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14th Annual Immigration Law and Policy Conference

In a year when immigration has been prominent in the headlines, the 14th annual Immigration Law and Policy Conference provides timely policy and legal analysis, with expert discussion covering the shifting immigration policy priorities under a new administration, including changes in immigration enforcement, border enforcement, refugee resettlement, the treatment of unaccompanied minors and their families, Temporary Protected Status, and DACA, along with the responses from the judicial and congressional branches, various stakeholders, and state and local governments. 




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Immigration under Trump: A Review of Policy Shifts in the Year Since the Election

On the campaign trail, Donald Trump made immigration the centerpiece of his campaign, offering a more detailed policy agenda than on any other issue. In the year since the election that propelled the Republican into the White House, how has the Trump administration’s record matched up with the rhetoric? This policy brief examines the executive orders and other changes to existing policy and practice made during 2017.




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Trump Administration Ratchets up Pressure on “Sanctuary” Jurisdictions

The Trump administration has been steadily building a case to penalize "sanctuary" cities—those jurisdictions that in some way limit their cooperation with federal immigration authorities—after threatening to cut federal funding. Despite court rulings that seemed to strike a blow against these efforts, the Justice Department is moving forward with its strategy, relying on a broad interpretation of a federal statute, as this article explores.




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15th Annual Immigration Law and Policy Conference

At a time of intense and fast-moving action on immigration, 2018's Immigration Law and Policy Conference offered an excellent opportunity to go beyond the headlines with thoughtful analysis from leading experts.




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15th Annual Immigration Law and Policy Conference

At the 15th annual Immigration Law and Policy Conference, held in October 2018, leading experts and government officials discussed the role that immigration is playing in the mid-term elections; how the courts are handling key immigration questions; and recent changes in the U.S. asylum system, border and interior enforcement, and regulations surrounding legal immigration.   




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Facts about English Learners and the NCLB/ESSA Transition in Select States

These fact sheets provide a sketch of key characteristics of the foreign-born and English Learner (EL) populations in select states. The fact sheets look at the demographics of these states, discuss EL student outcomes as measured by standardized tests, and conclude with an overview of state accountability mechanisms that affect ELs under relevant provisions of the Every Student Succeeds Act and predecessor No Child Left Behind Act.




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Building the Foundations for Inclusion: What Does the Future Hold for Immigrant Integration in Europe?

This meeting highlighted lessons from MPI Europe’s flagship Integration Futures initiative, which seeks to develop creative and strategic approaches to addressing today’s most difficult and pressing integration challenges—and to better plan for those around the corner.




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Social Innovation for Refugee Inclusion: A Sense of Home

The third Social Innovation for Refugee Inclusion conference in Brussels, co-organized by MPI Europe with the U.S. and Canadian Missions to the European Union and the European Economic and Social Committee, explored how innovations in living situations for refugees can promote community-driven inclusion, overcome divisions, facilitate economic opportunities, and foster a sense of "home."




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Noncitizens in the U.S. Military: Navigating National Security Concerns and Recruitment Needs

Noncitizens have long served in the U.S. military, often encouraged by the promise of a fast track to U.S. citizenship. In recent years, however, Congress and the Defense Department have made it more difficult for noncitizens to enlist. This brief give context to these policy changes and explores ways the military could better balance concerns about national security and the need for recruits with key cultural and professional skills.




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10th Annual Immigration Law and Policy Conference

The 10th annual Immigration Law and Policy Conference featured keynotes by U.S. Senator John McCain (R-AZ) and former Mississippi Governor Haley Barbour, and panel discussions on the prospects for legislative action, policy options, and political mobilization; lessons learned from past immigration legislation and programs; and an assessment of current conditions at the U.S. border and considerations for future policy. 




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African Countries Relax Short-Term Visa Policies for Chinese in Sign of Increased Openness to China

China has been Africa’s largest trading partner since 2009, and as commerce and investment have increased, so have flows of people in both directions. With an estimated 1 million to 2 million Chinese migrants across Africa, some countries have relaxed their short-term visa requirements in hopes of facilitating cultural and business exchanges. High levels of Chinese investment do not, however, correlate with more liberal visa policies, as this article explores.




