The invention provides a phenolsulfonic acid aryl ester represented by formula (1) wherein each symbol is as defined in the description. The phenolsulfonic acid aryl ester is useful as a developer to provide a thermal recording material with good color-developing sensitivity, image density when printed at a low application energy (i.e., high start-up sensitivity), and heat and plasticizer resistance. The invention also provides a thermal recording material using the developer.

The present invention provides a thermosensitive multiple recording sheet characterized in that a second base material having light transmission properties is attached to the side of a first thermosensitive recording layer of a first thermosensitive recording sheet comprising a first base material and the first thermosensitive recording layer formed on one surface of the first base material, through a temporary adhesive layer, the second base material is composed of an information disclosing portion and an information non-disclosing portion, a shielding layer is formed at the position corresponding to the information non-disclosing portion on the second base material, and an ultraviolet curable resin layer are formed as an outermost layer of the sheet.

To provide a thermosensitive recording material, which contains: a support; a thermosensitive recording layer provided on one surface of the support; and a back layer provided on the other surface of the support, wherein the support has a surface formed of a resin, and wherein the back layer contains a combination of a core-shell acrylic resin and an oxazoline resin, or a reaction product thereof, or both thereof.

A method of increasing the solubility and/or dispersibility of a perylene dye in a liquid medium. The method comprises binding the perylene dye to a polymer which is soluble in the liquid medium. This abstract is neither intended to define the invention disclosed in this specification nor intended to limit the scope of the invention in any way.

The invention describes a thermally-responsive record material substantially free of aromatic isocyanate. The record material comprises a support having provided thereon a heat-sensitive composition comprising a substantially colorless dye precursor comprising a fluoran; and a developer material selected from the group consisting of 4,4'-diaminodiphenylsulfone and 3,3'-diaminodiphenylsulfone, which upon being heated react with said dye precursor to develop color, and including a binder material. Optionally, a modifier compound is included in the heat-sensitive composition. The modifier compound can be selected from the group consisting of a fatty acid amide, preferably a saturated fatty acid amide such as an alkyl amide, a bis methylene alkyl amide, or a bis ethylene alkyl amide, or any of 1,2-diphenoxy ethane, dimethyl diphenoxy ethane, and dimethyl phthalate.

A system and method for reducing the CO2 in a gaseous stream between 33% up to and even in excess of 90%, by reducing CO2. A gaseous stream that includes substantial amounts of CO2 is provided to a reaction chamber along with H2O (steam) and a carbon source such as charcoal, coke or other carbonaceous material. Carbon is provided to the chamber at a ratio (C/CO2) of between about 0.100 to 0.850, and between about 0.200 to 0.900 of H2O to the provided CO2. The CO2, H2O and carbon are heated to between about 1500° F. and about 3000° F. at about one atmosphere to produce syngas (i.e. carbon monoxide (CO) and hydrogen (H2)) and reduces the amount of CO2. The Syngas may then be cleaned and provided to a Fischer-Tropsch synthesis reactor or a Bio-catalytic synthesis reactor to produce a fuel, such as Methanol, Ethanol, Diesel and Jet Fuel.

A method is described for optimizing the operation of a reaction section for the synthesis of hydrocarbons from a feed comprising synthesis gas, operated in the presence of a catalyst comprising cobalt, said method comprising the following steps: a) determining the theoretical partial pressure of CO in the reaction section;b) optionally, adjusting the partial pressure of CO determined in step a) to a value of 4 bar or higher;c) determining a new value for the theoretical partial pressure of CO in the reaction section.

A biomass gasification gas purification system includes a dust collector for removing dust in biomass gasification gas (containing tar components) acquired by gasifying biomass by a biomass gasification furnace, a desulfurizer for removing sulfur oxide components in the dust-removed biomass gasification gas, a pre-reforming reactor for reforming tar components in the desulfurized biomass gasification gas, a steam feed unit for feeding steam to an upstream side of the pre-reforming reactor, and a natural-gas feed unit for feeding natural gas on an upstream side of the desulfurizer.

The invention relates to a process for increasing the carbon monoxide content of a feed gas mixture comprising carbon dioxide, hydrogen and carbon monoxide via a catalytic reversed water gas shift reaction, comprising the steps of (1) heating the feed gas mixture having an initial feed temperature of at most 350° C. in a first zone to a temperature within a reaction temperature range in the presence of a first catalyst; and (2) contacting the heated feed gas in a second zone within the reaction temperature range with a second catalyst. This process shows relatively high conversion of carbon dioxide, and virtually no methane or coke is being formed, allowing stable operation.

