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Oligonucleotide and use thereof

Provided is an oligonucleotide containing an azobenzene derivative, represented by Formula (1) or (2) below: (in the formulae, A1 and A2 each independently represent a hydrogen atom, nucleotide or oligonucleotide, B1 and B2 each independently represent a hydroxyl group, nucleotide or oligonucleotide, R11 and R12 each independently represent a C1-20 alkyl group, R21 and R22 each independently represent a hydrogen atom or C1-20 alkyl group, and R13 to R18 and R23 to R28 each independently represent a hydrogen atom; a C1-20 alkyl group or alkoxy group optionally substituted with a halogen atom, hydroxyl group, amino group, nitro group or carboxyl group; a C2-20 alkenyl group or alkynyl group optionally substituted with a halogen atom, hydroxyl group, amino group, nitro group or carboxyl group; a hydroxyl group; a halogen atom; an amino group; a nitro group; or a carboxyl group).




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Nuclear fuel reprocessing

A spent fuel reprocessing method including the steps of partitioning U and Pu(III) in a solvent by solvent extraction and subsequently polishing the solvent in a neptunium rejection operation for removing Np therefrom. The solvent obtained from the neptunium rejection operation (the polished solvent or NpA solvent product) is then recycled to a U/Pu partitioning operation. The method enables a reduction in solvent feed and solvent effluent volumes.




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Method for dissolving plutonium or a plutonium alloy and converting it into nuclear fuel

The present invention relates to a process to dissolve plutonium or a plutonium alloy, by placing it in contact with an aqueous dissolution mixture, wherein said dissolution mixture comprises nitric acid, a carboxylic acid with complexing properties with respect to plutonium, and a compound comprising at least one —NH2 radical such as urea. The invention also relates to a process to convert plutonium or a plutonium alloy into plutonium oxide and to manufacture nuclear fuel from said oxide.The invention particularly applies to the dismantling of plutonium contained in nuclear weapons with a view to its use in civilian nuclear reactors, particularly in the form of MOX fuel.




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Pyrochemical reprocessing method for spent nuclear fuel and induction heating system to be used in pyrochemical reprocessing method

This invention is provided for improvement of corrosion-resistant property of a crucible and for promotion of safety in a pyrochemical reprocessing method for the spent nuclear fuel. The spent nuclear fuel is dissolved in a molten salt placed in the crucible. In a pyrochemical reprocessing method, the nuclear fuel is deposited, and the crucible (2) is heated by induction heating. Cooling media (5, 6) are supplied to cool down, and a molten salt layer (7) is maintained by keeping balance between the heating and the cooling, and a solidified salt layer (8) is formed on inner wall surface of the crucible.




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Method of separating uranium from irradiated nuclear fuel

The invention provides a method of separating uranium from at least fission products in irradiated nuclear fuel, said method comprising reacting said irradiated nuclear fuel with a solution of ammonium fluoride in hydrogen fluoride fluorinating said reacted irradiated nuclear fuel to form a volatile uranium fluoride compound and separating said volatile uranium fluoride compound from involatile fission products. The invention thus provides a reprocessing scheme for irradiated nuclear fuel. The method is also capable of reacting, and breaking down Zircaloy cladding and stainless steel assembly components. Thus, whole fuel elements may be dissolved as one thereby simplifying procedures over conventional Purex processes.




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Vol-oxidizer for spent nuclear fuel

A vol-oxidizer of spent nuclear fuel, the spent nuclear fuel is injected to a reaction portion, the reaction portion is connected to a driving portion and oxidizes the spent nuclear fuel by rotating and back-rotating the spent nuclear fuel. The oxidized powder of the spent nuclear fuel is gathered in a discharge portion located in a lower portion of the reaction portion. By providing minute powder particles for recycling and a post process of the spent nuclear fuel, even though a size of an apparatus is small, processing a large amount is possible. Time required for oxidation can be reduced, and the powder is readily discharged by gravity since the apparatus is vertically configured.




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Separation and receiving device for spent nuclear fuel rods

Disclosed is a separation and receiving apparatus for a spent nuclear fuel rod. The spent nuclear fuel rod is mounted and downwardly transferred by a pin. At this time, a blade peels the hull of the spent nuclear fuel rod. The hull and a pellet positioned therein are separated by a separator. The peeled hull and pellet are each received in respective receiving vessels. Accordingly, since the hull and pellet made of uranium oxide (UO2) may be automatically separated and received in each respective vessel, safety and automation may be guaranteed.