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Labor Migration from Myanmar: Remittances, Reforms, and Challenges

Having emerged from a long era of military rule, Myanmar's leaders and many citizens are looking outward. In particular, with Burmese labor migration abroad on the rise, policymakers are examining ways in which to harness remittances as a vehicle for economic development, particularly in impoverished rural areas. This article explores Burmese labor migration flows, financial reforms, and challenges on migration and development.




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After Revolution, Tunisian Migration Governance Has Changed. Has EU Policy?

In the face of an uptick in unauthorized arrivals in Italy from Tunisia in 2017, the European Union dusted off earlier policy proposals such as funding to increase Tunisia’s border-control capabilities and the creation of disembarkation platforms. This article explores why contemporary developments, including a fragile Tunisian political system, suggest the need for a different approach.




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Global Governance of International Migration 2.0: What Lies Ahead?

The vast majority of UN Member States in December 2018 adopted the first-ever international agreement to cooperate on migration. This policy brief traces the trajectory of the Global Compact for Safe, Orderly, and Regular Migration's negotiation and endorsement. It also explores the factors that will determine whether the compact lives up to its aim of improving how states cooperate on international migration.   




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Increased Focus on Forced Return of Migrants and Asylum Seekers Puts Many in Peril

Governments on the receiving end of migrants and refugees reinforced their commitment to returns in 2017, sending or coercing migrants to move back to impoverished or violent homelands. The Dominican Republic pushed out some 70,000 Haitians and native born of Haitian descent, while more than 500,000 Afghans left Iran and Pakistan. Though many of these migrants chose to return, in practice the line between forced and voluntary returns is blurry.




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Making the Global Compact on Migration a Reality: Ideas for Enhancing Regular Migration Pathways at All Skill Levels

As the final phase of preparations for the historic adoption of a Global Compact for Safe, Orderly, and Regular Migration approaches, this webinar explores two central objectives of the compact: enhancing the availability and flexibility of pathways for regular migration, and investing in skills development. 




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Making the Global Compact on Migration a Reality: Ideas for Enhancing Regular Migration Pathways at All Skill Levels

As the final phase of preparations for the historic adoption of a Global Compact for Safe, Orderly, and Regular Migration approaches, this webinar explores two central objectives of the compact: enhancing the availability and flexibility of pathways for regular migration, and investing in skills development.




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Balancing Acts: Policy Frameworks for Migrant Return and Reintegration

In recent years, questions of whether, when, and how to return failed asylum seekers and other migrants to their origin countries have dominated migration debates in many countries. These issues were also taken up in the negotiation of the Global Compact for Safe, Orderly, and Regular Migration, moving the discussion beyond the typical bilateral one. This policy brief outlines how states might more constructively work together on returns and reintegration programs.




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A Once-Smooth Path for the Global Compact on Migration Becomes Rocky

The world’s first international agreement on migration was approved by 164 countries in December 2018, but not without turbulence. U.S. withdrawal from the nonbinding Global Compact on Safe, Orderly, and Regular Migration, on grounds it could impinge on sovereignty, triggered similar actions by others, particularly in Eastern Europe. Amid ongoing political ripple effects, attention now turns to implementation of the deal's goals.




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El Salvador: Civil War, Natural Disasters, and Gang Violence Drive Migration

El Salvador is the smallest country in Central America yet the most densely populated. A stagnant economy, high levels of crime and violence, and natural disasters have pushed growing numbers of people to migrate without authorization or seek asylum abroad, mostly in the United States. This article explores historical and contemporary emigration from El Salvador.




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Migration in the Netherlands: Rhetoric and Perceived Reality Challenge Dutch Tolerance

The Netherlands has witnessed a rise in far-right populism, challenging its reputation as a humanitarian haven. Yet, public fears equating immigration with a rise in religious extremism do not necessarily reflect the facts. This profile explores historical and contemporary migration in a country where population growth relies largely on immigration, and analyzes to what extent policymaking has been shaped by rising populism.




