Questions surrounding Hillary Clinton and the Clinton Foundation continue to grow. On Sunday, Democratic National Committee interim chairperson Donna Brazile defended Clinton’s meetings as secretary of state with Clinton Foundation donors, saying, "When Republicans meet with their donors, with their supporters, their activists, they call it a meeting. When Democrats do that, they call it a conflict." Donna Brazile’s comments come in response to an Associated Press investigation revealing that while Hillary Clinton served as secretary of state, more than half of the private citizens she met with during the reporting period had donated to the Clinton Foundation. The AP investigation comes after a three-year battle to gain access to State Department calendars. The analysis shows that at least 85 of 154 people Hillary Clinton had scheduled phone or in-person meetings with were foundation donors. We speak to Pulitzer Prize-winning journalist Glenn Greenwald of The Intercept. His most recent piece is headlined "Why Did the Saudi Regime and Other Gulf Tyrannies Donate Millions to the Clinton Foundation?" Continue reading →

IBM today announced that as part of its Celebration of Service, designed to allow employees, retirees, clients and business partners to donate their time and expertise during the company's Centennial year, 300,000 IBMers around the world -- close to three quarters of its global workforce -- are volunteering in more than 5,000 projects in 120 countries, meeting civic and societal challenges and serving millions in need.

From an email from Paul Foster: From my perch, there are two primary reasons the right doesn’t more passionately oppose child abuse. The first has to do with parents’ rights. The general conservative view of the child welfare system is of a group of liberal ladies who think they know better than parents and who […]

The post Why is child abuse not opposed more passionately on the Right appeared first on Marginal REVOLUTION.

Crafters began making fabric masks when the public learned that COVID-19 was causing a major shortage of personal protective equipment. But since the CDC changed its recommendation on April 3 to urge that everyone wears a mask when leaving the house, sewing machines around the world have been working harder than ever. Here’s what you need to know if you plan to make fabric masks to wear or to donate.[...]

WASHINGTON (April 6, 2020) — Today, the U.S. Environmental Protection Agency (EPA) announced that it has identified approximately 225,000 pieces of personal protective equipment (PPE) available to support the COVID-19 response.

We're all in this together. It's far better for society if folks choose to help their fellow humans rather than rip the last roll of toilet paper from their hands.

As COVID-19 spreads across the United States, only a few areas are breaking down the numbers of infections and deaths by racial and ethnic groups.

A philanthropic group founded by Clippers owner Steve Ballmer and his wife says it has pledged more than $25 million toward the coronavirus outbreak.

Glenn Gould's "Solitude Trilogy" uses dialogue as though it were musical counterpoint and explores a kind of isolation familiar in our coronavirus era.

Author James Patterson is donating $500,000 to help indie bookstores across the country. For many L.A. booksellers, that could be a life saver.

England players have donated more than £1million to the NHS to help the continued fight against the coronavirus crisis.

2020-04-07 -

The cousin of Grace Millane, who was murdered in New Zealand, says she would have been "so proud".

In his first tweet the billionaire said 500,000 testing kits and one million masks were going to the US.

The internet is a scary enough place as it is, and now with the added misinformation and panic surrounding the coronavirus pandemic, it's even scarier. Thanks to the United Nations and dozens of artists, however, the internet just got a little more beautiful. 

In late March, the UN put a call out to artists to help combat the spread of COVID-19. They sought creatives to create content around six areas of WHO and UN priority actions: personal hygiene, social distancing, knowing the symptoms, spreading kindness, myth-busting, and doing more/donating. Tens of thousands of artists answered the call in two weeks, and now the COVID-19 Response Creative Content Hub is available for browsing.  Read more...

Essex County OPP have released a composite drawing of a suspect reported to be impersonating a police officer in Lakeshore.

