Giant-scale physics experiments are increasingly reliant on big data and complex algorithms fed into powerful computers, and managing this multiplying mass of data presents its own unique challenges. To better prepare for this data deluge posed by next-generation upgrades and new experiments, physicists are turning to the fledgling field of quantum computing.

Tiny meteorites that fell to Earth 2.7 billion years ago suggest that the atmosphere at that time was high in carbon dioxide, which agrees with current understanding of how our planet's atmospheric gases changed over time.

UC San Diego Health launches pilot project using drones to move medical samples, supplies and documents between Jacobs Medical Center, Moores Cancer Center and the Center for Advanced Laboratory Medicine, speeding delivery of services and patient care currently managed through ground transport.

During the plague, I’ve been amusing myself by watching a show about immortality. In the world of Ad Vitam, a French series on Netflix, Covid-19 wouldn’t exist; disease apparently doesn’t and death hardly at all.
The reason for this is “regeneration”, a process finagled from jellyfish that allows humans to renew themselves. As the series begins, billions of people have just celebrated the birth of the world’s oldest woman, who is 169, but doesn’t look a day over 45.
The lead character, detective Darius Asram (Yvan Attal) is 119, his wife, who is newly pregnant, is 84.
Ah, but imagine…

Regular readers will know that I've been hanging out for the "market allocation" parts of the proposed Cannabis Legalisation and Control Bill, which will be the subject of a referendum this year.
While most media outlets ran inane stories last year on how many joints 14 grams added up to, it was clear to anyone who took the subject seriously that the questions of who would get to produce and sell cannabis and how licences would be awarded were vastly more important. And we've had to wait for answers to those.
Well, they're here. And it's very good news. From…

My 19 year old cat had to be euthanized a couple of days before Christmas. I must admit the guilt was horrible and all I could do is wonder where my dear

Friends! I put a fun piece of original art up on eBay, starting at one penny: Go snag it! --> https://www.ebay.com/itm/293555003346

For cost-benefit analysis, the usual ballpark figure for the value of a life is about $10,000,000. But I keep hearing it suggested that when it comes to fighting a disease like Covid-19, which mostly kills the elderly, this value is too high. In other words, an old life is worth less than a young life. […]

The PHP development team announces the immediate availability of PHP 7.2.30. This is a security release.All PHP 7.2 users are encouraged to upgrade to this version.For source downloads of PHP 7.2.30 please visit our downloads page, Windows source and binaries can be found on windows.php.net/download/. The list of changes is recorded in the ChangeLog.

Have you heard of Heath Freeman? He's a thirty-something hedge fund boss, who runs "Alden Global Capital," which owns a company misleadingly called "Digital First Media." His business has been to buy up local newspapers around the country and basically cut everything down to the bone, and just milk the assets for whatever cash they still produce, minus all the important journalism stuff. He's been called "the hedge fund asshole", "the hedge fund vampire that bleeds newspapers dry", "a small worthless footnote", the "Gordon Gecko" of newspapers and a variety of other fun things.

Reading through some of those links above, you find a standard playbook for Freeman's managing of newspapers:

These are the assholes who a few years ago bought the Denver Post, once one of the best regional newspapers in the country, and hollowed it out into a shell of its former self, then laid off some more people. Things got so bad that the Post’s own editorial board rebelled, demanding that if “Alden isn’t willing to do good journalism here, it should sell the Post to owners who will.”

And here's one of the other links from above telling a similar story:

The Denver newsroom was hardly alone in its misery. In Northern California, a combined editorial staff of 16 regional newspapers had reportedly been slashed from 1,000 to a mere 150. Farther down the coast in Orange County, there were according to industry analyst Ken Doctor, complained of rats, mildew, fallen ceilings, and filthy bathrooms. In her Washington Post column, media critic Margaret Sullivan called Alden “one of the most ruthless of the corporate strip-miners seemingly intent on destroying local journalism.”

And, yes, I think it's fair to say that many newspapers did get a bit fat and happy with their old school monopolistic hold on the news market pre-internet. And many of them failed to adapt. And so, restructuring and re-prioritizing is not a bad idea. But that's not really what's happening here. Alden appears to be taking profitable (not just struggling) newspapers, and squeezing as much money out of them directly into Freeman's pockets, rather than plowing it back into actual journalism. And Alden/DFM appears to be ridiculously profitable for Freeman, even as the journalism it produces becomes weaker and weaker. Jim Brady called it "combover journalism." Basically using skeleton staff to pretend to really be covering the news, when it's clear to everyone that it's not really doing the job.

