end Gender-smart Procurement: Policies for Driving Change By www.chathamhouse.org Published On :: Thu, 14 Dec 2017 15:48:45 +0000 Gender-smart Procurement: Policies for Driving Change Research paper sysadmin 14 December 2017 Governments should use public procurement policy as a strategic lever to accelerate gender-inclusive economic growth through the application of state spending power. — Entrepreneurs Virginia Santy and Melanie Ulle at Women in Kind, a co-working space aimed at small businesses run by women in Denver, US. Photo: Getty Images. Governments need to rethink public procurement policy. They need to use it as a strategic lever to accelerate gender-inclusive economic growth through the application of state spending power, while maintaining rigorous governance standards. Reform of public procurement to make it more gender-inclusive could create a ‘diversity dividend’ through increased job creation and economic growth. Gender-smart procurement policies could also mitigate economic and business risk by rendering supply chains more diverse. In 2014, G20 members agreed to reduce the gender gap in the labour market by 25 per cent by 2025. Procurement policy is one of the most powerful tools governments have to achieve this goal. All G20 members, regardless of the differences in their legal frameworks, can implement measures that will increase the ability of women to benefit from procurement policy. Public procurement accounts for around one-fifth of global gross domestic product (GDP). It is estimated that women entrepreneurs supply only 1 per cent of this market. Women’s businesses face considerable barriers to accessing procurement tenders and winning procurement contracts. The inadequate design of many procurement processes prevents more inclusive gender outcomes for citizens. Governments should redefine procurement policies to make explicit the requirement that increasing women’s workforce participation, through greater use of female suppliers, is a key objective when selecting bids for procurement contracts. Through the use of policy and spending levers, governments can play four primary roles in encouraging procurement from enterprises owned by women, or from businesses committed to promoting female labour participation. These roles are: - To direct reforms of government procurement – reviewing procurement policies and practices to ensure sustainable and inclusive procurement; - To reduce barriers to women’s participation in the economy – creating the support mechanisms to ensure an environment in which businesses owned by women can flourish; - To help scale up gender-smart procurement in the private sector – expanding government’s role in encouraging private companies to spend more of their procurement budgets with women’s businesses; and - To encourage increased transparency on the issues – creating and sharing procurement databases and lessons learned, especially at the regional level. Companies can also benefit from having more diverse supply chains and volunteering for accreditation schemes. They can start conversations with government about national regulation that encourages diversity in procurement, leading by example. The G20 should set measurable and time-bound targets in the area of gender-smart procurement, to build on the momentum of UN reforms and incorporate good practice in supply chain management. Gender-smart Procurement - 20.12.2017 (PDF) Full Article
end New Frontiers in Gender-responsive Governance: Five Years of the W20 By www.chathamhouse.org Published On :: Fri, 02 Nov 2018 11:41:53 +0000 New Frontiers in Gender-responsive Governance: Five Years of the W20 Research paper sysadmin 2 November 2018 After five years of the W20, women and gender equality remain at the margin of the G20. There is a real risk of the W20 representing a one-off territorial gain at a frontier that could easily be pushed back again. — A woman holds a female symbol model as workers take part in a rally to mark May Day, International Workers’ Day, in Istanbul, Turkey on 1 May 2016. Photo: Berk Ozkan/Anadolu Agency/Getty Images. Summary 2018 marks the fifth anniversary of the first grouping of the W20, the engagement group of the G20 that focuses on gender-inclusive economic growth and advocates for gender equality across the G20 agenda. Formally launched under the Turkish G20 presidency in 2015, the W20 is made up of women from business, international organizations, civil society, think-tanks and academia across the G20 member states. This paper takes stock of the critical steps in the development of the W20 over the last five years, examining its background, rationale and foundations, and identifying the areas of economic governance where it has so far contributed the most – and those where more action is needed. The W20 has filled a gap, it but needs to carefully assess its coherence with the UN agencies, the private sector, the G7 and other G20 engagement groups. The establishment of the W20 has contributed to defining new frontiers for economic governance and shifting the traditional approach from gender-neutral to gender-responsive. Whereas in 2013 gender in the G20 was considered a marginal issue better dealt with by ministers for equal opportunities, now gender equality and women’s economic empowerment are part of the mainstream economic dialogue. The next step is to ensure more