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Improving the Governance of International Migration

This volume from MPI's Transatlantic Council on Migration aims to fill the analytical gap regarding the question of what greater global cooperation on governing the flow of international migrants could achieve. The book focuses on a set of fundamental questions: What are the key steps to building a better, more cooperative system of governance? What are the goals that can be achieved through greater international cooperation? And, most fundamentally, who (or what) is to be governed?




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Spiraling Violence and Drought Drive Refugee Crisis in South Sudan

Nearly 4 million South Sudanese have been driven from their homes by violence or food insecurity since late 2013, roughly half seeking refuge in neighboring countries. Drought and conflict have converged in the young country to fuel one of the world's most severe humanitarian emergencies. This article examines refugee flows from South Sudan, underlying drivers, and regional and international responses to the crisis.




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Many Psychology Experiments Lack Evidence of Validity, Says Report

Source:

An examination of nearly 350 published psychological experiments found that nearly half failed to show that they were based on a valid foundation of empirical evidence, suggesting that a wide swath of psychological science may be based on an "untested foundation."






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How One Woman Fled Domestic Violence During COVID-19 Pandemic

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When the coronavirus initially hit Colorado in early March, many flocked to grocery stores and cleared shelves, preparing to hunker down in their homes. But for Jeara and her four young children, those first days of the pandemic were different: They were settling into a domestic violence shelter after an incident involving her husband days earlier.






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U.N. Chief Says Disabled People Should Be Included in COVID-19 Plans

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Disabled people are among the hardest hit by the coronavirus pandemic, United Nations Secretary-General Antonio Guterres said Wednesday, and the inequalities that they already experience are being further intensified by the crisis. To address the problem, Guterres released a report recommending an integrated approach aimed at ensuring people with disabilities are included in response and recovery plans.






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Calls to European Domestic Violence Hotlines Soar Amid Lockdowns

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Calls to domestic violence hotlines in Europe are up by as much as three-fifths as alcohol and drug abuse combine with close confinement in coronavirus lockdowns to fuel abuse of the most vulnerable, the World Health Organization has said.






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Research Uses Artificial Intelligence to Measure Human Emotions

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New research presented online at the Cognitive Neuroscience Society annual meeting shows how data-driven computational methods are being used to understand and detect emotions. Investigators believe their findings have the potential to overturn old ideas about the structure of emotions across humanity.






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After 6 More Months, 31 Million New Domestic Violence Cases, Warns U.N.

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Women and children are experiencing unprecedented levels of abuse and violence at home as stress and anxiety continue to mount due to the pandemic. Data from the United Nations reveal a 600% increase in the number women who have experienced partner violence, and projections suggest that if coronavirus lockdowns continue for six more months, there will be an estimated 31 million additional domestic violence cases around the world.






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French Philosopher Latour Urges No Return to Pre-Lockdown Normal

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What if rather than hurrying back to a pre-lockdown "business as usual" to revive economies hammered by the coronavirus pandemic, countries built a new normal where the fight against climate change was paramount?






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La Situación de Cambio Constante entre EE UU y México: Tendencias y Políticas de Migración, Incluyendo Menores No Acompañados

Una llamada en español que analiza las dinámicas cambiantes y las cuestiones políticas relacionadas con la migración a través de México a los Estados Unidos.




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La Situación de Cambio Constante entre EE UU y México: Tendencias y Políticas de Migración, Incluyendo Menores No Acompañados

Durante este seminario, ponentes presentaron hallazgos de un reciente informe que utiliza datos de agencias gubernamentales mexicanas, entrevistas con funcionarios clave y relatos de la sociedad civil para examinar el marco legal para la protección de menores no acompañados y su aplicación, al igual que las brechas entre este marco y su aplicación durante los procesos de detención, interrogación y alojamiento. El presidente de MPI, Andrew Selee, también expuso cómo el cambio en la dinámica política en Estados Unidos puede afectar las cuestiones migratorias con México, así como los efectos en la relación bilateral en medio de tensiones sobre el muro fronterizo, la renegociación del acuerdo del TLCAN y una cifra significativa de repatriaciones de migrantes mexicanos.




