In accordance with embodiments, there are provided mechanisms and methods for controlling a process using a process map. These mechanisms and methods for controlling a process using a process map can enable process operations to execute in order without necessarily having knowledge of one another. The ability to provide the process map can avoid a requirement that the operations themselves be programmed to follow a particular sequence, as can further improve the ease by which the sequence of operations may be changed.

The disclosure generally describes computer-implemented methods, software, and systems for creating and using two-tier mobile applications. A computer-implemented method includes identifying at least a portion of a database to be associated with a mobile application, retrieving a set of metadata associated with the at least a portion of the identified database, automatically generating a set of mobile application source code for directly accessing the at least a portion of the database based on the set of retrieved metadata, and compiling the set of mobile application source code into a distributable mobile application, the distributable mobile application configured to directly access the identified database associated with the mobile application. In some instances, the identifying, retrieving, generating, and compiling operations are performed at design time, while at runtime, the mobile application is executable by a mobile device and, during runtime execution, can request database-related information directly from the identified database.

An electronic system and method of operation thereof includes: a control unit for receiving a patterned signal; a recognizer module, coupled to the control unit, for recognizing an unique trigger from the patterned signal; an operation module, coupled to the recognizer module, for detecting an operational mode from the unique trigger; and a change module, coupled to the operation module, for configuring a system state change of a memory sub-system based on the operational mode.

The invention relates to a process for rectificative separation of compositions of matter containing diastereomers of 2-isopropyl-5-methylcyclohexanol by using ionic liquids as extractants.

A method for isolating 2,2,4,4-tetramethyl-1,3-cyclobutanediol (TMCD) solids from an isolated feed slurry formed in a TMCD process comprising TMCD, a liquid phase, and impurities by (a) treating the isolated feed slurry in a product isolation zone to produce an isolated TMCD product wet cake, a mother liquor, and impurities; wherein the product isolation zone can comprise at least one rotary pressure drum filter.

The present invention is directed to processes for the recovery of ethanol from a crude ethanol product obtained from the hydrogenation of acetic acid using a low energy process. The crude ethanol product is separated in one or more columns. At least one of the columns is operated at a controlled pressure to enhance separation of ethanol and organics. In one embodiment, there are at least two columns that operate at controlled pressures.

Disclosed herein are processes for alcohol production by reducing an esterification product, such as ethyl acetate. The processes comprise esterifying acetic acid and an alcohol such as ethanol to produce an esterification product. The esterification product may be recovered using an extractive separation. The esterification product is reduced with hydrogen in the presence of a catalyst to obtain a crude reaction mixture comprising the alcohol, in particular ethanol, which may be separated from the crude reaction mixture.

A para-methoxy protected benzaldehyde useful in preparation of treprostinil, and of formula: (Formula (1)) is prepared by subjecting to Claisen re-arrangement a substituted benzaldehyde of formula (1a): (Formula (Ia)) to form the m-hydroxy-substituted benzaldehyde of formula (1b): (Formula (Ib)) and then reacting compound (1b) with a p-methoxybenzyl (PMB) compound to form a PMB-substituted benzaldehyde of formula (1).

The present invention relates to a process for heat integration in the preparation of saturated C3-C20-alcohols, in which a hydrogenation feed comprising at least one C3-C20-aldehyde is hydrogenated in the presence of a hydrogen-comprising gas in a hydrogenation zone and a discharge is taken off from the hydrogenation zone and subjected to distillation in at least one distillation column to give a fraction enriched in saturated C3-C20-alcohols.