structural and monitored policy reforms at the G20 level. Already, the W20 can count among its achievements the ‘25 by 25’ female labour force participation commitment adopted at the G20’s Brisbane summit in 2014, and the Women Entrepreneurs Finance Initiative (We-Fi) and Business Women Leaders’ Taskforce, both agreed at the Hamburg summit in 2017. The W20 is constrained in its policy impact by limited engagement with the finance track and a lack of consistent resourcing levels. Addressing these issues would strengthen its role as a credible player in shifting global economic governance while contributing to good gender-responsive domestic policies. Progress on gender equality has been too slow and too peripheral to drive change in the relatively short term – over one generation, for example. G20 governments must therefore embrace active, credible policies to bring more women into the labour market, improve access to education and finance, close the pay gap, invest in social infrastructure – especially childcare and assistance for the elderly – and support female entrepreneurs. These domestic policies need to be internationally coordinated so that action and benefits can be widespread. A feminist, inclusive agenda at the G20 level should highlight the current empirical evidence of women’s exclusion from the benefit of their economic activity, both in G20 members and beyond. The W20 should also focus on efforts to remedy the lack of women’s representation in G20 processes and in economic governance as a whole. 2018-11-06-gender-responsive-governance-five-years-w20-subacchi-rimmer (PDF) Full Article
end Gender, think-tanks and international affairs: A toolkit By www.chathamhouse.org Published On :: Tue, 09 Feb 2021 15:02:41 +0000 Gender, think-tanks and international affairs: A toolkit Other resource NCapeling 9 February 2021 Encouraging a more gender-sensitive approach for think-tank activities such as convening and debate, research and analysis, and communications and publishing. Compiled by staff at Chatham House, the Centre for Feminist Foreign Policy and the British American Security Information Council, the toolkit provides think-tanks with guidance on ways of adapting organizational structures, activities and practices in order to embed greater awareness of gender issues and adopt gender-sensitive approaches throughout their work. The toolkit is designed for all people working in international affairs think-tanks, regardless of role, experience or level of seniority. It will be particularly useful for those think-tanks that are just beginning the process of raising greater awareness of gender issues internally, as well as for those that have already begun to make changes but wish to expand this work further. The work to develop the toolkit came as a response to the commonly gendered nature of think-tanks and their activities. The toolkit recognizes the discrimination and under-representation that women often experience within the sector, as well as the relative absence of women among executive leadership, governance structures and senior researcher positions in many think-tanks. The toolkit’s focus on gender is a starting point for wider intersectional analysis and action within the think-tank community. Embedding inclusive research, convening and communication practices is not just ‘the right thing to do’. When diversity and inclusion initiatives succeed, organizations are more resilient, innovative and better at decision-making. While there has already been incremental change within think-tanks, the toolkit’s authors intend that their work will build on the important body of research and practices that already exist by encouraging think-tanks to examine their own processes and develop ways of working that focus not just on women’s representation, but on the structures and systems that perpetuate biases and inequalities. Gender, think-tanks and international affairs: a toolkit (PDF) Full Article
end Segura moving forward with contending Phillies By mlb.mlb.com Published On :: Sat, 16 Feb 2019 18:17:05 EDT Jean Segura became one of the Phillies' most notable offseason acquisitions, a two-time All-Star expected to give the organization its best overall production at shortstop since Jimmy Rollins left town, in part because of a little brawl he had late last season with Mariners teammate Dee Gordon. Full Article
end Upton out with tendinitis; Harvey starts to throw By mlb.mlb.com Published On :: Mon, 18 Feb 2019 16:34:07 EDT The Angels will be without left fielder Justin Upton early in Spring Training, as he's dealing with right knee patellar tendinitis but is expected to be ready for Opening Day, manager Brad Ausmus said on Monday. Full Article
end Covid-19: NHS staff will be offered vaccine this autumn, but JCVI recommends more limited rollout By www.bmj.com Published On :: Monday, August 5, 2024 - 09:51 Full Article
