Disclosed herein are a graphite crucible for electromagnetic induction-based silicon melting and an apparatus for silicon melting/refining using the same, which performs a melting operation by a combination of indirect melting and direct melting. The crucible is formed of a graphite material and includes a cylindrical body having an open upper part through which a silicon raw material is charged into the crucible, and an outer wall surrounded by an induction coil, wherein a plurality of slits are vertically formed through the outer wall and an inner wall of the crucible such that an electromagnetic force created by an electric current flowing in the induction coil acts toward an inner center of the crucible to prevent a silicon melt from contacting the inner wall of the crucible.

A graphite crucible for electromagnetic induction-based silicon melting and an apparatus for silicon melting/refining using the same, which performs a melting operation by a combination of indirect melting and direct melting. The crucible is formed of a graphite material and includes a cylindrical body having an open upper part through which a silicon raw material is charged into the crucible, and an outer wall surround by an induction coil, wherein a plurality of first slits are vertically formed through the outer wall and an inner wall of the crucible, and a plurality of second slits are vertically formed from an edge of the disc-shaped bottom of the crucible toward a center of the bottom.

A secondary or “sidebar” display within a process control environment may provide several small applications to allow business managers, engineers, maintenance personnel, or other non-operator personnel to organize and manage process control system information and to display selected diagnostics and summary information or “key operating parameters” for the process control system. Further, sidebar applications may communicate with other applications that are executing on a non-operator user's workstation to, thereby, retrieve information related to tasks that the user is currently completing. The sidebar application may then determine whether certain process control information may be useful for the main task the user is completing and display that process control information within the sidebar.

Substrates for detecting microorganisms are provided, wherein the substrate comprises a set of molecular markers linked, optionally with linker molecules or moieties, to a di-, or tripeptide consisting of amino acids X1 and X2, or X1, X2 and X3, in which one of them, for example, X1, is a D-amino acid and the others, for example, X2 and X3, may be any D- or L-amino acid. The substrate preferably is used for the detection of Bacillus anthracis. Also provided are substrates for detecting Pseudomonas aeruginosa, wherein the substrate comprises a set of molecular markers linked, optionally with linker molecules or moieties to a tri-, tetra-, or pentapeptide consisting of glycine amino acids. The invention further comprises methods for detecting microorganisms, specifically B. anthracis and P. aeruginosa, with the substrates of the invention and use of the substrate(s) in such a method.

The presently disclosed subject matter provides compositions that selectively bind cyclooxygenase-2 and comprise a therapeutic and/or diagnostic moiety. Also provided are methods for using the disclosed compositions for diagnosing (i.e., by imaging) a target cell and/or treating a disorder associated with a cyclooxygenase-2 biological activity.

The present disclosure relates to an azoquinone compound represented by formula (1) below. In formula (1), R1 to R4 are identical or different and each represents a hydrogen atom, a C1 to C6 alkyl group or a C6 to C12 aryl group, and Ar represents a C6 to C12 aryl group.

The present invention relates to antibody molecules against anticoagulants, in particular dabigatran, and their use as antidotes of such anticoagulants.

Provided are a support for affinity chromatography which has excellent alkali resistance, and a method for isolating immunoglobulin. A support for affinity chromatography, containing an immobilized protein ligand represented by the following formula (1): R—R2 (1) wherein R represents a polypeptide consisting of 4 to 30 amino acid residues that contains an amino acid sequence represented by ATK or ASK; and R2 represents a polypeptide consisting of 50 to 500 amino acid residues containing an immunoglobulin-binding domain consisting of an amino acid sequence represented by SEQ ID NO: 1 or SEQ ID NO: 2, the partial sequence thereof, or an amino acid sequence having 70% or more identity to these sequences; with the proviso that a terminus at which R2 binds to R is C-terminus or N-terminus of the immunoglobulin-binding domain.

A low profile, wrappable spacer and method for maintaining a pair of elongate members in fixed, spaced relation to one another is provided. The wrappable spacer includes a flexible elongate body having oppositely facing inner and outer faces extending along laterally spaced, lengthwise extending edges between opposite ends. The inner face has an adhesive surface. At least one member extends between the edges transversely to the lengthwise extending edges. The member extends outwardly from the adhesive surface, wherein the adhesive surface is configured for adhesion to at least one of the member, the elongate members or the outer face.