A filtration method is disclosed for recovering purified polyether polyol comprising the steps of providing an aqueous solution of a polyether polyol containing an alkali metal catalyst residual formed from a transesterification process utilizing an alkali metal catalyst, contacting the aqueous solution with a stoichiometric excess of magnesium sulfate, magnesium sulfite or a combination thereof to form a second aqueous solution, wherein said stoichiometric excess is based on the amount of said alkali metal catalyst residual. Water is removed from the second aqueous solution at a temperature above a set limit of said polyether polyol to produce a dehydrated slurry containing a polyether polyol phase substantially free of residual alkali metal and a precipitated solid phase comprising sulfate and/or sulfite salts of the alkali metal catalyst, magnesium hydroxide, and excess magnesium sulfate and/or sulfite, wherein the particle size distribution of said precipitated solid phase is controlled to minimize the amount of particles therein that are smaller than 3 microns. The dehydrated slurry is then passed through a filtration system to separate the polyether polyol phase from the precipitated solid phase.

An improved method for recovering a purified polyether polyol comprising the steps of providing an aqueous solution of a polyether polyol containing an alkali metal catalyst residual formed from a transesterification process, contacting the aqueous solution with a stoichiometric excess of magnesium sulfate to form a second aqueous solution, removing water from said second aqueous solution at a temperature above the melt temperature of said polyether polyol to produce a dehydrated slurry containing a molten polyether polyol phase essentially free of residual alkali metal and a precipitated solid phase comprising sulfate and/or sulfite salts of the alkali metal catalyst, magnesium hydroxide, and excess magnesium sulfate and/or sulfide, passing the dehydrated slurry of through a filtration system comprising a filtration press to separate the molten polyether polyol phase from the precipitated solid phase, wherein the filtration press is treated with a filter aid that is essentially free of transition metal oxide content, separating the molten polyether polyol phase substantially free of water, residual alkali metal catalyst and transition metal contaminants from the precipitated solid phase and recovering polyether polyol from the separated polyether polyol phase.

A method of operation of a navigation system includes: receiving an origin and a destination; receiving a route keyword for routing between the origin and the destination; identifying a via point matching the route keyword; calculating a keyword group locale based on the via point within a group distance threshold from a keyword group center; and calculating a travel route from the origin to the destination traversing the keyword group locale for displaying on a device.

This disclosure relates generally to field-programmable gate arrays (FPGAs). Some implementations relate to methods and systems for transmitting and integrating an intellectual property (IP) block with another user's design. The IP developer can design the IP block to include both a secret portion and a public portion. The IP block developer can send or otherwise provide the IP block to another IP user without disclosing the functional description of the secret portion of the IP block. In some implementations, the IP developer provides the public portion to the IP user at the register-transfer-level (RTL) level, as a hardware description language (HDL)-implemented design, or as a synthesizable netlist. In some implementations, the IP developer provides the secret portion of the IP block to the user in the form of programming bits without providing an HDL, RTL, or netlist implementation of the secret portion.

An inductive fault current limiter (1), has a normally conducting primary coil assembly (2) with a multiplicity of turns (3), and a superconducting, short-circuited secondary coil assembly (4). The primary coil assembly (2) and the secondary coil assembly (4) are disposed at least substantially coaxially with respect to each other and at least partially interleaved in each other. The secondary coil assembly (4) has a first coil section (4a) disposed radially inside the turns (3) of the primary coil assembly (2) and a second coil section (4b) disposed radially outside the turns (3) of the primary coil assembly (2). The fault current limiter has an increased inductance ratio.

A magnetic field generation device for a magnetic resonance tomography apparatus has a vacuum container that encloses a magnetic coil made of superconducting material, and a conduit of a pipe system is connected with the magnetic coil so as to conduct heat. The pipe system and the conduit are filled with a coolant that places the magnetic coil in a superconducting state during normal operation of the tomography system. A valve connects the pipe system to the interior of a capture container. In the event of non-normal operation, such as a quench, evaporated coolant passes through the valve into the capture container.

Methods, systems, and computer program products are provided for email administration for rendering email on a digital audio player. Embodiments include retrieving an email message; extracting text from the email message; creating a media file; and storing the extracted text of the email message as metadata associated with the media file. Embodiments may also include storing the media file on a digital audio player and displaying the metadata describing the media file, the metadata containing the extracted text of the email message.

