Ducks defensemen Christian Djoos and Jani Hakanpaa will stay with the team through the 2020-21 season after each signed a one-year, one-way contract extension.

UCLA guard Japreece Dean is primed to shine at the next level as she heads to the WNBA Draft in April. The do-it-all point-woman was an All-Pac-12 honoree last season, and one of only seven D-1 hoopers with at least 13 points and 5.5 assists per game.

Official counts of COVID-19 deaths have been criticized for potentially including people who did not die of COVID-19 but merely died with COVID-19. I address that critique by fitting a generalized additive model to weekly counts of all registered deaths in England and Wales during the 2010s. The model produces baseline rates of death registrations expected in the absence of the COVID-19 pandemic, and comparing those baselines to recent counts of registered deaths exposes the emergence of excess deaths late in March 2020. Among adults aged 45+, about 38,700 excess deaths were registered in the 5 weeks comprising 21 March through 24 April (612 $pm$ 416 from 21$-$27 March, 5675 $pm$ 439 from 28 March through 3 April, then 9183 $pm$ 468, 12,712 $pm$ 589, and 10,511 $pm$ 567 in April's next 3 weeks). Both the Office for National Statistics's respective count of 26,891 death certificates which mention COVID-19, and the Department of Health and Social Care's hospital-focused count of 21,222 deaths, are appreciably less, implying that their counting methods have underestimated rather than overestimated the pandemic's true death toll. If underreporting rates have held steady, about 45,900 direct and indirect COVID-19 deaths might have been registered by April's end but not yet publicly reported in full.

The next seminar in the 2017–18 History of Pre-Modern Medicine seminar series takes place on Tuesday 16 January. Speaker: Dr Catherine Rider (University of Exeter) Medieval Ideas about Infertility and Old Age Abstract: When they discussed fertility and reproductive disorders it was common… Continue reading

Ammunition Depot comments on Judge Roger T. Benitez ruling that Californians may again purchase ammo without a background check and order ammo online.

(PRWeb April 24, 2020)

Read the full story at https://www.prweb.com/releases/gun_rights_california_gun_owners_ammo_dealers_fire_back_against_proposition_63/prweb17075447.htm

Tsuyoshi Kunihama, Zehang Richard Li, Samuel J. Clark, Tyler H. McCormick.

Source: The Annals of Applied Statistics, Volume 14, Number 1, 241--256.

Abstract:
The distribution of deaths by cause provides crucial information for public health planning, response and evaluation. About 60% of deaths globally are not registered or given a cause, limiting our ability to understand disease epidemiology. Verbal autopsy (VA) surveys are increasingly used in such settings to collect information on the signs, symptoms and medical history of people who have recently died. This article develops a novel Bayesian method for estimation of population distributions of deaths by cause using verbal autopsy data. The proposed approach is based on a multivariate probit model where associations among items in questionnaires are flexibly induced by latent factors. Using the Population Health Metrics Research Consortium labeled data that include both VA and medically certified causes of death, we assess performance of the proposed method. Further, we estimate important questionnaire items that are highly associated with causes of death. This framework provides insights that will simplify future data

Braddock, William, 1798-1869 -- Correspondence.

The bombastic military parade through Moscow's Red Square on Saturday was slated to be the spectacle of the year on the Kremlin's calendar. Standing with Chinese leader Xi Jinping and French President Emmanuel Macron, President Vladimir Putin would have overseen a 90-minute procession of Russia's military might, showcasing 15,000 troops and the latest hardware. Now, military jets will roar over an eerily quiet Moscow, spurting red, white and blue smoke to mark 75 years since the defeat of Nazi Germany.

Georgia is one of four states that doesn't have a hate crime law. Arbery's killing has reignited calls for legislation.

London, [29 January 1994]

Treat the babe in your life to one (or two or three) of these indulgent gifts.

This is not a drill: You can get up to 50% off at Nordstrom right now.

You've got exactly four hours left to take advantage of these heavily discounted prices.

EndeavourOS is a rolling release Arch Linux-based distribution with some handy new features that improve the user experience. This latest version comes with graphical install options and preconfigured desktop environments. Several new in-house utilities improve package management and error reporting. There are lots of installation tips with the Calamares installer, which has a new look and feel.

Edge conditions and the change they drive are fascinating. Some people use the word "margin" because it's at the margin that things change. A situation exists more or less in equilibrium with the rest of its environment until in one way or another the stresses become so great that change happens. We have lots of metaphors, like "tipping point" and "the straw that broke the camel's back."