end Economic Recovery and Anticorruption in South Africa: Assessing Progress on the Reform Agenda By www.chathamhouse.org Published On :: Mon, 25 Nov 2019 16:10:01 +0000 Economic Recovery and Anticorruption in South Africa: Assessing Progress on the Reform Agenda 4 December 2019 — 3:00PM TO 4:00PM Anonymous (not verified) 25 November 2019 Chatham House | 10 St James's Square | London | SW1Y 4LE South Africa has significant economic potential based on its resource endowment, quality human capital and well-developed infrastructure compared to the region. However, the country’s economic growth rate has not topped 2 per cent since 2013, and in 2018, was below 1 per cent. This has put a strain on citizens and communities in a country that still suffers from structural inequality, poverty and high unemployment. Economic recovery and anti-corruption were the central pillars of President Cyril Ramaphosa’s 2019 electoral campaign and he has set an investment target of $100 billion. However, voters and investors alike are demanding faster and more visible progress from the country’s enigmatic leader who has a reputation for caution and calculation. At this event, Professor Nick Binedell will discuss the progress of and opposition to the president’s economic reform agenda and the opportunities for international investment to support long term inclusive and sustainable growth in South Africa. Attendance at this event is by invitation only. Full Article
end Lords recommend “passive immunisation” if bird flu reaches UK By www.bmj.com Published On :: Thursday, January 5, 2006 - 22:52 Full Article
end Endovascular treatment for acute ischaemic stroke in routine clinical practice: prospective, observational cohort study (MR CLEAN Registry) By www.bmj.com Published On :: Friday, March 9, 2018 - 14:16 Full Article
end NICE recommends implantable monitor to identify atrial fibrillation after stroke By www.bmj.com Published On :: Tuesday, January 14, 2020 - 00:30 Full Article
end NICE recommends hybrid closed loop systems for poorly controlled type 1 diabetes By www.bmj.com Published On :: Wednesday, November 8, 2023 - 11:31 Full Article
end GLP-1 agonist shortage will last until end of 2024, government warns By www.bmj.com Published On :: Friday, January 5, 2024 - 14:51 Full Article
end Diabetes UK defends partnership with Slimming World in face of criticism By www.bmj.com Published On :: Friday, April 26, 2024 - 14:01 Full Article
end Helen Salisbury: GP collective action to end unfunded work By www.bmj.com Published On :: Tuesday, August 13, 2024 - 10:16 Full Article
end War on Ukraine: The energy crisis and Europe’s impending long winter By www.chathamhouse.org Published On :: Tue, 04 Oct 2022 08:42:13 +0000 War on Ukraine: The energy crisis and Europe’s impending long winter 2 November 2022 — 5:00PM TO 6:00PM Anonymous (not verified) 4 October 2022 Online Can Europe remain unified over the long winter? Since Russia’s invasion of Ukraine, the global community has been responding to significant price shocks, especially energy. As Europe heads into a particularly difficult winter, policymakers are grappling with the costs, both political and economic, required to make sure Russian energy blackmail does not succeed. Retaining a unified front against Russia and providing continued support to the Ukrainian government will be great challenges. As the cold begins to bite, war fatigue may accelerate among the populations of Europe. Providing their people with adequate heat will not come cheaply for governments across the continent at a time of economic uncertainty. At this critical moment of Russia’s invasion, experts discuss: Have European preparations been sufficient to stave off an energy crisis this winter? What will be Russia’s reaction during and after the winter period, particularly if Europe avoids energy market failures? How will this ‘energy crisis’ ensure future dependencies on single state actors of goods and services do not occur in the future? Read the transcript. Full Article
end All women with suspected endometriosis should be offered ultrasound scans, says NICE By www.bmj.com Published On :: 2024-11-12T07:26:00-08:00 The National Institute for Health and Care Excellence (NICE) has recommended that all women with suspected endometriosis be offered an early transvaginal ultrasound scan, even if the pelvic or abdominal examination is normal.In its updated guideline1 on the diagnosis and management of endometriosis, NICE recommends specialist ultrasound as an alternative to magnetic resonance imaging for investigating suspected cases of the condition in secondary care.The updated guideline follows recent reports from both the National Confidential Enquiry into Patient Outcome and Death2 and Endometriosis UK which highlighted problems with delayed diagnoses, partly owing to a lack of awareness among healthcare professionals of the condition and how it presents. Such delays can result in prolonged suffering, ill health, and risks to fertility, the reports warned.Other new and updated recommendations include asking women with suspected endometriosis if any first degree relatives have a history of the condition, and considering neurodiversity when taking into account... Full Article
