In Delhi, the total number of coronavirus cases has risen to 6,923 with 381 new cases reported in the last 24 hours. 2069 people have recovered, and 73 people died, according to the data published in the Union Ministry of Health and Family Welfare website.

THE WEATHER it will shoot you

untravpaths:

Horseshoe Bend in the USA.

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Scientists from Princeton University and NOAA have produced the first global analysis of how climate change may affect the frequency of mild-weather days, which are defined as having temperatures between 64 and 86 degrees Fahrenheit (18 and 30 degrees Celsius) with low rain and humidity. The current global average of 74 mild days a year will drop by 10 days by 2100, with mid-latitude areas such as the United States experiencing more mild days and tropical areas seeing more hot and humid days.

Princeton University Professor of Mathematics John Mather, remembered as a "great mathematician" with a reserved and pleasant demeanor, died Jan. 28 of complications from prostate cancer at his home in Princeton. He was 74.

John Pardon, a Princeton University professor of mathematics, has received a National Science Foundation Alan T. Waterman Award, which is the nation's highest honor for scientists and engineers younger than 35. The prize carries a five-year, $1 million grant. Pardon was recognized for "revolutionary, groundbreaking results in geometry and topology" that "have extended the power of tools of geometric analysis to solve deep problems in real and complex geometry, topology and dynamical systems."

COVID-19 has killed at least 19,000 New Yorkers and dealt a body blow with lasting consequences to the city. Two paths lie ahead. If pandemics become common, then not only New York City but all of America’s service-based economy faces a bleak future. If this terrible plague is a unique event, then things will eventually get almost back to normal. To save both the nation’s biggest and most productive metropolis and tens of millions of service jobs across the county, we must invest enormously to prevent future pandemics.

Many mothers are pulling double and triple duty caring for kids, juggling jobs, homeschooling, navigating financial hardship and acting as unofficial family doctor at time with unprecedented health concerns.

Many mothers are pulling double and triple duty caring for kids, juggling jobs, homeschooling, navigating financial hardship and acting as unofficial family doctor at time with unprecedented health concerns.

Andre Harrell, a record executive who shepherded the careers of Mary J. Blige and Sean "Diddy" Combs and combined the sounds of R&B and hip-hop with his label, Uptown Records, has died.

The report comes as the government announced all states must now meet federal reporting guidelines. The type of information gathered by states up to now has been inconsistent.

Many mothers are pulling double and triple duty caring for kids, juggling jobs, homeschooling, navigating financial hardship and acting as unofficial family doctor at time with unprecedented health concerns.

Purdue's athletic department had its best finish in the Learfield Directors Cup standings in nearly a decade but more is expected in 2018-19

About 50 people gathered Saturday afternoon at West 62nd Street and Michigan Road to protest the fatal police shooting of Dreasjon "Sean" Reed.

Indianapolis Metropolitan Police Department are on the scene in the area of East 32nd Street and Baltimore Avenue.

Protests continued near 62nd Street and Michigan Road in Indianapolis on May 9, 2020, following the May 6 police shooting death of Dreasjon Reed.

Indianapolis Metropolitan Police Department are on the scene in the area of East 32nd Street and Baltimore Avenue.

Protests continued near 62nd Street and Michigan Road in Indianapolis on May 9, 2020, following the May 6 police shooting death of Dreasjon Reed.

As tests increase on the Island of Montreal, the city announced Saturday that 33 more people have died and 420 new cases have been confirmed in the past 24 hours.

The Vigi Home, located in the Town of Mont-Royal, has logged 64 deaths related to COVID-19 since the pandemic began.

Deaths and hospitalizations related to COVID-19 could increase dramatically in Montreal if social distancing measures are lifted, according to a new study.

Omar Taylor is at home with his family after six weeks in hospital battling coronavirus.

There have been 1,644 total lab-confirmed cases of COVID-19 since the first case was confirmed March 11.

The Dublin rock band had one of 2019's best albums - so what does the follow-up have in store?

More than 70 public figures sign an open letter to the prime minister calling for more transparency.

Alberta reported 59 new COVID-19 cases on Saturday, bringing the total number of active cases in the province to 1.837.

Dr. Bonnie Henry announced 15 new confirmed cases of the virus in the province, bringing the total number of positive tests since the pandemic began to 2,330.

7 October 2014

The investigation into the fatal shooting in Brunswick, Georgia, will also look at a neighbor of suspects Gregory and Travis McMichael who recorded video of the incident, authorities said.

Elizabeth Spiers wrote about an incident where Jared Kushner used the memorial of an employee to congratulate himself for success.

"I think it's always important to think about suicide as individual vulnerabilities and context," Eric Caine said.

The C-type lectin receptors (CLRs) form a family of pattern recognition receptors that recognize numerous pathogens, such as bacteria and fungi, and trigger innate immune responses. The extracellular carbohydrate-recognition domain (CRD) of CLRs forms a globular structure that can coordinate a Ca2+ ion, allowing receptor interactions with sugar-containing ligands. Although well-conserved, the CRD fold can also display differences that directly affect the specificity of the receptors for their ligands. Here, we report crystal structures at 1.8–2.3 Å resolutions of the CRD of murine dendritic cell-immunoactivating receptor (DCAR, or Clec4b1), the CLR that binds phosphoglycolipids such as acylated phosphatidyl-myo-inositol mannosides (AcPIMs) of mycobacteria. Using mutagenesis analysis, we identified critical residues, Ala136 and Gln198, on the surface surrounding the ligand-binding site of DCAR, as well as an atypical Ca2+-binding motif (Glu-Pro-Ser/EPS168–170). By chemically synthesizing a water-soluble ligand analog, inositol-monophosphate dimannose (IPM2), we confirmed the direct interaction of DCAR with the polar moiety of AcPIMs by biolayer interferometry and co-crystallization approaches. We also observed a hydrophobic groove extending from the ligand-binding site that is in a suitable position to interact with the lipid portion of whole AcPIMs. These results suggest that the hydroxyl group-binding ability and hydrophobic groove of DCAR mediate its specific binding to pathogen-derived phosphoglycolipids such as mycobacterial AcPIMs.