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Nuclear fuel cell repair tool

A method of repairing a nuclear fuel cell wall and tools useful for performing that repair are described. A repair tool may be used to align a jack near a region of a bent or distorted structural component of nuclear fuel cell and that jack may be used to apply a force to that structural component. Application of such a force may serve to bend the structural component of a nuclear fuel cell in a way to restore the structural component to its position before damage occurred. The repair tool includes a way of mounting that tool to a fuel cell, positioning elements to align the tool near a structural deformation or bent element and a jack that may be use to apply a force to at least one structural component in a fuel cell.




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Nuclear fission reactor, a vented nuclear fission fuel module, methods therefor and a vented nuclear fission fuel module system

Illustrative embodiments provide a nuclear fission reactor, a vented nuclear fission fuel module, methods therefor and a vented nuclear fission fuel module system.




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Compositions and methods for treating nuclear fuel

Compositions are provided that include nuclear fuel. Methods for treating nuclear fuel are provided which can include exposing the fuel to a carbonate-peroxide solution. Methods can also include exposing the fuel to an ammonium solution. Methods for acquiring molybdenum from a uranium comprising material are provided.




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Method for designing a fuel assembly optimized as a function of the stresses in use in light-water nuclear reactors, and resulting fuel assembly

A method for design of a fuel assembly for nuclear reactors, including structural components made from zirconium alloy: the mean uniaxial tensile or compressive stress to which the components are subjected during the assembly life is calculated, the zirconium alloy of which the components are made is selected according to the following criteria: those components subjected to an axial or transverse compressive stress of between −10 et −20 MPa are made from an alloy with a content of Sn between Sn=(=0.025σ−0.25)% and Sn=−0.05σ%: those components subjected to such a stress of between 0 et −10 MPa are made from an alloy the Sn content of which is between Sn=traces and Sn=(0.05σ+1)%: those components subjected to such a stress of between 0 and +10 MPa are made from an alloy the Sn content of which is between Sn=0.05% and Sn=(0.07σ+1)%: and those components subjected to such a stress of between +10 and +20 MPa are made from an alloy the content of SN of which is between 0.05% and 1.70%. A fuel assembly made according to the method.




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Compositions and methods for treating nuclear fuel

Compositions are provided that include nuclear fuel. Methods for treating nuclear fuel are provided which can include exposing the fuel to a carbonate-peroxide solution. Methods can also include exposing the fuel to an ammonium solution. Methods for acquiring molybdenum from a uranium comprising material are provided.




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Storage rack arrangement for the storage of nuclear fuel elements

A storage rack arrangement (10) for the storage of nuclear fuel elements in a storage pool includes at least two storage racks (1.1-1.3) which each contain a plurality of vertical channels (9) arranged next to one another for the reception of the fuel elements, with positioning elements (6) being provided at the storage racks at the bottom. The storage racks are connected to one another at the top and the storage rack arrangement (10) additionally includes one or more base plates (2.1-2.3) which are provided with positioning members (8) which fit with the positioning elements (6) of the storage racks (1.1-1.3) and which, together with the positioning elements, position the storage racks with respect to the base plate or base plates (2.1-2.3) to prevent a displacement of the storage racks on the base plate or plates.




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Nuclear fission reactor, a vented nuclear fission fuel module, methods therefor and a vented nuclear fission fuel module system

Illustrative embodiments provide a nuclear fission reactor, a vented nuclear fission fuel module, methods therefor and a vented nuclear fission fuel module system.




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Method for measuring the neutron flux in the core of a nuclear reactor using a cobalt detector and associated device

A method for measuring the neutron flux in the core of a nuclear reactor, the method including several steps recurrently performed at instants separated by a period, the method comprising at each given instant the following steps: acquiring a total signal by a cobalt neutron detector placed inside the core of the reactor; assessing a calibration factor representative of the delayed component of the total signal due to the presence of cobalt 60 in the neutron detector; assessing a corrected signal representative of the neutron flux at the detector from the total signal and from the calibration factor; assessing a slope representative of the time-dependent change of the calibration factor between the preceding instant and the given instant; the calibration factor at the given instant being assessed as a function of the calibration factor assessed at the preceding instant, of the slope, and of the time period separating the given instant from the preceding instant.