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Social Distancing

Social Distancing (date: 5/9/2020 - Rank: 6)




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Superior Long-term Survival for Simultaneous Pancreas-Kidney Transplantation as Renal Replacement Therapy: 30-Year Follow-up of a Nationwide Cohort

OBJECTIVE

In patients with type 1 diabetes and end-stage renal disease, it is controversial whether a simultaneous pancreas-kidney (SPK) transplantation improves survival compared with kidney transplantation alone. We compared long-term survival in SPK and living- or deceased-donor kidney transplant recipients.

RESEARCH DESIGN AND METHODS

We included all 2,796 patients with type 1 diabetes in the Netherlands who started renal replacement therapy between 1986 and 2016. We used multivariable Cox regression analyses adjusted for recipient age and sex, dialysis modality and vintage, transplantation era, and donor age to compare all-cause mortality between deceased- or living-donor kidney and SPK transplant recipients. Separately, we analyzed mortality between regions where SPK transplant was the preferred intervention (80% SPK) versus regions where a kidney transplant alone was favored (30% SPK).

RESULTS

Of 996 transplanted patients, 42%, 16%, and 42% received a deceased- or living-donor kidney or SPK transplant, respectively. Mean (SD) age at transplantation was 50 (11), 48 (11), and 42 (8) years, respectively. Median (95% CI) survival time was 7.3 (6.2; 8.3), 10.5 (7.2; 13.7), and 16.5 (15.1; 17.9) years, respectively. SPK recipients with a functioning pancreas graft at 1 year (91%) had the highest survival (median 17.4 years). Compared with deceased-donor kidney transplant recipients, adjusted hazard ratios (95% CI) for 10- and 20-year all-cause mortality were 0.79 (0.49; 1.29) and 0.98 (0.69; 1.39) for living-donor kidney and 0.67 (0.46; 0.98) and 0.79 (0.60; 1.05) for SPK recipients, respectively. A treatment strategy favoring SPK over kidney transplantation alone showed 10- and 20-year mortality hazard ratios of 0.56 (0.40; 0.78) and 0.69 (0.52; 0.90), respectively.

CONCLUSIONS

Compared with living- or deceased-donor kidney transplantation, SPK transplant was associated with improved patient survival, especially in recipients with a long-term functioning pancreatic graft, and resulted in an almost twofold lower 10-year mortality rate.




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Sex Difference in Effects of Low-Dose Aspirin on Prevention of Dementia in Patients With Type 2 Diabetes: A Long-term Follow-up Study of a Randomized Clinical Trial

OBJECTIVE

To evaluate and compare the efficacy of long-term use of low-dose aspirin for the prevention of dementia in men and women.

RESEARCH DESIGN AND METHODS

This study is a follow-up cohort study of the Japanese Primary Prevention of Atherosclerosis With Aspirin for Diabetes (JPAD) trial, which was a randomized, open-label, standard care–controlled trial examining the effects of low-dose aspirin on cardiovascular events. We followed up 2,536 Japanese patients with type 2 diabetes (T2D) enrolled in the JPAD trial from 2002 to 2017. The primary outcome of this post hoc analysis was the incidence of dementia, which was defined by the prescription of antidementia drugs or admission due to dementia.

RESULTS

Among the originally enrolled patients, 2,121 (84%) retained their original allocation. During a median follow-up of 11.4 years, 128 patients developed dementia. The overall effect of low-dose aspirin on the prevention of dementia adjusted for age, sex, and other established risk factors was not significant (hazard ratio [HR] 0.82, 95% CI 0.58–1.16). However, a significant reduction was seen in the risk of dementia in women (HR 0.58, 95% CI 0.36–0.95), but not in men (HR 1.27, 95% CI 0.75–2.13) (Pinteraction = 0.03).

CONCLUSIONS

Long-term use of low-dose aspirin may reduce the risk for dementia in women with T2D.




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Glucosamine Use, Inflammation, and Genetic Susceptibility, and Incidence of Type 2 Diabetes: A Prospective Study in UK Biobank

OBJECTIVE

Glucosamine is a widely used supplement typically taken for osteoarthritis and joint pain. Emerging evidence suggests potential links of glucosamine with glucose metabolism, inflammation, and cardiometabolic risk. We prospectively analyzed the association of habitual glucosamine use with risk of type 2 diabetes (T2D) and assessed whether genetic susceptibility and inflammation status might modify the association.

