-Album Details- Title: Chocobo’s Mystery Dungeon EVERY BUDDY! Original Soundtrack Publisher: Square Enix Music Catalog Number: SQEX-10710 Release Date: April 24th, 2019 Ripped by: Razakin -Info- Khew!  Some classic FF tracks arranged again for a Chocobo-game, the 2019 remaster of Final Fantasy Fables: Chocobo’s Dungeon. Enjoy. Purchase Link(s) CDJapan

Contes de fées aux enfants - Dodo le mouton et le landau mystérieux.

We previously established that global deletion of the enhancer of trithorax and polycomb (ETP) gene, Asxl2, prevents weight gain. Because proinflammatory macrophages recruited to adipose tissue are central to the metabolic complications of obesity, we explored the role of ASXL2 in myeloid lineage cells. Unexpectedly, mice without Asxl2 only in myeloid cells (Asxl2ΔLysM) were completely resistant to diet-induced weight gain and metabolically normal despite increased food intake, comparable activity, and equivalent fecal fat. Asxl2ΔLysM mice resisted HFD-induced adipose tissue macrophage infiltration and inflammatory cytokine gene expression. Energy expenditure and brown adipose tissue metabolism in Asxl2ΔLysM mice were protected from the suppressive effects of HFD, a phenomenon associated with relatively increased catecholamines likely due to their suppressed degradation by macrophages. White adipose tissue of HFD-fed Asxl2ΔLysM mice also exhibited none of the pathological remodeling extant in their control counterparts. Suppression of macrophage Asxl2 expression, via nanoparticle-based siRNA delivery, prevented HFD-induced obesity. Thus, ASXL2 controlled the response of macrophages to dietary factors to regulate metabolic homeostasis, suggesting modulation of the cells’ inflammatory phenotype may impact obesity and its complications.

Arterial cardiovascular events are the leading cause of death in patients with JAK2V617F myeloproliferative neoplasms (MPNs). However, their mechanisms are poorly understood. The high prevalence of myocardial infarction without significant coronary stenosis or atherosclerosis in patients with MPNs suggests that vascular function is altered. The consequences of JAK2V617F mutation on vascular reactivity are unknown. We observe here increased responses to vasoconstrictors in arteries from Jak2V617F mice resulting from a disturbed endothelial NO pathway and increased endothelial oxidative stress. This response was reproduced in WT mice by circulating microvesicles isolated from patients carrying JAK2V617F and by erythrocyte-derived microvesicles from transgenic mice. Microvesicles of other cellular origins had no effect. This effect was observed ex vivo on isolated aortas, but also in vivo on femoral arteries. Proteomic analysis of microvesicles derived from JAK2V617F erythrocytes identified increased expression of myeloperoxidase as the likely mechanism accounting for their effect. Myeloperoxidase inhibition in microvesicles derived from JAK2V617F erythrocytes suppressed their effect on oxidative stress. Antioxidants such as simvastatin and N-acetyl cysteine improved arterial dysfunction in Jak2V617F mice. In conclusion, JAK2V617F MPNs are characterized by exacerbated vasoconstrictor responses resulting from increased endothelial oxidative stress caused by circulating erythrocyte-derived microvesicles. Simvastatin appears to be a promising therapeutic strategy in this setting.

Lipid-rich myelin forms electrically insulating, axon-wrapping multilayers that are essential for neural function, and mature myelin is traditionally considered metabolically inert. Surprisingly, we discovered that mature myelin lipids undergo rapid turnover, and quaking (Qki) is a major regulator of myelin lipid homeostasis. Oligodendrocyte-specific Qki depletion, without affecting oligodendrocyte survival, resulted in rapid demyelination, within 1 week, and gradually neurological deficits in adult mice. Myelin lipids, especially the monounsaturated fatty acids and very-long-chain fatty acids, were dramatically reduced by Qki depletion, whereas the major myelin proteins remained intact, and the demyelinating phenotypes of Qki-depleted mice were alleviated by a high-fat diet. Mechanistically, Qki serves as a coactivator of the PPARβ-RXRα complex, which controls the transcription of lipid-metabolism genes, particularly those involved in fatty acid desaturation and elongation. Treatment of Qki-depleted mice with PPARβ/RXR agonists significantly alleviated neurological disability and extended survival durations. Furthermore, a subset of lesions from patients with primary progressive multiple sclerosis were characterized by preferential reductions in myelin lipid contents, activities of various lipid metabolism pathways, and expression level of QKI-5 in human oligodendrocytes. Together, our results demonstrate that continuous lipid synthesis is indispensable for mature myelin maintenance and highlight an underappreciated role of lipid metabolism in demyelinating diseases.