Jorge H. Capdevila
Feb 1, 2000; 41:163-181
Reviews

Reactive oxygen and nitrogen species have been implicated in many biological processes and diseases, including immune responses, cardiovascular dysfunction, neurodegeneration, and cancer. These chemical species are short-lived in biological settings, and detecting them in these conditions and diseases requires the use of molecular probes that form stable, easily detectable, products. The chemical mechanisms and limitations of many of the currently used probes are not well-understood, hampering their effective applications. Boronates have emerged as a class of probes for the detection of nucleophilic two-electron oxidants. Here, we report the results of an oxygen-18–labeling MS study to identify the origin of oxygen atoms in the oxidation products of phenylboronate targeted to mitochondria. We demonstrate that boronate oxidation by hydrogen peroxide, peroxymonocarbonate, hypochlorite, or peroxynitrite involves the incorporation of oxygen atoms from these oxidants. We therefore conclude that boronates can be used as probes to track isotopically labeled oxidants. This suggests that the detection of specific products formed from these redox probes could enable precise identification of oxidants formed in biological systems. We discuss the implications of these results for understanding the mechanism of conversion of the boronate-based redox probes to oxidant-specific products.

As the pandemic ebbed in China, alumni from the region raised more than $2.1 million to send crucial protective gear to New York healthcare workers.

The Chicago Dental Society and its members donated thousands of personal protective equipment to front-line health care workers in response to the COVID-19 pandemic.

Wisconsin dentists have answered the call for personal protective equipment by organizing drives and donating their surplus supplies to hospitals and urgent care facilities treating patients with COVID-19.

Oregon Dental Association dentists, volunteers donate more than 600,000 pieces of PPE to help emergency relief efforts

Six million immigrant workers are at the frontlines of keeping U.S. residents healthy and fed during the COVID-19 pandemic, representing disproportionate shares of physicians, home health aides, and retail-store pharmacists, for example. They also are over-represented in sectors most immediately devastated by mass layoffs, yet many will have limited access to safety-net systems and to federal relief, as this fact sheet details.

WASHINGTON — Six million immigrant workers are at the frontlines of keeping U.S. residents healthy, safe and fed during the COVID-19 pandemic, according to a Migration Policy Institute (MPI) analysis of U.S. Census Bureau data issued today. While the foreign born represented 17 percent of the 156 million civilians working in 2018, they account for larger shares in pandemic-response frontline occupations: 29 percent of all physicians in the United States, 38 percent of home health aides and 23 percent of retail-store pharmacists, for example.

This year's November elections—a preview to next year's nationwide showdowns—cast their own spotlight on education, a dynamic that played out most prominently in the Kentucky governor's race, where teachers organized to unseat a combative incumbent who'd sparred with them.

The university’s Center for Vaccine Research is working to create a coronavirus vaccine.

This year's November elections—a preview to next year's nationwide showdowns—cast their own spotlight on education, a dynamic that played out most prominently in the Kentucky governor's race, where teachers organized to unseat a combative incumbent who'd sparred with them.

The donation comes as Flint city and school leaders continue to grapple with the fallout from a contaminated-water crisis that began in 2015. The filtration systems, which will be installed by January, should allow students to once again district students and staff to drink from and fill up water bo

Peter Klivenyi
Jan 1, 2000; 20:1-7
Cellular

FAO is working to help typhoon-affected farmers to ensure the next harvests in 2014 – You can help as well. Philippine farmers need urgent assistance  to avoid a double tragedy befalling rural survivors of Typhoon Haiyan. The typhoon hit just as farmers were beginning a new planting season, and FAO estimates that over one million farmers have been affected and hundreds of [...]

According to OPP, a man allegedly pulled over a woman on April 23 driving on Naylor Side Road near the intersection of North Talbot Road, while "wearing clothing resembling the uniform of a police officer."

As college campuses closed and the COVID-19 virus began casting a larger shadow in south central Pennsylvania, members of the nursing and physical therapist assistant programs at Penn State Mont Alto took stock of all the medical personal protection equipment (PPE) items in their labs. The two programs were supplied with hundreds of gloves and dozens of medical gowns and masks, plus other items such as disposable stethoscopes, shoe covers and safety glasses — items no longer needed as the campus transitioned to remote instruction.

The United Nations on Thursday issued a new appeal for $4.7 billion in funding to "protect millions of lives and stem the spread of coronavirus in fragile countries."

This year's November elections—a preview to next year's nationwide showdowns—cast their own spotlight on education, a dynamic that played out most prominently in the Kentucky governor's race, where teachers organized to unseat a combative incumbent who'd sparred with them.