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Nuclear fission reactor, vented nuclear fission fuel module, methods therefor and a vented nuclear fission fuel module system

Disclosed embodiments include methods of assembling a vented nuclear fission fuel module. Given by way of non-limiting example and not of limitation, an illustrative method of assembling a vented nuclear fission fuel module includes receiving a nuclear fission fuel element capable of generating a gaseous fission product. A valve body is coupled to the nuclear fission fuel element, and the valve body defines a plenum therein for receiving the gaseous fission product. A valve is disposed in communication with the plenum for controllably venting the gaseous fission product from the plenum. A flexible diaphragm is coupled to the valve for moving the valve. A cap is mounted on the valve, and a manipulator extendable to the cap for manipulating the cap is received.




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Perpendicular magnetic recording disk with multiple magnetic layers and intermediate dual nucleation films for control of grain size

A perpendicular magnetic recording disk has a graded-anisotropy recording layer (RL) formed of at least two ferromagnetically exchange coupled CoPtCr-oxide magnetic layers (MAG1 and MAG2) with two nucleation films (NF1 and NF2) between the magnetic layers. NF1 is a metal film, preferably Ru or a Ru-based alloy like RuCr, sputter deposited on MAG1 at low pressure to a thickness between about 0.1-1.5 nm. NF2 is a metal oxide film, preferably an oxide of Ta, sputter deposited on NF1 at high pressure to a thickness between about 0.2-1.0 nm. MAG2 is sputter deposited over NF2. NF1 and NF2 provide a significant reduction in average grain size in the RL from a graded-anisotropy RL without nucleation films between MAG1 and MAG2, while also assuring that MAG1 and MAG2 are strongly exchange coupled.




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Recombinant DNA constructs encoding ribonuclease cleavage blockers and methods for modulating expression of a target gene

This invention provides recombinant DNA constructs and methods for manipulating expression of a target gene that is regulated by a small RNA, by interfering with the binding of the small RNA to its target gene. More specifically, this invention discloses recombinant DNA constructs encoding cleavage blockers, 5-modified cleavage blockers, and translational inhibitors useful for modulating expression of a target gene and methods for their use. Further disclosed are miRNA targets useful for designing recombinant DNA constructs including miRNA-unresponsive transgenes, miRNA decoys, cleavage blockers, 5-modified cleavage blockers, and translational inhibitors, as well as methods for their use, and transgenic eukaryotic cells and organisms containing such constructs.




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Chimeric T1R taste receptor polypeptides and nucleic acid sequences encoding and cell lines that express said chimeric T1R polypeptides

The invention relates to compounds that specifically bind a T1R1/T1R3 or T1R2/T1R3 receptor or fragments or sub-units thereof. The present invention also relates to the use of hetero-oligomeric and chimeric taste receptors comprising T1R1/T1R3 and T1R2/T1R3 in assays to identify compounds that respectively respond to umami taste stimuli and sweet taste stimuli. Further, the invention relates to the constitutive of cell lines that stably or transiently co-express a combination of T1R1 and T1R3; or T1R2 and T1R3; under constitutive or inducible conditions. The use of these cells lines in cell-based assays to identify umami and sweet taste modulatory compounds is also provided, particularly high throughput screening assays that detect receptor activity by use of fluorometric imaging.




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Method of determining the nucleotide sequence of oligonucleotides and DNA molecules

The present invention relates to a novel method for analyzing nucleic acid sequences based on real-time detection of DNA polymerase-catalyzed incorporation of each of the four nucleotide bases, supplied individually and serially in a microfluidic system, to a reaction cell containing a template system comprising a DNA fragment of unknown sequence and an oligonucleotide primer. Incorporation of a nucleotide base into the template system can be detected by any of a variety of methods including but not limited to fluorescence and chemiluminescence detection. Alternatively, microcalorimetic detection of the heat generated by the incorporation of a nucleotide into the extending template system using thermopile, thermistor and refractive index measurements can be used to detect extension reactions.




nuc

Method for detecting the presence of a nucleic acid in a sample

An automated method for detecting the presence of a nucleic acid in a sample, where the method is performed within a housing of a self-contained, stand-alone analyzer. The method includes purifying the nucleic acid after it has been immobilized on a magnetically-responsive solid support. A pipette of the analyzer is used to form a reaction mixture comprising the purified nucleic acid and all reagents required to perform a nucleic acid amplification. Amplification products are synthesized that include a nucleotide sequence contained in the nucleic acid or the complement of the nucleic acid. The amplification products are exposed to a probe in a mixture, where the probe forms a hybrid with one of the amplification products. The formation of the hybrid in the mixture provides an indication of the presence of the nucleic acid in the sample.