RESEARCH DESIGN AND METHODS

This study analyzed 404,508 participants from the UK Biobank who were free of diabetes, cancer, or cardiovascular disease at baseline and completed the questionnaire on supplement use. Cox proportional hazards models were used to evaluate the association between habitual use of glucosamine and risk of incident T2D.

RESULTS

During a median of 8.1 years of follow-up, 7,228 incident cases of T2D were documented. Glucosamine use was associated with a significantly lower risk of T2D (hazard ratio 0.83, 95% CI 0.78–0.89) after adjustment for age, sex, BMI, race, center, Townsend deprivation index, lifestyle factors, history of disease, and other supplement use. This inverse association was more pronounced in participants with a higher blood level of baseline C-reactive protein than in those with a lower level of this inflammation marker (P-interaction = 0.02). A genetic risk score for T2D did not modify this association (P-interaction = 0.99).

CONCLUSIONS

Our findings indicate that glucosamine use is associated with a lower risk of incident T2D.




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Targeting CXCR1/2 Does Not Improve Insulin Secretion After Pancreatic Islet Transplantation: A Phase 3, Double-Blind, Randomized, Placebo-Controlled Trial in Type 1 Diabetes

OBJECTIVE

Reparixin is an inhibitor of CXCR1/2 chemokine receptor shown to be an effective anti-inflammatory adjuvant in a pilot clinical trial in allotransplant recipients.

RESEARCH DESIGN AND METHODS

A phase 3, multicenter, randomized, double-blind, parallel-assignment study (NCT01817959) was conducted in recipients of islet allotransplants randomized (2:1) to reparixin or placebo in addition to immunosuppression. Primary outcome was the area under the curve (AUC) for C-peptide during the mixed-meal tolerance test at day 75 ± 5 after the first and day 365 ± 14 after the last transplant. Secondary end points included insulin independence and standard measures of glycemic control.

RESULTS

The intention-to-treat analysis did not show a significant difference in C-peptide AUC at both day 75 (27 on reparixin vs. 18 on placebo, P = 0.99) and day 365 (24 on reparixin vs. 15 on placebo, P = 0.71). There was no statistically significant difference between treatment groups at any time point for any secondary variable. Analysis of patient subsets showed a trend for a higher percentage of subjects retaining insulin independence for 1 year after a single islet infusion in patients receiving reparixin as compared with patients receiving placebo (26.7% vs. 0%, P = 0.09) when antithymocyte globulin was used as induction immunosuppression.

CONCLUSIONS

In this first double-blind randomized trial, islet transplantation data obtained with reparixin do not support a role of CXCR1/2 inhibition in preventing islet inflammation-mediated damage.




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The Dysfunction of Functions in Abstract Algebra

Kathleen Melhuish & Kristen Lew Texas State University “[Functions] are completely different, which is what makes this course so challenging.” – Abstract Algebra Student Functions are hard for students, even students in abstract algebra courses. Even if students have seen … Continue reading




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Soccer: Bundesliga return includes Dortmund on May 16, Bayern Munich, May 17

The German Bundesliga released its full soccer schedule Thursday after German officials announced that the league is allowed to resume games after they were suspended due to the coronavirus pandemic.




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Former Denver Broncos QB Joe Flacco underwent neck surgery

Former Denver Broncos quarterback Joe Flacco, who remains a free agent, could miss the start of the 2020 season after he underwent neck surgery.




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Weekend live sports include UFC 249, 14 baseball games in Asia

UFC 249 will be sandwiched between 14 live baseball broadcasts out of South Korea and Taiwan this weekend for American sports fans to watch as they wait for major sports leagues to return.