The invention discloses a combined preparation containing IL-10 and rapamycin, able to induce immunosuppression and antigen-specific immune tolerance, and the use thereof in the treatment of diseases involving an excessive, dysfunctional or uncontrolled immune responses mediated by T cells.

The present invention is directed to the use of the peptide compound Ac-Arg-Phe-Met-Trp-Met-Arg-NH2 as a therapeutic agent for the prophylaxis and/or treatment of cancer, autoimmune diseases, fibrotic diseases, inflammatory diseases, neurodegenerative diseases, infectious diseases, lung diseases, heart and vascular diseases and metabolic diseases. Moreover the present invention relates to pharmaceutical compositions preferably in form of a lyophilisate or liquid buffer solution or artificial mother milk formulation or mother milk substitute containing the peptide Ac-Arg-Phe-Met-Trp-Met-Arg-NH2 optionally together with at least one pharmaceutically acceptable carrier, cryoprotectant, lyoprotectant, excipient and/or diluent.

The present invention is directed to the use of the peptide compound Pyr-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2 as a therapeutic agent for the prophylaxis and/or treatment of cancer, autoimmune diseases, fibrotic diseases, inflammatory diseases, neurodegenerative diseases, infectious diseases, lung diseases, heart and vascular diseases and metabolic diseases. Moreover the present invention relates to pharmaceutical compositions preferably in form of a lyophilizate or liquid buffer solution or artificial mother milk formulation or mother milk substitute containing the peptide Pyr-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2 optionally together with at least one pharmaceutically acceptable carrier, cryoprotectant, lyoprotectant, excipient and/or diluent.

The present invention relates to fusion proteins comprising an antibody, functional fragment or functional derivative thereof having specific binding affinity to either the extracellular domain of oncofetal fibronectin (ED-B) or at least one of the extracellular domains of oncofetal tenascin fused to a cytokine selected from the group consisting of IL-10, IL15, IL-24 and GM-CSF, functional fragments and functional derivatives thereof. The invention is also directed to the use of at least one of said fusion proteins for the manufacture of a medicament. In particular, the invention concerns the use of said medicament for the treatment of tumors or chronic inflammatory diseases such as atherosclerosis, arthritis and psoriasis.

Plant viral vectors have great potential in rapid production of proteins, but no simple. Here a geminivirus-based system for high-yield and rapid production of oligomeric protein complexes, including virus-like particle (VLP) vaccines and monoclonal antibodies (mAbs) is described. In particular, a single vector that contains two non-competing replicons for transient expression in Nicotiana benthamiana leaves is described. The correct assembly of these subunit proteins into functional oligomeric structures (VLPs or full-size mAb) is also described. This system advances plant transient expression technology by eliminating the need for non-competing viruses, and thus, enhances the realistic commercial application of this technology for producing multiple-subunit protein complexes.

Disclosed is a drug effective in the treatment of fibromyalgia. Basically, the disclosed therapeutic agent was created on the basis of experiments showing improvement in symptoms when etanercept was administered to patients suffering from fibromyalgia. Etanercept is known as a therapeutic agent for rheumatoid arthritis, and the JFIQ score of patients not suffering from fibromyalgia improved considerably in the preferred embodiment. In other words, a therapeutic agent for fibromyalgia is disclosed that contains etanercept as an active ingredient in an effective amount.

The present invention provides processes for the manufacturing of polypeptide conjugates. In particular, the invention provides methods for the purification of polypeptide conjugates, which include at least one polymeric modifying groups, such as a poly(alkylene oxide) moiety. Exemplary poly(alkylene oxide) moieties include poly(ethylene glycol) (PEG) and poly(propylene glycol). In an exemplary process, hydrophobic interaction chromatography (HIC) is used to resolve different glycoforms of glycoPEGylated polypeptides.

A method for forming a nanocomposite material, the nanocomposite material formed thereby, and a battery made using the nanocomposite material. Metal oxide and graphene are placed in a solvent to form a suspension. The suspension is then applied to a current collector. The solvent is then evaporated to form a nanocomposite material. The nanocomposite material is then electrochemically cycled to form a nanocomposite material of at least one metal oxide in electrical communication with at least one graphene layer.