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Mutant receptors and their use in a nuclear receptor-based inducible gene expression system

This invention relates to the field of biotechnology or genetic engineering. Specifically, this invention relates to the field of gene expression. More specifically, this invention relates to novel substitution mutant receptors and their use in a nuclear receptor-based inducible gene expression system and methods of modulating the expression of a gene in a host cell for applications such as gene therapy, large scale production of proteins and antibodies, cell-based high throughput screening assays, functional genomics and regulation of traits in transgenic organisms.




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Deposition of integrated protective material into zirconium cladding for nuclear reactors by high-velocity thermal application

A zirconium alloy nuclear reactor cylindrical cladding has an inner Zr substrate surface (10), an outer volume of protective material (22), and an integrated middle volume (20) of zirconium oxide, zirconium and protective material, where the protective material is applied by impaction at a velocity greater than 340 meters/second to provide the integrated middle volume (20) resulting in structural integrity for the cladding.




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Integral helical coil pressurized water nuclear reactor

An integral pressurized water nuclear reactor for the production of steam utilizing a helical coil steam generator, a plurality of internal circulation pumps, and an internal control rod drive mechanism structure.




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Nuclear power plant using nanoparticles in emergency systems and related method

A nuclear power plant with an improved cooling system using nanoparticles in solid or fluid form is provided. The nanoparticles are delivered in locations such as the cold leg accumulator and high and low pressure pumps of an emergency core cooling system. Motor driven valves and pressurization can aid in the delivery. Methods for providing the nanoparticles are also provided.




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Apparatus, method and program for monitoring nuclear thermal hydraulic stability of nuclear reactor

An apparatus for monitoring nuclear thermal hydraulic stability of a nuclear reactor, contains: a calculation unit configured to calculate a stability index of a nuclear thermal hydraulic phenomenon based on nuclear instrumentation signals, the signals being outputted by a plurality of nuclear instrumentation detectors placed at regular intervals in a reactor core; a simulation unit configured to simulate the nuclear thermal hydraulic phenomenon based on a physical model by using information on an operating state of the nuclear reactor as an input condition; a limit value updating unit configured to update a limit value of the nuclear thermal hydraulic phenomenon based on a result of the simulation; and a determination unit configured to determine, based on the stability index and the limit value, whether or not to activate a power oscillation suppressing device.




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***WITHDRAWN PATENT AS PER THE LATEST USPTO WITHDRAWN LIST***Compact nuclear reactor

A pressurized water nuclear reactor (PWR) includes a once through steam generator (OTSG) disposed in a generally cylindrical pressure vessel and a divider plate spaced apart from the open end of a central riser. A sealing portion of the pressure vessel and the divider plate define an integral pressurizer volume that is separated by the divider plate from the remaining interior volume of the pressure vessel. An internal control rod drive mechanism (CRDM) has all mechanical and electromagnetomotive components including at least a motor and a lead screw disposed inside the pressure vessel. Optionally CRDM units are staggered at two or more different levels such that no two neighboring CRDM units are at the same level. Internal primary coolant pumps have all mechanical and electromagnetomotive components including at least a motor and at least one impeller disposed inside the pressure vessel. Optionally, the pumps and/or CRDM are arranged below the OTSG.




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Uranium dioxide nuclear fuel containing Mn and Al as additives and method of fabricating the same

UO2 nuclear fuel pellets are fabricated by adding additive powder comprising Mn compound and Al compound into UO2 powder.




