Lockheed Martin recently claimed to have designed a fusion reactor that can fit on the back of a truck. If viable, it really could change the world.

A new study finds the area around the former Fukushima power plant teeming with life.

If there ever were a super-tall public sculpture begging for a tunnel slide ....

A surprising aerodynamic innovation in wind turbine design called the 'wind lens' triples the output of a typical wind turbine, making it less costly than nucle

Earthquake in Japan raises concerns about what could happen in the U.S.

One year after Japan's Fukushima crisis began, the U.S. nuclear chief says American reactors should adopt safety reforms more quickly.

A recent study led by European researchers found Fukushima is not alone, as 22 other plants around the world may be similarly susceptible to destructive tsunami

An eye-opening photo essay documents the haunting towns that were forcibly abandoned following the 2011 Fukushima Daiichi nuclear disaster.

American chemists are searching for new and resourceful ways to extract uranium from deposit-rich oceans in order to reduce the expensive mining process's cost.

Elon Musk says nuclear detonations on the red planet offer the quickest path to making it habitable. But what other options are there?

Woodland hawks, attracted by the songbirds that love backyard feeders, are thriving in cities.

After World War II, a government program called Atoms for Peace aimed to find a peaceful use for nuclear power. And thus, the atomic garden was born.

Banks won't touch them they are so financially risky. So why does Obama want U.S. taxpayers to fund nuclear plants when there is a 50% chance they will fail?

Experts argue that the downsized power sources can provide safe, efficient energy.

They don't have a queen or any larvae, but these resilient insects are still trying to eke out an existence.

A $2.5 billion investment in a renewable energy hub will bring about 2/3 of the power that the nuclear plant once did.

With renewed momentum but no plans to store its waste, American nuclear energy sits in limbo.

Zeke Wilson of Mills, PA was named Man of the Year by the Bare Knuckle Boxing Hall of Fame on July 13, 2013 as part of the annual Induction Weekend festivities.

The World cannot wait for 30 years to have fusion clean energy, so that PULSOTRON "B" plan is designed to reach ignition in less than 3 years that is by far the fastest way as it was demonstrated by certify ignition in 2013

The Mesothelioma Compensation Center is offering to make certain a coal, natural gas, or nuclear power worker with mesothelioma has on-the-spot access to attorney Erik Karst of Karst von Oiste-one of the nation's most skilled mesothelioma lawyers.

How The Answer Company Supports Local Communities

Named Remodeler of the Month by Qualified Remodelers in 2019, Mr. Pagnucco is the founder of the 19-year-old IHS Building Corporation

Margaret Parker, MD, MCCM, speaks with George P. Liao, MD and Charles S. Cox, MD

The Global Times is published by the People's Daily, the official newspaper of China's ruling Communist Party. The party has been known to float ideas and guide public sentiments via the Global Times, which tends to take a nationalistic stance on issues involving other countries.

In recent years, a large class of nuclear $C^ast$-algebras have been classified, modulo an assumption on the Universal Coefficient Theorem (UCT). We think this assumption is redundant and propose a strategy for proving it. Indeed, following the original proof of the classification theorem, we propose bridging the gap between reduction theorems and examples. While many such bridges are possible, various approximate ideal structures appear quite promising.

We present a simple introduction to the decision tree algorithm using some examples from nuclear physics. We show how to improve the accuracy of the classical liquid drop nuclear mass model by performing Feature Engineering with a decision tree. Finally, we apply the method to the Duflo-Zuker model showing that, despite their simplicity, decision trees are capable of improving the description of nuclear masses using a limited number of free parameters.

By Lauren McCauley Common Dreams In landmark agreement, California’s last remaining nuclear plant will be replaced by greenhouse-gas-free energy sources A plan to shutter the last remaining nuclear power plant in California and replace it with renewable energy is being … Continue reading →

The invention relates to a process for the preparation of oligonucleotides by the following steps: reaction of a nucleoside with a phosphine derivative, reaction of the nucleotide derivative thus obtained with a nucleoside bonded to a polymeric carrier, oxidation of the carrier-bound nucleoside-nucleotide thus obtained with formation of phosphotriester groups, blocking of free primary 5'--OH groups, elimination of a protective group from the terminal 5'--OH group, where appropriate single or multiple repetition of the abovementioned steps to introduce further nucleoside phosphate or oligonucleoside phosphate units, and cleavage of the nucleoside-carrier bond and, where appropriate, elimination of all protective groups present in the oligonucleoside phosphates. The phosphine derivative used is a compound of the general formula III ##STR1## in which X and L can react with OH groups of the sugar units in the oligonucleotides, and R3 is a protective group which can be liberated by β-elimination.