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Diabetes in the Emergency Department: Acute Care of Diabetes Patients

Candace D. McNaughton
Apr 1, 2011; 29:51-59
Feature Articles




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Elevated Liver Function Tests in Type 2 Diabetes

Elizabeth H. Harris
Jul 1, 2005; 23:115-119
Feature Articles




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Glucose, Advanced Glycation End Products, and Diabetes Complications: What Is New and What Works

Melpomeni Peppa
Oct 1, 2003; 21:
Council's Voice




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Improving Patient Adherence

Alan M. Delamater
Apr 1, 2006; 24:71-77
Feature Articles




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Treatment Approach to Patients With Severe Insulin Resistance

Timothy J. Church
Apr 1, 2016; 34:97-104
Feature Articles




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Case Study: New-Onset Diabetes: How to Tell the Difference Between Type 1 and Type 2 Diabetes

Joseph Largay
Jan 1, 2012; 30:25-26
Case Studies




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Diabetes and Erectile Dysfunction

Neelima V. Chu
Jan 1, 2001; 19:
Practical Pointers




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Plasma Lipidome and Prediction of Type 2 Diabetes in the Population-Based Malmö Diet and Cancer Cohort

OBJECTIVE

Type 2 diabetes mellitus (T2DM) is associated with dyslipidemia, but the detailed alterations in lipid species preceding the disease are largely unknown. We aimed to identify plasma lipids associated with development of T2DM and investigate their associations with lifestyle.

RESEARCH DESIGN AND METHODS

At baseline, 178 lipids were measured by mass spectrometry in 3,668 participants without diabetes from the Malmö Diet and Cancer Study. The population was randomly split into discovery (n = 1,868, including 257 incident cases) and replication (n = 1,800, including 249 incident cases) sets. We used orthogonal projections to latent structures discriminant analyses, extracted a predictive component for T2DM incidence (lipid-PCDM), and assessed its association with T2DM incidence using Cox regression and lifestyle factors using general linear models.

RESULTS

A T2DM-predictive lipid-PCDM derived from the discovery set was independently associated with T2DM incidence in the replication set, with hazard ratio (HR) among subjects in the fifth versus first quintile of lipid-PCDM of 3.7 (95% CI 2.2–6.5). In comparison, the HR of T2DM among obese versus normal weight subjects was 1.8 (95% CI 1.2–2.6). Clinical lipids did not improve T2DM risk prediction, but adding the lipid-PCDM to all conventional T2DM risk factors increased the area under the receiver operating characteristics curve by 3%. The lipid-PCDM was also associated with a dietary risk score for T2DM incidence and lower level of physical activity.

CONCLUSIONS

A lifestyle-related lipidomic profile strongly predicts T2DM development beyond current risk factors. Further studies are warranted to test if lifestyle interventions modifying this lipidomic profile can prevent T2DM.




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Distinct Growth Phases in Early Life Associated With the Risk of Type 1 Diabetes: The TEDDY Study

OBJECTIVE

This study investigates two-phase growth patterns in early life and their association with development of islet autoimmunity (IA) and type 1 diabetes (T1D).

RESEARCH DESIGN AND METHODS

The Environmental Determinants of Diabetes in the Young (TEDDY) study followed 7,522 genetically high-risk children in Sweden, Finland, Germany, and the U.S. from birth for a median of 9.0 years (interquartile range 5.7–10.6) with available growth data. Of these, 761 (10.1%) children developed IA and 290 (3.9%) children were diagnosed with T1D. Bayesian two-phase piecewise linear mixed models with a random change point were used to estimate children’s individual growth trajectories. Cox proportional hazards models were used to assess the effects of associated growth parameters on the risks of IA and progression to T1D.

RESULTS

A higher rate of weight gain in infancy was associated with increased IA risk (hazard ratio [HR] 1.09 [95% CI 1.02, 1.17] per 1 kg/year). A height growth pattern with a lower rate in infancy (HR 0.79 [95% CI 0.70, 0.90] per 1 cm/year), higher rate in early childhood (HR 1.48 [95% CI 1.22, 1.79] per 1 cm/year), and younger age at the phase transition (HR 0.76 [95% CI 0.58, 0.99] per 1 month) was associated with increased risk of progression from IA to T1D. A higher rate of weight gain in early childhood was associated with increased risk of progression from IA to T1D (HR 2.57 [95% CI 1.34, 4.91] per 1 kg/year) in children with first-appearing GAD autoantibody only.

CONCLUSIONS

Growth patterns in early life better clarify how specific growth phases are associated with the development of T1D.