This year's 12-nation Copa America was also postponed until 2021 on Tuesday, the South American Football Confederation (CONMEBOL) said.

If the Coronavirus goes on to postpone the Tokyo Olympics scheduled in July this year, it will hit yet another prominent sporting event after it delayed the Indian Premier League to April 15 from the scheduled March 29 start.

"Human lives take precedence over everything, including the staging of the Games." -- International Olympic Committee president Thomas Bach, announcing on Sunday that a postponement was under consideration.

IOC officials are studying a postponement, among other options, but they have said a decision would be "premature" four months from the scheduled start.

Japan has asked for a one-year postponement of the Tokyo 2020 Games over the global coronavirus pandemic, and the International Olympic Committee has agreed, the country's prime minister said Tuesday.

The Games were scheduled for July 24-August 9, but after telephone discussions between IOC president Thomas Bach and Japanese Prime Minister Shinzo Abe, a historic joint decision was taken for the first postponement of an Olympics in peacetime.

The deadly COVID-19 pandemic caused an unprecedented postponement as the International Olympic Committee (IOC), the Japanese government and the athletes world over agreed that Olympics in July-August this year could not have gone ahead in the present circumstances.

ISRO's GISAT-1, which weighs around 2,268 kgs, was slated to be the first Earth observation satellite to be placed in the Geosynchronous Transfer Orbit.

Bank Unions postpone 4 day strike on assurance of IBA on wage settlement

CarolinaCon, which was to be hosted in Charlotte at the Embassy Suites April 10th through the 11th, 2020, has been postponed due to COVID-19.

North Rhine-Westphalia is fDi's top large region for FDI Strategy, with the Basque Country topping the table for mid-sized regions and Ireland South East first among small regions. 

IOWA AgTech 2 week immersion program 24 August – 4 September.

THE Expo 2020 global trade fair, hosted by Dubai, has been postponed by a year due to the coronavirus outbreak and will be held from October 1, 2021, to March 31, 2022, the Paris-based organizer said

Come along to an interactive workshop when Alison Oldfield of Eversheds Sutherland and Paul Greatorex from 11 Kings Bench Walk Chambers will take a look at mediation as a route to settlement. When to use it, what’s involved and practical tips for ...

As part of the EU’s general clampdown on certain forms of aggressive tax planning, Directive 2011/16/EU (commonly known as DAC6) will soon require taxpayers and intermediaries across the EU to start reporting information in relation to certain...

With the coronavirus pandemic sweeping the planet and the governments of both wealthy and poorer nations overwhelmed by the demands of managing a response, the scheduling of this year’s critical UN Climate Summit is suddenly in doubt. COP26 (formally, the 26th annual Conference of the Parties of the UN Framework Convention on Climate Change) is […]

The post Is It Time to Postpone the 2020 Climate Summit? appeared first on Inter Press Service.

Swimmer Katsuhiro Matsumoto is headed back to the drawing board

[New Era] The trial of Affirmative Repositioning (AR) land activist Dimbulukeni 'Dee' Nauyoma has been postponed to 19 May this year.

The murder trial over human rights lawyers, Willy Kimani death had to be postponed when lawyer, Cliff Ombeta failed to pitch in court.

The ADB Sanitation Dialogue 2020, to be held on 29 June to 1 July 2020 in Manila, engages ADB's developing members and other development partners toward achieving Sustainable Development Goal 6.2 on sanitation for all.

The ADB Sanitation Dialogue 2020, to be held on 29 June to 1 July 2020 in Manila, engages ADB's developing members and other development partners toward achieving Sustainable Development Goal 6.2 on sanitation for all.

(Postponed) We will be holding Dentons' first Global Competition Summit on Friday 19 June at our London office. Please join us for a series of panel discussions, in which we will provide insights on key current themes and issues in competition law.

Potbelly Corp said on Friday it is unable to file its quarterly report with the U.S. SEC by the May 8 deadline due to the COVID-19 crisis, adding to the restaurant chain's pandemic-led woes.

