si Interfaces for digital media processing By www.freepatentsonline.com Published On :: Tue, 26 May 2015 08:00:00 EDT APIs discussed herein promote efficient and timely interoperability between hardware and software components within the media processing pipelines of media content players. A PhysMemDataStructure API facilitates a hardware component's direct access to information within a memory used by a software component, to enable the hardware component to use direct memory access techniques to obtain the contents of the memory, instead of using processor cycles to execute copy commands. The PhysMemDataStructure API exposes one or more fields of data structures associated with units of media content stored in a memory used by a software component, and the exposed fields store information about the physical properties of the memory locations of the units of media content. SyncHelper APIs are used for obtaining information from, and passing information to, hardware components, which information is used to adjust the hardware components' timing for preparing media samples of synchronously-presentable media content streams. Full Article
si Information processing system By www.freepatentsonline.com Published On :: Tue, 26 May 2015 08:00:00 EDT An information processing system includes a CPU that is connected to a bus; a device that is connected to the bus; a memory that is accessed by the CPU or the device; and a power mode control circuit that sets a power consumption mode. The power mode control circuit sets the power consumption mode based on first information that indicates a cache hit or a cache miss of a cache memory in the CPU and second information that indicates an activated state or a non-activated state of the device. Full Article
si System and method for using state replication between application instances to provide a collaborative desktop environment By www.freepatentsonline.com Published On :: Tue, 26 May 2015 08:00:00 EDT Described herein are systems and methods for enabling a collaborative remote desktop environment. The system includes a computing device and a first application instance that has an application state associated therewith. The first application instance includes, or is associated with, a current state component and application data/data files. The system further includes an application launcher that is used to instantiate a second application instance operating either on the same or on a different computing device. The second application instance similarly has an application state associated therewith and is associated with the application launcher. Upon receiving a request from the second user to interact with the first application instance, the application state and the application data/data files are communicated to the application launcher, and the application launcher instantiates the second application instance so that its state is substantially identical to that of the first application instance. Full Article
si Systems and methods for dynamic development and deployment of computing applications using blueprints By www.freepatentsonline.com Published On :: Tue, 26 May 2015 08:00:00 EDT Systems and methods for dynamic development and deployment of computing applications including a development framework, a visual design subsystem, and a deployment subsystem, where at runtime the deployment subsystem is operable to dynamically deploy a computing application realized by a blueprint by sending a request at runtime for graphs and components instantiated by the blueprint. Full Article
si Simulated network By www.freepatentsonline.com Published On :: Tue, 26 May 2015 08:00:00 EDT Systems, methods, and computer-readable and executable instructions are provided for providing a simulated network. Providing a simulated network can include collecting a number of network parameters for a plurality of locations and determining an application frequency of an application for the plurality of locations. Furthermore, providing a simulated network can include providing a simulated network with the number of network parameters to a number of testers of the application, wherein the number of network parameters are provided proportionally to the application frequency. Full Article
si Facilitating context delivery during communication sessions By www.freepatentsonline.com Published On :: Tue, 07 Jul 2015 08:00:00 EDT An approach is disclosed that facilitates context delivery during communication sessions. The approach may be implemented in a computer infrastructure having computer executable code tangibly embodied on a computer readable storage medium having programming instructions operable to: render at least one service to a user device through a communication session; collect information of the communication session; and send the information of the communication session to a service provider when a call is setup between the user device and the service provider. The service provider renders the information of the communication session for viewing by the service provider. Full Article
