LIVE. De Wever over eventuele tweede piek: “Normale quarantaine is er een van zieken, niet van gezonde mensen”  Het Laatste Nieuws

Join Alissa Schapiro, assistant curator of the exhibition Life Magazine and the Power of Photography, for a presentation on the work of three female Life photographers—Margaret Bourke-White, Marie Hansen, and Nina Leen. The talk will focus on their photo essays about American women in the context of World War II. With the status of female labor in the United States in continuous flux during the war and in its immediate aftermath, these photographers captured the various roles available to women—paying close attention to race and class in addition to gender—while simultaneously solidifying their own positions within Life’s male-dominated photography and editorial staff. The talk will be followed by a conversation on gender politics at Life with media scholar Dolores Flamiano from James Madison University and Katherine A. Bussard from the Art Museum. Zoom webinar: https://artmuseum.princeton.edu/calendar/2020-05/female-gaze-life-magazine-gender-and-world-war-ii Presented by Princeton Art Museum  

Audio recordings of two 911 calls placed moments before Ahmaud Arbery was killed confirm that at least two people were concerned that a black man was running in their Georgia neighborhood.

Audio recordings of two 911 calls placed moments before Ahmaud Arbery was killed confirm that at least two people were concerned that a black man was running in their Georgia neighborhood.

For more than 150 years, only male cadets were allowed to attend the Citadel, an elite military college in South Carolina. The first female cadet gained the right to enroll after a legal battle in 1995, but she left after less than a week. The following year, Nancy Mace, the daughter of US Army Brigadier General Emory Mace, enrolled. She went on to become the first female graduate of the Citadel in 1999. How did early female cadets' barrack doors differ from those of male cadets?

Researchers used rabbits and antidepressants to search for a link between orgasm and ovulation in female mammals.

Audio recordings of two 911 calls placed moments before Ahmaud Arbery was killed confirm that at least two people were concerned that a black man was running in their Georgia neighborhood.

Barbara Neely's novels pushed past mystery and explored racism, class boundaries and violence against women.

Tonie Marshall addressed the issue of sexism in her film work and was a #MeToo crusader.

Three London firefighters, and three from South Wales, will be strapping on skis for an arduous 1900km trek across the Antarctic.

The Times examined the filmographies of the last five years' worth of lead-actor academy award nominees to see how many female filmmakers they've worked with.

Natalie Portman arrived at the 92nd Academy Awards wearing a cape with the names of female directors who weren't nominated Sunday.

"Betty," the new series from "Skate Kitchen" and "The Wolfpack" director Crystal Moselle, premieres Friday on HBO.

On 15 February 2017 we published an article headlined "‘Call me Lian' Soham murderer Ian Huntley gives himself FEMALE name amid sex change report".

PIRATES OF THE CARIBBEAN 6 is separate to a possible female-led spin-off, according to a Disney insider. We could be looking at two movies with Johnny Depp's Jack Sparrow returning.

Many slave women outlived their children and husbands or were abandoned by them. They had no where to turn.

Opha Johnson — born Opha May Jacob in Kokomo, Indiana — was honored 100 years later, thanks to the Women Marines Association.

More than 100 companies and nonprofits have pledged support for the Your Life Matters initiative, created to help the city's most vulnerable residents. That's a great start, but momentum is critical.

The Vasquez family makes tamales to sell at the Carmel Farmer's Market

It wasn’t the typical retirement ceremony at the headquarters of the London Police Service on Dundas Street Friday.