A method for producing a gas comprising at least 80 vol % carbon monoxide from a Fischer-Tropsch off-gas comprises: (1) feeding Fischer-Tropsch off-gas through a column comprising an adsorbent bed at high pressure and discharging effluent; (2) reducing the pressure in the column and the bed slightly; (3) rinsing the column and the adsorbent bed with methane or a mixture of methane and carbon dioxide; (4) reducing the pressure of the column and adsorbent bed to a low pressure; (5) rinsing the column and adsorbent bed with a mixture of hydrogen and nitrogen; (6) pressurizing the column and adsorbent bed to a high pressure using a mixture of hydrogen and nitrogen. The product stream obtained in step (3) comprising at least 80 vol % carbon monoxide can be sent as feed to a Fischer-Tropsch reaction. In an embodiment, a gas comprising at least 80 vol % hydrogen is also produced.

A methanol synthesis process includes reacting a process gas containing hydrogen, carbon dioxide and carbon monoxide over a catalyst including shaped units formed from a reduced and passivated catalyst powder the powder including copper in the range 10-80% by weight, zinc oxide in the range 20-90% by weight, alumina in the range 5-60% by weight and optionally one or more oxidic promoter compounds selected from compounds of Mg, Cr, Mn, V, Ti, Zr, Ta, Mo, W, Si and rare earths in the range 0.01-10% by weight, to form a product gas, and condensing methanol, water and oxygenate by-products therefrom, wherein the total oxygenate by-product level in the condensate is below 500 ppm.

Systems and methods are provided for enhancing the integration of processes for recovering products from algae-derived biomass. The enhanced process integration allows for increased use of input streams and other reagents that are derived from renewable sources. This increases the overall renewable character of the products extracted from the algae-derived biomass. The process integration can include exchange of input streams or energy between an algae processing system and a system for processing non-algal biomass. One example of improving process integration is using oxygenates that are generated in a renewable manner as a reagent for enhancing the algae processing system.

The invention relates to a catalyst and process for making syngas mixtures including hydrogen, carbon monoxide and carbon dioxide. The process comprises contacting a gaseous feed mixture containing carbon dioxide and hydrogen with the catalyst, where the catalyst comprises Mn oxide and an auxiliary metal oxide selected from the group consisting of La, Ca, K, W, Cu, Al and mixtures or combinations thereof. The process enables hydrogenation of carbon dioxide into carbon monoxide with high selectivity, and good catalyst stability over time and under variations in processing conditions. The process can be applied separately, but can also be integrated with other processes, both up-stream and/or down-stream including methane reforming or other synthesis processes for making products like alkanes, aldehydes, or alcohols.

Iron/carbon (Fe/C) nanocomposite catalysts are prepared for Fischer-Tropsch synthesis reaction. A preparation method includes steps of mixing iron hydrate salts and a mesoporous carbon support to form a mixture, infiltrating the iron hydrate salts into the carbon support through melt infiltration of the mixture near a melting point of the iron hydrate salts, forming iron-carbide particles infiltrated into the carbon support through calcination of the iron hydrate salts infiltrated into the carbon support under a first atmosphere, and vacuum-drying the iron-carbide particles after passivation using ethanol. Using such catalysts, liquid hydrocarbons are produced.

A fuel processing system for converting a logistical fuel and air into a liquid product comprising methanol. One such system comprises a fuel injection system configured to combine a logistical fuel and ambient air to produce a logistical fuel and air mixture, a synthesis gas production system configured to convert the logistical fuel and air mixture to synthesis gas, and a methanol synthesis system configured to convert the synthesis gas to a crude methanol liquid. Related methods are additionally disclosed.