end Why Europe must end limbo for Afghans seeking asylum By www.chathamhouse.org Published On :: Thu, 14 Oct 2021 08:58:48 +0000 Why Europe must end limbo for Afghans seeking asylum Expert comment Anonymous (not verified) 14 October 2021 With a focus on evacuations from Afghanistan, the situation in Europe is often forgotten as thousands of asylum seekers continue to wait for their cases to be settled. Following the Taliban’s takeover of Afghanistan, European leaders shared messages to welcome those evacuated, but the reality of European responses to displacement in Afghanistan paints a more contentious picture. As of July 2021, 33,325 cases of Afghan asylum applicants were pending in Germany, in France 18,410 people were waiting on a decision, while in Greece the numbers were 13,660. Arguably, such numbers are manageable given European states’ size and their functioning asylum systems but, while 56 per cent of Afghans in Europe receive protection status, a large proportion is still in limbo in differing European countries’ asylum systems. Europe hosts fewer than ten per cent of the three million UN-registered displaced Afghans globally, as neighbouring countries carry the burden of Afghanistan’s forced displacement: Iran hosts almost one million Afghan refugees and Pakistan 1.5 million, and these numbers double when adding undocumented or Afghan passport holders. But despite these manageable numbers, national authorities in Europe often leave people waiting for months or even years to receive an asylum decision. Deportations to Afghanistan were halted only after the Taliban’s takeover of Kabul and even then there was resistance to this from certain European countries, while Austria suggested setting up ‘deportation centres’ in countries neighbouring Afghanistan. Europe remains a fortress The European Commission’s Draft Action Plan responding to the events in Afghanistan confirmed the willingness of the European Union (EU) to continue returns to non-European ‘third countries’. So Europe remains a fortress, despite pledging support for ‘the safe and orderly departure of foreign nationals and Afghans who wish to leave the country’. The wall by Greece at its border with Turkey and Poland’s treatment of Afghan asylum seekers trapped at its border with Belarus illustrate this hardline stance. The president of the European Council Charles Michel and EU Home Affairs Chief Ylva Johansson both confirm the priority is to secure European borders. This is further backed up by the European Council’s latest set of Conclusions on Afghanistan which focuses on security and ‘preventing illegal migration’ while avoiding reference to any domestic asylum efforts or the establishment of protection pathways for Afghans. Afghans in Europe need answers from European policymakers and, by strengthening domestic asylum responses alongside international humanitarian commitments, Europe’s actions would increasingly match its words. This disconnect is not new. At the national level, reports of illegal pushbacks on European land and sea borders alarmingly intensified in 2020 as authorities intercepted and sent migrants back to neighbouring countries without assessing asylum claims. At the EU level, development aid to countries such as Afghanistan has long been conditional on their governments’ adherence to the bloc’s migration objectives of preventing asylum seekers from reaching European borders and facilitating the repatriation of those refused asylum in Europe. But this latest displacement crisis from Afghanistan exposes clear inconsistencies in European approaches to asylum and humanitarianism. Migration remains a divisive issue in European politics, but European governments must act promptly to support Afghans already residing in their territories alongside establishing robust international commitments. Time for concrete action European countries should firstly improve the treatment of those Afghans currently in limbo within their respective asylum systems by expediting pending Afghan asylum applications and family reunification cases, re-examining rejected asylum applications, and facilitating integration. Secondly, national authorities should not return asylum seekers to Afghanistan or any third countries deemed ‘safe’. For Europe to coordinate evacuations from Afghanistan while simultaneously deporting asylum seekers undermines the international refugee regime and threaten Europe’s global credibility. Full Article
end The law as a tool for EU integration could be ending By www.chathamhouse.org Published On :: Fri, 15 Oct 2021 08:29:03 +0000 The law as a tool for EU integration could be ending Expert comment NCapeling 15 October 2021 Poland is not the only EU member state challenging the supremacy of European law, as historic change is happening in how European integration functions. The Polish Constitutional Tribunal’s ruling that several articles of the European treaties are incompatible with the Polish constitution is prompting much debate, especially in terms of both the similarities and differences between it and rulings by the German constitutional court which have also challenged the European Court of Justice (ECJ). Pro-Europeans are keen to draw a sharp distinction between the reasoning deployed by the two courts. They see the Polish court’s challenge as an exceptional case which the European Union (EU) cannot ‘tolerate’ because it would lead to the ‘demolition of the EU’s legal order from within’ and argue the EU must take a tough approach to Poland by re-asserting the supremacy of EU law. But this view misses a bigger long-term shift in the EU. Both the German and Polish cases illustrate some of the basic conflicts within the EU’s legal system for decades. What is being challenged increasingly openly – even since the UK left the EU – is the idea of the EU as a de facto federation in which non-majoritarian institutions such as the ECJ have final say about the quality of democracy in member states. ECJ’s quiet