Apparatus and methods are provided for using automatic speech recognition to analyze a voice interaction and verify compliance of an agent reading a script to a client during the voice interaction. In one aspect of the invention, a communications system includes a user interface, a communications network, and a call center having an automatic speech recognition component. In other aspects of the invention, a script compliance method includes the steps of conducting a voice interaction between an agent and a client and evaluating the voice interaction with an automatic speech recognition component adapted to analyze the voice interaction and determine whether the agent has adequately followed the script. In yet still further aspects of the invention, the duration of a given interaction can be analyzed, either apart from or in combination with the script compliance analysis above, to seek to identify instances of agent non-compliance, of fraud, or of quality-analysis issues.

A device may include a physical phenomenon detector. The physical phenomenon detector may detect a physical phenomenon related to the device. In response to detecting the physical phenomenon, the device may record audio data that includes speech. The speech may be transcribed with a speech recognition engine. The speech recognition engine may be included in the device, or may be included with a remote computing device with which the device may communicate.

In one embodiment, a view in a graphical user interface includes a selection area that includes identifiers associated with a plurality of attributes, each of the attributes having a plurality of possible values. The area further includes one or more graphical tools to define filter criteria based at least in part on selected ones of the plurality of possible values of one or more of the attributes. The area further includes one or more switch controls each being associated with a respective one of the one or more of the attributes and indicating presentation criteria including: whether selected ones of the possible values of the respective attribute are to be shown in a report, and a dimension of the report in which to space the selected ones of the possible values from one another if the selected ones of the possible values are to be shown in the report.

The present disclosure relates to devices and methods for the preparation of amyl nitrite formulations at a point of use location from relatively shelf-stable reagents employing acidic cationic exchange resins.

Fluoroalkyl alkyl carbonates and fluorosubstituted carbamates which are suitable as additives or solvents in lithium ion batteries are prepared from fluoroalkyl fluoroformates and the respective alcohol or amine. Methanol is the preferred alcohol, dimethylamine and diethylamine are preferred amines. Fluoromethyl methyl carbonate is the preferred compound to be produced. Fluoroalkyl fluoroformates can be prepared from aldehydes and carbonyl fluoride.

The present invention relates to a process for the synthesis of 2-cyanophenylboronic acid and the esters and salts thereof of formula (II), which are intermediates of the synthesis of active pharmaceutical ingredients such as Perampanel or E2040. formula (II): (II).

Preparation method of aromatic boronate compound is provided, in which the is as follows: reacting aromatic amine Ar-NH2, with diboronic ester and alkyl nitrite in the presence of organic solvent, where Ar represents non-heterocyclic aryl. It enables for the first time the preparation of aromatic boronate from aromatic amine in one step by the present method.

Internet streaming from broadcast radio or television stations is described wherein triggers for dynamic content from internal or external systems cause an encoder system to generate command messages, and to optionally synchronize those command messages with any delays associated with the triggering events. Command messages are delivered through a streaming media distribution system to client media players which obtain or present the dynamic content, in association with any desired configuration changes to the appearance of the media player or the method or manner in which the dynamic content is presented.

Various systems and methods are described for configuring a logical data storage container. In one embodiment, an instruction to perform an operation to modify an attribute of the logical data storage container that is an abstraction of a plurality of pertinent storage containers is received. A translated instruction to perform a sub-operation associated with the operation is transmitted to each of a number of the plurality of pertinent storage containers. A level of success of the performing of the operation on the logical data storage container is detected based on a comparison of a threshold value to a level of success of the performing of the sub-operation on each of the number of the plurality of pertinent storage containers. A report of the detected level of success is communicated.

A dispersed storage (DS) unit for use within a dispersed storage network is capable of self-configuring using registry information provided to the DS unit. The registry information includes a slice name assignment indicating a range of slice names corresponding to a plurality of potential data slices of potential data objects to be stored in the DS unit. Based on the registry information, the DS unit allocates a portion of physical memory to store the potential data slices.

