This analysis aimed to identify clinical factors associated with positivity on repeat ⁶⁸Ga-PSMA-11 PET/CT after a negative scan in patients with recurrent prostate cancer (PCa) under observation. Methods: This single-center, retrospective analysis included patients who underwent at least 2 ⁶⁸Ga-PSMA-11 PET/CT scans (PET1 and PET2) at UCLA between October 2016 and June 2021 for recurrent PCa with negative PET1 and no PCa-related treatments between the 2 scans. Using Prostate Cancer Molecular Imaging Standardized Evaluation criteria to define negative and positive scans, the final cohort was divided into PET2-negative (PET2-Neg) and PET2-positive (PET2-Pos). The same PET1 was used twice in the more than 2 PET cases with inclusion criteria fulfilled. Patient characteristics and clinical parameters were compared between the 2 cohorts using Mann–Whitney U test and Fisher exact test. Areas under the curve (AUCs) of the receiver operating characteristic and the Youden index were computed to determine the discrimination ability of statistically significant factors and specific cut points that maximized sensitivity and specificity, respectively. Results: The final analysis included 83 sets of 2 PET/CT scans from 70 patients. Thirty-nine of 83 (47%) sets were PET2-Neg, and 44 of 83 (53%) sets were PET2-Pos. Prostate-specific antigen (PSA) increased from PET1 to PET2 for all 83 (100%) sets of scans. Median PSA at PET1 was 0.4 ng/mL (interquartile range, 0.2–1.0) and at PET2 was 1.6 ng/mL (interquartile range, 0.9–3.8). We found higher serum PSA at PET2 (median, 1.8 vs. 1.1 ng/mL; P = 0.015), absolute PSA difference (median, 1.4 vs. 0.7 ng/mL; P = 0.006), percentage of PSA change (median, +270.4% vs. +150.0%: P = 0.031), and median PSA velocity (0.044 vs. 0.017 ng/mL/wk, P = 0.002) and shorter PSA doubling time (DT; median, 5.1 vs. 8.3 mo; P = 0.006) in the PET2-Pos cohort than in the PET2-Neg cohort. Receiver operating characteristic curves showed cutoffs for PSA at PET2 of 4.80 ng/mL (sensitivity, 34%; specificity, 92%; AUC, 0.66), absolute PSA difference of 0.95 ng/mL (sensitivity, 62%; specificity, 71%; AUC, 0.68), percentage of PSA change of a positive 289.50% (sensitivity, 48%; specificity, 82%; AUC, 0.64), PSA velocity of 0.033 ng/mL/wk (sensitivity, 57%; specificity, 80%; AUC, 0.70), and PSA DT of 7.91 mo (sensitivity, 71%; specificity, 62%; AUC, 0.67). Conclusion: Patients with recurrent PCa under observation after a negative ⁶⁸Ga-PSMA-11 PET/CT scan with markedly elevated serum PSA levels and shorter PSA DT are more likely to have positive findings on repeat ⁶⁸Ga-PSMA-11 PET/CT.

Prognosticators anticipate the Federal Reserve on Thursday will announce a second rate cut after lowering the federal lending rate by 0.5% in September.

SANTA CLARA, Calif., Oct. 25, 2024 — ServiceNow has announced that enterprise software industry veteran Amit Zavery will join the company as president, chief product officer (CPO), and chief operating officer […]

The post Google Cloud and Oracle Veteran Amit Zavery to Spearhead Product and Engineering at ServiceNow appeared first on HPCwire.

SAN ANTONIO, Nov. 5, 2024 — Rackspace Technology has announced the expansion of Rackspace Spot with a new geographic location and an on-demand GPU-as-a-Service powered by NVIDIA. The expansion comes […]

The post Rackspace Expands Spot Platform with On-Demand NVIDIA GPU-as-a-Service for AI Workloads appeared first on HPCwire.

FREMONT, Calif., Nov. 6, 2024 — AMAX, an AMD Elite Partner and a global leader in end-to-end GPU cluster solutions and advanced cooling technologies, announced its latest lineup of servers powered […]

The post AMAX Expands Server Portfolio with New AMD EPYC 9005 Series Processors for AI and HPC Workloads appeared first on HPCwire.