Approaches to improving hard disk drive far track interference problems include utilizing a wrap-around shield having recessed high magnetic moment layer(s). Embodiments include tapering the high-moment portion away from the air bearing surface (ABS) in the cross-track direction away from the write pole, thereby reducing exposure of high moment layers at the ABS to reduce the risk of unwanted track erasure away from the main pole. Embodiments include positioning the high magnetic moment layers in their entirety away from the ABS, such as with a laminate structure of high magnetic moment and low magnetic moment materials laid down in a direction away from the pole tip trailing edge.

A strap comprising a propylene and 1-hexene copolymer containing from 0.3 wt % to less than 5 wt % of 1-hexene derived units said copolymer having a melt flow rate (MFR) determined according to ISO method 1133 (230° C., 2.16 kg ranging from 0.3 to less than 11 g/10 min.

A mat with an upper road side and a lower ground contacting side, the mat comprising: a frame supporting one or more boards; and a grapple receiver formed in an interior portion of the mat and indented from one or both of the upper road side and the lower ground contacting side to allow grapple jaws to grip the grapple receiver between the grapple jaws.

A system for occluding a physical anomaly. One embodiment comprises a shape memory material body wherein the shape memory material body fits within the physical anomaly occluding the physical anomaly. The shape memory material body has a primary shape for occluding the physical anomaly and a secondary shape for being positioned in the physical anomaly.

A secret stream of bits begins by receiving a public random stream contained in a wireless communication signal at a transmit/receive unit. The public random stream is sampled and specific bits are extracted according to a shared common secret. These extracted bits are used to create a longer secret stream. The shared common secret may be generated using JRNSO techniques, or provided to the transmit/receive units prior to the communication session. Alternatively, one of the transmit/receive unit is assumed to be more powerful than any potential eavesdropper. In this situation, the powerful transmit/receive unit may broadcast and store a public random stream. The weaker transmit/receive unit selects select random bits of the broadcast for creating a key. The weaker transmit/receive unit sends the powerful transmit/receive unit the selected bit numbers, and powerful transmit/receive unit uses the random numbers to produce the key created by the weaker transmit/receive unit.

A welding workbench assembly comprises a base. The welding workbench assembly further comprises a first wraparound barrier comprising at least three panels, including a first panel, a second panel, and a third panel. The second panel is adjacent to the first panel at a first end of the first panel and the third panel is adjacent to the first panel at a second end of the first panel. The welding workbench assembly further comprises a second wraparound barrier comprising at least three panels, including a fourth panel, a fifth panel, and a sixth panel. The fifth panel is adjacent to the fourth panel at a first end of the fourth panel and the sixth panel is adjacent to the fourth panel at a second end of the fourth panel.

In general, the subject matter described in this specification can be embodied in methods, systems, and program products for identifying proximity of a mobile computing device to another mobile computing device. A computing system determines that a set of mobile computing devices are geographically proximate to a first mobile computing device based on identifying that each of the mobile computing devices received a first type of signal from an emitting device for which the first mobile computing device also received the first type of signal. The computing system determines a subset of the mobile computing devices that share a physical space with the first mobile computing device based on identifying that each of the mobile computing devices emitted a second type of signal that was detected by the first mobile computing device, or detected the second type of signal that was emitted by the first mobile computing device.

A system and method for creating a plurality of denaturation curves is disclosed. In accordance with certain embodiments, one variable, such as salt content, pH or another parameter, is varied to create a plurality of different buffer solutions. Each is then used to create a denaturation graph. The plurality of denaturation graphs allows analysis of the effect of that variable on protein stability.

An instrument is configured to receive a staple cartridge to staple tissue and expel a fluid from within a container in the staple cartridge. The staple cartridge has an upper deck including staple apertures and orifices formed therein. The orifices are in fluid communication with the containers. The staple cartridge includes staple drivers having a driver body to translate a staple and a container protrusion to expel the fluid out the orifices. The fluid may be expelled while driving the staples out through the staple apertures. The container may be vertically compressible container or, in one alternative, may be a container having a channel and a sealant that is configured to be pierced as the fluid is expelled. Some configurations for the fluid include a hemostatic agent, thrombin, a gel, or a medicament. The containers may also be formed as reservoirs defined within the upper deck and/or cartridge body.

