Ying Zou
Dec 1, 2020; 61:1589-1604
Research Articles

Beiging of white adipose tissue (WAT) has beneficial effects on metabolism. Although it is known that beige adipocytes are active in lipid catabolism and thermogenesis, how they are regulated deserves more explorations. In this study, we demonstrate that stearoyl-CoA desaturase 1 (SCD1) in subcutaneous WAT (scWAT) responded to cold stimulation and was able to promote mobilization of triacylglycerol [TAG (triglyceride)]. In vitro studies showed that SCD1 promoted lipolysis in C3H10T1/2 white adipocytes. The lipolytic effect was contributed by one of SCD1’s products, oleic acid (OA). OA upregulated adipose TAG lipase and hormone-sensitive lipase expression. When SCD1 was overexpressed in the scWAT of mice, lipolysis was enhanced, and oxygen consumption and heat generation were increased. These effects were also demonstrated by the SCD1 knockdown experiments in mice. In conclusion, our study suggests that SCD1, known as an enzyme for lipid synthesis, plays a role in upregulating lipid mobilization through its desaturation product, OA.

The Biden administration is reportedly considering capping sales of advanced artificial intelligence (AI) chips from US-based manufacturers like AMD and Nvidia to certain countries, including those in the Middle East.  The […]

The post White House Mulls Expanding AI Chip Export Bans Beyond China appeared first on HPCwire.

President Joe Biden will hold a White House meeting with President Prabowo Subianto of Indonesia on Tuesday to celebrate 75 years of U.S.-Indonesian relations and discuss ways to strengthen their countries' cooperation.

A new HBO Max teaser offers a glimpse of the upcoming shows viewers can look forward to in the next year.

Learn about this often misunderstood creature

Identified as an Arctic fox, the animal is believed to have been kept in captivity far from its native habitat in the tundra. Now, it's receiving care from wildlife officials

Authorities have not yet identified the cause of death for the 12.5-foot-long shark, which was named Koala

The public tours of the historic residence hadn't been overhauled in decades. For two years, the first lady's office has been working to make them more interactive and educational

Pat White, an entrepreneur who launched EVAS Air and the Gander Flight Training, has died. He was 69 years old.

Yukon appeal court Justice Karen Horsman granted a temporary stay of the requirement on Friday, the latest development in an ongoing legal battle over the property between the territorial government, cabin-owner Len Tarka and tenant Eric DeLong. 

A Whitehorse homeowner has been charged in connection with an explosion last year that destroyed his home and killed a man in a neighbouring house. 

The 1898 Wilmington massacre left dozens of Black North Carolinians dead. Conspirators also forced the city's multiracial government to resign at gunpoint

LAFC opened the series with a narrow 2-1 victory in California and Vancouver replied with a decisive 3-0 win at home to set up a do-or-die matchup on Friday, but they failed to overcome L.A. and suffered a 1-0 defeat.

Malloree Enoch alleges she was sexually coerced by former Whitecaps coach Hubert Busby Jr., who was recently reinstated as head coach of the Jamaican women's national team.

The impact of Donald Trump's election win on Nov. 5 will be felt globally, especially in China — one of the world's emerging superpowers and one of the United States' biggest trading partners. The relationship could also affect Canada.

Concerningly for South Africa, the question of whether our laws and regulations provide sanctions and penalties that are commensurate to the harm caused by white-collar criminals remains a matter of contested viewpoints, writes Khaya Sithole.

SINGAPORE, Nov 8 - Asia and even China are shaping up as surprisingly resilient investment markets as Donald Trump returns to the White House, with fund managers optimistic the region can withstand tariffs better than Europe.

President Joe Biden hosted Israeli President Isaac Herzog at the White House on Tuesday as the outgoing administration seeks cease-fire progress in Gaza and Lebanon.

Vice President Kamala Harris received a grand welcome to the White House on Tuesday afternoon — cheered on by hundreds of administration staff as her SUV pulled up to the West Wing.

Here are five takeaways on the teaching profession from the newly released 2017-18 National Teacher and Principal Survey.

Jill Biden won't be the first educator to live in the White House. Here are the other 19 teachers who became presidents and first ladies.

Agnes Kim, associate professor of physics at Penn State Scranton, has received a National Science Foundation grant aimed at enhancing the understanding of white dwarf stars.

As black-white achievement gaps widen in schools, so, too, do disparities in discipline rates between black and white students, according to a study published Wednesday of 2,000 schools.

Why don’t black students perform as well as white students on tests? One reporter considers her personal history to understand this disparity.

US President Joe Biden on Monday hosted a Diwali celebration at the White House that was attended by more than 600 eminent Indian Americans, including Congressmen, officials, and corporate executives, from across the country.

Some 1,000 pounds of 12- to 13-inch rainbow trout were stocked in White Clay Creek by the DNREC Division of Fish and Wildlife from near the Pennsylvania state line downstream to Newark, offering fall and winter fishing opportunities for Delaware anglers.