A gasification-liquefaction disposal method, system and equipment for MSW are disclosed. The method involves the MSW pretreatment of dehydrating and separating, thus reducing water and inorganic substance content of the waste. Then, the MSW is introduced into a plasma gasifier (23) by a carbon dioxide air-sealed feeding device (13) and gasified therein to obtain hydrogen-rich syngas. The hydrogen-rich syngas is then cooled, deacidified, dedusted and separated to obtain carbon dioxide. Then, the hydrogen-rich syngas is catalyzed to produce methanol product in a methanol synthesis reactor (52). The separated carbon dioxide is sent back to a carbonation reaction chamber (2007) of a gasification system to perform carbonation reaction with calcium oxide, thereby releasing heat to provide assistant heat energy for gasification and avoiding greenhouse gas from being discharged into environment. Exhaust gas is returned to the plasma gasifier (23) for remelting treatment, thus forming a closed-loop circulation production system and realizing the disposal of the MSW with zero discharge and no pollution, thereby avoiding dioxin pollution and converting the MSW to chemical raw materials and fuel needed by mankind. The method, system and equipment are suitable for harmless and recycling disposal of MSW, industrial high polymer waste, composting waste and waste in waste sorting sites.

In a synthesis gas methanation process, at least one first fraction of synthesis gas to treat is fed, together with steam, to a shift reactor where a shift reaction occurs; the gas flow produced in the shift reactor is then fed to a first methanation reactor where a methanation reaction occurs and then to further second methanation reactors in series, where further methanation reactions, performed with the addition of fresh synthesis gas which has not been subjected to the shift reaction.

The invention provides for a method of forming methanol by combining a mixture of methane, water and carbon dioxide under reaction conditions sufficient to form a mixture of hydrogen and carbon monoxide. Hydrogen and carbon monoxide are reacted under conditions sufficient to form methanol. The molar ratio of hydrogen to carbon monoxide is at least two moles of hydrogen to one mole of carbon monoxide and the overall molar ratio between methane, water and carbon dioxide is about 3:2:1. Methane, carbon dioxide and water are bi-reformed over a catalyst. The catalyst includes a single metal, a metal oxide, a mixed catalyst of a metal and a metal oxide or a mixed catalyst of at least two metal oxides.

A process for improving the hydrogen content of a synthesis gas stream to a synthesis loop, comprising the steps of: (a) removing a purge stream comprising hydrogen and hydrocarbons from a synthesis loop; (b) separating hydrogen from the purge stream; (c) passing the purge stream to a reformer and reacting with steam and oxygen to produce a stream comprising hydrogen and carbon monoxide; (d) subjecting the reformed reaction product stream to a shift reaction to produce a stream comprising carbon dioxide and hydrogen; (e) subjecting the product stream from the shift reaction to separation to separate hydrogen from carbon dioxide; (f) supplying the separated hydrogen to the synthesis loop; and (g) removing the carbon dioxide.

The present invention provides a process for producing a hydrocarbon oil by performing a Fischer-Tropsch synthesis reaction using a reactor for a Fischer-Tropsch synthesis including a reaction apparatus having a slurry containing catalyst particles and a gaseous phase located above the slurry to obtain a hydrocarbon oil, wherein the Fischer-Tropsch reaction is performed while controlling a temperature of the slurry so that a difference T2−T1 between the average temperature T1 of the slurry and a temperature T2 at the liquid level of the slurry in contact with the gaseous phase is 5 to 30° C.

Disclosed is a process for converting a reactant composition comprising H2 and CO to a product comprising at least one aliphatic hydrocarbon having at least about 5 carbon atoms, the process comprising: flowing the reactant composition through a microchannel reactor in contact with a Fischer-Tropsch catalyst to convert the reactant composition to the product, the microchannel reactor comprising a plurality of process microchannels containing the catalyst; transferring heat from the process microchannels to a heat exchanger; and removing the product from the microchannel reactor; the process producing at least about 0.5 gram of aliphatic hydrocarbon having at least about 5 carbon atoms per gram of catalyst per hour; the selectivity to methane in the product being less than about 25%. Also disclosed is a supported catalyst comprising Co, and a microchannel reactor comprising at least one process microchannel and at least one adjacent heat exchange zone.

A synthesis gas conversion process and system are disclosed. Fresh syngas from a methane reformer is used as a sweep zone gas feed which is caused to flow across a water permselective membrane in a membrane reactor. The water permselective membrane is adjacent a synthesis gas conversion reaction zone in which synthesis gas is contacted with a catalyst and converted to effluent including water. Water is removed from the reaction zone through the membrane and passes out of the reactor with the sweep zone gas. The water is then removed from the sweep zone gas forming a modified gas feed which is fed to the reaction zone. The modified gas feed has a preferred H2/CO ratio to feed into the reaction zone.