revolution Historically ‘integration through law’ was central to the European project and the ECJ was a key institution driving forward integration – usually benefiting from what Erik Stein called ‘benign neglect by the powers that be and the mass media’. Even when European integration in the form of treaties stalled in the 1960s and 1970s, ‘judicial integration’ through the ECJ continued, including its notable 1964 decision that EU law was supreme. According to the German court’s theory of ‘constitutional pluralism’, there is in effect a constant dialogue and accommodation between the national and EU level rather than a simple primacy of EU law over national law This self-empowerment of the ECJ – what another scholar of European constitutionalism Joseph Weiler calls ‘a quiet revolution’ – was possible because there was a ‘permissive consensus’ in member states which allowed judicial integration to continue largely unchallenged. But this has now changed as both politicians and national courts are more willing to challenge what they see as judicial overreach. There are important differences between the approach of the German and the Polish constitutional courts. The Law and Justice Party has politicized the Polish court, packing it with judges sympathetic to that party, whereas the German court is more independent. In addition, whereas the German court made qualified and subdued objections to measures taken in response to the euro crisis during the past decade and, in particular, the steps towards the mutualization of eurozone debt – but often backed down with ‘all bark and no bite’ as Christoph Schmid put it – the Polish court is driven by political considerations and has challenged the supremacy of EU law in a more direct and general way. However, the German court has made it clear it is the guardian of the German constitution and seeks to impose limits on the ECJ’s self-empowerment by arguing Europe is not a federation. According to the German court’s theory of ‘constitutional pluralism’, there is in effect a constant dialogue and accommodation between the national and EU level rather than a simple primacy of EU law over national law. The court sees itself as the ultimate arbiter of whether steps in European integration are consistent with the German constitution, and is likely to challenge any further steps in fiscal integration even if the ECJ deems them in accordance with the treaties – as it did with the European Central Bank’s quantitative easing programme. Supremacy of EU law is under pressure Right across Europe, courts and politicians are increasingly challenging the ECJ and questioning the supremacy of EU law. Michel Barnier called for France to regain ‘legal sovereignty’ and should no longer be subject to the judgments of the ECJ – an extraordinary demand from the EU Brexit negotiator who regularly lectured the UK about the sanctity of the EU’s legal order. The Polish challenge is part of a historic change in how European integration functions – or does not function Other possible French presidential candidates such as Valérie Pécresse and Eric Zemmour are also openly challenging the primacy of EU law. The UK, of course, is fighting its own battle with the EU about the ECJ’s role in the Northern Ireland Protocol. It was not the current Polish government but the people of France and the Netherlands who blocked the attempt at explicit constitutionalisation of the EU in a referendum just one year after the 2004 enlargement. Whereas the Constitutional Treaty ‘would have codified the doctrine of EU legal supremacy’, that provision was dropped from its successor the Lisbon Treaty, again indicating consensus on EU legal supremacy is not as strong as is often claimed. Full Article
end Independent Thinking: Sweden, Finland, and NATO By www.chathamhouse.org Published On :: Fri, 31 Mar 2023 09:24:17 +0000 Independent Thinking: Sweden, Finland, and NATO Audio NCapeling 31 March 2023 Episode 21 of our weekly podcast examines the latest developments relating to Sweden and Finland’s proposed accession to NATO. The Hungarian parliament has finally ratified Finland’s membership to the NATO alliance, two weeks after President Erdogan in Turkey gave his seal of approval following a meeting with the Finnish president. Sweden however remains trapped in limbo, with both Turkey and Hungary delaying Stockholm’s membership and Erdogan in particular asking for more concessions. The panel discusses why Turkey and Hungary took issue with Sweden and Finland, what the strategic situation in the Baltic looks like now with only Finland joining NATO, and the challenges facing Sweden amid its fraught ties with President Erdogan. We also look ahead to Turkey’s presidential election in May as recent opinion polls point to a neck-and-neck race, with some polls even showing President Erdogan falling behind the opposition. The panel examines what the sentiment is like in Turkey ahead of the election, and how the world would respond if there was a change in power in Ankara for the first time in 20 years. Joining Bronwen Maddox on the podcast this week is Henri Vanhanen, research fellow with the Finnish Institute of International Affairs, and Galip Dalay, associate fellow with our Middle East and North Africa programme. About Independent Thinking A weekly podcast hosted by Chatham House director Bronwen Maddox, in conversation with leading policymakers, journalists, and Chatham House experts providing insight on the latest international issues. Full Article