In a process for the separation and drying of crude carboxylic acid crystals from a slurry in a solvent, the slurry is supplied to a filter operating at pressure and at a temperature above the atmospheric boiling point of the solvent. A cake of separated crystals is removed from the filter and passed to a thermal dryer. In a system for the separation and drying of crude carboxylic acid from a slurry in a solvent, a pressure filter device has a slurry inlet and an outlet for a cake of carboxylic acid crystals. The system also has a thermal dryer and means for transporting the cake of carboxylic acid crystals from the pressure filter device to the dryer. The pressure filter device is configured to operate at a pressure and temperature above the atmospheric boiling point of the solvent.

A thermal separation process between a gas ascending in a separating column and a liquid descending in the separating column, which comprise (meth)acrylic monomers, wherein the separating column comprises a sequence of crossflow mass transfer trays, the crossflow mass transfer trays of which have passage orifices for the ascending gas in crossflow direction both in front of and beyond a downcomer for the descending liquid, and such crossflow mass transfer trays and one such crossflow mass transfer tray in a sequence of crossflow mass transfer trays present in a separating column.

A process for preparing a pure alanylglutamine comprises the steps of: 1) reacting N-(α-chloro)-propionyl-glutamine and hydrazine compound to obtain an alanylglutamine crude product; 2) mixing anhydrous methanol and the alanylglutamine crude product to provide a filter cake; 3) dissolving the filter cake in water, heating, adding ethanol, and cooling to yield the pure alanylglutamine.

In a process for removing aromatic carboxylic acid from a slurry thereof in solvent, the slurry is split into sub streams and each of said sub streams is supplied to a respective rotary pressure filter such that the sub stream pass through the filters in parallel. Gas is passed through the rotary pressure filters in series in an open-loop arrangement.

The present invention relates to methods for safe and efficient use of hydrogen and oxygen in ozonolysis operations. The invention also relates to an ozonolysis process involving elements of both reductive and oxidative ozonolysis which are integrated in a continuous process. In one embodiment, the ozonolysis process of the present invention uses hydrogen and/or oxygen generated from water and electricity, which may be recycled to generate water and/or electricity.

Methods of producing arginine bicarbonate solutions in very high concentrations including reacting an arginine slurry containing a first portion of arginine with a source of carbon dioxide gas at elevated pressure and temperature, adding subsequent portions of arginine to the resulting solution and further reacting with compressed carbon dioxide until a final solution containing in excess of 50% by weight are provided which include preparing an arginine solution by subjecting an arginine water slurry to elevated pressure and temperature and reacting the arginine solution with a source of carbon dioxide gas to form a solution comprising arginine and bicarbonate anion and recovering arginine bicarbonate from the solution.

Disclosed is a process for the production and purification of glycolic acid or glycolic acid derivatives by the carbonylation of aqueous formaldehyde. The water in the hydrocarboxylation zone is reduced via reaction with the ester bonds in a recycle stream comprising glycolic acid oligomers and/or methyl glycolate oligomers.

A cytosine analog, a method of preparation of a cytosine analog, a DNA methyltransferase 1 inhibitor, and a method for DNA methylation inhibition, is provided for the treatment of diseases associated with deviations from normal DNA methylation. The analog of cytosine may be comprised of 1, N4, 5 and 6-substituted derivatives of cytosine or 5,6-dihydrocytosine, wherein the analog can be described by the chemical formula where R1 is H, R3, R4, 2'-deoxyribosyl, R4 is alkyl or aryl, X is N or C, wherein if X in the analog of formula I is N, then R5 is no substituent and if X in the analog of formula I and/or II is C or if X in the analog of formula II is N, then R5 and R6 are independently alkyl, aryl, hydroxyalkyl, aminoalkyl, hydroxyl, carboxyl, amino group, alkoxyl, aryloxyl, aminoalkyl, aminoaryl, thio group, sulfonyl, sulfinyl or halogen.