In designing supersonic aircrafts, a method of designing a natural laminar flow wing is provided which reduces friction drag by delaying boundary layer transition under flight conditions of actual aircrafts. A target Cp distribution on wing upper surface, suited to natural laminarization in which boundary layer transition is delayed rearward in desired Reynolds number states, is defined by a functional type having as coefficients parameters depending on each spanwise station, a sensitivity analysis employing a transition analysis method is applied to the parameters, and a search is performed for the optimum combination of parameters to delay transition rearward.

A fluid flow is simulated by causing a computer to perform operations on data stored in the memory to compute at least one eddy of a fluid flow at a first scale and perform operations to compute at least one eddy of the fluid flow at both the first scale and a second scale. The second scale is a finer scale than the first scale, and the computation of the at least one eddy of the fluid flow at the second scale is constrained by results of the computation of the at least one eddy of the fluid flow at the first scale.

A production simulator (2), for simulating a mature hydrocarbon field, providing quantity produced (Qφktb) per phase, per well, per layer (or group of layers) and per time as a function of production parameters (PP), wherein the production simulator (2) matches history data (HD) of the mature hydrocarbon field and verifies a Vapnik condition.

A computer-implemented method, system, and computer program product are disclosed for updating simulation models of a subterranean reservoir. An ensemble of reservoir models representing a subterranean reservoir having non-Gaussian characteristics is provided and the ensemble of reservoir models is updated using a subspace ensemble Kalman filter. Kemal principle component analysis parameterization or K-L expansion parameterization can be used to update the ensemble of reservoir models.

Method and system are disclosed for statistical circuit simulation. In one embodiment, a computer implemented method for statistical circuit simulation includes providing descriptions of a circuit for simulation, wherein the descriptions include variations of statistical parameters of the circuit, partitioning the circuit into groups of netlists according to variations of statistical parameters of the circuit, simulating the groups of netlists using a plurality of processors in parallel to generate a plurality of output data files, and storing the plurality of output data files in a memory. The method of partitioning the circuit into groups of netlists includes forming the groups of netlists to be simulated in a single instruction multiple data environment, and forming the groups of netlists according to proximity of variations of statistical parameters of the circuit.

Methods and systems are provided for executing a simulation of an operation in a data processing system. In one implementation, the method includes executing an operation under a first set of conditions, determining a characteristic associated with the execution of the operation under the first set of conditions, and executing a simulation of the operation under a second set of conditions different from the first set of conditions. The simulation of the operation is constrained by the determined characteristic. The method can further include determining a cost/benefit of executing the operation under a set of conditions different from the first set of conditions based at least in part on the simulation.

The present disclosure includes methods, systems, and devices for prioritization of three dimensional dental elements. One method for prioritizing three dimensional dental elements includes receiving a virtual initial dental data set (IDDS) of teeth having spatial information regarding the positions of a number of teeth in the virtual IDDS with respect to each other for presentation of the teeth in a virtual three dimensional space to be viewed on a user interface, setting prioritization values of a number of elements of one or more of the number of teeth, and prioritizing the number of elements to be selected by a user based upon their prioritization values.

A computer-implemented method for simulating flow and acoustic interaction of a fluid with a porous medium includes simulating activity of a fluid in a first volume adjoining a second occupied by a porous medium, the activity of the fluid in the first volume being simulated so as to model movement of elements within the first volume and using a first model having a first set of parameters, simulating activity of the fluid in the second volume occupied by the porous medium, the activity in the second volume being simulated so as to model movement of elements within the second volume and using a second model having a second set of parameters and differing from the first model in a way that accounts for flow and acoustic properties of the porous medium, and simulating movement of elements between the first volume and the second volume at an interface between the first volume and the second volume.

The present invention aims to simulate a response more similar to a actual machine while inhibiting load increase in analog operation. Program configuration of the present invention is a component of a simulation program for circuit design, which is executed by a computer. The computer includes an operation portion, a storage portion, a manipulation portion, and a display portion, so that the computer exerts a function of a circuit design simulator, and as a macro model of an operational amplifier for use in the circuit design simulator, enabling the computer to act by simulating a response of the operational amplifier on the circuit design simulator. The macro model of the operational amplifier includes a control portion (LMT1) for generating output exception in the event of input exception or power supply exception of the operational amplifier.

Dynamics simulations are described. Dynamics simulations can include identifying a number of ink related components and a number of printing interactions. Dynamics simulations can also include generating a granular representation of the number of ink related components and calculating a number of Hamaker constants based on the granular representation of the number of ink related components. Dynamics simulations can include performing a dynamics simulation based on the number of Hamaker constants, the granular representation of the number of ink related components, and the number of printing interactions.

