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Mitochondrial DNA targeting and impairment by a dinuclear Ir–Pt complex that overcomes cisplatin resistance

By pubs.rsc.org
Published On ::

Inorg. Chem. Front., 2020, 7,1864-1871
DOI: 10.1039/D0QI00224K, Research Article

Cheng Zhang, Ruilin Guan, Xinxing Liao, Cheng Ouyang, Jiangping Liu, Liangnian Ji, Hui Chao
A dinuclear complex [(ppy)Ir(tpy)PtCl]²⁺ (Ir–Pt) can exhibit strong antitumor activity towards cisplatin-resistant cancer cells and induce cell necrosis via mtDNA damage and mitochondrial dysfunction.
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