All of that is prelude to the latest news that Freeman, who basically refuses to ever talk to the media, has sent a letter to other newspaper bosses suggesting they collude to force Google and Facebook to make him even richer.

You can see the full letter here:

Let's go through this nonsense bit by bit, because it is almost 100% nonsense.

These are immensely challenging times for all of us in the newspaper industry as we balance the two equally important goals of keeping the communities we serve fully informed, while also striving to safeguard the viability of our news organizations today and well into the future.

Let's be clear: the "viability" of your newsrooms was decimated when you fired a huge percentage of the local reporters and stuffed the profits into your pockets, rather than investing in the actual product.

Since Facebook was founded in 2004, nearly 2,000 (one in five) newspapers have closed and with them many thousands of newspaper jobs have been lost. In that same time period, Google has become the world's primary news aggregation service, Apple launched a news app with a subsription-based tier and Twitter has become a household name by serving as a distribution service for the content our staffs create.

Correlation is not causation, of course. But even if that were the case, the focus of a well-managed business would be to adapt to the changing market place to take advantage of, say, new distribution channels, new advertising and subscription products, and new ways of building a loyal community around your product. You know, the things that Google, Facebook and Twitter did... which your newspaper didn't do, perhaps because you fired a huge percentage of their staff and re-directed the money flow away from product and into your pocket.

Recent developments internationally, which will finally require online platforms to compensate the news industry are encouraging. I hope we can collaborate to move this issue forward in the United States in a fair and productive way. Just this month, April 2020, French antitrust regulators ordered Google to pay news publishers for displaying snippets of articles after years of helping itself to excerpts for its news service. As regulators in France said, "Google's practices caused a serious and immediate harm to the press sector, while the economic situation of publishers and news agencies is otherwise fragile." The Australian government also recently said that Facebook and Google would have to pay media outlets in the country for news content. The country's Treasurer, Josh Frydenberg noted "We can't deny the importance of creating a level playing field, ensuring a fair go for companies and the appropriate compensation for content."

We have, of course, written about both the plans in France as well as those in Australia (not to mention a similar push in Canada that Freeman apparently missed). Of course, what he's missing is... well, nearly everything. First, the idea that it's Google that's causing problems for the news industry is laughable on multiple fronts.

If newspapers feel that Google is causing them harm by linking to them and sending them traffic, then they can easily block Google, which respects robots.txt restrictions. I don't see Freeman's newspaper doing that. Second, in most of the world, Google does not monetize its Google News aggregation service, so the idea that it's someone making money off of "their" news, is not supported by reality. Third, the idea that "the news" is "owned" by the news organizations is not just laughable, but silly. After all, the news orgs are not making the news. If Freeman is going to claim that news orgs should be compensated for "their" news, then, uh, shouldn't his news orgs be paying the actual people who make the news that they're reporting on? Or is he saying that journalism is somehow special?

Finally, and most importantly, he says all of this as if we haven't seen how these efforts play out in practice. When Germany passed a similar law, Google ended up removing snippets only to be told they had to pay anyway. Google, correctly, said that if it had to license snippets, it would offer a price of $0, or it would stop linking to the sites -- and the news orgs agreed. In Spain, where Google was told it couldn't do this, the company shut down Google News and tons of smaller publications were harmed, not helped, but this policy.

This surely sounds familiar to all of us. It's been more than a decade since Rupert Murdoch instinctively observerd: "There are those who think they have a right to take our news content and use it for their own purposes without contributing a penny to its production... Their almost wholesale misappropriation of our stories is not fair use. To be impolite, it's theft."

First off, it's not theft. As we pointed out at the time, Rupert Murdoch, himself, at the very time he was making these claims, owned a whole bunch of news aggregators himself. The problem was never news aggregators. The problem has always been that other companies are successful on the internet and Rupert Murdoch was not. And, again, the whole "misappropriation" thing is nonsense: any news site is free to block Google's scrapers and if it's "misappropriation" to send you traffic, why do all of these news organizations employ "search engine optimizers" who work to get their sites higher in the rankings? And, yet again, are they paying the people who make the actual news? If not, then it seems like they're full of shit.