Methods, systems, and apparatus, including computer program products, for determining energy indicator values for a plurality of thermoplastic materials. An energy indicator value represents expected energy requirements for performing an injection of the material in a mold cavity. An injection of each of a plurality of thermoplastic materials in a first modeled mold cavity is simulated. A respective value of a first expected energy parameter is determined for each of the plurality of thermoplastic materials based on the simulated injections. A respective energy indicator is determined, for each of the plurality of thermoplastic materials, based at least on the corresponding value of the first expected energy parameter. The respective energy indicator value of one or more of the plurality of thermoplastic materials is presented.

Methods are provided herein for: calculating cell growth rates in various environments and genetic backgrounds; calculating the order of substrate utilization from a defined growth medium; calculating metabolic flux reorganization in various environments and at various growth rates; and calculating the maximum metabolic rate and optimal metabolite concentrations and enzyme activities by applying a computational optimization method to a kinetic model of a metabolic pathway. The optimization methods use intracellular molecular crowding parameters and/or well as kinetic rates to assist in modeling metabolic activity.

In a method for simulating temperature and electrical characteristics within an circuit, a temperature of at least one volume within the circuit as a function of a resistance within the at least one volume is repeatedly calculated and the resistance as a function of the temperature is repeatedly calculated until the temperature is within a predetermined tolerance of a previous temperature result and until the resistance is within a predetermined tolerance of a previous resistance result. Once the temperature is within a predetermined tolerance of the previous temperature result and the resistance is within a predetermined tolerance of the previous resistance, then an output indicative of the temperature is generated.

The cost necessary for introducing and maintaining a development environment that includes multiple simulators is suppressed, and a sharing of designing information is promoted, to make parameter adjustment of simulators easy. Provided is a service that unifies development environment on a computer provided with: a working computer system that can guarantee that there is no leaking of designing files; a user behavior monitoring system that collects utilization history of simulators or software, for each of the users, and selects development process of each of the users from the collected information; and a dynamic computational-resource distribution system that can conduct an automatic optimization of a complex simulation configuration, from information collected by the aforementioned user behavior monitoring system.

Methods and apparatuses for circuit design are described. In one embodiment, the method comprises determining a distribution of nets of a circuit, the distribution of the nets comprising numbers of blocks that each of the nets has in each of a plurality of partitions of the circuit in a partitioning solution, moving a first block of the circuit from a source partition to a destination partition to modify the partitioning solution, and updating the distribution of the nets after the moving.

A device for the collection and processing of information relating to the exposure of one or more persons to one or more products of chemical or biological origin has: at least one coded sensor for automatic or semi-automatic identification of a person likely to be exposed to at least one product,at least one coded sensor for the collection of information relating to the handling of at least one product by the person likely to be exposed to the product,at least one sensor for validating the information collected by the identification and collection sensors,at least one module for reading at least one coded sensor, anda module for processing information collected by the sensors.

The embodiments relate to modeling resistance in a multi-fin multi-gate field effect transistor (MUGFET). In these embodiments, a design for a multi-fin MUGFET comprises a gate structure with a horizontal portion traversing multiple semiconductor fins and comprising a plurality of first resistive elements connected in series, with vertical portions adjacent to opposing sides of the semiconductor fins and comprising second resistive elements connected in parallel by the horizontal portion, and with contact(s) comprising third resistive element(s). The total gate resistance is determined based on resistance contributions from the first resistive elements, the second resistive elements and the third resistive element(s), particularly, where each resistive contribution is based on a resistance value of the resistive element, a first fraction of current from the semiconductor fins entering the resistive element and a second fraction of the current from the semiconductor fins exiting the resistive element.

A method (and system) of emulation in a multiprocessor system, includes performing an emulation in which a host multiprocessing system of the multiprocessor system supports a weak consistency model, and the target multiprocessing system of the multiprocessor system supports a strong consistency model.

A method and apparatus for data processing. The method calculates correlations between a plurality of attributes in a dataset. The attributes are factors involved in transaction processing. The method generates a relationship graph by using the plurality of attributes and the correlations between the plurality of attributes; and extracts a sub-graph from the relationship graph to represent a hypothesis. The hypothesis describes the impacts of the factors on the transaction processing. Also provided is an apparatus for implementing the above data processing method.