Older Boomers: Single Females Buying Homes

Many clinical studies and epidemiological investigations have clearly demonstrated that women are twice as likely to develop cholesterol gallstones as men, and oral contraceptives and other estrogen therapies dramatically increase that risk. Further, animal studies have revealed that estrogen promotes cholesterol gallstone formation through the estrogen receptor (ER) α, but not ERβ, pathway. More importantly, some genetic and pathophysiological studies have found that G protein-coupled estrogen receptor (GPER) 1 is a new gallstone gene, Lith18, on chromosome 5 in mice and produces additional lithogenic actions, working independently of ERα, to markedly increase cholelithogenesis in female mice. Based on computational modeling of GPER, a novel series of GPER-selective antagonists were designed, synthesized, and subsequently assessed for their therapeutic effects via calcium mobilization, cAMP, and ERα and ERβ fluorescence polarization binding assays. From this series of compounds, one new compound, 2-cyclohexyl-4-isopropyl-N-(4-methoxybenzyl)aniline (CIMBA), exhibits superior antagonism and selectivity exclusively for GPER. Furthermore, CIMBA reduces the formation of 17β-estradiol-induced gallstones in a dose-dependent manner in ovariectomized mice fed a lithogenic diet for 8 weeks. At 32 μg/day/kg CIMBA, no gallstones are found, even in ovariectomized ERα (^–/–) mice treated with 6 μg/day 17β-estradiol and fed the lithogenic diet for 8 weeks. In conclusion, CIMBA treatment protects against the formation of estrogen-induced cholesterol gallstones by inhibiting the GPER signaling pathway in female mice. CIMBA may thus be a new agent for effectively treating cholesterol gallstone disease in women.­

The virtual-based office hours is to connect female founders with early-stage VC investors who will provide business advice and investments

(King's College London) A study of female astronauts has assessed the risk of blood clots associated with spaceflight.The study, published in Aerospace Medicine and Human Performance, in collaboration with King's College London, the Centre for Space Medicine Baylor College of Medicine, NASA Johnson Space Centre and the International Space University, examines the potential risk factors for developing a blood clot (venous thromboembolism) in space.

Lawrence Fisher
Oct 1, 2004; 17:215-219
Articles

Chelsea DeLeon
May 1, 2020; 61:767-777
Research Articles

Many clinical studies and epidemiological investigations have clearly demonstrated that women are twice as likely to develop cholesterol gallstones as men, and oral contraceptives and other estrogen therapies dramatically increase that risk. Further, animal studies have revealed that estrogen promotes cholesterol gallstone formation through the estrogen receptor (ER) α, but not ERβ, pathway. More importantly, some genetic and pathophysiological studies have found that G protein-coupled estrogen receptor (GPER) 1 is a new gallstone gene, Lith18, on chromosome 5 in mice and produces additional lithogenic actions, working independently of ERα, to markedly increase cholelithogenesis in female mice. Based on computational modeling of GPER, a novel series of GPER-selective antagonists were designed, synthesized, and subsequently assessed for their therapeutic effects via calcium mobilization, cAMP, and ERα and ERβ fluorescence polarization binding assays. From this series of compounds, one new compound, 2-cyclohexyl-4-isopropyl-N-(4-methoxybenzyl)aniline (CIMBA), exhibits superior antagonism and selectivity exclusively for GPER. Furthermore, CIMBA reduces the formation of 17β-estradiol-induced gallstones in a dose-dependent manner in ovariectomized mice fed a lithogenic diet for 8 weeks. At 32 μg/day/kg CIMBA, no gallstones are found, even in ovariectomized ERα (^–/–) mice treated with 6 μg/day 17β-estradiol and fed the lithogenic diet for 8 weeks. In conclusion, CIMBA treatment protects against the formation of estrogen-induced cholesterol gallstones by inhibiting the GPER signaling pathway in female mice. CIMBA may thus be a new agent for effectively treating cholesterol gallstone disease in women.­

Amylin, a pancreatic hormone and neuropeptide, acts principally in the hindbrain to decrease food intake and has been recently shown to act as a neurotrophic factor to control the development of AP->NTS and ARC->PVN axonal fiber outgrowth. Amylin is also able to activate ERK signaling specifically in POMC neurons independently of leptin. To investigate the physiological role of amylin signaling in POMC neurons, the core component of the amylin receptor, calcitonin receptor (CTR) was depleted from POMC neurons using an inducible mouse model. The loss of CTR in POMC neurons leads to increased body weight gain, increased adiposity, and glucose intolerance in male knockout mice, characterized by decreased energy expenditure (EE) and decreased expression of uncoupling protein 1 (UCP1) in brown adipose tissue (BAT). Furthermore, a decreased spontaneous locomotor activity and absent thermogenic reaction to the application of the amylin receptor agonist were observed in male and female mice. Together, these results show a significant physiological impact of amylin/calcitonin signaling in CTR-POMC neurons on energy metabolism and demonstrate the need for sex-specific approaches in obesity research and potentially treatment.