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Lid frame for nuclear fuel assembly shipping container and shipping container for nuclear fuel assemblies

A lid frame for a nuclear fuel assembly shipping container and a shipping container for nuclear fuel assemblies are provided. The shipping container can include a lower container in which a cradle is installed, an upper container detachably coupled to the lower container, and a base frame coupled to the cradle with at least one nuclear fuel assembly placed thereon. The lid frame can include a plurality of supports installed apart from each other so as to surround the nuclear fuel assembly placed on the base frame, and a plurality of clamps separated from each other, coupled to the plurality of supports perpendicular to the plurality of supports, rotatably hinged to the base frame, and configured to clamp the nuclear fuel assembly. The lid frame safely protects the nuclear fuel assembly that is being transported.




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Chemistry probe assemblies and methods of using the same in nuclear reactors

Electrochemical corrosion potential (ECP) probe assemblies may be used to monitor ECP of materials due to coolant chemistry in an operating nuclear reactor. Example embodiment assemblies include at least one ECP probe that detects ECP of potentially several different materials, a structural body providing a fluid flow path for the coolant over the ECP probes, and a signal transmitter that transmits or carries ECP data to an external receiver. The ECP probes may be of any number and/or type, so as to detect ECP for different component materials, including stainless steel, a zirconium alloys, etc. The ECP probes may further detect ECP due to ion concentration, pH, etc. The ECP data may be transmitted through wired or wireless signal transmitters. Example methods include installing and using example embodiment ECP probe assemblies in nuclear reactors and facilities.




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System and method for reclaiming energy from heat emanating from spent nuclear fuel

The present invention provides a system and method for reclaiming energy from the heat emanating from spent nuclear fuel contained within a canister-based dry storage system. The inventive system and method provides continuous passive cooling of the loaded canisters by utilizing the chimney-effect and reclaims the energy from the air that is heated by the canisters. The inventive system and method, in one embodiment, is particularly suited to store the canisters below-grade, thereby utilizing the natural radiation shielding properties of the sub-grade while still facilitating passive air cooling of the canisters. In another embodiment, the invention focuses on a special arrangement of the spent nuclear fuel within the canisters so that spent nuclear fuel that is hotter than that which is typically allowed to be withdrawn from the spent fuel pools can be used in a dry-storage environment, thereby increasing the amount energy that can be reclaimed.




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Method and system for in situ depositon and regeneration of high efficiency target materials for long life nuclear reaction devices

Aspects of the invention relate to several methods to deposit and regenerate target materials in neutron generators and similar nuclear reaction devices. In situ deposition and regeneration of a target material reduces tube degradation of the nuclear reaction device and covers impurities on the surface of the target material at the target location. Further aspects of the invention include a method of designing a target to generate neutrons at a high efficiency rate and at a selected neutron energy from a neutron energy spectrum.




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Sheathed, annular metal nuclear fuel

A sheathed, annular metal fuel system is described. A metal fuel pin system is described that includes an annular metal nuclear fuel alloy. A sheath may surround the metal nuclear fuel alloy, and a cladding may surround the sheath. A gas plenum may also be present. Mold arrangements and methods of fabrication of the sheathed, annular metal fuel are also described.




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System and method for annealing nuclear fission reactor materials

Illustrative embodiments provide systems, methods, apparatuses, and applications related to annealing nuclear fission reactor materials.




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Nuclear fuel assembly tie plate, upper nozzle and nuclear fuel assembly comprising such a tie plate

A nuclear fuel assembly tie plate is provided. The nuclear fuel assembly tie plate is formed by intersecting strips delimiting between them tubular guide cells each for allowing a fuel rod to extend through the tie plate. The strips delimit between them tubular flow cells separate from the guide cells, each flow cell for allowing coolant flow through the tie plate. Guide cells and flow cells are arranged at nodes of a lattice defined by a repeating pattern comprising four corner nodes in a square lattice arrangement and a central node at the center of the four corner nodes, with one guide cell at each corner nodes, separated by a pair of parallel spaced strips intersecting a pair of parallel spaced strips, the two pairs of strips delimiting a four-walled central flow cell at the center node.




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Nuclear fuel assembly with a lock-support spacer grid

An improved grid for a nuclear reactor fuel assembly that has an egg-crate base grid as the primary support structure with each support cell of the base grid that supports a fuel rod having a lock-support sleeve that is rotatable within the support cell between a first and second orientation. In the first orientation the lock-support sleeve fits loosely within the support cell of the base grid and respectively, loosely receives the fuel rods that are loaded therein. The lock-support sleeves are then rotated to a second orientation that locks the fuel rods axially within the support cells.