With Facebook and Google recently showing some contrition by launching token programs that provide a modest amount of funding, it's heartening to see that the tech giants are beginning to understand their moral and social responsibility to support and safeguard local journalism.

Spare me the "moral and social responsibility to support and safeguard local journalism," Heath. You're the one who cut 1,000 journalism jobs down to 150. Not Google. You're the one who took profitable newspapers that were investing in local journalism, fired a huge number of their reporters and staff, and redirected the even larger profits into your pockets instead of local journalism.

Even if someone wants to argue this fallacy, it should not be you, Heath.

Facebook created the Facebook Journalism Project in 2017 "to forge stronger ties with the news industry and work with journalists and publishers." If Facebook and the other tech behemoths are serious about wanting to "forge stronger ties with the news industry," that will start with properly remunerating the original producers of content.

Remunerating the "original producers"? So that means that Heath is now agreeing to compensate the people who create the news that his remaining reporters write up? Oh, no? He just means himself -- the middleman -- being remunerated directly into his pocket while he continues to cut jobs from his newsroom while raking in record profits? That seems... less compelling.

Facebook, Google, Twitter, Apple News and other online aggregators make billions of dollars annually from original, compelling content that our reporters, photographers and editors create day after day, hour after hour. We all know the numbers, and this one underscores the value of our intellectual property: The New York Times reported that in 2018, Google alone conservatively made $4.7 billion from the work of news publishers. Clearly, content-usage fees are an appropriate and reasonable way to help ensure newspapers exist to provide communities across the country with robust high-quality local journalism.

First of all, the $4.7 billion is likely nonsense, but even if it were accurate, Google is making that money by sending all those news sites a shit ton of traffic. Why aren't they doing anything reasonable to monetize it? And, of course, Digital First Media has bragged about its profitability, and leaked documents suggest its news business brought in close to a billion dollars in 2017 with a 17% operating margin, significantly higher than all other large newspaper chains.

This is nothing more than "Google has money, we want more money, Google needs to give us the money." There is no "clearly" here and "usage fees" are nonsense. If you don't want Google's traffic, put up robots.txt. Google will survive, but your papers might not.

One model to consider is how broadcast television stations, which provide valuable local news, successfully secured sizable retransmission fees for their programming from cable companies, satellite providers and telcos.

There are certain problems with retransmission fees in the first place (given that broadcast television was, by law, freely transmitted over the air in exchange for control over large swaths of spectrum), and the value they got was in having a large audience to advertise too. But, more importantly, retransmission involved taking an entire broadcast channel and piping it through cable and satellite to make things easier for TV watchers who didn't want to switch between an antenna and a cable (or satellite receiver). An aggregator is not -- contrary to what one might think reading Freeman's nonsense -- retransmitting anything. It's linking to your content and sending you traffic on your own site. The only things it shows are a headline and (sometimes) a snippet to attract more traffic.

There are certainly other potential options worth of our consideration -- among them whether to ask Congress about revisiting thoughtful limitations on "Fair Use" of copyrighted material, or seeking judicial review of how our trusted content is misused by others for their profit. By beginning a collective dialogue on these topics we can bring clarity around the best ways to proceed as an industry.

Ah, yes, let's throw fair use -- the very thing that news orgs regularly rely on to not get sued into the ground -- out the window in an effort to get Google to funnel extra money into Heath Freeman's pockets. That sounds smart. Or the other thing. Not smart.

And "a collective dialogue" in this sense appears to be collusion. As in an antitrust violation. Someone should have maybe mentioned that to Freeman.

Our newspaper brands and operations are the engines that power trust local news in communities across the United States.

Note that it's the brands and operations -- not journalists -- that he mentions here. That's a tell.

Fees from those who use and profit from our content can help continually optimize our product as well as ensure our newsrooms have the resources they need.

Again, Digital First Media, is perhaps the most profitable newspaper chain around. And it just keeps laying off reporters.

My hope is that we are able to work together towards the shared goal of protecting and enhancing local journalism.

You first, Heath, you first.

So, basically, Heath Freeman, who has spent decade or so buying up profitable newspapers, laying off a huge percentage of their newsrooms, leaving a shell of a husk in their place, then redirecting the continued profits (often that exist solely because of the legacy brand) into his own pockets rather than in journalism... wants the other newspapers to collude with him to force successful internet companies who send their newspapers a ton of free traffic to pay him money for the privilege of sending them traffic.