Clinical studies have shown a link between hyperuricemia (HU) and diabetes, while the exact effect of soluble serum urate on glucose metabolism remains elusive. This study aims to characterize the glucose metabolic phenotypes and investigate the underlying molecular mechanisms using a novel spontaneous HU mouse model in which the Uricase (Uox) gene is absent. In an attempt to study the role of HU in glycometabolism, we implemented external stimulation on Uox-knockout (KO) and wild-type (WT) males with a high-fat diet (HFD) and/or injections of multiple low-dose streptozotocin (MLD-STZ) to provoke the potential role of urate. Notably, while Uox-KO mice developed glucose intolerance in the basal condition, no mice spontaneously developed diabetes, even with aging. HFD-fed Uox-KO mice manifested similar insulin sensitivity compared with WT controls. HU augmented the existing glycometabolism abnormality induced by MLD-STZ and eventually led to diabetes, as evidenced by the increased random glucose. Reduced β-cell masses and increased terminal deoxynucleotidyl TUNEL-positive β-cells suggested that HU-mediated diabetes was cell death dependent. However, urate-lowering treatment (ULT) cannot ameliorate the diabetes incidence or reverse β-cell apoptosis with significance. ULT displayed a significant therapeutic effect of HU-crystal– associated kidney injury and tubulointerstitial damage in diabetes. Moreover, we present transcriptomic analysis of isolated islets, using Uox-KO versus WT mice and streptozotocin-induced diabetic WT (STZ-WT) versus diabetic Uox-KO (STZ-KO) mice. Shared differentially expressed genes of HU primacy revealed Stk17β is a possible target gene in HU-related β-cell death. Together, this study suggests that HU accelerates but does not cause diabetes by inhibiting islet β-cell survival.

National 400m hurdles champion Rushell Clayton is concerned about what she says are inequalities between men and women in track and field. Clayton was speaking at a Women in Sports Conference in Kingston recently and discussed issues of inequality...

The U.S. Coast Guard named Rear Adm. Melissa Bert as its first female judge advocate and chief counsel, its top legal position.

Dr. Bettie R. McKaig, who served as the Association’s first vice president from 1998-99, died Feb. 3. She was 70.

A 29 years old female presented to us in the metabolic clinic of the University of Port Harcourt Teaching Hospital (UPTH) on account of a week history of easy fatigability, weakness, and lower extremity muscle cramps associated with numbness and tingling sensation in the peri-oral area, fingers and toes. Two weeks prior to the onset of her presenting symptoms, she had visited a local pharmaceutical shop on account of a distressing epigastric discomfort and was subsequently placed on daily oral omeprazole 20mg daily for a month by a pharmacist. She had been on the omeprazole medication for two weeks before her present symptoms manifested. Her past medical history was not suggestive of hypoparathyroidism nor pancreatitis. She was married with three children and has an uneventful family, social and obstetric histories. On examination, she was a healthy well-oriented young female with positive Trousseau’s, Chvostek’s and epigastric tenderness signs. Further Laboratory evaluation revealed she had low plasma magnesium, low plasma albumin-corrected calcium, and low serum parathyroid hormone levels, while other laboratory parameters were essentially normal. A diagnosis of omeprazole-induced electrolyte disorders (hypomagnesaemia and hypocalcaemia) associated with hypoparathyroidism was made following the review of her clinical examination and laboratory findings. She was subsequently managed with oral magnesium supplements following the withdrawal of the omeprazole medication (replaced with oral ranitidine), monitored weekly, and full recovery was achieved after three weeks.

(I am in the USA). There was 8 Henry s https://en.wikipedia.org/wiki/Henry_VIII_of_England

Neuropsychology.

Women immigrants -- Australia -- History.

Lisbonne : Impr. de l'Académie royale des sciences, 1881.

[Wien] : [publisher not identified], 1860.

Wiesbaden : Bergmann, 1900.

Cassel : T. Fischer, 1884.

Paris : G. Steinheil, 1892.

Paris : V. Adrien Delahaye, 1879.

Amanda Avona
May 29, 2019; 39:4323-4331
Systems/Circuits

Gert Holstege
Oct 8, 2003; 23:9185-9193
BehavioralSystemsCognitive