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Nonconjugated conductive polymers for protection against nuclear radiation including radioactive iodine

Nonconjugated conductive polymers absorb radioactive iodine, therefore are useful for protection against nuclear radiation. These polymers have at least one double bond per repeat unit. The ratio of the number of double bonds to the total number of bonds along the polymer chain is less than half. Examples of nonconjugated conductive polymers include: cis-1,4-polyisoprene (natural rubber), trans-1,4-polyisoprene (gutta percha), polybutadiene, polydimethyl butadiene, poly(b-pinene), styrene butadiene rubber (SBR), polyalloocimene, polynorbornene and many others. Through interaction with iodine atoms the double bonds in the nonconjugated polymers transform into radical cations leading to a dark color. The iodine atoms remain (immobile) bound to the polymer chain through the charge-transfer interaction, these polymers are very inexpensive and can be easily processed into any shape, structure and size. Therefore, these are useful for protection against nuclear radiation including radioactive iodine. These polymers when used as a thick cover can provide safe storage of nuclear waste materials including spent fuel rods.




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Transverse in-core probe monitoring and calibration device for nuclear power plants, and method thereof

A method and apparatus for the calibration of neutron flux monitoring devices used in a nuclear reactor core. The apparatus includes a transverse in-core probe (TIP) cable with a neutron absorber located a fixed distance apart from a TIP detector. The neutron absorber may be passed within close proximity of the neutron flux monitoring device such that a perceived drop in measured neutron flux occurs, whereupon the cable may be repositioned relative to the monitoring device to ensure that the TIP detector is within close proximity of the monitoring device for purposes of calibrating the monitoring device.




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Nuclear fuel cladding with high heat conductivity and method for making same

The invention relates to a nuclear fuel cladding totally or partially made of a composite material with a ceramic matrix containing silicon carbide (SiC) fibers as a matrix reinforcement and an interphase layer provided between the matrix and the fibers, the matrix including silicon carbide as well as at least one of the following additional carbides: titanium carbide (TiC), zirconium carbide (Zrc), and ternary titanium silicon carbide (Ti3SiC2). When irradiated and at temperatures of between 800° C. and 1200° C., said cladding can mechanically maintain the nuclear fuel within the cladding while enabling optimal thermal-energy transfer towards the coolant. The invention also relates to a method for making the nuclear fuel cladding.




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Nuclear reactor green and sintered fuel pellets, corresponding fuel rod and fuel assembly

A sintered fuel pellet for a water nuclear reactor fuel rod including a peripheral wall extending along a central axis and two end faces. At least one of the end faces includes at least a first chamfer extending from the peripheral wall towards the central axis with a first non-zero slope with respect to a plane perpendicular to the central axis and a second chamfer extending from the first chamfer towards the central axis with a second non-zero slope with respect to a plane perpendicular to the central axis, wherein the first slope is different from the second slope.




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Compact nuclear reactor

A pressurized water nuclear reactor (PWR) includes a once through steam generator (OTSG) disposed in a generally cylindrical pressure vessel and a divider plate spaced apart from the open end of a central riser. A sealing portion of the pressure vessel and the divider plate define an integral pressurizer volume that is separated by the divider plate from the remaining interior volume of the pressure vessel. An internal control rod drive mechanism (CRDM) has all mechanical and electromagnetomotive components including at least a motor and a lead screw disposed inside the pressure vessel. Optionally CRDM units are staggered at two or more different levels such that no two neighboring CRDM units are at the same level. Internal primary coolant pumps have all mechanical and electromagnetomotive components including at least a motor and at least one impeller disposed inside the pressure vessel. Optionally, the pumps and/or CRDM are arranged below the OTSG.




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Compact nuclear reactor with integral steam generator

In an illustrative embodiment, a pressurized water nuclear reactor (PWR) includes a pressure vessel (12, 14, 16), a nuclear reactor core (10) disposed in the pressure vessel, and a vertically oriented hollow central riser (36) disposed above the nuclear reactor core inside the pressure vessel. A once-through steam generator (OTSG) (30) disposed in the pressure vessel includes vertical tubes (32) arranged in an annular volume defined by the central riser and the pressure vessel. The OTSG further includes a fluid flow volume surrounding the vertical tubes and having a feedwater inlet (50) and a steam outlet (52). The PWR has an operating state in which feedwater injected into the fluid flow volume at the feedwater inlet is converted to steam by heat emanating from primary coolant flowing inside the tubes of the OTSG, and the steam is discharged from the fluid flow volume at the steam outlet.