Sounds credible.

The 2020 Ultimate Work From Home Starter Kit has 16 courses designed to help you do your best while you work from home. There are courses on how to start your own business, how to become a freelancer or copywriter, and how to do affiliate marketing. Other courses focus on how to increase your productivity, how to lead virtual meetings, how to work with virtual teams, and more. It's on sale for $40.

Note: The Techdirt Deals Store is powered and curated by StackCommerce. A portion of all sales from Techdirt Deals helps support Techdirt. The products featured do not reflect endorsements by our editorial team.

For years, the Orleans Parish District Attorney's Office in Louisiana issued fake subpoenas to witnesses and crime victims. Unlike subpoenas used in ongoing prosecutions, these were used during the investigation process to compel targets to talk to law enforcement. They weren't signed by judges or issued by court clerks but they did state in bold letters across the top that "A FINE AND IMPRISONMENT MAY BE OPPOSED FOR FAILURE TO OBEY THIS NOTICE."

Recipients of these bogus subpoenas sued the DA's office. In early 2019, a federal court refused to grant absolute immunity to the DA's office for its use of fake subpoenas to compel cooperation from witnesses. The court pointed out that issuing its own subpoenas containing threats of imprisonment bypassed an entire branch of the government to give the DA's office power it was never supposed to have.

Allegations that the Individual Defendants purported to subpoena witnesses without court approval, therefore, describe more than a mere procedural error or expansion of authority. Rather, they describe the usurpation of the power of another branch of government.

The court stated that extending immunity would be a judicial blessing of this practice, rather than a deterrent against continued abuse by the DA's office.

The DA's office appealed. The Fifth Circuit Appeals Court took the case, but it seemed very unimpressed by the office's assertions. Here's how it responded during oral arguments earlier this year:

“Threat of incarceration with no valid premise?” Judge Jennifer Elrod said at one point during arguments. She later drew laughter from some in the audience when she said, “This argument is fascinating.”

“These are pretty serious assertions of authority they did not have,” said Judge Leslie Southwick, who heard arguments with Elrod and Judge Catharina Haynes.

The Appeals Court has released its ruling [PDF] and it will allow the lawsuit to proceed. The DA's office has now been denied immunity twice. Absolute immunity shields almost every action taken by prosecutors during court proceedings. But these fake subpoenas were sent to witnesses whom prosecutors seemingly had no interest in ever having testify in court. This key difference means prosecutors will have to face the state law claims brought by the plaintiffs.

Based upon the pleadings before us at this time, it could be concluded that Defendants’ creation and use of the fake subpoenas was not “intimately associated with the judicial phase of the criminal process,” but rather fell into the category of “those investigatory functions that do not relate to an advocate’s preparation for the initiation of a prosecution or for judicial proceedings.” See Hoog-Watson v. Guadalupe Cty., 591 F.3d 431, 438 (5th Cir. 2009)

[...]

Defendants were not attempting to control witness testimony during a break in judicial proceedings. Instead, they allegedly used fake subpoenas in an attempt to pressure crime victims and witnesses to meet with them privately at the Office and share information outside of court. Defendants never used the fake subpoenas to compel victims or witnesses to testify at trial. Such allegations are of investigative behavior that was not “intimately associated with the judicial phase of the criminal process.”

Falling further outside the judicial process was the DA's office itself, which apparently felt the judicial system didn't need to be included in its subpoena efforts.

In using the fake subpoenas, Individual Defendants also allegedly intentionally avoided the judicial process that Louisiana law requires for obtaining subpoenas.

The case returns to the lower court where the DA's office will continue to face the state law claims it hoped it would be immune from. The Appeals Court doesn't say the office won't ultimately find some way to re-erect its absolute immunity shield, but at this point, it sees nothing on the record that says prosecutors should be excused from being held responsible for bypassing the judicial system to threaten crime victims and witnesses with jail time.

I'm lucky enough to own a decades old Nintendo 64 and a handful of games, including the classic Mario 64. My kids love that game. Still, the first thing they asked when I showed it to them the first time is why the screen was letterboxed, why the characters looked like they were made of lego blocks, and why I needed weird cords to plug it all into the flat screen television. The answer to these spoiled monsters' questions, of course, is that the game is super old and wasn't meant to be played on modern televisions. It's the story of a lot of older games, though many PC games at least have a healthy modding community that will take classics and get them working on present day hardware. Consoles don't have that luxury.

