New archaeological finds show that New Guinea developed sophisticated cultural practices around the same time as they were emerging in Europe and Asia

When it comes to electric vehicles, there’s no denying the multitude of benefits for manufacturers, consumers, and the environment – from reduced emissions to lower fuel costs, increased efficiency, and lower noise pollution. These benefits continue to...

CES 2020, LAS VEGAS – JANUARY 6, 2020 – Harman International, a wholly-owned subsidiary of Samsung Electronics Co., Ltd. focused on connected technologies for automotive, consumer and enterprise markets, today announced its EV Plus+ Solutions, a new...

Shanghai Auto Show 2019 – SHANGHAI – April 16, 2019 – HARMAN , a wholly-owned subsidiary of Samsung Electronics Co., Ltd., focused on connected technologies for automotive, consumer and enterprise markets, today announced a continued partnership with the...

Shanghai Auto Show 2019 – SHANGHAI – April 16, 2019 –HARMAN , a wholly-owned subsidiary of Samsung Electronics Co., Ltd., focused on connected technologies for automotive, consumer and enterprise markets, today announced that the company has entered into...

As a leading technology company with applications across a range of industries including automotive, audio and enterprise technology, HARMAN has a strong focus on recognizing our talented in-house engineers, developers and designers who help bring ...

For eight consecutive days beginning on April 18th, the world’s largest motor show attracted hundreds of thousands of visitors from the automotive world. With China becoming a leading market for electromobility, autonomous driving and connected car...

STAMFORD, Conn. –  SEPTEMBER 26, 2019 – HARMAN International, a wholly-owned subsidiary of Samsung Electronics Co., Ltd., focused on connected technologies for automotive, consumer and enterprise markets, today announced a new automotive partnership with...

A Backstage Pass with Christopher Dragon: Creating that HARMAN Experience at the World's Largest Technology Show Around the world, many companies are preparing to close out the year, but for HARMAN, it’s time to head to Las Vegas once again for the...

Each year, HARMAN kicks off the New Year at CES, the premier consumer electronics show that takes place each January in Las Vegas. From the legendary HARMAN showcase at the Hard Rock, we’ll be once again showing what’s coming next when it comes to...

CES 2020 – LAS VEGAS, Nev. – January 6, 2020 – HARMAN, a wholly-owned subsidiary of Samsung Electronics Co. Ltd., focused on connected technologies for automotive, consumer and enterprise markets, today launched the HARMAN Ignite Marketplace, an...

STAMFORD, CT –  January 16, 2020 –  HARMAN, a wholly-owned subsidiary of Samsung Electronics Co., Ltd., focused on connected technologies and solutions for automotive, consumer and enterprise markets, today announced HARMAN RCP, a remote patient...

In an industry driven by incremental technology advancements, droning on from one model year to the next, automotive innovation can sometimes stall out. Functionally, and spiritually, what was created to move you, doesn’t deliver as advertised. As a...

STAMFORD, CT – May 4, 2020 – HARMAN, a wholly-owned subsidiary of Samsung Electronics Co. Ltd., focused on connected technologies for automotive, consumer and enterprise markets, announced today that it has entered into a multi-year, global partnership...

To figure out what makes some people more vulnerable to severe cases of covid-19, we need to rethink what we know about infection

Climate models show that as the world warms, tropical cyclones will travel more slowly, dumping more rain in one place and making high-speed winds batter buildings for longer

Satellites have revealed the fracking heartland of the US is leaking methane, a powerful greenhouse gas, at a record-breaking rate.

The ongoing spread of bluetongue virus among European farm animals may have started when a cow was inseminated with infected bull semen stored from an earlier outbreak

A robot that uses artificial intelligence to find and remove weeds could eventually be used as an alternative to chemical insecticides

To figure out what makes some people more vulnerable to severe cases of covid-19, we need to rethink what we know about infection

A white former police officer and his son were arrested in Georgia on Thursday and charged with murder in the death of an unarmed black man, an incident that has sparked furor in the community and among civil rights activists across the United States. Gloria Tso reports.