si Information processing system, information processing apparatus and information processing system control method, capable of providing, regardless of execution/non-execution of an application, data usable by the application to other information processing By www.freepatentsonline.com Published On :: Tue, 28 Jul 2015 08:00:00 EDT A CPU executes a communication partner search process for searching for a communication partner (another game machine). The CPU confirms received data content. If identification information included in the received data matches, application identification information saved in a wireless communication module is compared with application identification information included in the received data. When the pieces of application identification information match, a notice that another game machine having exchange data corresponding to the matched application identification information is found is given to a main body. Then, giving/receiving of exchange data is executed to/from another game machine. Full Article
si System and method for supporting video processing load balancing for user account management in a computing environment By www.freepatentsonline.com Published On :: Tue, 29 Sep 2015 08:00:00 EDT A system and method can support user account management in a computing environment. The computing environment can include a video encoding pool to support load balancing and a managing server, such as a privileged account manager server. The video encoding pool includes a set of nodes that are able to perform one or more video processing tasks for another node. Furthermore, the managing server can receive a request from a managed node in the computing environment for delegating a video processing task, and can select one or more nodes from the video encoding pool to load babalance and to perform the video processing task. Full Article
si Software-based aliasing for accessing multiple shared resources on a single remote host By www.freepatentsonline.com Published On :: Tue, 22 Dec 2015 08:00:00 EST In order to allow a single user registered on a single local host or other machine to access multiple shared resources on a remote host, an aliasing mechanism is employed so that multiple concurrent connections can be established by the user to a single remote host, with each connection using a different identity. Each connection can therefore be used to access a different shared resource on the remote host. In some illustrative examples, a user's identifier such as his or her machine log-in identification may be associated with two or more resource sharing aliases. As a result, two or more resource sharing sessions can be established by the user with a single remote host, with each of the sessions using a different one of the aliases. The resource sharing sessions are usually established in accordance with a resource sharing protocol such as the Server Block Message (SBM) protocol. Full Article
si Apparatus and method for controlling peripheral in wireless communication system using an IP address By www.freepatentsonline.com Published On :: Tue, 16 Feb 2016 08:00:00 EST An apparatus and method control a connection between peripheral devices in a control server of a wireless communication system providing an IP-based communication service. The method for controlling the connection between peripheral devices includes registering at least one device in a group list classified by user identification information. The method also includes, if a control node including a user identifier of the group list requests a control of any one device included in the group list, checking an IP address of the device that is requested to be controlled by the control node. The method further includes sending a control command of the control node using the IP address. Full Article
si Methods and apparatus to determine impressions using distributed demographic information By www.freepatentsonline.com Published On :: Tue, 17 May 2016 08:00:00 EDT An example method to monitor media exposure involves receiving, at a first internet domain, a first request from a client computer, the first request indicative of access to the media at the client computer. The example method also involves determining if the client computer is known. If the client computer is not known, a response is sent from the first internet domain to the client computer, the response to instruct the client computer to send a second request to a second internet domain, the second request to be indicative of access to the media at the client computer. If the client computer is known, an impression of the media is logged. Full Article
si System and method for transmission of data By www.freepatentsonline.com Published On :: Tue, 28 Jun 2016 08:00:00 EDT A system and method for data communication connecting on-line networks with on-line and off-line computers. The present system provides for broadcast of up to the minute notification centric information thereby providing an instant call to action for users who are provided with the ability to instantaneously retrieve further detailed information. The notification centric portions of information is wirelessly broadcast to wireless receiving devices which are attached to computing devices. Upon receipt of the information at the personal computer, the user is notified through different multimedia alerts that there is an incoming message. Wirelessly broadcasted URL's, associated with the data, are embedded in data packets and provide an automated wired or wireless connection back to the information source for obtaining detailed data. Full Article