Well, usually, that is. It turns out that enough folks were interested in modernizing Mario 64 that a group of fans managed to pull off porting it to PC. And, because this is a port and not emulation, they managed to update it to run in 4k graphics and added a ton of modern visual effects.

Last year, Super Mario 64's N64 code was reverse-engineered by fans, allowing for all kinds of new and exciting things to be done with Nintendo’s 1996 classic. Like building a completely new PC port of the game, which can run in 4K and ultra-wide resolutions.

This is a very new and cool thing! Previously, if you were playing Super Mario 64 on PC, you were playing via emulation, as your PC ran code pretending to be an N64. This game is made specifically for the PC, built from the ground up, meaning it not only runs like a dream, but even supports mod stuff like ReShade, allowing for graphical tweaks (like the distance blur seen here).

As you'll see, the video the Kotaku post is referencing can't be embedded here because Nintendo already took it down. Instead, I'll use another video that hasn't been taken down at the time of this writing, so you can see just how great this looks.

In addition to videos of the project, Nintendo has also been busy firing off legal salvos to get download links for the PC port of the game taken down from wherever it can find them. Now, while Nintendo's reputation for IP protectionism is such that it would almost certainly take this fan project down under virtually any circumstances, it is also worth noting that the company has a planned re-release of Mario 64 for its latest Nintendo console. That likely only supercharged the speed with which it is trying to disappear this labor of love from fans of an antiquated game that have since moved on to gaming on their PCs.

But why should the company do this? Nintendo consoles are known for many things, including user-friendly gaming and colorful games geared generally towards younger audiences. You know, exactly not the people who would take it on themselves to get an old Mario game working on their PC instead of a Nintendo console. What threat does this PC port from fans represent to Nintendo revenue? It's hard to imagine that threat is anything substantial.

And, yet, here we are anyway. Nintendo, after all, doesn't seem to be able to help itself.

Microsoft Excel is one of the most widely used applications in business. It’s the backbone for almost all companies. Why? Because Excel helps you accomplish tasks and solve problems more quickly. The better you are at Excel, the faster you can complete tasks and the more complex problems you can solve. That's what exactly the 2020 Excel Certification School Bundle is going to help you do. With 300 lessons and projects to follow along, you'll develop basic to more advanced skills and knowledge that is greater than most Excel users. It's on sale for $50.

Note: The Techdirt Deals Store is powered and curated by StackCommerce. A portion of all sales from Techdirt Deals helps support Techdirt. The products featured do not reflect endorsements by our editorial team.

Six months ago, which feels like roughly an eternity at this point, we discussed how Jerry Seinfeld and others won an absolutely ludicrous copyright suit filed against them by Christian Charles, a writer and director Seinfeld hired to help him create the pilot episode of Comedians In Cars Getting Coffee. What was so strange about the case is that this pilot had been created in 2012, whereas the lawsuit was only filed in 2018. That coincides with Seinfeld inking a lucrative deal with Netflix to stream his show.

It's not the most well known aspect of copyright law, but there is, in fact, a statute of limitations for copyright claims and it's 3 years. The requirement in the statute is that the clock essentially starts running once someone who would bring a copyright claim has had their ownership of a work disputed publicly, or has been put on notice. Seinfeld argued that he told Charles he was employing him in a work-for-hire arrangement, which would satisfy that notice. His lawyers also pointed out that Charles goes completely uncredited in the pilot episode, which would further put him on notice. The court tossed the case based on the statute of limitations.

For some reason, Charles appealed the ruling. Well, now the Court of Appeals has affirmed that lower ruling, which hopefully means we can all get back to not filing insane lawsuits, please.

We conclude that the district court was correct in granting defendants’ motion to dismiss, for substantially the same reasons that it set out in its well-reasoned opinion. The dispositive issue in this case is whether Charles’s alleged “contributions . . . qualify [him] as the author and therefore owner” of the copyrights to the show. Kwan, 634 F.3d at 229. Charles disputes that his claim centers on ownership. But that argument is seriously undermined by his statements in various filings throughout this litigation which consistently assert that ownership is a central question.