Being back in a cold and rainy climate reminds me of Tokyo. No, seriously. Washington has four seasons, just like Tokyo did, and just like Hawaii didn’t. I suppose that’s what has been making me feel really nostalgic these days. I’m in a place with the weather of Japan, but way less awesome. I have seriously owned around seventeen kajillion books about Japan in my lifetime, and I’ve given away, donated, or sold back almost the same amount. Some of them I bought, some of them were given to me, and I even found one or two. But the thing is that I have moved so many times that the only ones I’ve kept are those that I absolutely, positively, do not want to live without. (Well, maybe I could live without them, but then would I really be living?) Anyays! Right now, I only own three books in English about Japan, and these are them, and here is why I really like them:   1. The Otaku Encyclopedia: An Insider’s Guide to the Subculture of Cool Japan Disclaimer: A friend of mine wrote this, but that’s not why I’m recommending it.  Pat has written a bunch of books and papers, and they’re all great, but this is the one that I wish that every single otaku in the world could have. What is it? It’s seriously a dictionary, but not the kind of dictionary that we used when I was a little kid to look up stuff for our school essays. I never had a dictionary like this. You probably know what Hatsune Miku is, but do you know what a Heta-uma is? How about a kuchi-paku? Guess where you can find all of that information that you didn’t know that you needed to have? In this freaking book. I know a fair amount about Otaku culture. I lived and breathed it in Japan for almost a whole decade. But I didn’t know half of the stuff that Patrick wrote about in his book, and that’s why you need it. Plus, it’s got a lot of color, a cute mascot, and some really cool exclusive interviews. You can even learn about Tenimyu!   2. Tokyo on Foot So. I saw this book in the book store in Japan, even though it’s written in English. Maybe that’s because although there is a story in it, it’s mostly drawings and you don’t need to be able to read to get the gist of it. It was written/drawn by an artist that came to stay in Tokyo while his girlfriend was there for an internship. He spent almost every day of his six months there wandering the city with colored pencils and a pad of paper and drawing what he saw. Not only are his drawings aces, I absolutely love his little comments about places and people and things. Right after I bought this book (years ago), I was so enamored that I tried emulating his style with less than stellar results. Me and colored pencils don’t mix, which kind of makes this book even more cool (somehow)! Part of the reason that I really enjoyed this book was because it made me nostalgic for my own first days in Tokyo. I remembered thinking a lot of the same things. I just wish that I’d been good with colored pencils (and had enough confidence to write a book). You can read about my first year here on my blog, though! Honestly, I don’t think that this book is as much a must-have for otaku as the other two, but if art and impressions of Japan is your thing, I think you will love it as much as I do. I seriously only brought two English-language books back with me when I moved out of Japan, and this was one. The other was an ancient copy of The Mysterious Island that my father got when he was a kid and passed on to me.   3. Tokyo Geek’s Guide Aaaaalright. I was really, really skeptical about this one. I’ve seen a hundred other “guides to Tokyo” for otaku, but I didn’t keep any of them. This one, though? I am not only keeping it forever, I am going to give a copy to any of my friends traveling to Japan on their own to go otaku-shopping. Holy cow, I wish this book had existed when I first moved to Japan, because it covers things that it took me years of living there to find on my own! It’s a bona-fide travel guide, minus all of the generic stuff that you can find in a normal travel guide. It doesn’t focus on hotels or nice restaurants. Instead, it lists maid cafes, anime shops, and AWESOME stuff like Swallowtail (don’t know what that is? You need to get this book and find out because it is awesome!). The book is split into districts of Tokyo, and lists otaku-related info about each area along with detailed maps and how to get to all of these places. It’s kind of big and heavy for a travel guide, but it’s seriously the only one that I’m interested in having with me next time that I travel to Tokyo. There are places in it that I haven’t even been to. Oh, and bonus? There is a whole section in the latter part of the book talking about Geeky festivals like Comicket and JUMP Festa. I REALLY, REALLY WISH THAT THIS HAD BEEN AROUND WHEN I MOVED TO JAPAN. It’s 14 years too late for that, but not too late for my next trip, and not too late for yours! It’s also in full color. If you’re reading this, I think that you will probably want this book. GO BUY IT.   This has absolutely NOT been a paid advertisement. I am just a geeky girl honestly recommending things that she likes to you that she thinks you need. :3 See you again soon la la la!