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Oligonucleotide analogs as therapeutic agents

The invention relates to design of short oligonucleotides and analogs thereof (such as, di-, and trinucleotide compounds) useful for various therapeutic applications. It is believed that the compounds of the invention can be used as antiviral agents, anticancer agents and so on. In certain embodiments, the compounds of the invention can modulate immune-stimulatory pathways and non-TLR pathways. The invention also relates to design modified oligonucleotides for therapeutic applications, by excluding nucleotide segments having off-target effects from the modified oligonucleotides. In another aspect, the invention provides pharmaceutical compositions including one or more compounds of the invention. It is believed that the compounds and compositions as described herein have therapeutic utility against a variety of diseases, including viral diseases, autoimmune diseases (such as, allergy, asthma, and inflammatory disorders) and cancer.




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Knuckle formed without a finger core

A railcar coupler knuckle includes a tail section, a hub section, and a nose section. The tail, hub, and nose sections define internal cavities including (i) a kidney cavity, (ii) a pivot pin cavity, and (ii) a finger cavity. The kidney and pivot pin cavities are formed using at least one internal core during manufacturing of the coupler knuckle. The finger cavity is formed from a finger section of cope and drag mold portions of a mold used during manufacturing of the coupler knuckle, wherein the finger section of the mold defines the entirety of the finger cavity of the coupler knuckle.




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Knuckle formed from pivot pin and kidney core and isolated finger core

A railroad coupler knuckle includes a single, solid rib at a horizontal centerline of the knuckle that passes through a pivot pin hub thereof. The single, solid rib extends generally from a flag hole of a finger cavity of the knuckle to an opposite side of the knuckle from the flag hole. In another aspect, a railcar coupler knuckle includes a tail section, a hub section, and a nose section. The tail, hub, and nose sections define internal cavities including (i) a combined void that defines a pivot pin hub cavity and a kidney cavity and (ii) an isolated finger cavity. The combined void is formed using a first internal core during manufacturing of the coupler knuckle. The isolated finger cavity is formed using a second internal core during manufacturing of the coupler knuckle, such that molten alloy substantially separates the combined void and the isolated finger cavity.




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Railway coupler core structure for increased strength and fatigue life of resulting knuckle

A finger core for forming the front part of a knuckle for a railcar, said finger core comprising a single opening to form a single rib at the horizontal center line of the resulting knuckle.




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Railcar coupler knuckle cores and knuckles produced by said cores

A core assembly for forming the interior spaces of a railcar coupler knuckle has a first transition section between the C-10 portion of the core and the finger portion of the core. The first transition section has a first side, a second side, a third side and a fourth side and the first and second sides form the vertical axis of the first transition section and the third and fourth sides form the horizontal axis of said first transition section. The vertical axis of the first transition section has a height along a horizontal plane of the vertical axis of at least 2.5″ and the horizontal axis of said first transition section has a width along a vertical plane of the horizontal axis of at least 0.925″.




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Coupler knuckle system and method

A method for manufacturing a railcar coupler knuckle includes providing a first mold section having internal walls defining at least in part perimeter boundaries of a first coupler knuckle mold cavity. The method includes providing a second mold section having internal walls defining at least in part perimeter boundaries of a second coupler knuckle mold cavity. The second coupler mold cavity of the second mold section is offset from the first coupler mold cavity of the first mold section. The method includes closing the first and second mold sections and at least partially filling the first and second coupler knuckle mold cavities with a molten alloy, the molten alloy solidifying after filling to form the coupler knuckle.




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Railway coupler body improvements to improve knuckle rotation

An improved coupler body having an area of increased material in the upper lock chamber.




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Railcar coupler knuckle cores with rear core support

A core assembly for creating interior spaces in a railcar coupler knuckle is designed to be set in a cavity with cope and drag sections. The cavity is shaped to form a railcar coupler knuckle and includes a first wall that forms the substantially vertical outside wall of the tail of the knuckle. The core includes a kidney section with a rear core support section that extends at least 0.5″ outside the first wall of the cavity when the core is set in the drag.