Extracytoplasmic sugar decoration of glycopolymer components of the bacterial cell wall contributes to their structural diversity. Typically, the molecular mechanism that underpins such a decoration process involves a three-component glycosylation system (TGS) represented by an undecaprenyl-phosphate (Und-P) sugar-activating glycosyltransferase (Und-P GT), a flippase, and a polytopic glycosyltransferase (PolM GT) dedicated to attaching sugar residues to a specific glycopolymer. Here, using bioinformatic analyses, CRISPR-assisted recombineering, structural analysis of cell wall–associated polysaccharides (CWPS) through MALDI-TOF MS and methylation analysis, we report on three such systems in the bacterium Lactococcus lactis. On the basis of sequence similarities, we first identified three gene pairs, csdAB, csdCD, and csdEF, each encoding an Und-P GT and a PolM GT, as potential TGS component candidates. Our experimental results show that csdAB and csdCD are involved in Glc side-chain addition on the CWPS components rhamnan and polysaccharide pellicle (PSP), respectively, whereas csdEF plays a role in galactosylation of lipoteichoic acid (LTA). We also identified a potential flippase encoded in the L. lactis genome (llnz_02975, cflA) and confirmed that it participates in the glycosylation of the three cell wall glycopolymers rhamnan, PSP, and LTA, thus indicating that its function is shared by the three TGSs. Finally, we observed that glucosylation of both rhamnan and PSP can increase resistance to bacteriophage predation and that LTA galactosylation alters L. lactis resistance to bacteriocin.

ROSEAU, Dominica (CMC): Well-travelled Barbadian umpire Gregory Brathwaite has been tipped to become the next Test umpire from the region. WEST INDIES Cricket Umpires Association secretary, Vivian Johnson, said the 50-year-old Brathwaite was...

THE LAST two months have been two of the worst in the life of former national netball star Nichala Gibson. She lives in New York City, the epicentre for the COVID-19 virus in the United States. Gibson and her sister suffered, then recovered from...

At least 10 stores inside the Portmore Mall have fallen casualty to the economic chokehold brought on by the COVID-19 pandemic, with several others struggling to stay afloat as St Catherine businesses grapple with revenue losses. And with a 14-day...

(AP): Many people saw more than the last moments of Ahmaud Arbery’s life when a video emerged this week of white men armed with guns confronting the black man; a struggle with punches thrown; three shots fired and Arbery collapsing...

The discovery of an inhibitory memory circuit could lead to novel treatments for conditions such as PTSD

In order to remember, we must forget. Recent research shows that when your brain retrieves newly encoded information, it suppresses older related information so that it does not interfere with the process of recall. Now a team of European researchers has identified a neural pathway that induces forgetting by actively erasing memories. The findings could eventually lead to novel treatments for conditions such as post-traumatic stress disorder (PTSD).

We’ve known since the early 1950s that a brain structure called the hippocampus is critical for memory formation and retrieval, and subsequent work using modern techniques has revealed a great deal of information about the underlying cellular mechanisms. The hippocampus contains neural circuits that loop through three of its sub-regions – the dentate gyrus and the CA3 and CA1 areas – and it’s widely believed that memories form by the strengthening and weakening of synaptic connections within these circuits.

Related: Light switches memories on and off | Mo Costandi

Related: The Homer Simpson effect: forgetting to remember

A toxin isolated from the Togo starburst tarantula provides new insights into pain mechanisms and could lead to new treatments for irritable bowel syndrome

With their large, hairy bodies and long legs, tarantulas are an arachnophobe’s worst nightmare. For pain researchers, however, these outsized spiders are a dream come true: Their venom contains a cocktail of toxins, each of which activates pain-sensing nerve fibres in different ways, and researchers in the United States have now identified one such toxin that will help them to better understand pain, and could also lead to treatments for the chronic pain associated with irritable bowel syndrome.

Physical pain signals are transmitted from the body to the brain by specialised sensory neurons called nociceptors. These pain-sensing neurons have cell bodies located just outside the spinal cord, and possess a single conductive fibre that splits in two, with one branch extending out towards the skin surface, and the shorter one entering the back of the cord.

Related: Uncomfortably numb: The people who feel no pain

Related: Researchers identify gatekeeper neurons that control pain and itch

New research shows that the rhythm of breathing directly impacts neural activity in a network of brain areas involved in smell, memory and emotions

The rhythm of breathing co-ordinates electrical activity across a network of brain regions associated with smell, memory, and emotions, and can enhance their functioning, according to a new study by researchers at Northwestern University. The findings, published in the Journal of Neuroscience, suggest that breathing does not merely supply oxygen to the brain and body, but may also organise the activity of populations of cells within multiple brain regions to help orchestrate complex behaviours.

Related: Your nose knows death is imminent | Mo Costandi

Related: A cooler way to evaluate brain surgery patients

I know AB and angle ABD, does anyone know how to work out BD and the area of ABD? Thanks

Is this some sort of properties for fractions? I know how to arrive at step 1 from step 2 but not step 1 to step 2.