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Barcelona suffered a shock 1-0 LaLiga defeat at Real Sociedad on Sunday that ended their seven-match winning streak in all competitions.

WASHINGTON (April 28, 2020) —  Today, the U.S. Environmental Protection Agency (EPA) and State of Indiana announced that recent air monitoring data show the city of Indianapolis, and the areas of Muncie, Lake and Porter counties are meeting federal air quality standards.

Indianapolis Metropolitan Police Department are on the scene in the area of East 32nd Street and Baltimore Avenue.

Indianapolis Metropolitan Police Department are on the scene in the area of East 32nd Street and Baltimore Avenue.

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A new imaging technique may give researchers fresh insights into brain development, function, and disease

The human brain is often said to be the most complex object in the known universe, and there’s good reason to believe that it is. That lump of jelly inside your head contains at least 80 billion nerve cells, or neurons, and even more of the non-neuronal cells called glia. Between them, they form hundreds of trillions of precise synaptic connections; but they all have moveable parts, and these connections can change. Neurons can extend and retract their delicate fibres; some types of glial cells can crawl through the brain; and neurons and glia routinely work together to create new connections and eliminate old ones.

These processes begin before we are born, and occur until we die, making the brain a highly dynamic organ that undergoes continuous change throughout life. At any given moment, many millions of them are being modified in one way or another, to reshape the brain’s circuitry in response to our daily experiences. Researchers at Yale University have now developed an imaging technique that enables them to visualise the density of synapses in the living human brain, and offers a promising new way of studying how the organ develops and functions, and also how it deteriorates in various neurological and psychiatric conditions.

Related: Brain’s immune cells hyperactive in schizophrenia

Related: 3D model of a nerve terminal in atomic detail | Mo Costandi

New research provides evidence for the idea that sleep restores cellular homeostasis in the brain and helps us to forget irrelevant information

We spend one third of our lives sleeping, but we still do not know exactly why we sleep. Recent research shows that that the brain does its housekeeping while we sleep, and clears away its waste. According to another hypothesis, sleep plays the vital role of restoring the right balance of brain synapses to enhance learning, and two studies published in today’s issue of Science now provide the most direct evidence yet for this idea.

We do know that sleep is important for consolidating newly formed memories. During waking hours, we learn all kinds of new information, both consciously and unconsciously. To store it, the brain modifies large numbers of synaptic connections, making some of them stronger and larger, and it’s now thought that as we sleep other synapses are weakened or destroyed, so that the important new information is stored for later use, while irrelevant material, which could interfere with learning, is not.

Related: The Homer Simpson effect: forgetting to remember

Related: How to optimise your brain's waste disposal system

Officials in Italy say an Italian aid worker who was kidnapped in Kenya in late 2018 has been freed in Somalia

Investors witnessed a wealth erosion of Rs 5.81 lakh crore in BSE-listed companies. The market capitalisation of BSE-listed companies fell by Rs 5,81,182.15 crore to Rs 1,23,60,438 crore

On MCX, gold June futures rose Rs 37 to Rs 45,788 per 10 grams. Similarly, silver July futures were trading Rs 403 or 0.96 per cent higher at Rs 42,299 per kg

The rally in Sensex and Nifty was supported by buying in financial counters with HDFC Bank, HDFC, ICICI Bank and Bajaj Finance as top index contributors

Western African maritime regions are prone to pirate activity, and it is expected that the number of incidents, notably those involving kidnapping for ransom, will increase in upcoming years. ......

The Rivers State Police Command has rescued a Lebanese, Bilal Nosser from a kidnappers’ den in Ndashi forest, Etche Local Government Area of the state. Bilal, popularly known as Mister Bee is said to be a renowned Nollywood actor, who was kidnapped in the early hours of Friday in Imo State and taken to a […]

Police rescue popular Nollywood actor from kidnappers’ den

Silvia Romano was 23 and working as a volunteer in the orphanage in Chakama village in southeast Kenya when she was seized by gunmen in November 2018

Italian PM says the volunteer, who was taken from Kilifi in 2018, has been released.

ROME: A young Italian woman who was kidnapped in late 2018 from an orphanage in Kenya, has been freed, Prime Minister Giuseppe Conte announced on Saturday.Silvia Romano was 23 and working as a...

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ROME: A young Italian woman who was kidnapped in late 2018 from an orphanage in Kenya, has been freed, Prime Minister Giuseppe Conte announced on Saturday.Silvia Romano was 23 and working as a volunteer in the orphanage in Chakama village in southeast Kenya when she was seized by gunmen in...

House Speaker Nancy Pelosi took a swipe at President Trump as she and fellow Democrats are plowing forward with another massive coronavirus relief package.

In a single-arm trial, the 3.1% 1-year rate of patients who received at least one inappropriate shock was the lowest reported for the S-ICD, and lower than in many transvenous ICD device studies.
Medscape Medical News

High-resolution pictures or atomic-level detail of chikungunya virus interacting with a protein found on the cell surface in the joints was snapped by

In 2015, three economies in China participated in the OECD Programme for International Student Assessment, or PISA, for the first time: Beijing, a municipality, Jiangsu, a province on the eastern coast of the country, and Guangdong, a southern coastal province. Shanghai, which, like Beijing, is also a Chinese megacity of over 20 million people, has participated in PISA since 2009.

Countries have seen a major increase in the educational attainment level of their populations. In 1965, only 43% of young adults aged 25-34 had attained upper secondary education or higher on average across OECD countries. Fifty years later, upper secondary education had almost doubled with attainment levels reaching 84% in 2015.

China has the largest education system in the world. With almost 260 million students and over 15 million teachers in about 514 000 schools (National Bureau of Statistics of China, 2014), excluding graduate education institutions, China’s education system is not only immense but diverse.