end Dual Somatostatin Receptor/18F-FDG PET/CT Imaging in Patients with Well-Differentiated, Grade 2 and 3 Gastroenteropancreatic Neuroendocrine Tumors By jnm.snmjournals.org Published On :: 2024-10-01T04:08:08-07:00 Our purpose was to prospectively assess the distribution of NETPET scores in well-differentiated (WD) grade 2 and 3 gastroenteropancreatic (GEP) neuroendocrine tumors (NETs) and to determine the impact of the NETPET score on clinical management. Methods: This single-arm, institutional ethics review board–approved prospective study included 40 patients with histologically proven WD GEP NETs. 68Ga-DOTATATE PET and 18F-FDG PET were performed within 21 d of each other. NETPET scores were evaluated qualitatively by 2 reviewers, with up to 10 marker lesions selected for each patient. The quantitative parameters that were evaluated included marker lesion SUVmax for each tracer; 18F-FDG/68Ga-DOTATATE SUVmax ratios; functional tumor volume (FTV) and metabolic tumor volume (MTV) on 68Ga-DOTATATE and 18F-FDG PET, respectively; and FTV/MTV ratios. The treatment plan before and after 18F-FDG PET was recorded. Results: There were 22 men and 18 women (mean age, 60.8 y) with grade 2 (n = 24) or grade 3 (n = 16) tumors and a mean Ki-67 index of 16.1%. NETPET scores of P0, P1, P2A, P2B, P3B, P4B, and P5 were documented in 2 (5%), 5 (12.5%), 5 (12.5%) 20 (50%), 2 (5%), 4 (10%), and 2 (5%) patients, respectively. No association was found between the SUVmax of target lesions on 68Ga-DOTATATE and the SUVmax of target lesions on 18F-FDG PET (P = 0.505). 18F-FDG/68Ga-DOTATATE SUVmax ratios were significantly lower for patients with low (P1–P2) primary NETPET scores than for those with high (P3–P5) primary NETPET scores (mean ± SD, 0.20 ± 0.13 and 1.68 ± 1.44, respectively; P < 0.001). MTV on 18F-FDG PET was significantly lower for low primary NETPET scores than for high ones (mean ± SD, 464 ± 601 cm3 and 66 ± 114 cm3, respectively; P = 0.005). A change in the type of management was observed in 42.5% of patients after 18F-FDG PET, with the most common being a change from systemic therapy to peptide receptor radionuclide therapy and from debulking surgery to systemic therapy. Conclusion: There was a heterogeneous distribution of NETPET scores in patients with WD grade 2 and 3 GEP NETs, with more than 1 in 5 patients having a high NETPET score and a frequent change in management after 18F-FDG PET. Quantitative parameters including 18F-FDG/68Ga-DOTATATE SUVmax ratios in target lesions and FTV/MTV ratios can discriminate between patients with high and low NETPET scores. Full Article
end Quantitative SPECT/CT Metrics in Early Prediction of [177Lu]Lu-DOTATATE Treatment Response in Gastroenteropancreatic Neuroendocrine Tumor Patients By jnm.snmjournals.org Published On :: 2024-10-01T04:08:08-07:00 Our objective is to explore quantitative imaging markers for early prediction of treatment response in patients with gastroenteropancreatic neuroendocrine tumors (GEP-NETs) undergoing [177Lu]Lu-DOTATATE therapy. By doing so, we aim to enable timely switching to more effective therapies in order to prevent time-resource waste and minimize toxicities. Methods: Patients diagnosed with unresectable or metastatic, progressive, well-differentiated, receptor-positive GEP-NETs who received 4 sessions of [177Lu]Lu-DOTATATE were retrospectively selected. Using SPECT/CT images taken at the end of treatment sessions, we counted all visible tumors and measured their largest diameters to calculate the tumor burden score (TBS). Up to 4 target lesions were selected and semiautomatically segmented. Target lesion peak counts and spleen peak counts were measured, and normalized peak counts were calculated. Changes in TBS (TBS) and changes in normalized peak count (nPC) throughout treatment sessions in relation to the first treatment session were calculated. Treatment responses were evaluated using third-month CT and were binarized as progressive disease (PD) or non-PD. Results: Twenty-seven patients were included (7 PD, 20 non-PD). Significant differences were observed in TBSsecond-first, TBSthird-first, and TBSfourth-first (where second-first, third-first, and fourth-first denote scan number between the second and first, third and first, and fourth and first [177Lu]Lu-DOTATATE treatment cycles), respectively) between the PD and non-PD groups (median, 0.043 vs. –0.049, 0.08 vs. –0.116, and 0.109 vs. –0.123 [P = 0.023, P = 0.002, and P < 0.001], respectively). nPCsecond-first showed significant group differences (mean, –0.107 vs. –0.282; P = 0.033); nPCthird-first and nPCfourth-first did not reach statistical significance (mean, –0.122 vs. –0.312 and –0.183 vs. –0.405 [P = 0.117 and 0.067], respectively). At the optimal threshold, TBSfourth-first exhibited an area under the curve (AUC) of 0.957, achieving 100% sensitivity and 80% specificity. TBSsecond-first and TBSthird-first reached AUCs of 0.793 and 0.893, sensitivities of 71.4%, and specificities of 85% and 95%, respectively. nPCsecond-first, nPCthird-first, and nPCfourth-first showed AUCs of 0.764, 0.693, and 0.679; sensitivities of 71.4%, 71.4%, and 100%; and specificities of 75%, 70%, and 35%, respectively. Conclusion: TBS and nPC can predict [177Lu]Lu-DOTATATE response by the second treatment session. Full Article