A method of depositing a crystalline strontium titanate film on a substrate is provided, comprising carrying out an atomic layer deposition (ALD) process with strontium and titanium precursors, wherein the strontium precursor is bis(n-propyltetramethylcyclopentadienyl)strontium.

An image photographing apparatus capable of maintaining the size of a sensor plate even in a case when the size of a shutter assembly is increased, the image photographing apparatus including a shutter assembly configured to control an amount of light entered, an image sensor disposed at a rear of the shutter assembly to change the light to an electrical signal, a sensor plate configured to support the image sensor, and a main frame configured such that the shutter assembly and the sensor plate are be mounted thereon, wherein the main frame includes a frame base, and a shutter mounting portion protrudedly formed from the frame base such that the shutter assembly is mounted in a sliding manner on the shutter mounting portion.

A bilateral cargo strap system is provided as a means of securing a variety of different cargo within a storage area. The bilateral cargo strap system utilizes a combination of elastic straps with perpendicularly positioned stabilizing rods to improve retention of a variety of cargo within a storage area. The elastic straps extend over the retained cargo and are used as the means of engaging mounting features within the storage area. The stabilizing rods effectively distribute the tension force of the elastic straps over the retained cargo securing it in place within the storage space. The bilateral cargo strap system is versatile and may be used to secure a wide variety of cargo including, but not limited to, kayaks, coolers, bicycles, lumber, and construction equipment.

Some embodiments include a novel laced strapping system that provides a plurality of attachment points by which a tie-down lace can adjust the fit of a cargo mesh webbing to secure loads of items in an open bed of a vehicle. In some embodiments, the vehicle is a pick-up truck with a cargo bed. In some embodiments, the mesh webbing comprises a first truck bed mesh, a second truck bed mesh, and the plurality of attachment points. In some embodiments, tie-down lace interconnects the attachment points to secure together the first mesh and the second mesh.

Stake pocket formations are secured to a cargo bed frame of a land vehicle such as trailers and flatbed trucks for removably supporting sidewall supporting members. The formations include sidewalls secured to and projecting from the frame and an end wall extending between the sidewalls. An opening extends through the end wall and is adapted to receive the terminal end of a J-hook therethrough. The J-hook is secured to the formation by inserting the terminal end thereof into the pocket placing an upper edge of the end wall into the J-hook gap and rolling/rotating the J-hook thereby inserting the terminal end into the opening. The J-hook cannot be removed from the pocket unless it is rolled/rotated in the opposite direction. While within the stake pocket and without strap tension, the J-hook abuts the trailer frame and formation end wall and is, thereby, maintained within the pocket.

A floorplan for a Structured ASIC chip is shown having a core region containing memory and VCLB logic cells surrounded by a plurality of IO connection fabrics that include a first IO connection fabric comprising IO sub-banks connecting the core of the chip to pins for external signals to the core, a first high-speed routing fabric disposed along the east-west vertical top of the core and connects the core to high-speed IO such as SerDes; a network-aware connection fabric connects the core to a microcontroller primarily for testing and repair of the memory in the core; and a second-high speed routing fabric is disposed on the north-south vertical sides of the core and communicates with the IO sub-banks. The VCLB Structured ASIC chip is manufactured on a 28 nm CMOS process lithographic node or smaller, having several metal layers and preferably is programmed on a single via layer.

Monoclonal antibodies (mAbs) having thyroid stimulating activity (TSAb), especially full or considerably agonistic activity, or thyroid blocking activity (TBAb), which are obtainable by genetic immunization of mice, or fragments (F(ab')2, Fab or Fv) or humanized forms of such monoclonal antibodies or single chain forms (SCA; scFv) of such fragments, which antibodies, or their fragments, compete with bovine TSH for epitopes of the human TSHr, compete with autoantibodies from sera from Graves' patients as well as with autoantibodies from sera from patients harboring blocking autoantibodies for epitopes of the human TSHr, bind to conformational epitopes of the human TSHr located in the first 281 amino acids of the human TSHr, and usually also bind to TSFR receptors (TSHr) from different animals. Various uses of such antibodies, or of peptides corresponding to variable regions of such antibodies, are also described and claimed.