si Method of depositing a decorative wear-resistant coating layer on a substrate By www.freepatentsonline.com Published On :: Tue, 27 Nov 1990 08:00:00 EST A method for depositing a wear-resistant decorative coating on a substrate, comprising a first stage of vacuum deposition on the surface of the substrate of a layer of at least one metal of the group titanium, zirconium, hafnium, vanadium, niobium, tantalum, chromium, molybedenum, tungsten and aluminium, to which is added at least one element of the group carbon, nitrogen, oxygen, boron, silicon, fluorine, chlorine, sulfur and phosphorus; a second stage including activation of the first layer by ionic bombardment under vacuum conditions and simultaneous deposition of a second fine layer of a metal or metal alloy; and a third stage involving galvanic deposition of a third layer of a decorative metal coating over the second layer. Full Article
si Watch case including a sintered caseband By www.freepatentsonline.com Published On :: Tue, 27 Nov 1990 08:00:00 EST The watch case of this invention includes a caseband (2) made from sintered material and a back cover (10) secured to the caseband by means of at least two pins (12). Each pin passes through a first hole (14) provided in a first projection (16) formed in the caseband and two second holes (13, 15) provided respectively in two second projections (17, 18) formed in the back cover, said second projections being arranged respectively on either side of said first projection. Each pin being axially retained in its holes by the elastic effect provided by the seal when the caseband lies on the back cover. Full Article
si Apparatus for recording and quickly retrieving video signal parts on a magnetic tape By www.freepatentsonline.com Published On :: Tue, 29 Jan 1991 08:00:00 EST In an apparatus for recording and quickly retrieving video signal parts on a magnetic tape, during recording information about the local position of each video signal part is automatically stored in a memory associated with the apparatus, which is designed for storing identifying information for a large number of magnetic tape cassettes. The retrieval of each video signal part on each of the cassettes can be effected substantially without delay in the quick rewind mode of operation. Full Article
si Arrangement for automatically switching a videorecorder on and off in the absence of a code signal but in presence of a FBAS signal By www.freepatentsonline.com Published On :: Tue, 05 Feb 1991 08:00:00 EST The disclosed device enables the recording of television broadcasts which are preprogrammed in a memory. The presence of data lines of the television signal in combination with the presence of a color television signal is checked. When the data lines stop, the video recorder is switched on in real time by a clock time signal. Full Article
si Method for detecting the time messages in the faulty signal of a time-signal transmitter By www.freepatentsonline.com Published On :: Tue, 06 Oct 1998 08:00:00 EDT A method is described for detecting the time messages in the faulty signal of a time-signal transmitter comprising the steps below. Probabilities are assigned to the received information/bits as they are received and whose sign specifies the value of the bit and whose numerical value indicates the certainty of reception. Except for the bits designating the minute information, the probabilities of successive time messages are totaled with time correctness in a one-dimensional memory field. From the totaled probabilities, a reduced time message is reconstructed that initially contains no information on the minutes. If the reconstructed time message does not change over two successive time intervals, and if preset minimum values for the number of probabilities are exceeded for all bits, then the reduced time message is recognized as being correct. The minutes are determined separately and added to the time message recognized as being correct. Full Article
si Apparatus and method for optical transmission of serial data using a serial communications port By www.freepatentsonline.com Published On :: Tue, 10 Nov 1998 08:00:00 EST Accessory for a laptop computer with LCD display which is connected to the laptop serial communications port and optically transmits data to a portable information device, such as a wristwatch designed to receive data as sequential pulses of light. The accessory includes a microcomputer with an RC timebase which is calibrated each time it is used by a special internal program, so that the input baud rate to the accessory matches the communications baud rate of the data received from the laptop. The internal program also permits selection of an output baud rate for the optically transmitted data. Full Article
si Apparatus for measuring intervals between signal edges By www.freepatentsonline.com Published On :: Tue, 12 Jun 2001 08:00:00 EDT An apparatus for measuring a time interval between a start signal edge and a stop signal edge provides a stable clock signal as input to a delay line formed by a series of similar logic gates. The output signal of the last gate of the series is phase locked to the clock signal by adjusting a bias signal controlling the switching speed of all gates. The clock signal and the output signal of each gate form a set of phase distributed periodic timing signals applied to a start time measurement unit (TMU) and a similar stop TMU. The start TMU counts edges of one of the timing signals occurring between an edge of an arming signal and the start signal edge and generates output data representing a time delay between the arming signal and the start signal edge. The data represents the start delay as a whole and fractional number of clock signal periods by conveying the counter output and by indicating which of the timing signals had an edge most closely following the start signal edge. The stop TMU similarly produces output data indicating a whole an fractional number of clock cycles occurring between the arming signal and the stop signal edge. The delay represented by the start TMU output data is subtracted from the delay represented by the stop TMU output data to determine the interval between the start and stop signal edges. Full Article