Hepatocyte growth factor (HGF) is a multifunctional protein that signals through the MET receptor. HGF stimulates cell proliferation, cell dispersion, neuronal survival, and wound healing. In the inner ear, levels of HGF must be fine-tuned for normal hearing. In mice, a deficiency of HGF expression limited to the auditory system, or an overexpression of HGF, causes neurosensory deafness. In humans, noncoding variants in HGF are associated with nonsyndromic deafness DFNB39. However, the mechanism by which these noncoding variants causes deafness was unknown. Here, we reveal the cause of this deafness using a mouse model engineered with a noncoding intronic 10 bp deletion (del10) in Hgf. Male and female mice homozygous for del10 exhibit moderate-to-profound hearing loss at 4 weeks of age as measured by tone burst auditory brainstem responses. The wild type (WT) 80 mV endocochlear potential was significantly reduced in homozygous del10 mice compared with WT littermates. In normal cochlea, endocochlear potentials are dependent on ion homeostasis mediated by the stria vascularis (SV). Previous studies showed that developmental incorporation of neural crest cells into the SV depends on signaling from HGF/MET. We show by immunohistochemistry that, in del10 homozygotes, neural crest cells fail to infiltrate the developing SV intermediate layer. Phenotyping and RNAseq analyses reveal no other significant abnormalities in other tissues. We conclude that, in the inner ear, the noncoding del10 mutation in Hgf leads to developmental defects of the SV and consequently dysfunctional ion homeostasis and a reduction in the EP, recapitulating human DFNB39 nonsyndromic deafness.

SIGNIFICANCE STATEMENT Hereditary deafness is a common, clinically and genetically heterogeneous neurosensory disorder. Previously, we reported that human deafness DFNB39 is associated with noncoding variants in the 3'UTR of a short isoform of HGF encoding hepatocyte growth factor. For normal hearing, HGF levels must be fine-tuned as an excess or deficiency of HGF cause deafness in mouse. Using a Hgf mutant mouse with a small 10 bp deletion recapitulating a human DFNB39 noncoding variant, we demonstrate that neural crest cells fail to migrate into the stria vascularis intermediate layer, resulting in a significantly reduced endocochlear potential, the driving force for sound transduction by inner ear hair cells. HGF-associated deafness is a neurocristopathy but, unlike many other neurocristopathies, it is not syndromic.

On February 9, 1945, two submarines are poised to engage in a direct, underwater confrontation. It's the first - and only - underwater submarine dog fight

After four months of unexpected dimming, the red supergiant star has perked back up, and astronomers may have a new explanation for the fluke

The new findings raises questions about the authenticity of a collection of texts known as the "post-2002" scrolls

The marble slab appears to be Greek in origin and may have been written in response to the death of a tyrant on the island of Kos

The exact molecule behind the Minamata mercury disaster, caused by a chemical plant’s wastewater, remains a point of disagreement

Researchers compared tree rings from around the world to determine that a volcano on Santorini probably erupted in 1560 B.C.

Scientists discover neurotoxin-producing bacteria living on the skin of rough-skinned newts

The 1888 historical account is likely the first ever confirmed case of a human being struck dead by an interstellar interloper

The 72-year-old animal was the third oldest in the North American population

Yellowknife RCMP confirmed the death of the missing 22-year-old woman on Friday and charged 27-year-old Devon Larabie in connection with her death.

Days before Saint John council passed a motion to ensure Saint John Energy could not be sold, the Ontario cities of Peterborough and Orillia both got approval to sell their municipally owned power distribution companies.

Some New Brunswick business owners already facing a cash crunch because of COVID-19 have received an unwelcome shock from NB Power: electricity bills that don’t take into account how little energy they’ve been consuming.

When Elizabeth May, parliamentary leader of the federal Green Party, proclaimed on Tuesday that "oil is dead," she was correct in a philosophical sense. But not in a practical, real world sense.

Residents are cleaning up damage to hundreds of homes and businesses caused by floods in the northern Alberta hamlet of Fort Vermilion.

The Porcupine Health Unit is reporting the fifth COVID-19 related death in its area.

Just across town from the Library of Congress in Washington, D.C., stands Gallaudet University, an institute for higher learning for the deaf and hard-of-hearing. In 1864, President Abraham Lincoln signed the law that allowed the school to begin issuing college degrees, a milestone for deaf people seeking higher education. Edward M. Gallaudet (right) was the […]

The latest death was at the Northwood long-term care home in Halifax.

The current deconfinement plan in the Montreal area could lead to a rapid increase in deaths in the city, according to findings by Quebec's public health institute. 

Live professional baseball games could be televised in the United States as early next week, with South Korea's Yonhap News Agency reporting Monday that ESPN and the Korea Baseball Organization are nearing an agreement.

Visit our four downtown locations where you can taste euphoria in our creative and delicious all natural ice-cream, yogurts and sorbets!

Bike the Sites of the Nation's Capital! It's the fun and easy way to get to get up close and personal with Washington's landmarks

Double Decker Tours offers the best experience. Our Double Decker buses have the most visible sights like US Capitol, White House, Museums and Memorials

Discover the real George Washington through his restored home and gardens, over 1,000 artifacts, and an immersive Revolutionary War "snow" experience

Voted "Washington's Best Tour" by Washingtonian Magazine. See the best of Washington aboard on our 2 hour tour with live narration

Take a bus tour to the sites of movies and TV shows. Your guide will entertain you as you visit over 30 locations used in West Wing, The Exorcist and more