end Boeing machinists agree to new contract, ending weeks-long strike By www.upi.com Published On :: Mon, 04 Nov 2024 10:28:03 -0500 Tens of thousands of striking Boeing machinists voted Monday to ratify a new contract, ending their seven-week work stoppage. Full Article
end 23andMe to cut 40% of workforce, end therapeutics program By www.upi.com Published On :: Mon, 11 Nov 2024 23:04:10 -0500 Genetic-testing lab 23andMe plans to cut its workforce by 40% and end its therapeutics program in an effort to cut costs, the company announced Monday. Full Article
end ‘Loopholes’ let warring parties use incendiary weapons in Ukraine, Middle East: HRW By www.upi.com Published On :: Sun, 10 Nov 2024 11:43:33 -0500 Loopholes in international laws governing the use of incendiary weapons in warfare are allowing warring parties in Ukraine and the Middle East to exploit the use of such weapons without adequately protecting civilians. Full Article
end Capitals' Alex Ovechkin nets game winner vs. Predators, extends goal streak By www.upi.com Published On :: Thu, 07 Nov 2024 08:11:02 -0500 Alex Ovechkin calmly slid into the right circle and sniped a snapshot past a blinded Juuse Saros to lead the Washington Capitals to a 3-2 triumph over the Nashville Predators. Full Article
end Fantasy football: Gesicki, Smith among 4 must-start Week 10 tight ends By www.upi.com Published On :: Thu, 07 Nov 2024 14:50:46 -0500 Mike Gesicki and Jonnu Smith are among UPI senior sports writer Alex Butler's four must-start fantasy football tight ends for Week 10. Full Article
end Lane's End Farm has banner weekend in U.S. turf racing By www.upi.com Published On :: Mon, 11 Nov 2024 09:50:44 -0500 American horse racing turned to turf during the weekend, and Kentucky's Lane's End Farm enjoyed a banner weekend in the top contests. Full Article
end Premier League referee David Coote suspended for Jurgen Klopp comments By www.upi.com Published On :: Mon, 11 Nov 2024 14:14:24 -0500 Premier League reference David Coote is suspended indefinitely after videos surfaced that appeared to show him criticizing former Liverpool coach Jurgen Klopp, officials announced Monday. Full Article
end Dallas Cowboys quarterback Dak Prescott to have season-ending hamstring surgery By www.upi.com Published On :: Tue, 12 Nov 2024 12:35:21 -0500 Veteran quarterback Dak Prescott will undergo season-ending surgery to repair his injured hamstring, Dallas Cowboys owner Jerry Jones announced Tuesday. Full Article
end Friend's advice leads Maryland woman to $30,000 lottery prize By www.upi.com Published On :: Wed, 06 Nov 2024 14:50:59 -0500 A Maryland Lottery player said following a friend's advice led to her winning a $30,000 prize from a Fast Play game. Full Article
end 'Weekend warrior' exercise can cut risk of cognitive decline, study indicates By www.upi.com Published On :: Tue, 29 Oct 2024 21:54:07 -0400 Being a "weekend warrior" -- engaging in exercise once or twice per week -- may be as beneficial as regular sessions in decreasing the risk of cognitive decline that often leads to dementia, a new study concludes. Full Article
end Lottery to Determine Major AI Conference Attendees Amid Registration Boom By www.hpcwire.com Published On :: Thu, 31 Oct 2024 14:03:04 +0000 A boom in AI has created a problem for the organizers of the NeurIPS conference, which is considered an essential machine-learning research conference. The sheer number of registrations has overwhelmed […] The post Lottery to Determine Major AI Conference Attendees Amid Registration Boom appeared first on HPCwire. Full Article Short Takes
end 23andMe to cut 40% of workforce, end therapeutics program By www.upi.com Published On :: Mon, 11 Nov 2024 23:04:10 -0500 Genetic-testing lab 23andMe plans to cut its workforce by 40% and end its therapeutics program in an effort to cut costs, the company announced Monday. Full Article
end Cameron Crowe has a baby girl with girlfriend Anais Smith By www.upi.com Published On :: Mon, 11 Nov 2024 12:18:55 -0500 Cameron Crowe, the writer and director behind "We Bought a Zoo," "Almost Famous" and "Jerry Maguire," has a new baby girl with girlfriend Anais Smith. Full Article
end Wendi McLendon-Covey, David Alan Grier, Allison Tolman enjoying flawed 'St. Denis' roles By www.upi.com Published On :: Tue, 12 Nov 2024 14:57:59 -0500 Wendi McLendon-Covey, David Alan Grier and Allison Tolman discuss the comedy in their harried medical characters on "St. Denis Medical," premiering Tuesday on NBC. Full Article
end SpaceX sends 22 Starlink satellites into orbit in record-setting launch By www.upi.com Published On :: Sat, 26 Oct 2024 18:41:17 -0400 SpaceX on Saturday successfully launched a Falcon 9 rocket carrying a payload of 22 Starlink Internet communications satellite from Cape Canaveral in Florida, marking a state record 73rd orbital rocket launch this year. Full Article
end NASA offers virtual launch attendance, guest passport for next SpaceX supply mission By www.upi.com Published On :: Fri, 01 Nov 2024 15:41:27 -0400 NASA is inviting pubic participation in some virtual activities to watch the SpaceX space station resupply mission scheduled for a Monday night liftoff from NASA's Kennedy Space Center in Florida. Full Article