My figure skating romance has a new (old) title! Misha and Dev’s story was originally two novellas published through Loose Id called Cold War and Holding the Edge. I later combined them into one volume to give you more bang for your buck. To avoid confusion, I called the book The Winning Edge. However, Cold War is frankly just a much better […]

Cornel West and Tavis Smiley criticize President Barack Obama for being to the right of even President Richard Nixon. Continue reading →

Are you a taxpreparer who is unsatisfied with the quality of Intuit's ProSeries tax software program? I am not a happy user of ProSeries tax software. Choose your tax software carefully. I will be searching for an alternative tax software vendor for the year 2014. Continue reading →

The response of Senator Richard Blumenthal to my letter in opposition to the Trans-Pacific Partnership (TPP). Ask yourselves how American labor can compete against Vietnamese workers earning on average $0.56 per hour. Continue reading →

Jimmy Dore says that voting your conscience means voting for Jill Stein if you are a progressive. Continue reading →

The Brainwashing Of Hillary Voters Is Complete. Hillary Clinton voters are either getting paid or have been brainwashed into defending her pro-corporate status quo policies. Jimmy Dore breaks it down on his broadcast, October 20, 2016. Continue reading →

Donald Trump sold out his supporters and the 99% by selecting Wall Streeters and war mongers for his top cabinet positions. Continue reading →

I've hosted Google Ads on this website for over 10 years, but I've decided to remove them. I realized that having the ads, and wanting to maximize the amount of revenue they could generate, was keeping me from writing as much I'd like. With the ads, I felt that I had to be careful not […]

The best way I know to cook beans, and the one I always return to. A version of the much-loved Tuscan bean recipe - fagioli al fiasco. Traditionally, beans were baked overnight in a Chianti bottle placed near the embers of that night's fire. While not exactly authentic (no fire here), I do a riff on the general idea, using a low-temperature oven and enamel-lined pot.

Continue reading How to Cook Beans that are Tender, Creamy, and Nearly Perfect on 101 Cookbooks

IBM announced today that the U.S. Army’s Logistics Support Activity awarded IBM a contract to continue providing cloud services, software development and cognitive computing, constituting the technical infrastructure for one of the U.S. federal government’s biggest logistics systems.

Last year I had an incredible night with the Rocky Challenge table in Sacramento. I offered people an opportunity to try something weird (drinking raw eggs) and it was a big hit! Since then, I've set up the Compliment Exchange table a few times, but I always had my mind on creating some kind of physical or psychological challenge. In August, I came up with a plan: Mystery Shots.

A 3D printer is a desktop fabrication machine. I can make almost anything, and it is crazy.

Are my tools going to be stolen? Is my car going to be stolen? What if she refuses to leave? What if she leaves in the middle of the night? What if she leaves the door open? What if she has lice or bedbugs or hepatitis? What if she locks herself in the bathroom? What if she never wakes up? And I'm sure she worried about me.

Unitec today announced that the number of people employed in two Delivery Centres at its Mount Albert campus now exceeds 500, and continue to drive benefits for Unitec students and the Auckland economy.

Cette semaine, des chercheurs d’IBM Research et de l’Université de Yamagata au Japon ont annoncé leur collaboration pour utiliser l’IA d’IBM, couplée à des algorithmes de machine learning et des données géospatiales, afin d’en découvrir davantage à propos de ces mystérieux anciens géoglyphes. Grâce à IBM Power Systems, ce partenariat a déjà abouti à la découverte d’un nouveau géoglyphe à figure humaine avec trois éléments décoratifs sur la tête, le premier grâce à l’IA.

IBM (NYSE: IBM) today announced that Digital Alchemy, a leading Australian database marketing service provider, has extended its commitment to IBM’s Enterprise Marketing Management (EMM) software to more quickly and easily enable cross-channel interactive campaigns for its clients.

Moving was always stressful, but to be placed in a nationwide lockdown only a few weeks after moving was just too much for Ginny to think about. At least she had a fit neighbor keep her company... from two meters away, of course.

Tomorrow (Friday 5/8) I'll be taking over the HarperCollins Library Love Fest Instagram to show you my writing space, with a video tour at 11am EDT. Come visit my writing room, meet my cat, and see where I create my monsters and the women who ride them! https://www.instagram.com/harperlibrary

TODAY!!! Come visit me on the HarperCollins Library Love Fest Instagram today (Fri 5/8)! I'm taking over their Instagram account all day to show you pictures and videos of my writing space! Just posted the video tour! 

https://www.instagram.com/harperlibrary

On Saturday, January 26, 2019, I had the privilege of giving this year’s Paul Sykes Memorial Lecture to the Vancouver Centre of the Royal Astronomical Society of Canada. My topic was “Astronomy and Science Fiction” and during the talk I mentioned the following SF novels (listed in italics) and short stories (listed in quotation marks):H.G. […]

Emmy Nominee Leslye Headland to write, produce, and serve as showrunner for new untitled Star Wars series for Disney+.