LONDON, Nov. 1, 2024 — Quantum Motion, a UK-based quantum computing scale-up founded by Professor John Morton, University College London (UCL), and Professor Simon Benjamin, University of Oxford, has worked […]

The post Quantum Motion and Goldman Sachs Identify Quantum Applications in Financial Services Project appeared first on HPCwire.

COLLEGE PARK, Md., Nov. 8, 2024 — IonQ, a leader in the quantum computing industry, has announced a partnership with NKT Photonics, a subsidiary of Hamamatsu Photonics, to procure next-generation laser […]

The post IonQ and NKT Photonics Collaborate on Next-Gen Laser Tech for Quantum Data Centers appeared first on HPCwire.

CALGARY, Alberta, Nov. 5, 2024 — Computer Modelling Group Ltd. (CMG) has announced it is collaborating with NVIDIA to further develop and optimize CMG subsurface simulation solutions for increased speed, […]

The post CMG Targets Faster Simulation Solutions with NVIDIA for Enhanced Reservoir Modeling appeared first on HPCwire.

BUFFALO, N.Y., Nov. 11, 2024 — Motivair Corporation, a leading global provider of advanced liquid cooling solutions, will be showcasing its cutting-edge MI300X Dynamic Cold Plates at the upcoming International […]

The post Motivair to Showcase MI300X Cold Plates at SC24 for AI Servers appeared first on HPCwire.

TEL AVIV, Israel, Nov. 12, 2024 — LightSolver today announced that it will be exhibiting and presenting at SC24, the international conference for high-performance computing (HPC), networking, storage, and analysis […]

The post LightSolver Highlights Laser Computing Advancements for HPC at SC24 appeared first on HPCwire.

Researchers have a clearer picture than ever before of how common conditions that involve aggressive behavior emerge and how treatment can help

Paramount Pictures is teasing "Mission: Impossible -- The Final Reckoning," starring Tom Cruise.

Country music star Blake Shelton and writer-producer Taylor Sheridan are working on a new reality competition series for CBS called "The Road."

A team of U.S. employees at Hachette wrote an open letter to management in protest over a new conservative book imprint created in wake of last week's Donald Trump victory headed by a known far-right publisher.

Google is educating users about the lunar cycle with its latest interactive Doodle released Thursday.

"Memories are the architects of our identity," says technologist Pau Aleikum Garcia, but they're not permanent. Photos can be lost amid political unrest or natural disaster, while illnesses like Alzhemier's can rob people of their past. He puts forward a novel solution — "synthetic memories," or dreamlike visualizations of long-gone moments created through generative AI — and explores how it could reconnect families or even enhance cognitive abilities.

Health experts agree that there is a clear connection between an individual’s dental health and mental health. But although this fact is supported by a number of clinical studies, it is rarely explored or discussed among health professionals. A person with poor oral health may experience bad breath, tooth loss, compromised speech and other symptoms […]

The post How Innovations in Dental Services Transform Patient Care and Improve Mental Health first appeared on What is Psychology?.

Police in northeast Ohio have placed a school resource officer on unpaid leave for activating a Taser to wake up a sleeping student.

High school teacher Jenefer Pasqua is running for Wyoming's state legislature to fight against education funding cuts.

States’ efforts so far suggest there won’t be enough money to go around for all the learning losses of students with disabilities from COVID-19 school shutdowns.

Felton Williams shares insights from his 16 years as one of the few Black members on the Long Beach, Calif., school board.

States’ efforts so far suggest there won’t be enough money to go around for all the learning losses of students with disabilities from COVID-19 school shutdowns.

Just because a rural school system has internet doesn’t mean everyone can afford it. That’s why James Barrett delivers paper work packets, along with meals, to his students during the COVID-19 crisis.

A small school district in Oklahoma plans to offer low-cost daycare services to its employees next year in an effort to better compete with larger districts when it comes to recruiting and retaining teachers.

The U.S. Supreme Court ruled that a large swath of land in Oklahoma is still an American Indian reservation, a decision that may have ramifications for education.

Maine Gov. Paul LePage says he plans to forgo the process of selecting a new commissioner for the state education department and will instead take on the role himself.

A school cook in Nebraska was canned after he mixed kangaroo meat into chili made for students.