Charles’s infringement claim is therefore time-barred because his ownership claim is time-barred. The district court identified two events described in the Second Amended Complaint that would have put a reasonably diligent plaintiff on notice that his ownership claims were disputed. First, in February 2012, Seinfeld rejected Charles’s request for backend compensation and made it clear that Charles’s involvement would be limited to a work-for-hire basis. See Gary Friedrich Enters., LLC v. Marvel Characters, Inc., 716 F.3d 302, 318 (2d Cir. 2013) (noting that a copyright ownership claim would accrue when the defendant first communicates to the plaintiff that the defendant considers the work to be a work-for-hire). Second, the show premiered in July 2012 without crediting Charles, at which point his ownership claim was publicly repudiated. See Kwan, 634 F.3d at 227. Either one of these developments was enough to place Charles on notice that his ownership claim was disputed and therefore this action, filed six years later, was brought too late.

And that should bring this all to a close, hopefully. This seems like a pretty clear attempt at a money grab by Charles once Seinfeld's show became a Netflix cash-cow. Unfortunately, time is a measurable thing and his lawsuit was very clearly late.

It's a long, long buildup to CEO's soliloquy, it's a long way to go

Knowledge 2020 With the long flights, late nights and early starts, IT conferences might seem endless. But with the shift to the online format becoming standard, for now at least, participants might be spared the trial of endurance.…

Decades-old theory may require a rethink thanks to Japanese probe

The Moon is believed to have formed from the leftovers of a proto-Earth smashing into a Mars-sized Theia nearly 4.5 billion years ago.…

'B' is for basic controls that up and disappeared

A study of the UK online advertising market, conducted by global accounting firm PwC, has found that publishers get just half of what advertisers spend, with the other half siphoned off by ad-supply chain intermediaries.…

We all need to tighten our belts

For the first time in over three decades, BT has suspended its dividend scheme as the former state-owned teleco grapples with the fallout from the novel coronavirus pandemic, and the financial uncertainty that'll inevitably ensue.…

John Cena!* Online resources only for free and end users due to the 'unprecedented period'

Video conferencing darling of the hour, Zoom, has tightened up support rules in order to "better serve" users.…

It's like three buses showing up at once carrying $8bn

India’s largest mobile carrier, Jio, has just scored a third new investor in three weeks!…

Zero-click remote-code exec hole found by Googler, updates emitted

Samsung has patched a serious security hole in its smartphones that can be exploited by maliciously crafted text messages to hijack devices.…

-Album Details- Title: NJBP Concert Archives I ~ANCIENT FESTIVAL~ Publisher: SuperSweep Catalog Number: SRVD-5001 Release Date: July 6th, 2019 Ripped by: Razakin -Info- Recording of the New Japan BGM Philharmonic Orchestra’s Ancient Festival concert, which was full of Yuzo Koshiro goodness from the Scheme to Streets of Rage and Etrian Odyssey, and as a main […]

A review by SomeRandomHEFan (46). An excellent showcase of Humongous Entertainment's sense of humour. And I guess there's an acceptable edutainment game in there somewhere, too.

Codemasters готовят одиночную кампанию, восемь режимов гонок, события и мультиплеер.

Благодаря чипу Kirin 710F смартфон получил предустановленные чипы Google.

Drive more reaction when you fabricate your image story at the purpose of decision. A point of decision is where a possibility or purchaser will make a move activity to move to the subsequent stage in the purchasing procedure. Research,… Continue Reading →

This flow chart, created by University of Virginia Psychology Professors Jim Coan and Daniel Willingham, is just plain terrific. “Could a child do this alone?” asks the chart. Then let ’em! “Could a child do this with some instruction?” Then let ’em. Etc. etc. Check it out — print it out! — by clicking here. […]

Spiegel has a piece Inside the Desperate Battle against Sports Doping. Lots of athletes get away with it. Pretty unfair for the ones who do not cheat. I've made this argument many times: anti-doping efforts are a losing cause. Doping techniques will become harder to detect. They will also become more powerful. But there is hope of a sort on the horizon: In 10 years time we have orders of magnitude more understanding of how genetic variants cause differences in human performance. This is inevitable due to the plunging costs of DNA sequencing. As a result it will become possible to measure a person's genetic potential to perform in various sports. Test the genetic potential. Then report for each athlete...

Nitrozac had to undergo an emergency endodontic procedure, *ouch*, so she is off for a few days to let her recover. We'll be back with a new smile soon, in the meantime, here's one of our fave retros...