Deep Water Games provided me a review copy of Mystery of The Temples , an abstract area control game designed by Wei-Min Ling. It's one of three games in my collection from the Deep Water Games catalog that were originally published by EmperorS4 and feature artwork by Maisherly Chan (Shadows in Kyoto and Hanamikoji are the other two).

In Mystery of the Temples, players take on the role of adventurers on a quest to collect ancient runes protected by dark curses.  In order to break the curses, crystals must be collected and aligned. During game setup, five temple cards are arranged face up in a circle and two wilderness cards are placed in between each pair of temple cards (the picture below shows an alternative arrangement for a 2-player game). A stack of rune cards (4 cards per stack; these cards provide valuable crystal bonuses) are placed face down above each temple card and the top card in each stack is flipped face up. Temple objective cards are laid out; these cards provide additional victory points for breaking temple curses. Each player is given a grid to collect crystals on.

During the game, each player moves their curse breaker meeple clockwise across the temples and wilderness, obeying the detailed rules provided in the rule book. Ending a turn on a wildness card allows a player to collect crystals to carefully arrange on their grid.

Ending a turn on a temple card allows a player to turn in crystals (which must be connected on their grid sheet in the precise order specified on the temple card) to break a curse and earn victory points. There are multiple strategic decisions to be made during a turn as each wilderness card offers up different crystal gathering opportunities and each temple card provides victory points ranging from 3 to 8, depending on how many crystals a player is able to pattern match and discard. Each of the various crystal combinations on the temple cards can only be claimed once so a player must decide whether to amass the minimum amount of crystals to quickly fill in the lower victory point slots before their opponents can, or work at a slower pace, giving themselves time to collect and arrange longer chains of crystals on their grid sheets that will be worth more victory points.

The game ends at the conclusion of the first round in which a player has broken their fifth curse. Victory points are then tallied and the player with the highest victory point total wins the game. Once players are comfortable with the standard rules of play, they can experiment with the advanced rules, which provide for more complexity and variability in play and scoring. As with most area control games, scaling player counts can be an issue. The designer has addressed this in Mystery of the Temples by providing a 2-player variant that uses extra player markers (to block off temple curse claim spots), less wilderness cards, and an extra player meeple (to occupy random temple and wildness card spaces and block movement to those spaces; the meeple moves after each player’s turn). We found these adjustments allowed for the 2-player game to be just as compelling as with higher player counts.

Replayability is high due to the abstract nature of the game play in Mystery of the Temples. There are no narrative cards to tire of and the unique move combinations that can be sequenced to earn victory points are numerous as the temple and wilderness card layout vary each game. There is a moderate amount of analysis paralysis but it is manageable. Game play lasts around 45 minutes on average.

Game components include beautifully illustrated plastic coated cards (everything Maisherly Chan creates is visually appealing and the card and box cover art here are no exception), cardboard tokens, wooden player markers and meeples, and acrylic crystals. Everything should hold up well under regular use. The crystals are sparkly and fun; I absolutely love them.

While the other Deep Water Games titles didn’t work for me (too frustrating in the depth of analysis required), this one is a keeper. It’s the only one of the three games that hits the conceptual sweet spot for me of challenging but still fun. There is a nice flow to the game; the rhythm of moving my meeple each turn and collecting crystals is pleasant.  Mystery of the Temples provides plenty of intellectual challenge in a small box (this game is not easy by any means) with beautiful artwork and an affordable price point.

-------------------------------------------------

Publisher: Deep Water Games
Players: 2-4
Actual Playing Time (vs the guideline on the box): About 45 minutes per game
Game type: area control, abstract

Rating:

Jenni’s rating scale:
OUI: I would play this game again; this game is ok. I probably would not buy this game myself but I would play it with those who own it and if someone gave it to me I would keep it.
OUI OUI: I would play this game again; this game is good. I would buy this game.
OUI OUI OUI: I LOVE THIS GAME. I MUST HAVE THIS GAME.
NON: I would not play this game again. I would return this game or give it away if it was given to me.

Prostřednictvím amerického Programu ochrany mezd pro malé podniky získal uhelný průmysl v USA více než 31 milionů dolarů. Ozývají se rozhořčené hlasy z řad environmentalistů. Administrativa Donalda Trumpa podle nich využívá finanční pomoc na záchranu odvětví, které mělo potíže již před krizí.