A method of providing data included in a building information modeling (BIM) data file using a server is provided. The method includes retrieving mapping data corresponding to a user request, extracting data corresponding to at least one entity mapped to the mapping data from the BIM data file, and transmitting the extracted data to a client.

According to one aspect, an apparatus for computing a solution to a power flow problem for an electrical power system comprising a plurality of buses. The apparatus includes (a) at least one processor comprising a plurality of cores; and (b) memory coupled to the at least one processor for storing an admittance matrix for the power system, real power and reactive power for each bus, and an initial complex voltage for each bus; (c) wherein the at least one processor is configured to: (i) perform a Jacobi power flow calculation for each bus to determine the complex voltage for each bus, the Jacobi power flow calculation using the admittance matrix, the real power and reactive power for each bus, and the initial complex voltage for each bus as inputs, wherein at least two Jacobi power flow calculations are performed concurrently on the plurality of cores; (ii) calculate a power mismatch at each bus based on the complex voltages; and (iii) determine whether the Jacobi power flow calculations have converged based on the power mismatch and repeat (i) to (iii) if the Jacobi power flow calculations have not converged.

Methods, systems, and computer readable media for simulating realistic movement of user equipment in an LTE network are disclosed. According to one method, a logical topology of a long term evolution (LTE) access network is defined that includes defining connections between one or more eNodeBs (eNBs). A physical topology of the LTE access network is defined that includes defining locations of the eNBs and sectors, where the physical network topology is mapped to the logical network topology. One or more problem areas are defined within the physical network topology, where the one or more problem areas include locations where signal quality is degraded. One or more paths are defined through the physical network topology. A traffic profile for a user equipment (UE) device is defined. A plurality of messages is generated for simulating the movement of a UE device along a path through the physical network topology.

A proposed feature vector for a first deign is received and an existing feature vector for an existing design is retrieved for a given task. The proposed design is evaluated against the existing design using task-based scores associated with each design and based on their performances for the given task.

A coating composition comprising: an aqueous dispersion comprising: the melt-kneading product of (A) a base polymer which comprises one or more thermoplastic polymers, (B) a stabilizing agent which comprises at least one component selected from the group consisting of acrylic acid grafted ethylene-based polymers and maleic anhydride grafted polyolefins; (C) a neutralizing agent; and (D) water; wherein the aqueous dispersion has a volume average particle size of less than about 5 μm is provided.

Systems and methods for controlling the damping of magnetic media for heat assisted magnetic recording are provided. One such system includes a heat sink layer, a growth layer on the heat sink layer, a magnetic recording layer on the growth layer, where the growth layer is configured to facilitate a growth of a preselected crystalline structure of the magnetic recording layer, and a capping magnetic recording layer on the magnetic recording layer, the capping recording layer including a first material configured to increase a damping constant of the capping recording layer to a first preselected level.

Disclosed are polysulfone-based materials that can be used as active and/or passive components in various electronic, optical, and optoelectronic devices, particularly, metal-oxide-semiconductor field-effect transistors. For example, various metal-oxide-semiconductor field-effect transistors can include a dielectric layer and/or a passivation layer prepared from such polysulfone-based materials and exhibit good device performance.

A method for perfusing a biocompatible material graft with a perfusion liquid includes the steps of: introducing the graft (100) in a perfusion chamber (2), arranging a transfer chamber (3) partly filled with the perfusion liquid (101), coupling in a tight manner the perfusion chamber (2) and the transfer chamber (3) for establishing a fluid communication between them, lowering the pressure in the transfer chamber (3) for transferring therein part of the air existing in the perfusion chamber (2), increasing the pressure within the transfer chamber (3) for injecting in the perfusion chamber (2) the perfusion liquid (101) existing in the transfer chamber (3). A perfusion kit includes a perfusion chamber (2) apt to contain a graft (100) to be perfused with a liquid (101) and a transfer chamber (3) apt to contain a liquid (101) to be perfused, the perfusion chamber (2) being connectable in a tight manner with the transfer chamber (3) for allowing a fluid exchange between the two chambers (2, 3) and inhibiting a fluid exchange between the two chambers (2, 3) and the external environment.

The present disclosure relates to a method of melt processing an active agent. The method may include encapsulating an active agent in a first polymer material exhibiting a first processing temperature T1 and forming capsules including the active agent. The method may also include melt processing the capsules with a second polymer material exhibiting a second processing temperature T2, wherein T1>T2.