Read the in depth Review of Microsoft Xbox One S 500GB Console White Gaming. Know detailed info about Microsoft Xbox One S 500GB Console White configuration, design and performance quality along with pros & cons, Digit rating, verdict based on user opinions/feedback.

Read the in depth Review of Kindle Paperwhite Signature Edition Tablets. Know detailed info about Kindle Paperwhite Signature Edition configuration, design and performance quality along with pros & cons, Digit rating, verdict based on user opinions/feedback.

Valve says that customers are limited to one purchase per account.

The post You can Soon Get the Steam Deck OLED in White, but You’d Better Hurry appeared first on Phandroid.

Valve's new white Steam Deck colourway, the Steam Deck OLED: Limited Edition White, has the same specs as the black 1TB model.

white house — President Joe Biden and President Prabowo Subianto met Tuesday at the White House, marking the 75th anniversary of U.S.-Indonesia relations, part of a multination visit by the newly inaugurated leader of Southeast Asia's largest economy. "I will work very hard to strengthen Indonesia and United States relationship," said Prabowo, who goes by his first name. Biden said he looks forward to deepening the Comprehensive Strategic Partnership, the highest level among nontreaty allies, which the two countries signed in 2023. "That includes deepening our security cooperation," he said before their meeting. In brief remarks to the press, Biden twice raised an issue of concern for Washington: freedom of navigation in the South China Sea. He said he wanted to strengthen the U.S. partnership with Indonesia, "by advancing [a] free and open Indo-Pacific." "We'll discuss, also, global challenges, including in Gaza and the South China Sea," he said. China's nine-dash line The White House meeting came days after Prabowo's meeting with Chinese President Xi Jinping in Beijing, where Indonesia and China signed a series of agreements valued at about $10 billion and focusing on infrastructure, green energy, digital technology and agriculture. "In the present situation, geopolitical and geoeconomic, Indonesia and China have become very close partners in many, many fields," Prabowo said. One of the deals is to jointly develop fisheries, and oil and gas exploration in waters around Indonesia's Natuna Islands where China's "nine-dash line" marking its expansive claims in the South China Sea overlaps with Indonesia's Exclusive Economic Zone. Critics say the agreement risks implicitly validating China's territorial claims in the South China Sea, which, according to the United Nations, has no basis in international law. VOA asked the White House whether Biden was specifically referring to this deal in his meeting with Prabowo. "We continue to encourage Indonesia to work with their legal experts to make sure any agreement they make with the PRC [People's Republic of China] is in accordance with international law, especially the U.N. Convention on the Law of the Sea," said White House press secretary Karine Jean-Pierre. Beijing claims the major shipping route almost entirely, infringing into the EEZs of Indonesia, Vietnam, Malaysia, Brunei and the Philippines. All but Indonesia formally dispute the Chinese claim while Taiwan makes a claim to the sea similar to Beijing's. "It's a big deal for Indonesia," as a non-claimant country in the South China Sea dispute that supports the concept of a "free and open Indo-Pacific," said Klaus Heinrich Raditio, author on South China Sea issues and lecturer at Indonesia's Driyarkara School of Philosophy. "People will question our position," he told VOA. The Indonesian Foreign Ministry clarified Sunday that it remains firm in rejecting China's nine-dash line. Beijing's claim, Jakarta said, "does not comply" with the 1982 United Nations Convention on the Law of the Sea and "therefore has no bearing" on Indonesia's sovereignty and jurisdiction over the North Natuna Sea. Jakarta's agreement with Beijing highlights a "new phase of building the China-Indonesia community with a shared future," according to the joint statement. This reference supports "China's vision of a new global order that is anti-Western hegemony," Raditio said. It's unclear whether this language was an intentional signaling of a geopolitical shift or merely an overlook from a new administration eager to bolster ties with great powers. The Indonesian Embassy in Washington has not responded to VOA's queries. "Most likely, it is a bureaucratic mistake," Raditio said. "We put too much attention on economic cooperation. How many investments that we can attract from China? We kind of sideline other important issues." Prabowo's outreach to Trump Just as important to Jakarta as the White House meeting is Prabowo's outreach to U.S. President-elect Donald Trump. Jakarta is gearing up for Trump's new administration that begins in January. "Wherever you are, I'm willing to fly to congratulate you personally, sir," Prabowo said in a call to Trump that was posted Monday on his social media. The Trump team has not responded to VOA's queries on the conversation. U.S. foreign policy under Trump "may become more transactional and more focused on elements related to U.S.-China, competition," said Andreyka Natalegawa, associate fellow for the Southeast Asia Program at the Center for Strategic and International Studies. "The downside risk of this as it relates to Southeast Asian countries, is that it may limit some of the decision-making space they have in their diplomatic affairs," Natalegawa said. Prabowo has voiced ambitions to raise Indonesia's international profile and has made early foreign policy moves, including a surprise decision to join Southeast Asia's largest economy to the BRICS bloc. BRICS, which stands for Brazil, Russia, India, China and South Africa, is a growing group of emerging economies seen as a counterweight to the West. In October, BRICS added Indonesia as one of the group's 13 new "partner countries." The move could be a shift away from the position taken by Prabowo's predecessor, Joko Widodo, who took in massive amounts of infrastructure investments from Beijing but remained mostly nonaligned geopolitically. The White House visit marks a milestone for Prabowo, who was barred from entering the U.S. under the Clinton, Bush and Obama administrations over his role in abducting activists of the 1998 "Reformasi" movement that ousted President Suharto, Prabowo's then father-in-law. The Trump administration lifted the visa ban for then-Defense Minister Prabowo, for his visit in 2020.