Hand made RSS feeds made by me to you and ATOM feeds generated by www.blogger.com

On accorde "The World of Art Award" (WAA) aux artistes, aux galeries et aux musées qui poursuivent les "meilleures pratiques" dans l'art et la culture. Cette concurrence cherche à attirer dies artistes, galeries, les musées qui redéfinissent des normes de l'excellence d'art. Ceux qui défie des trends et des tendances existantes dans l'art et la culture.

A pirate is starting his first day aboard his new ship and the captain is giving him the tour. ”There’s the plank for trouble makers, there’s the deck that needs swabbing everyday and there’s the barrel for all you sexual needs.” ”Whatcha mean? my sexual needs?” ”Well, you stick your willy in the hole and […]

The post Those Dirty Pirates appeared first on Funny & Jokes.

The post What’s Cooking: Why Bleeding your Fish is Important? appeared first on Ocean Blue Fishing Adventures.

The post Unpacking After a Fishing Trip: Why is it so Important? appeared first on Ocean Blue Fishing Adventures.

Arterial cardiovascular events are the leading cause of death in patients with JAK2V617F myeloproliferative neoplasms (MPNs). However, their mechanisms are poorly understood. The high prevalence of myocardial infarction without significant coronary stenosis or atherosclerosis in patients with MPNs suggests that vascular function is altered. The consequences of JAK2V617F mutation on vascular reactivity are unknown. We observe here increased responses to vasoconstrictors in arteries from Jak2V617F mice resulting from a disturbed endothelial NO pathway and increased endothelial oxidative stress. This response was reproduced in WT mice by circulating microvesicles isolated from patients carrying JAK2V617F and by erythrocyte-derived microvesicles from transgenic mice. Microvesicles of other cellular origins had no effect. This effect was observed ex vivo on isolated aortas, but also in vivo on femoral arteries. Proteomic analysis of microvesicles derived from JAK2V617F erythrocytes identified increased expression of myeloperoxidase as the likely mechanism accounting for their effect. Myeloperoxidase inhibition in microvesicles derived from JAK2V617F erythrocytes suppressed their effect on oxidative stress. Antioxidants such as simvastatin and N-acetyl cysteine improved arterial dysfunction in Jak2V617F mice. In conclusion, JAK2V617F MPNs are characterized by exacerbated vasoconstrictor responses resulting from increased endothelial oxidative stress caused by circulating erythrocyte-derived microvesicles. Simvastatin appears to be a promising therapeutic strategy in this setting.

BACKGROUND The live attenuated BPZE1 vaccine candidate induces protection against B. pertussis and prevents nasal colonization in animal models. Here we report on the responses in humans receiving a single intranasal administration of BPZE1.METHODS We performed multiple assays to dissect the immune responses induced in humans (n = 12) receiving BPZE1, with particular emphasis on the magnitude and characteristics of the antibody responses. Such responses were benchmarked to adolescents (n = 12) receiving the complete vaccination program of the currently used acellular pertussis vaccine (aPV). Using immunoproteomics analysis, potentially novel immunogenic B. pertussis antigens were identified.RESULTS All BPZE1 vaccinees showed robust B. pertussis–specific antibody responses with regard to significant increase in 1 or more of the following parameters: IgG, IgA, and memory B cells to B. pertussis antigens. BPZE1–specific T cells showed a Th1 phenotype, and the IgG exclusively consisted of IgG1 and IgG3. In contrast, all aPV vaccines showed a Th2-biased response. Immunoproteomics profiling revealed that BPZE1 elicited broader and different antibody specificities to B. pertussis antigens as compared with the aPV that primarily induced antibodies to the vaccine antigens. Moreover, BPZE1 was superior at inducing opsonizing antibodies that stimulated ROS production in neutrophils and enhanced bactericidal function, which was in line with the finding that antibodies against adenylate cyclase toxin were only elicited by BPZE1.CONCLUSION The breadth of the antibodies, the Th1-type cellular response, and killing mechanisms elicited by BPZE1 may hold prospects of improving vaccine efficacy and protection against B. pertussis transmission.TRIAL REGISTRATION ClinicalTrials.gov NCT02453048, NCT00870350.FUNDING ILiAD Biotechnologies, Swedish Research Council (Vetenskapsrådet), Swedish Heart-Lung Foundation.