Na jednorázový příspěvek 500 korun denně budou mít nově nárok i malé společnosti s ručením omezeným postižené šířením koronaviru. „Čekáme na schválení Senátem a prezidentem, žádosti budou moci podávat zřejmě do týdne,“ uvedla ve čtvrtek ministryně financí Alena Schillerová.

Firmy si budou moci odložit platby za sociální pojištění za tři měsíce. Odvody za květen, červen a červenec smí uhradit až do 20. října, rozhodla vláda. Odložená částka se však bude úročit.

     It looks as though my first 3 mile cycle came back with negative results!!  Picture this: 


     I'm deep in concentration, the sweat dripping from my brow; the race is on.  I don't know if I'll finish, thoughts are pouring over me like warm syrup, I'm near the home stretch : King Edward and Queen Elizabeth Riveres are being held captive while the fate of their English lands are in turmoil and being held captive by the evil Lord Warwick!
      All of a sudden, the concentration of my exercise, as opposed to the concentration on King Edward and his "golden body" stop. My foot slips off the pedal and all of Phillipa Gregory's glorious characters go tumbling down the cycle along with the rest of my Kindle. 
     I finish off my 3 mile cycle near tears! What will become of King Edward and his lands? Will Queen Elizabeth be able to survive after the loss of her mother? Will Henry Tudor (yes the cute Henry Tudor that is the star of the hit SHOW time series, The Tudors) obtain the crown (even though if you have read any of Phillipa Gregory's novels, or seen the movie The Other Boleyn Girl you know the answer to that question)?
    Lukily, I get to find out more on Tuesday when Amazon.Com sends me another kindle to replace the one that, malfunctioned. Hey, she asked me if I dropped it, not if it fell...
     On to exerceise news!  Currently weighing in at 245 LBS.  Thats 2 LBS less that I did when I started the blog, lord knows weight flucuation sucks.  I plan to never be 250 + again.  Hello world, don't hate me because I'm beautiful!!!!
    I'll be blogging my exercise routine for the next 8 months later on today. I welcome all comments!!

Donald Trump is getting nervous. Internal polls show him losing in November unless the economy comes...

 A lovely thing happened to me this month. The Writer's Guild of Great Britain gave me their Outstanding Contribution to Writing Award.

Well, April felt simultaneously short and long! I should have just posted these at the beginning of the month, my SIGBOVIK papers from 2020:

Is this the longest chess game? is another needless chess paper, here trying to figure out the longest possible legal game. There are several rules that make sure games can't go on forever, and some surprisingly subtle details/ambiguity to those rules. The whole game is of course included in the paper (17697 moves), but I was far from being the largest waste of space in this year's proceedings, as one provocateur had a paper with 150 pages of citations. Mathieu made a 5-hour video of the chess game I computed for his companion blog post.

What is the best game console? A market-based approach is a silly idea taken too far. It was a year in the making (mostly waiting) and didn't quite turn out the way I was expecting due to world events, but that's part of the "fun" I guess!

Conditional Move For Shell Script Acceleration was another collaboration with Jim (mostly his doing, but I like to lather on an additional patina of absurdity).

This month I have mostly been trying to keep sane and healthy during the shelter-in-place order. It's been harder than usual to find the energy to be creative, but I have had some spurts. I basically only leave the house to run (not going anywhere near other people). But I have been doing that pretty regularly, so between that and the prohibition against going out to bars and ice cream, I'd say I'm currently in the best I have been in ~6 years. Yesterday I claimed some course records for some Strava segments in my neighborhood! I also finished up Doom: Eternal, which was good but you pretty much already know what it's like and I'm playing Animal Crossing and haven't yet gotten sick of that. The timing for the release of that latter game couldn't have been more perfect, huh? Sometimes I need something with a little challenge, so I just started Nuclear Throne. I'm liking it but not sure if I have decided whether it's good enough to invest the time in to win (I almost always play games to the end but these randomized roguelikes demand a certain kind of potentially infinite investment. Like I never did beat the last boss in Wizard of Legend, and even in Dead Cells, which I loved, I had to settle for some modest personal criteria for "winning.") Any other recs? Could use a good Metroidvania perhaps?

Hey.  This isn’t a real post but I thought you might enjoy. Recently the Yorkshire Museum had a curator battle where they challenged museums to post the #creepiestobject in their collection on twitter.  And it was fantastic and a million … Continue reading →

Really serious about staying out of airplanes now. Two airplane trips this year. A low key summer not feeling terrific. Lots of time doing more local stuff and not regretting it at all. Here is the short list of places. Four states. Stars indicate multiple visits to the exact same place. Past years: 2018, 2017, […]