end Why People Are More Bored Than Ever — Despite Endless Online Content (M) By www.spring.org.uk Published On :: Mon, 21 Oct 2024 17:00:13 +0000 Discover why more content isn’t solving your boredom but making it worse. Full Article Emotion subscribers-only
end Why Quick Decisions Tend To Sabotage Your Success (M) By www.spring.org.uk Published On :: Thu, 31 Oct 2024 18:00:34 +0000 Quick decisions could be costing you—find out how to improve them. Full Article Cognitive Psychology Sleep subscribers-only
end Persuasion: 10 Techniques Psychologists Recommend To Influence Anyone (P) By www.spring.org.uk Published On :: Sun, 10 Nov 2024 18:00:00 +0000 Many people overthink persuasion, when it is the most natural approaches that work best. Full Article Persuasion premium-only
end What makes a good life? A neuroscientist and a global financial CEO answer | Annabel Spring and Wendy Suzuki By www.ted.com Published On :: Fri, 27 Sep 2024 14:18:29 +0000 What's the connection between long-term health and financial stability? Neuroscientist Wendy Suzuki and HSBC Global Private Banking and Wealth's CEO Annabel Spring explore the critical components of a good life — and how simple actions like exercise and financial planning can boost your present and future well-being. They discuss how to maximize your sense of joy, transform your anxiety into a force for good and keep your brain healthy over the course of your life. (This content is made possible by HSBC. It however does not necessarily reflect the views of HSBC.) Full Article Higher Education
end Will the end of economic growth come by design — or disaster? | Gaya Herrington By www.ted.com Published On :: Fri, 18 Oct 2024 14:46:41 +0000 What if solving poverty, caring for nature and fostering well-being were the ultimate goals of the economy, instead of growth for its own sake? Environmentalist and economist Gaya Herrington proposes a shift in thinking from "never enough" to "enough for each," asking us to contemplate whether the end of exponential growth on a finite planet will come by design — or disaster. Full Article Higher Education
end How to defend democracy — and fight autocracy | Leopoldo Lopez By www.ted.com Published On :: Thu, 31 Oct 2024 17:18:54 +0000 Seventy-two percent of the world's population lives under some sort of autocratic rule, says freedom fighter Leopoldo Lopez. In a rousing call to defend democracy worldwide, he shares the story of his imprisonment and exile for leading the movement against Venezuela's authoritarian regime — and shares his vision for uniting across borders to champion freedom and stamp out autocracy. Full Article Higher Education
end Why spending smarter beats bigger budgets | Karthik Muralidharan By www.ted.com Published On :: Mon, 11 Nov 2024 15:54:37 +0000 Billions of dollars are poured into global development every year, but results are lacking, says economist Karthik Muralidharan. Diving into an example with public education, he outlines how smarter resource allocation and evidence-based interventions, like learning software that dynamically responds to students and teaches at the level that's right for them, can accelerate global development worldwide — not by spending more, but by spending smarter. Full Article Higher Education
end Why friendship can be just as meaningful as romantic love | Rhaina Cohen By www.ted.com Published On :: Tue, 12 Nov 2024 15:37:50 +0000 We tend to consider romantic partners and family ties to be our most important relationships, but deep friendships can be just as meaningful. In a perspective-shifting talk, author Rhaina Cohen introduces us to the people unsettling norms by choosing a friend as a life partner — and shows why we're all better off recognizing there's more than one kind of significant other. Full Article Higher Education
end Black Parents Force District to End Academic Tracking By www.edweek.org Published On :: Tue, 03 Mar 2020 00:00:00 +0000 Fed up with their district’s unmet pledges to stop steering African American students into low-level classes, parents take action. Full Article Pennsylvania
end What's Behind the Gender Pay Gap Among Educators? By blogs.edweek.org Published On :: Fri, 15 Jun 2018 00:00:00 +0000 Female teachers, principals, and superintendents in Pennsylvania earn significantly less money than their male counterparts, a new study shows. Full Article Pennsylvania
end Per-Pupil Spending in Rhode Island Schools (Map) By www.edweek.org Published On :: Tue, 27 Feb 2018 00:00:00 +0000 This map of Rhode Island shows per-pupil spending by school and just how much spending varies among the schools within individual districts. Full Article Rhode_Island
end Rhode Island to Promote Blended Learning Through Nonprofit Partnership By blogs.edweek.org Published On :: Fri, 08 Aug 2014 00:00:00 +0000 The Rhode Island Department of Education and the nonprofit Learning Accelerator are teaming to develop a strategic plan and a communications strategy aimed at expanding blended learning. Full Article Rhode_Island
end States Must Change, Too For Blended Learning By blogs.edweek.org Published On :: Tue, 10 Mar 2015 00:00:00 +0000 Lisa Duty of The Learning Accelerator, a Rhode Island Department of Education (RIDE) and Highlander Institute funding partner, outlines the Rhode Islands's commitment to a blended learning future. She describes how the state is developing its new five-year strategic plan that's engaging RIDE's Ambas Full Article Rhode_Island