Title: Menopause May Someday Disappear as Women Postpone Pregnancy: Study
Category: Health News
Created: 4/24/2020 12:00:00 AM
Last Editorial Review: 4/27/2020 12:00:00 AM

Nutrient acquisition is a central challenge for all organisms. For the fungal pathogen Candida albicans, utilization of amino acids has been shown to be critical for survival, immune evasion, and escape, while the importance of catabolism of host-derived proteins and peptides in vivo is less well understood. Stp1 and Stp2 are paralogous transcription factors (TFs) regulated by the Ssy1-Ptr3-Ssy5 (SPS) amino acid sensing system and have been proposed to have distinct, if uncertain, roles in protein and amino acid utilization. We show here that Stp1 is required for proper utilization of peptides but has no effect on amino acid catabolism. In contrast, Stp2 is critical for utilization of both carbon sources. Commensurate with this observation, we found that Stp1 controls a very limited set of genes, while Stp2 has a much more extensive regulon that is partly dependent on the Ssy1 amino acid sensor (amino acid uptake and catabolism) and partly Ssy1 independent (genes associated with filamentous growth, including the regulators UME6 and SFL2). The ssy1/ and stp2/ mutants showed reduced fitness in a gastrointestinal (GI) colonization model, yet induced greater damage to epithelial cells and macrophages in a manner that was highly dependent on the growth status of the fungal cells. Surprisingly, the stp1/ mutant was better able to colonize the gut but the mutation had no effect on host cell damage. Thus, proper protein and amino acid utilization are both required for normal host interaction and are controlled by an interrelated network that includes Stp1 and Stp2.

In the context of type 2 diabetes, the definition of therapeutic inertia should include the failure not only to intensify therapy, but also to deintensify treatment when appropriate and should be distinguished from appropriate inaction in cases justified by particular circumstances. Therapy should be intensified when glycemic control deteriorates to prevent long periods of hyperglycemia, which increase the risk of complications. Strategic plans to overcome therapeutic inertia must include actions focused on patients, prescribers, health systems, and payers. Therapeutic inertia affects the management of glycemia, hypertension, and lipid disorders, all of which increase the risk for cardiovascular diseases. Thus, multifactorial interventions that act on additional therapeutic goals beyond glycemia are needed.

ABSTRACTIntroduction:We evaluated a 2-way short message service (SMS) communication platform to improve continuation of pre-exposure prophylaxis (PrEP) for HIV prevention among Kenyan women who initiated PrEP within routine maternal child health (MCH) and family planning clinics.Methods:We adapted an existing SMS platform (Mobile WACh [mWACh]) to send PrEP-tailored, theory-based SMS and allow clients to communicate with a remote nurse. Women who did not have HIV and who were initiating PrEP at 2 MCH/family planning clinics in Kisumu County, Kenya, from February to October 2018, were offered enrollment into the mWACh-PrEP program; SMS communication was free. We evaluated acceptability, satisfaction, and implementation metrics. In a pre/postevaluation, we compared PrEP continuation at 1-month postinitiation among women who initiated PrEP in the period before (n=166) versus after mWACh-PrEP implementation, adjusting for baseline differences.Results:Of the 334 women who were screened for enrollment into the mWACh-PrEP program; 193 (58%) were eligible and of those, 190 (98%) accepted enrollment. Reasons for ineligibility (n=141) included no phone access (29%) and shared SIM cards (25%). Median age was 25 years (interquartile range=22–30), and 91% were MCH clients. Compared to women who initiated PrEP in the month before mWACh-PrEP implementation, women who enrolled in mWACh-PrEP were more likely to return for their first PrEP follow-up visit (40% vs. 53%; adjusted risk ratio [aRR]=1.26; 95% confidence interval [CI]= 1.06, 1.50; P=.008) and more likely to continue PrEP (22% vs. 43%; aRR=1.75; 95% CI=1.21, 2.55; P=.003). Among those who returned, 99% reported successful receipt of SMS through the mWACh-PrEP system and 94% reported that mWACh-PrEP helped them understand PrEP better. Concerns about PrEP use, how it works, and side effects accounted for the majority (80%) of issues raised by participants using SMS.Conclusions:Two-way SMS expanded support for PrEP and opportunities for dialogue beyond the clinic and enabled women to ask and receive answers in real time regarding PrEP, which facilitated its continued use.