The present invention relates to a composition useful for the diagnosis of diseases associated with aberrant expression of the genes encoding the secreted proteins Futrin 1, 2, 3 and/or 4(=R-Spondin 2, 3, 1 and 4, respectively), e.g. in connection with tumors or diseases of the muscle, kidneys or bones. The present invention also relates to a pharmaceutical composition containing a compound which is capable of modifying (a) the expression of the gene encoding Futrin 1, 2, 3 and/or 4 or (b) the activity of the Futrin 1, 2, 3 and/or 4 protein.

A method and to a device for dispensing data from a tachograph to an endless printing medium. A first division is plotted in the longitudinal direction of the printing medium, and a second division is plotted transversely with respect to the longitudinal direction of the printing medium. The first division represents a predetermined unit of time, in particular a day in generalized time coordinates, and the second division represents at least one variable recorded by the tachograph during the unit of time, the at least one variable is depicted by at least one graph.

Disclosed are methods of lithography using a tip array having a plurality of pens attached to a backing layer, where the tips can comprise a metal, metalloid, and/or semi-conducting material, and the backing layer can comprise an elastomeric polymer. The tip array can be used to perform a lithography process in which the tips are coated with an ink (e.g., a patterning composition) that is deposited onto a substrate upon contact of the tip with the substrate surface. The tips can be easily leveled onto a substrate and the leveling can be monitored optically by a change in light reflection of the backing layer and/or near the vicinity of the tips upon contact of the tip to the substrate surface.

A cargo strap with carrying handle and mechanism for securing the cargo strap around a load. A first end of the cargo strap is preferably removably anchored to the strap securing mechanism by a clevis pin that permits rapid and easy disconnection of the first end of the cargo strap from the strap securing mechanism. The second end of the cargo strap is retained within the strap securing mechanism and prevented from removal therefrom by a stop proximate the second end of the cargo strap. The stop is preferably constructed as a loop formed in the second end of the cargo strap and sewn to the strap with a strap flap portion intermediate the second end of the cargo strap and the strap securing mechanism. The strap securing mechanism preferably has either a ratchet style mechanism with a reel or a modified cam buckle mechanism.

A graphic may include a consumable and having optically encoded information.

A frequency tripler device is disclosed. The frequency tripler device includes a first graphene based field effect transistor (FET) of a first dopant type, having a gate, a drain, and a source, and a second graphene based FET of a second dopant type, having a gate, a drain, and a source, the gate of the first FET coupled to the gate of the second FET and coupled to an input signal having an alternating current (AC) signal of a first frequency, the combination of the first and second FETs generates an output signal with a dominant AC signal of a frequency of about three times the first frequency.

A method of preparing functionalized graphene, comprises treating graphene with an alkali metal in the presence of an electron transfer agent and coordinating solvent, and adding a functionalizing compound. The method further includes quenching unreacted alkali metal by addition of a protic medium, and isolating the functionalized graphene.

Providing a roaster that operates at temperatures in the range of 800° Celsius to 2000° Celsius with inert, optional oxidizing and reducing gases to treat graphite contaminated with radionuclides including tritium, carbon-14, and chlorine-36. The combination of temperatures and gases allow for the removal of most to substantially all the carbon-14 within the graphite while substantially limiting gasifying the bulk graphite.

In the case of a package (1) for single-dose films (2) containing active substances, comprising an upper packaging material element (3) and a lower packaging material element (4) which are connected together by a peripheral seal area or respectively sealing seam (5) such that a cavity (6) for holding the film (2) is formed, said cavity being enclosed on all sides, wherein the upper packaging material element (3) and the lower packaging material element (4) each have at least one cut (7, 8) in the region of the seal area or respectively, the sealing seam (5), said cuts being congruent, andat least one cut (7, 8) is crossed by a folding or bending line (10), the folding or bending line (10) is formed in a weakened manner.

A method is provided for constructing a tomographic reconstruction through the application of statistical inversion. Unknowns associated with points of a reconstruction grid are represented with components of a vector-valued variable. A next version of the vector-valued variable is repeatedly created by drawing for each component a value from a conditional distribution. The components of a so generated version of the vector-valued variable are used as the tomographic reconstruction. The components are divided into sets, so that components in a set represent unknowns associated with mutually independent points of the reconstruction grid, or into independent collections. For at least two components of a set or at least two collections, the drawing of values from a conditional distribution is performed in parallel in a computer-implemented process.