Joe Biden pledged a peaceful transfer of power Thursday after Donald Trump's decisive US election win, while the Republican showed his intent to ditch the outgoing president's policies by suggesting he would talk to Vladimir Putin.

Trump says Musk, Ramaswamy will form outside group to advise White House on government efficiency

Title: New Drug Approved for Lack of Certain White Blood Cells
Category: Health News
Created: 8/30/2012 2:05:00 PM
Last Editorial Review: 8/31/2012 12:00:00 AM

Valve has announced Steam Deck OLED: Limited Edition White.

The handheld is a limited edition white version of the Steam Deck OLED that will be available in limited quantities for $679.

Pre-orders will open up on Steam on November 18 at 3:00 pm PT / 6:00 pm ET / 11:00 pm UK.

A life-long and avid gamer, William D'Angelo was first introduced to VGChartz in 2007. After years of supporting the site, he was brought on in 2010 as a junior analyst, working his way up to lead analyst in 2012 and taking over the hardware estimates in 2017. He has expanded his involvement in the gaming community by producing content on his own YouTube channel and Twitch channel. You can contact the author on Twitter @TrunksWD.

Full Article - https://www.vgchartz.com/article/463040/valve-announces-steam-deck-oled-limited-edition-white/

The Steam Deck OLED – which is like a Steam Deck but better in almost every way – is getting a new, if potentially more smudge-susceptible Limited Edition. A successor to the translucent version that only went on sale in the US and Canada last year, the Steam Deck OLED: Limited Edition White offers both a snowy look and, for those of us outside North America, the chance to actually buy one. It’ll go on sale November 18th, in all the countries that the Steam Deck currently ships in.

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President-elect Donald Trump has chosen lawyer Willian McGinley to serve as his White House counsel.

William McGinley is returning to the Trump White House to serve as his White House Counsel, President-elect Trump announced.

President-elect Donald Trump revealed on Tuesday evening that he had chosen William McGinley to serve as his White House Counsel.

The post President-Elect Donald Trump Picks William McGinley to Serve as White House Counsel appeared first on Breitbart.

As White House Counsel, McGinley will be the point legal adviser for the president in regards to ethics, oversight and judicial nominations. He served as cabinet secretary during Trump's first term.

The radio host criticized Jenner, a transgender woman, for supporting Donald Trump

After briefly offering a transparent Steam Deck OLED last year, Valve has announced its next limited edition variant featuring a bold new color: "white." It'll cost you $679 when it's available on November 18, and it features the exact same hardware as the 1TB Steam Deck OLED. (Most importantly, it sports that gorgeous 7.4-inch display with HDR and a 90Hz refresh rate). There's also a white carrying case, naturally. While the perils of white console hardware are hard to ignore (especially for a hefty portable that'll surely trap plenty of hand grease), this new variant may convince early Steam Deck owners to make the jump. 

As we covered in our review, the Steam Deck OLED's display looks significantly bolder than the original LCD models, especially with the addition of HDR support. This time around, Valve says it's also shipping the limited edition white model worldwide where Steam Decks are already available (including Australia).

"We're curious to see what the response is, and will use what we learn to inform future decisions about any potential new color variants down the line," Valve said in an e-mail. "We've always said our intent is to continually work on improving Steam Deck, and that's true from both a software perspective (continuing to ship improvements) and a hardware one (Steam Deck OLED, as well as ongoing work toward the future of Steam Deck and other hardware plans)."

Mike Waltz, the man reportedly tapped for the top international role inside the Trump White House isn’t just predicting the impending defeat of Canada’s Trudeau government: He’s celebrating it.

Prime Minister Justin Trudeau sounded an upbeat note Tuesday on the prospect of working with U.S. president-elect Donald Trump, saying Canada has dealt with his trade threats before and can do so again.

Les White Stripes ont abandonné leur plainte sur les droits d'auteur contre le président des États-Unis nouvellement réélu, Donald Trump.