Title: Being Chained to Your Desk Might Harm Your Thyroid
Category: Health News
Created: 3/31/2020 12:00:00 AM
Last Editorial Review: 3/31/2020 12:00:00 AM

Title: High Calcium, Vitamin D Intake May Harm Aging Brain
Category: Health News
Created: 5/2/2007 2:00:00 AM
Last Editorial Review: 5/2/2007 12:00:00 AM

Title: Steroids Could Harm Heart's Pumping Ability
Category: Health News
Created: 4/27/2010 4:10:00 PM
Last Editorial Review: 4/28/2010 12:00:00 AM

Title: Tight Blood Sugar Control May Not Harm Diabetics
Category: Health News
Created: 4/28/2010 12:10:00 PM
Last Editorial Review: 4/29/2010 12:00:00 AM

Title: Leprosy May Pass Between Armadillos and People
Category: Health News
Created: 4/28/2011 11:01:00 AM
Last Editorial Review: 4/28/2011 12:00:00 AM

Title: Prenatal Pesticide Exposure May Harm Kids' Brains
Category: Health News
Created: 5/1/2012 11:01:00 AM
Last Editorial Review: 5/1/2012 12:00:00 AM

Title: Many Asthmatic Kids Harmed by Secondhand Smoke: Study
Category: Health News
Created: 5/1/2012 10:05:00 AM
Last Editorial Review: 5/1/2012 12:00:00 AM

Title: Too Much Drinking, Weight May Harm Liver
Category: Health News
Created: 4/26/2013 6:36:00 PM
Last Editorial Review: 4/29/2013 12:00:00 AM

Title: Cosmetic Procedures for Arms on the Rise, Plastic Surgeons Say
Category: Health News
Created: 4/29/2013 12:35:00 PM
Last Editorial Review: 4/30/2013 12:00:00 AM

Title: Paralyzed Patient Moves Prosthetic Arm With Her Mind
Category: Health News
Created: 4/30/2013 12:35:00 PM
Last Editorial Review: 5/1/2013 12:00:00 AM

Title: Ironclad Findings About Red Meat's Harms?
Category: Health News
Created: 4/29/2014 12:35:00 PM
Last Editorial Review: 4/30/2014 12:00:00 AM

Title: Traumatic Life Events May Harm Women's Hearts, Study Suggests
Category: Health News
Created: 4/29/2015 12:00:00 AM
Last Editorial Review: 4/30/2015 12:00:00 AM

Title: FDA Proposes Ban on 'Shock' Device Used to Curb Self-Harm
Category: Health News
Created: 4/22/2016 12:00:00 AM
Last Editorial Review: 4/25/2016 12:00:00 AM

Title: Pharmacists Can Manage Some Chronic Conditions Effectively, Study Suggests
Category: Health News
Created: 4/25/2016 12:00:00 AM
Last Editorial Review: 4/26/2016 12:00:00 AM

Title: Spanking: More Harm Than Good?
Category: Health News
Created: 4/27/2016 12:00:00 AM
Last Editorial Review: 4/28/2016 12:00:00 AM

Title: Are Smartphones Helping or Harming Kids' Mental Health?
Category: Health News
Created: 5/3/2017 12:00:00 AM
Last Editorial Review: 5/3/2017 12:00:00 AM

Title: Teen Suicide Thoughts, Self-Harm Cases Double in a Decade
Category: Health News
Created: 5/4/2017 12:00:00 AM
Last Editorial Review: 5/4/2017 12:00:00 AM

Title: Even Living Near a Farm Might Help Prevent Allergies
Category: Health News
Created: 5/1/2018 12:00:00 AM
Last Editorial Review: 5/1/2018 12:00:00 AM