OBJECTIVE

Debate continues regarding the influence of dietary fats and sugars on the risk of developing metabolic diseases, including insulin resistance and nonalcoholic fatty liver disease (NAFLD). We investigated the effect of two eucaloric diets, one enriched with saturated fat (SFA) and the other enriched with free sugars (SUGAR), on intrahepatic triacylglycerol (IHTAG) content, hepatic de novo lipogenesis (DNL), and whole-body postprandial metabolism in overweight males.

Childbirth at any age confers a transient increased risk for breast cancer in the first decade postpartum and this window of adverse effect extends over two decades in women with late-age first childbirth (>35 years of age). Crossover to the protective effect of pregnancy is dependent on age at first pregnancy, with young mothers receiving the most benefit. Furthermore, breast cancer diagnosis during the 5- to 10-year postpartum window associates with high risk for subsequent metastatic disease. Notably, lactation has been shown to be protective against breast cancer incidence overall, with varying degrees of protection by race, multiparity, and lifetime duration of lactation. An effect for lactation on breast cancer outcome after diagnosis has not been described. We discuss the most recent data and mechanistic insights underlying these epidemiologic findings. Postpartum involution of the breast has been identified as a key mediator of the increased risk for metastasis in women diagnosed within 5–10 years of a completed pregnancy. During breast involution, immune avoidance, increased lymphatic network, extracellular matrix remodeling, and increased seeding to the liver and lymph node work as interconnected pathways, leading to the adverse effect of a postpartum diagnosis. We al discuss a novel mechanism underlying the protective effect of breastfeeding. Collectively, these mechanistic insights offer potential therapeutic avenues for the prevention and/or improved treatment of postpartum breast cancer.

Getting married is one of life’s most memorable — and emotional — milestones in life. But with tight restrictions on gatherings due to COVID-19 pandemic, couples throughout Windsor and Essex County who had scheduled their weddings for this spring or summer have had little choice but to postpone their big day. “Weddings are an extremely […]

Anna Marie loses her mind as well as control of her mouth. Chris investigates the impacts of bringing Diet Coke into Mementos. Peter buys more games. Nathan finishes Final Fanatasy VIII just in time to start playing Final Fantasy VIII. And Kelley just tries to survive Bloodstained's framerate on the Switch.

1. Coronavirus Lockdown 3.0: Suspension of labour laws by fiat can only be an immediate-term response to the...  Firstpost
2. Odisha govt extends work shift to 12 hours  The Hindu
3. Now, Maharashtra tweaks labour laws to increase working hours  The Hindu
4. View Full coverage on Google News

(Pias)
Since his last outing, the south London musician and producer has eased up and moved to Margate. Yet this atmospheric return still carries the weight of the world

Ghostpoet – the brooding alias of south London-born Obaro Ejimiwe – is roughly a decade old this year. This dour bard has long been an artist ahead of his time. A track such as Cash and Carry Me Home, one of the highlights of his eclectic, jazz-inflected debut album – 2011’s Peanut Butter Blue and Melancholy Jam – defied genre as it mourned the self-inflicted pain of one drink too many. It now locates Ghostpoet as roughly adjacent to the south London jazz renaissance of the past few years – a multi-hyphenate scene in which most things go. Were it to be released today, its languorous, self-aware aperçus would find an even more receptive audience.

Victoria Cross recipient’s suit against Nine newspapers can’t be held until in-person hearings resume after coronavirus

The highly anticipated defamation trial brought by Victoria Cross recipient Ben Roberts-Smith against the Age and the Sydney Morning Herald will not go ahead next month after the federal court ruled a remote hearing under Covid-19 rules may breach national security.

The delay in the case came as justice Anthony Besanko said he had to consider whether to delay the trial despite a submission that Roberts-Smith and his family are suffering from the ongoing publication of articles by the Nine newspapers.

Hollywood star Johnny Depp's libel battle against The Sun newspaper has been postponed thanks to coronavirus as the actor is stuck in France and unable to fly to London.

The winner will be announced 'late summer', organisers say

Tottenham's stadium will be used as a hospital unit for expecting mothers during the coronavirus pandemic.

The final memorial service to honour those who died in the Hillsborough tragedy has been postponed due to the coronavirus pandemic.

Welcome to the Evening Standard's LIVE coverage as the coronavirus crisis continues to heavily impact sport across the globe.

The Women's 2021 European Championship in England will be delayed by a year and played from July 6 to 31, 2022, at the same venues as originally planned, UEFA has announced.