si Equatorial sundial apparatus utilizing one or more concave cylindrical focusing mirrors By www.freepatentsonline.com Published On :: Tue, 16 Oct 2001 08:00:00 EDT An equatorial sundial apparatus with an adjustable base assembly utilizing one or more concave cylindrical focusing mirrors. One of the benefits that is derived from this apparatus is the use of one or more concave cylindrical mirrors to project a focused beam of light onto a calibrated surface from which the time can be read. This sundial has the additional benefit of not suffering from blurring of the time indicator in a shadow or non-focused beam of light typical of other sundials. This sundial's focused light forms a sharply demarcated indicator from which time can be read to the minute. A further benefit of this apparatus is the ability to incorporate multiple concave cylindrical focusing mirrors to reduce the size of the visual field or screen where the time is read and to incorporate various shapes and designs for ornamental purposes without significant compromise of the sundials accuracy for telling time. An additional benefit of this apparatus is the ability to quickly, accurately and easily adjust the apparatus to the proper tilt upon setup according to the latitude where it will be located by means of an adjustable base assembly. Full Article
si Information expressing method By www.freepatentsonline.com Published On :: Tue, 19 Jan 2010 08:00:00 EST A musical rhythm is expressed by the number of the timing marks (for example, three timing marks when in simple triple time); and a musical tempo is expressed by the distance among the timing marks and a timing ball that moves at a fixed speed among those timing marks. Accordingly, a player may easily grasp the tempo of the music and easily determine the rhythm of the music in a sound game. Full Article
si Writing of new data of a first block size in a raid array that stores both parity and data in a second block size By www.freepatentsonline.com Published On :: Tue, 26 May 2015 08:00:00 EDT A Redundant Array of Independent Disks (RAID) controller receives new data that is to be written, wherein the new data is indicated in blocks of a first block size. The RAID controller reads old data, and old parity that corresponds to the old data, stored in blocks of a second block size that is larger in size than the first block size. The RAID controller computes new parity based on the new data, the old data, and the old parity. The RAID controller writes the new data and the new parity aligned to the blocks of the second block size, wherein portions of the old data that are not overwritten by the RAID controller are also written to the blocks of the second block size. Full Article
si Writing of new data of a first block size in a raid array that stores both parity and data in a second block size By www.freepatentsonline.com Published On :: Tue, 26 May 2015 08:00:00 EDT A Redundant Array of Independent Disks (RAID) controller receives new data that is to be written, wherein the new data is indicated in blocks of a first block size. The RAID controller reads old data, and old parity that corresponds to the old data, stored in blocks of a second block size that is larger in size than the first block size. The RAID controller computes new parity based on the new data, the old data, and the old parity. The RAID controller writes the new data and the new parity aligned to the blocks of the second block size, wherein portions of the old data that are not overwritten by the RAID controller are also written to the blocks of the second block size. Full Article
si Efficient processing of cache segment waiters By www.freepatentsonline.com Published On :: Tue, 26 May 2015 08:00:00 EDT For a plurality of input/output (I/O) operations waiting to assemble complete data tracks from data segments, a process, separate from a process responsible for the data assembly into the complete data tracks, is initiated for waking a predetermined number of the waiting I/O operations. Full Article
si Single instance buffer cache method and system By www.freepatentsonline.com Published On :: Tue, 26 May 2015 08:00:00 EDT Provided is a method and system for reducing duplicate buffers in buffer cache associated with a storage device. Reducing buffer duplication in a buffer cache includes accessing a file reference pointer associated with a file in a deduplicated filesystem when attempting to load a requested data block from the file into the buffer cache. To determine if the requested data block is already in the buffer cache, aspects of the invention compare a fingerprint that identifies the requested data block against one or more fingerprints identifying a corresponding one or more sharable data blocks in the buffer cache. A match between the fingerprint of the requested data block and the fingerprint from a sharable data block in the buffer cache indicates that the requested data block is already loaded in buffer cache. The sharable data block in buffer cache is used instead thereby reducing buffer duplication in the buffer cache. Full Article
