Spongy water harvester prototype that uses only sunlight was tested successfully in the Arizona desert.

The massive Mars colony simulation located in the Dubai desert will be designed by Danish architect Bjake Ingels.

A new book, 'The 8-Hour Diet,' has science and sensibility behind it.

Celebrity doctor's unofficial audience test promises weight loss with no change in diet or exercise, but there is one downside.

Human trials are set to begin on the treatment, which cured 100 percent of mice during animal trials.

Actress will front marketing campaign targeted at getting more involved in turning off the lights on March 26th.

Supermodel once again named Global Earth Hour Ambassador in preparation for the lights-out moment on March 31.

Kenaf, the carbon-sequestering monster plant, provides food, shelter and carbon credits.

Rescuers spent months nursing a paralyzed leopard until the day he stood on his own paws.

Running cars on air or water? Solar roadways? They're all cool concepts, but either hugely expensive or plain unworkable.

Trapped, starving dog is rescued weeks after Hurricane Dorian barreled through the Bahamas.

Crazy for Coconuts: Ford and The Scotts Miracle-Gro Company Research Using Coconut Fibers in Vehicles

David Stevens will be replaced by Milena Mondini de Focatiis, currently head of UK and European Insurance.

The business is to return £110m to car and van customers as part of Stay At Home Refunds as it becomes first to bow to pressure to give back as policyholders use vehicles less.

'Power of literacy education' brings change and hope on World Literacy Day

Exclusive insight on Russia Games from American champion.

The Ministry of Health boasts today the largest network of ISO-certified labs in the region with total lab accreditation of 14.

Best Lawyers employs peer review process to identify top attorneys in multiple practice areas throughout the country

WPG's Flair Collection Continues The Design Excellence This Award-Winning Builder Has Delivered To California Desert Communities

Freehold Communities' Miralon Is One of The Nation's Largest New "Agri-hoods"

Now This Nashville Recording Artist Releases a New Single "Cumberland Falls" and Hopes She Can Survive a Pandemic by Bringing Her Projects to Life from Home

Simon Cowell was moved to tears by rescue dog Miracle on Britain's Got Talent who has a very traumatic past

Mirage JS is helping simplify modern front-end development by providing the ability for front-end engineers to craft applications without relying on an actual back-end service. In this article, I’ll be taking a framework-agnostic approach to show you Mirage JS models and associations. If you haven’t heard of Mirage JS, you can read my previous article in which I introduce it and also integrate it with the progressive framework Vue.js.

Admiralty House was converted into flats in the early 21st century, but it's origins are rather different.

During a recent SAG Foundation Conversations at Home interview, the Oscar winner talks about the main differences between what happens to her Jeanne Crandall character and herself in real life.

"We're praying for you all ... you're all heroes." Continue reading…

In this episode of “This Song,” Taylor Wallace sits down with Holly Miranda to talk about how a song she heard as a teenager opened her up to being open. Elizabeth McQueen sits down with musician and “how did I get here”  host Johnny Goudie to hear about a song from his teens that made him long for […]

In this fun, illustrated picture book, Little Claudette lives in the magic kingdom of Motown, where all the happy children sing

Farmers are gathering in Merredin this weekend to give thanks for what they believe was 'divine intervention' in the last cropping season.

A 79-year-old "miracle man" blows kisses to the medical team at Dubbo Base Hospital and fights back tears as he heads home after making a full recovery from coronavirus.

Alexander McCall Smith

Stephen Keal was diagnosed with COVID-19 after travelling with his wife onboard the Ruby Princess cruise ship. The hospital asked his family to say their final goodbyes.

It has been six years since Samira Elagoz was raped by her ex-boyfriend. So she decided to own the narrative and write a performance about what had happened to her.

The Opposition Leader acknowledges the mountain his party must climb if it hopes to end 19 years of Labor government.

(United States First Circuit) - In another appeal in a protracted employment dispute between two former colleagues in which plaintiff sought payment of his promised wages and loan money, the District Court's decision to use Federal Rule of Civil Procedure 25(c) to hold defendant and related entities liable for the judgment originally entered against defendant's company only is affirmed where the District Court did not plainly err in joining related entities as alter egos of defendant's company and holding them liable for the judgment entered in favor of plaintiff.

(United States Ninth Circuit) - Held that there was no basis for personal jurisdiction over a United Arab Emirates bank in a commercial dispute with a technology firm. The firm argued that the bank had waived its personal-jurisdiction defense through its litigation conduct. Disagreeing, the Ninth Circuit reversed and remanded with directions to dismiss the case because the bank lacked sufficient minimum contacts with the U.S.