Methods and a kit. A cement forming method includes nucleating an acidic metallophosphate reaction mixture with first particles, resulting in forming a settable metallophosphate cement from the acidic metallophosphate reaction mixture. The first particles include a first metal oxide. Each particle of the first particles independently have a particle size in a range from about 15 microns to about 450 microns. A method for applying cement includes seeding a solution with particles, resulting in forming a settable cement from the solution. The particles have a size in a range from about 15 microns to about 450 microns. The solution includes a first metal oxide reacting with phosphate. The settable cement is applied to a substrate. A cement application kit is also described.

The instant invention provides for novel cationic lipids that can be used in combination with other lipid components such as cholesterol and PEG-lipids to form lipid nanoparticles with oligonucleotides. It is an object of the instant invention to provide a cationic lipid scaffold that demonstrates enhanced efficacy along with lower liver toxicity as a result of lower lipid levels in the liver. The present invention employs low molecular weight cationic lipids with one short lipid chain to enhance the efficiency and tolerability of in vivo delivery of siRNA.

A method of disposing nuclear waste in underground rock formations is presented. The method includes the steps of selecting a land area having a rock formation positioned there-below of a depth able to prevent radioactive material placed therein from reaching the surface and drilling a vertical wellbore from the surface, to a depth ranging between 5,000 feet and 25,000 feet, into the underground rock formation or repository. A plurality of horizontal laterals or horizontal wellbores, ranging in length from 500 feet to 40,000 feet, are drilled from the vertical wellbore into the underground rock formation or repository. Nuclear waste to be stored within these laterals is encapsulated in a special waste canister and these nuclear waste canisters are positioned within the horizontal laterals wherein they are sealed to prevent loss and leakage. Means are also provided by which these canisters are adapted to allow retrievability of the canisters from the wellbore at a later date and to return the waste to the surface for use after retrieval.

Methods of capturing and immobilizing radioactive nuclei with metal fluorite-based inorganic materials are described. For example, a method of capturing and immobilizing radioactive nuclei includes flowing a gas stream through an exhaust apparatus. The exhaust apparatus includes a metal fluorite-based inorganic material. The gas stream includes a radioactive species. The radioactive species is removed from the gas stream by adsorbing the radioactive species to the metal fluorite-based inorganic material of the exhaust apparatus.

A method and device for limiting the degassing of tritiated waste issued from the nuclear industry are provided. The method reduces an amount of generated tritiated hydrogen (T2 or HT) and/or tritiated water (HTO or T2O) including at least one piece of tritiated waste from the nuclear industry. The method includes placing the package in contact with a mixture including manganese dioxide (MnO2) combined with a component that includes silver; and placing the package in contact with a molecular sieve.

The disclosure relates to methods of making polymer particles, said methods including the steps of: making an aqueous gel reaction mixture; forming an emulsion having dispersed aqueous phase micelles of gel reaction mixture in a continuous phase; adding an initiator oil comprising at least one polymerization initiator to the continuous phase; and performing a polymerization reaction in the micelles. Further, the initiator oil is present in a volume % relative to a volume of the aqueous gel reaction mixture of between about 1 vol % to about 20 vol %. The disclosure also relates to methods of making nucleic acid polymer particles having the same method steps and wherein the aqueous gel reaction mixture includes a nucleic acid fragment, such as a primer.

A method for producing a phenylphosphonic acid metal salt composition, including reacting a phenylphosphonic acid compound (a) with a metal salt, metal oxide or metal hydroxide (b) that is present in an amount beyond the equivalent, the phenylphosphonic acid metal salt composition containing phenylphosphonic acid metal salt, and a surplus amount of the metal salt, the metal oxide or the surplus metal hydroxide (b). A crystal nucleating agent comprises the phenylphosphonic acid metal salt composition produced by the method.

The present invention concerns a TCTP antagonist, in particular a nucleic acid targeting an m RNA encoding Translationally-Controlled Tumor Protein (TCTP), wherein said nucleic acid is capable of reducing the amount of TCTP in cells, for use in the treatment or prevention of hormone-independent cancer or chemo-resistant cancer, such as an androgen-independent prostate cancer.

The invention describes new structures of the nucleotide conjugates (nuc-macromolecules) comprising at lease one nucleotide moiety coupled to at least one macromolecular compound via a short linker. These conjugates can be used as substrates for various kinds of polymerizing enzymes in the enzymatic synthesis of nucleic acids. In particular, these compounds can be used for labeling nucleic acids.

The present invention is related to an L nucleic acid that binds to an SDF-1.

An antisense molecule capable of binding to a selected target site to induce exon skipping in the dystrophin gene, as set forth in SEQ ID NO: 1 to 202.