Little is known about the pharmacokinetics and required dosage of metronidazole in preterm neonates.

In this study the pharmacokinetics of metronidazole in preterm neonates was investigated by measurement of the drug in dried blood-spot samples. A dosage regimen is proposed that should result in more appropriate, less frequent dosing in the most preterm neonates. (Read the full article)

The use of steroids as a treatment for patients with Duchenne muscular dystrophy results in a slower progression in weakness. Bisphosphonates often are used in conjunction with steroid therapy to enhance bone health.

The combination of steroids and bisphosphonates seems to be associated with significantly improved survival rates compared with treatment with steroids alone. (Read the full article)

Recent studies have called into question the benefit of perioperative corticosteroids in children undergoing heart surgery, but have been limited by small sample size, the lack of placebo control, and the grouping of various steroid regimens together in analysis.

We evaluated outcomes across methylprednisolone regimens versus no steroids in a large cohort of neonates and found no mortality or length-of-stay benefit associated with any regimen, and a higher risk of infection in certain subgroups. (Read the full article)

The very preterm neonate is more susceptible to bacterial infection; this is thought to be due to immaturity of the innate immune response.

Monocytes have an anti-inflammatory profile at birth and are hyporesponsive to inflammatory stimuli in fetuses born very prematurely. This reflects the response to the pro-inflammatory events leading to preterm birth as well as gestational immaturity. (Read the full article)

High or low lymphocyte counts at birth have been reported as a marker for subsequent intraventricular hemorrhage, retinopathy of prematurity, and periventricular leukomalacia. However, this conclusion is questionable because reference ranges for lymphocyte counts have not been constructed by using large numbers of neonates.

This study provides reference ranges for lymphocytes of neonates. A high count at birth is associated with early onset sepsis and IVH and a low count with early onset sepsis, IVH, and retinopathy of prematurity. Among neonates with birth asphyxia, a low count identifies a high risk for death. (Read the full article)

Neonatal hyperbilirubinemia may progress to bilirubin encephalopathy. Findings from previous studies on long-term development of neonatal hyperbilirubinemia are conflicting.

Using Ages and Stages Questionnaire, we observed no association between bilirubin exposure and overall development in 1- to 5-year-old children who in the neonatal period had total serum bilirubin level ≥25 mg/dL and no or only minor neurologic symptoms. (Read the full article)

Although the natural course of bilirubin levels has been extensively studied in general neonatal populations, there is a paucity of data regarding bilirubin trends in neonates before the development of significant hyperbilirubinemia.

This study provides data on the natural course of transcutaneous bilirubin before the development of significant hyperbilirubinemia, and on the effect of different demographic and perinatal risk factors on the rate of bilirubin increase in neonates with borderline bilirubin values. (Read the full article)

Heated, humidified high-flow nasal cannula (HHHFNC) is a noninvasive mode of respiratory support that is commonly used in the majority of US NICUs. No large randomized trial has evaluated safety or efficacy of HHHFNC.

This large randomized controlled trial suggests that HHHFNC is as effective as nCPAP for noninvasive respiratory support and can be safely applied to a wide range of neonates. (Read the full article)

Extremely preterm infants are at high risk of neonatal mortality or morbidities. Existing prediction models focus on mortality, specific morbidities, or composite mortality and morbidity outcomes and ignore differences in outcome severity.

A simple and practical statistical model was developed that can be applied on the first day after NICU admission to predict outcome severity spanning from no morbidity to mortality. The model is highly discriminative (C-statistic = 90%) and internally valid. (Read the full article)

Peripherally inserted central catheters (PICCs) are essential to deliver life-saving treatment to neonates. Longer PICC dwell times may increase the risk of central line–associated bloodstream infections (CLABSIs) in neonates, but previous studies have yielded inconsistent results, likely due to different study designs, analytic methods, and small sample sizes.

The risk of CLABSIs increases during the 2 weeks after PICC insertion and remains elevated for the catheter duration. These data support daily review of PICC necessity, optimization of catheter maintenance practices, and consideration of novel strategies to prevent CLABSIs. (Read the full article)