(United States Ninth Circuit) - In an antitrust suit brought by professional minor league baseball players, the district court's dismissal of the suit is affirmed because professional minor league baseball is exempt from federal antitrust laws.

Producer Bekim! Releasing Masterpiece Single With Amilcar Singing

Jamira Burley has found her calling.

Jamira has dedicated her life to driving systematic change.

Jamira has dedicated her life to driving systematic change.

BACKGROUND Mirabegron is a β3-adrenergic receptor (β3-AR) agonist approved only for the treatment of overactive bladder. Encouraging preclinical results suggest that β3-AR agonists could also improve obesity-related metabolic disease by increasing brown adipose tissue (BAT) thermogenesis, white adipose tissue (WAT) lipolysis, and insulin sensitivity.METHODS We treated 14 healthy women of diverse ethnicities (27.5 ± 1.1 years of age, BMI of 25.4 ± 1.2 kg/m2) with 100 mg mirabegron (Myrbetriq extended-release tablet, Astellas Pharma) for 4 weeks in an open-label study. The primary endpoint was the change in BAT metabolic activity as measured by [18F]-2-fluoro-d-2-deoxy-d-glucose (18F-FDG) PET/CT. Secondary endpoints included resting energy expenditure (REE), plasma metabolites, and glucose and insulin metabolism as assessed by a frequently sampled intravenous glucose tolerance test.RESULTS Chronic mirabegron therapy increased BAT metabolic activity. Whole-body REE was higher, without changes in body weight or composition. Additionally, there were elevations in plasma levels of the beneficial lipoprotein biomarkers HDL and ApoA1, as well as total bile acids. Adiponectin, a WAT-derived hormone that has antidiabetic and antiinflammatory capabilities, increased with acute treatment and was 35% higher upon completion of the study. Finally, an intravenous glucose tolerance test revealed higher insulin sensitivity, glucose effectiveness, and insulin secretion.CONCLUSION These findings indicate that human BAT metabolic activity can be increased after chronic pharmacological stimulation with mirabegron and support the investigation of β3-AR agonists as a treatment for metabolic disease.TRIAL REGISTRATION Clinicaltrials.gov NCT03049462.FUNDING This work was supported by grants from the Intramural Research Program of the NIDDK, NIH (DK075112, DK075116, DK071013, and DK071014).

BACKGROUND Beige adipose tissue is associated with improved glucose homeostasis in mice. Adipose tissue contains β3-adrenergic receptors (β3-ARs), and this study was intended to determine whether the treatment of obese, insulin-resistant humans with the β3-AR agonist mirabegron, which stimulates beige adipose formation in subcutaneous white adipose tissue (SC WAT), would induce other beneficial changes in fat and muscle and improve metabolic homeostasis.METHODS Before and after β3-AR agonist treatment, oral glucose tolerance tests and euglycemic clamps were performed, and histochemical analysis and gene expression profiling were performed on fat and muscle biopsies. PET-CT scans quantified brown adipose tissue volume and activity, and we conducted in vitro studies with primary cultures of differentiated human adipocytes and muscle.RESULTS The clinical effects of mirabegron treatment included improved oral glucose tolerance (P < 0.01), reduced hemoglobin A1c levels (P = 0.01), and improved insulin sensitivity (P = 0.03) and β cell function (P = 0.01). In SC WAT, mirabegron treatment stimulated lipolysis, reduced fibrotic gene expression, and increased alternatively activated macrophages. Subjects with the most SC WAT beiging showed the greatest improvement in β cell function. In skeletal muscle, mirabegron reduced triglycerides, increased the expression of PPARγ coactivator 1 α (PGC1A) (P < 0.05), and increased type I fibers (P < 0.01). Conditioned media from adipocytes treated with mirabegron stimulated muscle fiber PGC1A expression in vitro (P < 0.001).CONCLUSION Mirabegron treatment substantially improved multiple measures of glucose homeostasis in obese, insulin-resistant humans. Since β cells and skeletal muscle do not express β3-ARs, these data suggest that the beiging of SC WAT by mirabegron reduces adipose tissue dysfunction, which enhances muscle oxidative capacity and improves β cell function.TRIAL REGISTRATION Clinicaltrials.gov NCT02919176.FUNDING NIH: DK112282, P30GM127211, DK 71349, and Clinical and Translational science Awards (CTSA) grant UL1TR001998.

About a month ago, we had yet another health worry with Butter Bib (a/k/a Zen). Since then she has bounced back and is in fine form, still going up and down the stairs, and also going up and down the little plastic steps we have by our bed. Now that the weather is colder, I... Continue Reading →