New state mandates start next school year aimed at identifying and supporting students with dyslexia. The 2016 law also led to development of training for teachers.

The Winnipeg Jets will be without defenceman Logan Stanley for the short-term future.

The Maple Leafs called up leading Marlies scorer Alex Steeves but aren't expected to play him. He deserves a good look while other bottom-six players struggle, says Adam Proteau.

The second College Football Playoff rankings produced some positives and negatives for teams. Here are the winners and losers from Tuesday's reveal:

The second College Football Playoff rankings dropped on Tuesday night with Oregon retaining its status as the No. 1 team in the country ahead of No. 2 Ohio State and No. 3 Texas. College Football Playoff:

From time to time, but not very often, former special-teams coordinators become NFL head coaches.

The court revived a lawsuit claiming that Mississippi's lack of a "uniform" education system violates the 1868 federal law that readmitted the state to the Union.

Nora D. Volkow
Dec 1, 2001; 21:9414-9418
Behavioral

Mitchell G. Spring
Oct 9, 2024; 44:e0602242024-e0602242024
BehavioralSystemsCognitive

Serotonin modulates diverse phenotypes and functions including depressive, aggressive, impulsive, and feeding behaviors, all of which have reward-related components. To date, research has focused on understanding these effects by measuring and manipulating dorsal raphe serotonin neurons and using single-receptor approaches. These studies have led to a better understanding of the heterogeneity of serotonin actions on behavior; however, they leave open many questions about the timing and location of serotonin's actions modulating the neural circuits that drive these behaviors. Recent advances in genetically encoded fluorescent biosensors, including the GPCR activation-based sensor for serotonin (GRAB-5-HT), enable the measurement of serotonin release in mice on a timescale compatible with a single rewarding event without corelease confounds. Given substantial evidence from slice electrophysiology experiments showing that serotonin influences neural activity of the striatal circuitry, and the known role of the dorsal medial striatal (DMS) in reward-directed behavior, we focused on understanding the parameters and timing that govern serotonin release in the DMS in the context of reward consumption, external reward value, internal state, and cued reward. Overall, we found that serotonin release is associated with each of these and encodes reward anticipation, value, approach, and consumption in the DMS.

Abnormal neuronal morphological features, such as dendrite branching, axonal branching, and spine density, are thought to contribute to the symptoms of depression and anxiety. However, the role and molecular mechanisms of aberrant neuronal morphology in the regulation of mood disorders remain poorly characterized. Here, we show that neuritin, an activity-dependent protein, regulates the axonal morphology of serotonin neurons. Male neuritin knock-out (KO) mice harbored impaired axonal branches of serotonin neurons in the medial prefrontal cortex and basolateral region of the amygdala (BLA), and male neuritin KO mice exhibited depressive and anxiety-like behaviors. We also observed that the expression of neuritin was decreased by unpredictable chronic stress in the male mouse brain and that decreased expression of neuritin was associated with reduced axonal branching of serotonin neurons in the brain and with depressive and anxiety behaviors in mice. Furthermore, the stress-mediated impairments in axonal branching and depressive behaviors were reversed by the overexpression of neuritin in the BLA. The ability of neuritin to increase axonal branching in serotonin neurons involves fibroblast growth factor (FGF) signaling, and neuritin contributes to FGF-2-mediated axonal branching regulation in vitro. Finally, the oral administration of an FGF inhibitor reduced the axonal branching of serotonin neurons in the brain and caused depressive and anxiety behaviors in male mice. Our results support the involvement of neuritin in models of stress-induced depression and suggest that neuronal morphological plasticity may play a role in controlling animal behavior.

The work, now on view at the Smithsonian American Art Museum, tells the story of two characters on the island—the last people alive in the world

The Thomson Reuters Foundation, the corporate charity of the world’s biggest news and information providers, is teaming up with the UN Food and Agriculture Organization (FAO) to improve [...]

Scala Mercalli hosted by Italian environmentalist Luca Mercalli begins filming in the Sheikh Zayed Centre in FAO this week! 

Episodes will be shot in front of a live audience every Thursday [...]

The Food and Agriculture Organization of the United Nations (FAO) has the pleasure to inform the Permanent Representatives of the launch of a series of Activity Books for young people. [...]

Today we celebrate the cultural heritage, health benefits and economic importance of tea.