The present invention relates to the field of cardiology. More specifically, the present invention provides methods and compositions for inducing proliferation of cardiomyocytes. In a specific embodiment, a method for inducing proliferation of cardiomyocytes comprises the step of administering an effective amount of an ALMS1 inhibitor.

Non-ionic water-soluble cellulose ethers modified with 3-azido-2-hydroxypropyl groups bound via an ether link are provided having a molar degree of substitution MSAHP in the range from 0.001 to 0.50. Exemplary cellulose ethers are alkyl celluloses, including methyl, hydroxyalkyl (e.g. hydroxyethyl or hydroxypropyl) or alkylhydroxyalkyl cellulose (e.g. methylhydroxyethyl). Reaction products with alkyne compounds are also provided, resulting in a terminal alkyne group. The reaction of azide with the alkyne proceeds as a 1,3-dipolar cycloaddition reaction, advantageously with Cu(I) or ruthenium catalysts. A multiplicity of cellulose ethers can be obtained from the conversion reaction. Variations in the macroscopic properties can be achieved by controlled modification, ranging from increased or reduced viscosity. The reaction, taking place within a few seconds, requires only minimal catalyst. Gel formation is reversible by adjustment of the pH such that a monophasic system (high-viscous fluid) arises again from a biphasic system (gel+low-viscous water phase).

Transcranial magnetic stimulation (TMS) is a remarkable tool for probing the brain. However, it is still unclear why specific regions in the cortex are excitable by TMS while others are not. This invention provides methods and tools for the design of efficient magnetic stimulators. Such stimulators can excite neuronal networks that were not sensitive to stimulation until now. Stimulation can be carried out both in-vitro and in-vivo. Novel systems and techniques of this invention will enable both treatment and diagnostics by stimulating regions of the brain or neuronal assemblies that were previously unaffected by TMS.

Apparatus and methods are described including acquiring a first set of extraluminal images of a lumen, using an extraluminal imaging device. At least one of the first set of images is designated as a roadmap image. While an endoluminal device is being moved through the lumen, a second set of extraluminal images is acquired. A plurality of features that are visible within images belonging to the second set of extraluminal images are identified. In response to the identified features in the images belonging to the second set of extraluminal images, a plurality of local calibration factors associated with respective portions of the roadmap image are determined. Other applications are also described.

The invention relates to improved process for the preparation of fesoterodine and its pharmaceutically acceptable salt, specifically fesoterodine fumarate of formula (1). The invention relates to solid state forms of a novel salt of fesoterodine and process for the preparation thereof. The invention also relates to highly pure fesoterodine fumarate substantially free of impurity X at RRT 1.37. The invention also provides solid particles of pure fesoterodine fumarate wherein 90 volume-percent of the particles (D90) have a size of higher than 200 microns.

The present invention provides drug conjugates comprising 5-aminolevulinic acid (ALA), an aldehyde and a carboxylic acid that may function as a histone deacetylase inhibitor (HDACI). These conjugates may serve as co-drugs which release a plurality of active species in vivo. The novel drug conjugates may be used, for the treatment or prevention of cancer in PDT-dependent and/or PDT-independent (nonPDT) treatments, as well as for cosmetic uses. In addition the present invention provides novel uses for both the novel and known compounds. According to some embodiments, the present invention provides drug conjugates (co-drugs) comprising (i) ALA, (ii) an aldehyde and (iii) a carboxylic acid that may function as a histone deacetylase inhibitor (HDACO for the treatment of anemia and/or for the induction of erythropoiesis.

The invention relates to a process for preparing pentabromobenzyl acrylate through the reaction of pentahalobenzyl halide with a salt of acrylic acid in water-immiscible solvent, wherein said salt is in aqueous form and the reaction is carried out in the presence of a phase transfer catalyst. A process for polymerizing the pentabromobenzyl acrylate in halogenated aromatic solvent and the poly (pentabromobenzyl acrylate) obtained are also disclosed.