si System and method for virtual machine conversion By www.freepatentsonline.com Published On :: Tue, 26 May 2015 08:00:00 EDT System and method for conversion of virtual machine files without requiring copying of the virtual machine payload (data) from one location to another location. By eliminating this step, applicant's invention significantly enhances the efficiency of the conversion process. In one embodiment, a file system or storage system provides indirections to locations of data elements stored on a persistent storage media. A source virtual machine file includes hypervisor metadata (HM) data elements in one hypervisor file format, and virtual machine payload (VMP) data elements. The source virtual machine file is converted by transforming the HM data elements of the source file to create destination HM data elements in a destination hypervisor format different from the source hypervisor format; maintaining the locations of the VMP data elements stored on the persistent storage media constant during the conversion from source to destination file formats without reading or writing the VMP data elements; and creating indirections to reference the destination HM data elements in the destination hypervisor format and the existing stored VMP data elements. Full Article
si Using extended asynchronous data mover indirect data address words By www.freepatentsonline.com Published On :: Tue, 25 Aug 2015 08:00:00 EDT An abstraction for storage class memory is provided that hides the details of the implementation of storage class memory from a program, and provides a standard channel programming interface for performing certain actions, such as controlling movement of data between main storage and storage class memory or managing storage class memory. Full Article
si Using extended asynchronous data mover indirect data address words By www.freepatentsonline.com Published On :: Tue, 01 Sep 2015 08:00:00 EDT An abstraction for storage class memory is provided that hides the details of the implementation of storage class memory from a program, and provides a standard channel programming interface for performing certain actions, such as controlling movement of data between main storage and storage class memory or managing storage class memory. Full Article
si α-keto alkylperacids and methods for producing and using the same By www.freepatentsonline.com Published On :: Tue, 28 Apr 2015 08:00:00 EDT The present invention provides α-keto alkylperacids and methods for producing and using the same. In particular, α-keto alkylperacids are useful as antimicrobial agents. Full Article
si Actinic-ray- or radiation-sensitive resin composition, compound and method of forming pattern using the composition By www.freepatentsonline.com Published On :: Tue, 05 May 2015 08:00:00 EDT According to one embodiment, an actinic-ray- or radiation-sensitive resin composition includes any of the compounds (A) of general formula (I) below that when exposed to actinic rays or radiation, generates an acid and a resin (B) whose rate of dissolution into an alkali developer is increased by the action of an acid. (The characters used in general formula (I) have the meanings mentioned in the description.) Full Article
si Radiation-sensitive composition, and compound By www.freepatentsonline.com Published On :: Tue, 05 May 2015 08:00:00 EDT A radiation-sensitive composition includes a compound represented by a formula (1), and a polymer having a structural unit that includes an acid-labile group. In the formula (1), R1 represents a group having a polar group; n is an integer of 1 to 4, wherein, in a case where R1 is present in a plurality of number, the plurality of R1s are identical or different, and optionally at least two R1s taken together represent a cyclic structure; A represents an alicyclic hydrocarbon group having a valency of (n+1); and M+ represents a monovalent onium cation. Full Article
si Deep-ultraviolet chemically-amplified positive photoresist By www.freepatentsonline.com Published On :: Tue, 05 May 2015 08:00:00 EDT The invention discloses a deep-ultraviolet chemically-amplified positive photoresist. The deep-ultraviolet chemically-amplified positive photoresist according to one embodiment of the invention includes a cyclopentenyl pimaric acid, a divinyl ether, a photoacid generator and an organic solvent. The deep-ultraviolet chemically-amplified positive photoresist according to the invention has a good sensitivity and a good transparency. Full Article
si Methods and compositions for the synthesis of multimerizing agents By www.freepatentsonline.com Published On :: Tue, 05 May 2015 08:00:00 EDT The invention features methods and compositions for the synthesis of multimerizing agents. An exemplary method for producing AP20187 may comprise: (a) coupling 2-N,Ndimethylaminomethyl-1,3-diaminopropane with AP20792 to produce the dimeric alcohol, AP20793; and (b) coupling the AP20793 so produced with API7362 to yield AP20187. In particular embodiments, the method further includes the step of producing API7362 by coupling API7360 with methyl-L-pipecolic acid, or a salt thereof. Full Article