This invention relates to a process for preparing an oligonucleotide 5'-triphosphate. The process comprises the steps of: (a) synthesizing an oligonucleotide having a 5' hydroxyl moiety; (b) reacting the 5' hydroxyl moiety with a reagent of formula I: to convert the 5' hydroxyl moiety to a 5'-H-phosphonate, wherein R1 and R2 are each independently selected from the group consisting of haloalkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, cycloalkyl, substituted cycloalkyl, heterocycle, and substituted heterocycle, acyl, phosphoryl, substituted alkyl acyl, substituted heteroalkyl acyl, substituted aryl acyl or substituted heteroaryl acyl, substituted alkyl phosphoryl, substituted heteroalkyl acyl, substituted aryl phosphoryl, and substituted heteroaryl phosphoryl; (c) activating the H-phosphonate of step (b) by reacting the H-phosphonate with a silylating agent, a halogenated oxidizing agent, a nitrogen-containing heteroaryl, or a combination thereof, to form an activated H-phosphonate; and (d) treating the oligonucleotide having an activated H-phosphonate from step (c) with a poly(alkylammonium)pyrophosphate.

The invention refers to polynucleotides selected from the group consisting of a) polynucleotides encoding for the polypeptide RBM20 comprising a P638L mutation for a human polypeptide RBM20, or a P641L mutation for a rat polypeptide RBM20, b) polynucleotides with a reverse complementary sequence of the polynucleotide of a) above, and c) polynucleotides with an identity at least 50% to a polynucleotide of a) or b) above.

The present disclosure provides reagents that can be used to label synthetic oligonucleotides with rhodamine dyes or dye networks that contain rhodamine dyes.

The present disclosure generally relates to dry solid matrices for the extraction, stabilization, and storage of nucleic acids, particularly RNA, in a dry format under ambient conditions for a prolonged period of time. Methods for collecting and recovering the nucleic acids stored in the dry solid matrix are also described.

A solid matrix for the extraction, stabilization, and storage of nucleic acids is provided. At least one protein denaturant, and at least one acid or acid-titrated buffer reagent are impregnated in a dry state therein the matrix; and the matrix is configured to provide an acidic pH on hydration. The matrix is configured to extract nucleic acids from a sample and stabilize the extracted nucleic acids, particularly RNA, in a dry format under ambient conditions for a prolonged period of time. Methods for collecting and recovering the nucleic acids stored in the dry solid matrix are also described.

The present disclosure generally relates to solid matrices for the extraction, stabilization, and storage of nucleic acids, particularly RNA, in a dry format under ambient conditions for a prolonged period of time. Methods for extracting, collecting, and recovering nucleic acids from the solid compositions are also described.

The instant invention provides for novel cationic lipids that can be used in combination with other lipid components such as cholesterol and PEG-lipids to form lipid nanoparticles with oligonucleotides. It is an object of the instant invention to provide a cationic lipid scaffold that demonstrates enhanced efficacy along with lower liver toxicity as a result of lower lipid levels in the liver. The present invention employs low molecular weight cationic lipids comprising at least one short lipid chain to enhance the efficiency and tolerability of in vivo delivery of siRNA.

The present invention relates to the field of organic chemistry and in particular to organic free radicals used as polarizing agents in the technique of Dynamic Nuclear Polarization (DNP), which involves transferring the polarization of electron spins to the nuclei of a compound whose Nuclear Magnetic Resonance (NMR) is being observed. It concerns Dinitroxide-type Biradical polarizing agents characterized by a rigid linkage between the aminoxyl groups of said nitroxide units. This particular structure enables, at low temperatures and high fields, optimal transfer of polarization and optimal enhancement of NMR/MAS signals of the polarized nuclei of the compound studied.

The present invention generally relates to use of compounds and compositions as a chemosensitizers and/or radiosensitizers and/or inhibitors of PNKP phosphatase activity. The present invention provides pharmaceutical combinations and/or a pharmaceutically acceptable salt thereof, kits containing such compounds and/composition and methods of using such compounds and/or compositions.

The invention encompasses devices and methods for treating one or more damaged, diseased, or traumatized intervertebral discs to reduce or eliminate associated back pain. Specifically, the invention encompasses intervertebral nucleus and annulus implants that are resistant to migration in and/or expulsion from an intervertebral disc space. The invention further encompasses kits including the implantable devices of the invention and associated delivery tools to treat annular and nuclear tissue.

A universal linker structure is provided, in which a functional group and activating leaving group are placed on a tether, allowing the placement of an electrophile at the end of any nucleic acid sequence. The electrophile on the tether can react with a second nucleic acid carrying a nucleophile when the two nucleic acids are hybridized near one another, resulting in release of the leaving group, and creation of a functional change. The linker can be designed to destabilize the ligation product without slowing the rate of reaction. This lowers product inhibition, and the target DNA or RNA can become a catalyst for isothermally generating multiple signals for detection. This enhanced signal is demonstrated in solution experiments and in solid supported assays. The universal linkers of the present invention are simple and inexpensive to prepare, and can be appended to any polynucleotide in automated steps on a standard DNA synthesizer.