A radio tomographic image generation device includes a reconstruction unit for generating a plurality of reconstructed images of different iteration numbers by a successive approximation process; a region segmentation unit for obtaining information about structure based on radiographic image signals, and segmenting, based on the information about structure, a region, of which the tomographic image is generated, into a plurality of segmented regions having different information about structure; and an image combining unit for generating partial tomographic images by using the reconstructed images of different iteration numbers for the individual segmented regions based on the information about structure of the individual segmented regions, and generating a tomographic image of a subject by using the generated partial tomographic images for the individual segmented regions.

The present invention pertains to a system and method for X-ray imaging wherein a targeted fluence at the detector for projection images can be achieved at a plurality of projection angles around the imaging subject by control of exposure times implemented during image acquisition. Exposure time for a second projection image may be determined by the fluence in a first projection image, and in a third projection image by the fluence in a second projection image, where projection images are acquired within two degrees of one another. An acquisition parameter calculation can be configured to calculate acquisition parameters, such as said exposure times, to achieve the targeted fluence in projection images and can be coupled to a rotation controller that implements the acquisition parameters by controlling a relative angle between the imaging subject and X-ray image acquisition device.

A mirror for the EUV wavelength range (1) having a layer arrangement (P) applied on a substrate (S), the layer arrangement having a periodic sequence of individual layers, where the periodic sequence has at least two individual layers—forming a period—composed respectively of silicon (Si) and ruthenium (Ru). Also disclosed are a projection objective for microlithography (2) including such a mirror, and a projection exposure apparatus for microlithography having such a projection objective (2).

A press plate that includes: a plate shaped press portion that is capable of resilient deformation; a first slit that is provided to a first wall portion of a support body with length direction along a first edge portion of the press portion, and that penetrates the first wall portion; second slits that are provided to a second wall portions of the support body with length direction along second edge portions of the press portion, and that penetrate the second wall portions; and a first corner portion slit that is provided straddling a corner portion between the first wall portion and the second wall portion and penetrating the corner portion, that is connected to the first slit, and that is disposed at a separation to the second slit.

An X-ray photography apparatus including: a turning arm that supports an X-ray generator and an X-ray detector which are opposed to each other so that the head of a patient can be interposed therebetween, and a moving mechanism that includes a turning part and a moving part. The turning part turns the turning arm about a turning axis with respect to the head. The moving part moves the turning arm relative to the head in a direction perpendicular to the turning axis. The X-ray photography apparatus also includes: an image processor that generates an X-ray image, a photographic region designation part that designates part of a row of teeth along a dental arch as a pseudo intraoral radiography region, and an X-ray forming mechanism that changes the irradiation direction in which the head is irradiated with an X-ray relative to the axial direction of the body axis of the patient.

An X-ray photography apparatus including: a turning arm that supports an X-ray generator and an X-ray detector while the X-ray generator and the X-ray detector are opposed to each other so that a head of a patient can be interposed therebetween; and a moving mechanism that turns the turning arm about a turning axis with respect to the head and moves the turning arm in a direction perpendicular to the turning axis with respect to the head. The X-ray photography apparatus further includes: an image processor that generates an X-ray image based on an electric signal output from the X-ray detector; and a photographic region designation receiving part that designates part of a row of teeth along a dental arch as a pseudo intraoral radiography region. The image processor generates plural tomographic images by applying convolution and filtered back projection to X-ray image data obtained by pseudo intraoral radiography.

A method for recording a four-dimensional angiography data record using an x-ray facility with a C-arm is proposed. Projection images are recorded from different projection directions at different time points of the cardiac cycle. A number of three-dimensional reconstruction image data records assigned respectively to a time segment of the cardiac cycle are reconstructed from the projection images and combined to form the four-dimensional angiography data record by temporal assignment in respect of the cardiac cycle. At least one recording parameter describing the temporal sequence is selected when recording the projection images as a function of cardiac stimulation performed to ensure a stable heart rate during recording so that the recording of the projection images takes place in such a manner that it is synchronized with the cardiac cycle.