Video shows civil dressed police officer thrashing two Muslim teenagers in the Hebbal-Sahakar Nagar area of Bangalore. People are calling out the police officer for using excessive force against the teenagers and are demanding action against the cop.

In this particular snap, Izabel can be seen showing off her incredible figure in a two-piece bikini while taking a shower in public.

Tony Cooke's eyes were drawn to a photograph of a group of women in pinafores hailing the end of war, conveying the relief, pride and exultant joy of VE Day.

SafeWork New South Wales has slapped Qantas with an improvement notice after observing cleaners handle used face masks, vomit, soiled nappies and dirty tissues without gloves or masks.

The singer, 45, opted for a black plunging tuxedo dress with a sequinned neckline and padded shoulders.

Greg James missed his second Radio 1 show on Thursday after being 'kidnapped' from a BRIT Awards after-party on Tuesday as part of an elaborate stunt.

Tony Cooke's eyes were drawn to a photograph of a group of women in pinafores hailing the end of war, conveying the relief, pride and exultant joy of VE Day.

The actress, 30, flaunted her bronzed physique in the sexy snap after telling fans on Friday she was meant to be on her sister's hen party before the UK was placed in lockdown.

The Love Island star, 29, donned a figure-hugging white dress and captioned the sun-kissed snap: 'Malibu dreaming.'

The Strictly host, 50, posted the sweet snap of Vernon, 45, standing next to a beautiful river while the couple were on a walk as part of their daily allowed exercise in lockdown.

The media personality's blog, set for release this summer, will feature updates on fashion, beauty, music and lifestyle topics.

The fitness fanatic, 28, looked incredible in the stunning selfie that showed her bronzed glow and teased fans with the cryptic caption: 'miss u...'

The former Love Island star, 22, uploaded a picture of her lounging on an armchair in a stunning emerald two-piece which showed off her svelte physique.

Napoli will return to training on March 25 despite appeals to wait until the nation's lockdown ends on April 3 and criticism from the AIC for endangering players' health.

We cannot implement policies for land reforms without a well-functioning land records system. And If we get this platform in place, we can enable all those interested in reform policy with the tools to ensure that their policy dreams get translated into ground realities, says Ramesh Ramanathan.

A 45-year-old man (P-764), who worked at a hotel in Padarayanapura in Bengaluru and returned to his hometown in Sira of Tumakuru district on May 4, te

The transmembrane intracellular lectin ER–Golgi intermediate compartment protein 53 (ERGIC-53) and the soluble EF-hand multiple coagulation factor deficiency protein 2 (MCFD2) form a complex that functions as a cargo receptor, trafficking various glycoproteins between the endoplasmic reticulum (ER) and the Golgi apparatus. It has been demonstrated that the carbohydrate-recognition domain (CRD) of ERGIC-53 (ERGIC-53CRD) interacts with N-linked glycans on cargo glycoproteins, whereas MCFD2 recognizes polypeptide segments of cargo glycoproteins. Crystal structures of ERGIC-53CRD complexed with MCFD2 and mannosyl oligosaccharides have revealed protein–protein and protein–sugar binding modes. In contrast, the polypeptide-recognition mechanism of MCFD2 remains largely unknown. Here, a 1.60 Å resolution crystal structure of the ERGIC-53CRD–MCFD2 complex is reported, along with three other crystal forms. Comparison of these structures with those previously reported reveal that MCFD2, but not ERGIC-53–CRD, exhibits significant conformational plasticity that may be relevant to its accommodation of various polypeptide ligands.

The title compound, C31H30O6, was obtained by protecting the six hy­droxy groups of apogossypol by acetalization with di­chloro­methane. The mol­ecule has a bridging dioxepine unit which hinders the rotation around the 2,2'-inter­naphthyl bond. The dihedral angle between the naphthyl units is 55.73 (3)°. In the crystal, very weak C—H⋯O inter­actions may help to consolidate the packing.

In the title compound, C21H18O4, the dihedral angle between the naphthelene ring system (r.m.s. deviation = 0.014 Å) and the benzene ring is 9.68 (1)°. The C atom of the meth­oxy group of the naphthalene ring system is almost coplanar with the ring [C—O—C—C = −2.0 (3)°], whereas the C atom of the meth­oxy group of the phenol ring is slightly twisted [C—O—C—C = 6.2 (3)°]. An intra­molecular O—H⋯O hydrogen bond generates an S(6) ring motif.

The title com­pound, C34H24O4S·0.5CH2Cl2, crystallizes with two independent mol­ecules and one di­chloro­methane solvent mol­ecule in the asymmetric unit. The crystal packing is consolidated by C—H⋯O hydrogen bonds.

In the title compound, C21H17N3O2, the triazole ring system is inclined at dihedral angles of 4.14 (18) and 69.24 (11)° with the naphthalene ring system and phenyl ring, respectively. In the crystal, mol­ecules are linked by C—H⋯O hydrogen bonds into double columns propagating along the b-axis direction.

The title naphthalene derivative, C24H20O2, features 4-methy­oxy-substituted benzene rings in the 1 and 4 positions of the naphthalene ring system. There are two crystallographically independent mol­ecules (A and B) in asymmetric unit. The independent mol­ecules have very similar conformations in which the naphthalene ring systems are only slightly bent, exhibiting dihedral angles between the constituent benzene rings of 3.76 (15) and 3.39 (15)° for A and B, respectively. The pendent 4-methyoxybenzene rings are splayed out of the plane through the naphthalene ring system to which they are connected [range of dihedral angles = 59.63 (13) to 67.09 (13)°]. In the crystal, the mol­ecular packing is consolidated by inter­molecular C—H⋯π inter­actions, leading to supra­molecular chains along the b axis. The chains assemble without directional inter­actions between them.