si Ammonium fluoroalkanesulfonates and a synthesis method therefor By www.freepatentsonline.com Published On :: Tue, 05 May 2015 08:00:00 EDT An ammonium hydroxyfluoroalkanesulfinate is obtained by using an organic base while sulfinating a bromofluoroalcohol with a sulfinating agent. An ammonium hydroxyfluoroalkanesulfonate is obtained by oxidizing the ammonium hydroxyfluoroalkanesulfinate. An onium fluoroalkanesulfonate is obtained by converting the ammonium hydroxyfluoroalkanesulfonate into an onium salt through esterification. This onium fluoroalkanesulfonate is useful as a photoacid generator in chemically amplified resists and the like. Full Article
si Methanol carbonylation process with rhodium catalyst and a metallic co-catalyst selected from transition metals, zinc, beryllium, indium, tin, strontium and barium By www.freepatentsonline.com Published On :: Tue, 05 May 2015 08:00:00 EDT A carbonylation process for making acetic acid using a metallic co-catalyst composition, effective as a rhodium stabilizer and/or rate promoter, at molar ratios of metal/rhodium of about 0.5 to 40. The process includes reacting methanol with carbon monoxide in the presence of a rhodium-based catalytic metal complex with about 1 to 20 weight percent methyl iodide, less than about 8 weight % water and about 0.5 to about 30 weight percent methyl acetate. The crude acetic acid is flashed and further purified. Full Article
si Method for increasing methionine productivity using a mixture of methyl mercaptan and dimethyl sulfide By www.freepatentsonline.com Published On :: Tue, 05 May 2015 08:00:00 EDT The present invention relates to a method for increasing L-methionine productivity and organic acid productivity. More particularly, the present invention relates to a method which involves adding a mixture containing methyl mercaptan and dimethyl sulfide at a appropriate ratio to O-acetyl homoserine or O-succinyl homoserine and to an enzyme having an activity of converting methionine precursor into L-methionine, so as to perform an enzyme reaction, to thereby improve the conversion rate of L-methionine and organic acid from the L-methionine precursor, and thus increasing L-methionine yield as compared to conventional method. Full Article
si Method for the conversion of methylmercaptopropionaldehyde formed from crude acrolein and crude methyl mercaptan By www.freepatentsonline.com Published On :: Tue, 12 May 2015 08:00:00 EDT A reactive rectification column suitable for the production of 2-hydroxy-4-methylmercaptobutyric acid and/or methionine contains a weir having a height of 100 mm or more. Full Article
si Composition for maintaining function of platelets By www.freepatentsonline.com Published On :: Tue, 19 May 2015 08:00:00 EDT A composition for maintaining a function of platelets, the composition comprising, as an active ingredient, a compound represented by the following general formula (I) or a salt thereof, or a solvate thereof: wherein X represents a phenylene group;Y represents any one of a hydrogen atom and —(CH2)mR1;wherein m represents an integer of any one of 0 to 4; andR1 is any one of —NR5COR2, —NR5SO2R2, and —NR3R4;wherein R2 represents any one of a C1 to C6 alkyl group, an aryl group, a C1 to C6 alkoxy group, and the like;R3 and R4 represent a C1 to C6 alkyl group or the like; andR5 represents any one of a hydrogen atom, a C1 to C6 alkyl group, and the like; and Z represents any one of a hydrogen atom and a C1 to C6 alkyl group. Full Article
si Modified carbon material and process of making and using the same By www.freepatentsonline.com Published On :: Tue, 19 May 2015 08:00:00 EDT A method of making modified carbon materials for use in fabricating fuel cell components. The modified carbon may comprise pendant fluorocarbon groups bonded covalently bonded thereto. In one embodiment, a mixture is formed and comprises carbon material suitable for use in a fuel cell component, an organic solvent, a compound having the general formula I—R wherein R is a fluorocarbon, and a reductant. Full Article
si Ozonolysis operations for generation of reduced and/or oxidized product streams By www.freepatentsonline.com Published On :: Tue, 19 May 2015 08:00:00 EDT The present invention relates to methods for safe and efficient use of hydrogen and oxygen in ozonolysis operations. The invention also relates to an ozonolysis process involving elements of both reductive and oxidative ozonolysis which are integrated in a continuous process. In one embodiment, the ozonolysis process of the present invention uses hydrogen and/or oxygen generated from water and electricity, which may be recycled to generate water and/or electricity. Full Article
si Method for producing reduced coenzyme Q10, method for stabilizing same, and composition comprising same By www.freepatentsonline.com Published On :: Tue, 26 May 2015 08:00:00 EDT An object of the present invention is to provide a substance characterized by ability to reduce oxidized coenzyme Q10 and ability to stabilize reduced coenzyme Q10, which contains nutrients, has a favorable taste, and is excellent in general versatility, and a method for using the same. The present invention relates to a method for producing reduced coenzyme Q10 comprising reducing oxidized coenzyme Q10 with a particular amino acid. The present invention also relates to a method for stabilizing reduced coenzyme Q10 in the presence of a particular amino acid and a composition stabilized by the method. Full Article