Aromatic isocyanates are produced by reacting one or more aromatic primary amines with phosgene in the gas phase. The phosgene and primary aromatic amine(s) are reacted at a temperature above the boiling temperature of the amine(s) in a reactor having a reaction space which is essentially rotationally symmetric to the direction of flow. The flow fate, averaged over the cross-section, of the reaction mixture along the axis of the essentially rotationally symmetric reaction space in the section of the reaction space in which the conversion of the amine groups into isocyanate groups is between 4 and 80% is not more than 8 m/sec. The flow rate averaged over the cross-section of the reaction mixture along the axis of the essentially rotationally symmetric reaction space in the section of the reaction space in which the conversion of the amine groups into isocyanate groups is 4 to 80% is always below the flow rate averaged over the cross-section at the start of this section.

Provided is a gem-dinitro ester compound, represented by Formula 1 below: wherein R is a substituted or unsubstituted straight-chain or side-chain alkyl group of C2˜C12.

Isocyanates are produced in the gas phase and by-products such as ammonium halides are selectively separated from the gas phase by desublimation.

The present invention relates to a covalently organo-modified LDH (LDH/APTES) was found to be an efficient and reusable heterogeneous catalyst for C—C bond forming reactions (i.e. Aldol condensation, Knoevenagel condensation, Henry reaction, Michael addition). More particularly, this catalyst shows consistent activity for several cycles in C—C bond forming reaction. These catalysts were successfully characterized by XRD, FT-IR, 29Si CP MAS NMR.

Chiral amino compounds, methods of preparation and uses thereof. Tamiflu can be obtained from the said compounds. Multi-substituted chiral tetrahydropyrrolyl amine which can be used as intermediate compounds of medicament can also be produced by the said compounds.

A catalytic process for dehydration of an aliphatic C2-C6 alcohol to its corresponding olefin is disclosed. The process continuously flows through a reaction zone a liquid phase containing an aliphatic C2-C6 alcohol to contact a non-volatile acid catalyst at a reaction temperature and pressure to at least partially convert the aliphatic C2-C6 alcohol in the liquid phase to its corresponding olefin. The reaction pressure is greater than atmospheric pressure and the reaction temperature is above the boiling point of the olefin at reaction pressure, but below the critical temperature of the alcohol, and the olefin product is substantially in the gaseous phase. After the contacting step, the olefin containing gaseous phase is separated from the liquid phase. The invention also relates to catalytic processes such as a hydrolysis of an olefin to an alcohol, an esterification, a transesterification, a polymerization, an aldol condensation or an ester hydrolysis.

A process to prepared bridged bis(indenyl)ligands, comprising the step of reacting a 2-indenylpinacolyl borane compound with a bromosubstituted compound in the presence of a Pd catalyst and a base to form the corresponding bridged bis(indenyl) ligand. The process may further comprise the step of reacting a 2-bromo indene compound with pinacolborane in the presence of a Pd catalyst and a base to form the corresponding 2-indenylpinacolylborane compound. These bridged bis(indenyl)ligands may suitably be used in the preparation of metallocene complexes, such as 2,2'-bis(2-indenyl)biphenyl ZrCl2 and 1,2-bis(2-indenyl)benzene ZrCl2. These metallocene complexes may be used for the polymerization, optionally in the presence of a cocatalyst, of one or more α-olefins, preferably for the polymerization of ethylene.

A method of continuously manufacturing organometallic compounds is provided where two or more reactants are conveyed to a reactor having a laminar flow contacting zone, a heat transfer zone, and a mixing zone having a turbulence-promoting device; and causing the reactants to form the organometallic compound.

An efficient process for synthesizing phosphaplatins in large quantities is disclosed by adding platinum complex to a concentrated pyrophosphate solution at pH from between about 6.0 to 8.5. After stirring, the temperature and pH are lowered to precipitate out desired phosphaplatins. Particularly, the disclosed processes reduce the need to use large volumes of starting materials, and shorten the reaction time. In addition, disclosed is a process for recycling un-reacted materials from a first phosphaplatins synthesis.