank location

Metallomics, 2020, Advance Article
DOI: 10.1039/D0MT00048E, Paper
Melissa Scholefield, Stephanie J. Church, Jingshu Xu, Sarah Kassab, Natalie J. Gardiner, Federico Roncaroli, Nigel M. Hooper, Richard D. Unwin, Garth J. S. Cooper
Metal findings in human Alzheimer brains are consistent despite differences in sample post-mortem delay, age, Braak stage and biobank location.
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In vitro selenium supplementation suppresses key mediators involved in myometrial activation and rupture of fetal membranes

Metallomics, 2020, Advance Article
DOI: 10.1039/D0MT00063A, Paper
Dineli Matheesha Kalansuriya, Ratana Lim, Martha Lappas
Selenium suppresses key mediators involved in preterm birth in human fetal membranes and myometrium.
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social and politics

BCCI set to appoint ad-hoc committee to run Delhi and District Cricket Association

The DDCA has been without a president since Rajat Sharma resigned, while general secretary Vinod Tihara is in jail for an alleged violation of the Customs Act.




social and politics

Covid-19: Cadila Pharmaceuticals shuts down Ahmedabad plant after 26 employees test positive

A senior government official said Cadila Pharmaceuticals closed its Ahmedabad plant as five employees tested positive last week, and 21 this week.




social and politics

Pause, rewind, play: Relive Ashes 2005 – one of the greatest Test series of all time

This documentary encapsulates the drama, the highs and lows, the animosity between the two teams, and England’s redemption as a cricketing power.




social and politics

Agra: Journalist among two new Covid-19 deaths

Priyanka Gandhi asked the Uttar Pradesh government to provide insurance cover for journalists.




social and politics

Covid-19: Migrant worker, wife die in road crash in Lucknow while trying to cycle to Chhattisgarh

Their children – a three-year-old son and a four-year-old daughter – survived.




social and politics

Delhi University forms working group to study on college exams

The working group will study the feasibility of conducting the exams online and review the preparedness, informs Indian Express.




social and politics

India’s tour of Australia logistically easier to organsise than T20 World Cup, says BCCI treasurer

Dhumal admitted that quarantining of Indian players upon their arrival is a possibility, if their tour Down Under goess as per schedule.




social and politics

Covid-19: China ‘either made a terrible mistake or it was incompetence’, says Donald Trump

Meanwhile, House Minority Leader Kevin McCarthy announced the formation of the China Task Force to investigate the country’s role in the spread of the pandemic.




social and politics

Covid-19: Migrant workers gather at Mangaluru railway station following rumours about special trains

Karnataka Revenue Minister R Ashok said the government was awaiting consent from other states to send the migrant workers home.




social and politics

Vizag gas leak case: NGT fines LG Polymers Rs 50 crore, issues notice to Centre

The tribunal said a five-member committee headed by a former judge of the Andhra Pradesh High Court will investigate the incident.




social and politics

As writers document the pandemic through poetry, here is a chance to understand this form

Rule number one: You don’t have to like it.




social and politics

Covid-19: CBSE to hold remaining Class 10, Class 12 exams from July 1 to 15

The exams had to be abruptly postponed in March due to a nationwide shutdown to combat the coronavirus outbreak.




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Coronavirus: I am being harassed for breaking lockdown rules, says Manchester City’s Kyle Walker

The defender was forced to issue an apology last month after media reports that he had hosted a party at his home.




social and politics

Banned Umar Akmal didn’t show remorse or seek apology, says PCB disciplinary panel head

Justice (retired) Fazal-e-Miran Chauhan submitted his detailed judgement on the case to the Pakistan Cricket Board, which made it public on its site.




social and politics

Babri Masjid demolition case: SC extends trial court’s deadline to deliver verdict to August 31

The top court also said the trial court judge should hold proceedings via videoconferencing during the period of the nationwide lockdown.




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India need to subdue Warner, Smith if they are to win series in Australia again, says Ian Chappell

Chappell highlighted the impact of the two batting mainstays should the much-anticipated series goes ahead as scheduled.