si Hydrocarboxylation of aqueous formaldehyde using a dehydrating recycle stream to decrease water concentration By www.freepatentsonline.com Published On :: Tue, 26 May 2015 08:00:00 EDT Disclosed is a process for the production and purification of glycolic acid or glycolic acid derivatives by the carbonylation of aqueous formaldehyde. The water in the hydrocarboxylation zone is reduced via reaction with the ester bonds in a recycle stream comprising glycolic acid oligomers and/or methyl glycolate oligomers. Full Article
si Nucleic acids targeting TCTP for use in the treatment of chemo- or hormone-resistant cancers By www.freepatentsonline.com Published On :: Tue, 19 May 2015 08:00:00 EDT The present invention concerns a TCTP antagonist, in particular a nucleic acid targeting an m RNA encoding Translationally-Controlled Tumor Protein (TCTP), wherein said nucleic acid is capable of reducing the amount of TCTP in cells, for use in the treatment or prevention of hormone-independent cancer or chemo-resistant cancer, such as an androgen-independent prostate cancer. Full Article
si Antisense modulation of PTP1B expression By www.freepatentsonline.com Published On :: Tue, 19 May 2015 08:00:00 EDT Provided herein are methods, compounds, and compositions for reducing expression of PTP1B mRNA and protein in an animal. Such methods, compounds, and compositions are useful to treat, prevent, delay, or ameliorate metabolic disease, for example, diabetes, or a symptom thereof. Full Article
si Tumor and infectious disease therapeutic compositions By www.freepatentsonline.com Published On :: Tue, 19 May 2015 08:00:00 EDT A pharmaceutical composition comprising lectins is anti-tumorigenic and anti-viral, bacterial or protozoan. The composition, termed BiOmune is also useful for imaging, diagnosis and therapy of cancer. Full Article
si Macromolecular nucleotide compounds and methods for using the same By www.freepatentsonline.com Published On :: Tue, 19 May 2015 08:00:00 EDT The invention describes new structures of the nucleotide conjugates (nuc-macromolecules) comprising at lease one nucleotide moiety coupled to at least one macromolecular compound via a short linker. These conjugates can be used as substrates for various kinds of polymerizing enzymes in the enzymatic synthesis of nucleic acids. In particular, these compounds can be used for labeling nucleic acids. Full Article
si Method to determine responsiveness of cancer to epidermal growth factor receptor targeting treatments By www.freepatentsonline.com Published On :: Tue, 19 May 2015 08:00:00 EDT Disclosed herein are methods and reagents for determining the responsiveness of cancer to an epidermal growth factor receptor (EGFR) targeting treatment. The detection of these mutations will allow for the administration of gefitinib, erlotinib and other tyrosine kinase inhibitors to those patients most likely to respond to the drug. Full Article
si Compositions and methods for silencing SMAD4 By www.freepatentsonline.com Published On :: Tue, 19 May 2015 08:00:00 EDT The present invention provides compositions comprising therapeutic nucleic acids such as interfering RNA (e.g., dsRNA such as siRNA) that target SMAD4 gene expression, lipid particles comprising one or more (e.g., a cocktail) of the therapeutic nucleic acids, methods of making the lipid particles, and methods of delivering and/or administering the lipid particles (e.g., for treating anemia of inflammation in humans). Full Article
si Process for triphosphate oligonucleotide synthesis By www.freepatentsonline.com Published On :: Tue, 19 May 2015 08:00:00 EDT This invention relates to a process for preparing an oligonucleotide 5'-triphosphate. The process comprises the steps of: (a) synthesizing an oligonucleotide having a 5' hydroxyl moiety; (b) reacting the 5' hydroxyl moiety with a reagent of formula I: to convert the 5' hydroxyl moiety to a 5'-H-phosphonate, wherein R1 and R2 are each independently selected from the group consisting of haloalkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, cycloalkyl, substituted cycloalkyl, heterocycle, and substituted heterocycle, acyl, phosphoryl, substituted alkyl acyl, substituted heteroalkyl acyl, substituted aryl acyl or substituted heteroaryl acyl, substituted alkyl phosphoryl, substituted heteroalkyl acyl, substituted aryl phosphoryl, and substituted heteroaryl phosphoryl; (c) activating the H-phosphonate of step (b) by reacting the H-phosphonate with a silylating agent, a halogenated oxidizing agent, a nitrogen-containing heteroaryl, or a combination thereof, to form an activated H-phosphonate; and (d) treating the oligonucleotide having an activated H-phosphonate from step (c) with a poly(alkylammonium)pyrophosphate. Full Article
si Method of preparing cationic starch using ultrahigh pressure By www.freepatentsonline.com Published On :: Tue, 19 May 2015 08:00:00 EDT Disclosed is a method of preparing cationic starch. The method includes preparing a starch suspension containing a cationization agent; performing ultrahigh pressure treatment on the starch suspension; and obtaining cationic starch from the starch suspension subjected to ultrahigh pressure treatment. Full Article