Title: Harms of Banned Pregnancy Drug Linger for Decades in Daughters
Category: Health News
Created: 5/2/2018 12:00:00 AM
Last Editorial Review: 5/3/2018 12:00:00 AM

Title: AHA News: Farms Flourish and Nourish in Philadelphia Neighborhood
Category: Health News
Created: 4/16/2020 12:00:00 AM
Last Editorial Review: 4/17/2020 12:00:00 AM

Title: On Some Farms, Washing Machines Give Leafy Greens a Spin -- But Is That Safe?
Category: Health News
Created: 4/24/2020 12:00:00 AM
Last Editorial Review: 4/24/2020 12:00:00 AM

Title: Drink Up! Coffee Won't Harm Your Heart, Study Finds
Category: Health News
Created: 5/7/2020 12:00:00 AM
Last Editorial Review: 5/8/2020 12:00:00 AM

Two new reports suggest that the warm summer months will not significantly slow the novel coronavirus as it spreads around the globe.

Title: Modern Livestock Farming Can Pose Public Health Risk
Category: Health News
Created: 5/7/2020 12:00:00 AM
Last Editorial Review: 5/8/2020 12:00:00 AM

Title: High-Tech Prosthetic Arm Melds With Patient's Anatomy
Category: Health News
Created: 4/30/2020 12:00:00 AM
Last Editorial Review: 4/30/2020 12:00:00 AM

Title: Recommended Diuretic Drug Tied to Harmful Side Effects
Category: Health News
Created: 2/18/2020 12:00:00 AM
Last Editorial Review: 2/19/2020 12:00:00 AM

Title: 2 in 3 Women Unhappy With Their Breast Size. Could That Harm Their Health?
Category: Health News
Created: 2/6/2020 12:00:00 AM
Last Editorial Review: 2/6/2020 12:00:00 AM

Title: Dangerously Hot Days for U.S. Farm Workers Could Double by 2050
Category: Health News
Created: 5/5/2020 12:00:00 AM
Last Editorial Review: 5/6/2020 12:00:00 AM

KRAS mutation is a negative predictive biomarker of anti-EGFR agents in patients with metastatic colorectal cancer (mCRC), and remains an elusive target. Pelareorep, a double-stranded RNA virus selectively replicates in KRAS-mutated cells, and is synergistic with irinotecan. A dose escalation trial of FOLFIRI/bevacizumab [irinotecan (150–180 mg/m²) and pelareorep (1 x 10¹⁰ TCID₅₀–3 x 10¹⁰ TCID₅₀)] was implemented in adult patients with oxaliplatin refractory/intolerant, KRAS-mutant mCRC. Pelareorep was administered intravenously over 1 hour on days 1–5 every 4 weeks. Additional studies included pharmacokinetics, tumor morphology, and immune responses. Among FOLFIRI-naïve patients, the highest dose of FOLFIRI/bevacizumab (180 mg/m² irinotecan) and pelareorep (3 x 10¹⁰ TCID₅₀) was well tolerated, without a dose-limiting toxicity. At the recommended phase II dose, 3 of 6 patients (50%) had a partial response; the median progression-free and overall survival (PFS, OS) were 65.6 weeks and 25.1 months, respectively. Toxicities included myelosuppression, fatigue, and diarrhea. Transmission electron microscopy revealed viral factories (viral collections forming vesicular structures), at various stages of development. Immunogold staining against viral capsid -1 protein demonstrated viral "homing" in the tumor cells. The nucleus displayed sufficient euchromatin regions suggestive of active transcription. Flow cytometry revealed rapid dendritic cell maturation (48 hours) with subsequent activation of cytotoxic T cells (7 days). The combination of pelareorep with FOLFIRI/bevacizumab is safe. The PFS and OS data are encouraging and deserve further exploration. Pelareorep leads to a clear recurrent immune stimulatory response with cytotoxic T-cell activation, and homes and replicates in the tumor.