hype Activation of Retinal Angiogenesis in Hyperglycemic pdx1-/- Zebrafish Mutants By diabetes.diabetesjournals.org Published On :: 2020-04-20T12:00:34-07:00 Progression from the initial vascular response upon hyperglycemia to a proliferative stage with neovacularizations is the hallmark of proliferative diabetic retinopathy. Here, we report on the novel diabetic pdx1–/– zebrafish mutant as a model for diabetic retinopathy that lacks the transcription factor pdx1 through CRISPR-Cas9–mediated gene knockout leading to disturbed pancreatic development and hyperglycemia. Larval pdx1–/– mutants prominently show vasodilation of blood vessels through increased vascular thickness in the hyaloid network as direct developmental precursor of the adult retinal vasculature in zebrafish. In adult pdx1–/– mutants, impaired glucose homeostasis induces increased hyperbranching and hypersprouting with new vessel formation in the retina and aggravation of the vascular alterations from the larval to the adult stage. Both vascular aspects respond to antiangiogenic and antihyperglycemic pharmacological interventions in the larval stage and are accompanied by alterations in the nitric oxide metabolism. Thus, the pdx1–/– mutant represents a novel model to study mechanisms of hyperglycemia-induced retinopathy wherein extensive proangiogenic alterations in blood vessel morphology and metabolic alterations underlie the vascular phenotype. Full Article
hype Design of the {beta}3-Adrenergic Agonist Treatment in Chronic Pulmonary Hypertension Secondary to Heart Failure Trial By www.basictranslational.onlinejacc.org Published On :: 2020-04-27T11:00:20-07:00 Combined pre-and post-capillary hypertension (CpcPH) is a relatively common complication of heart failure (HF) associated with a poor prognosis. Currently, there is no specific therapy approved for this entity. Recently, treatment with beta-3 adrenergic receptor (β3AR) agonists was able to improve pulmonary hemodynamics and right ventricular (RV) performance in a translational, large animal model of chronic PH. The authors present the design of a phase II randomized clinical trial that tests the benefits of mirabegron (a clinically available β3AR agonist) in patients with CpcPH due to HF. The effect of β3AR treatment will be evaluated on pulmonary hemodynamics, as well as clinical, biochemical, and advanced cardiac imaging parameters. (Beta3 Agonist Treatment in Chronic Pulmonary Hypertension Secondary to Heart Failure [SPHERE-HF]; NCT02775539) Full Article
hype Asthma and hypercapnic respiratory failure By breathe.ersjournals.com Published On :: 2020-03-18T06:44:39-07:00 A 40-year-old, male non-smoker was diagnosed with asthma 6 years ago. He now presents with a 1-week history of worsening breathlessness with fever, cough, and purulent expectoration. He has had >10 emergency department visits and two admissions to hospital in the last 3 months. At each admission, he received bronchodilators and systemic steroids resulting in rapid improvement within 24 h. However, in the current presentation, the patient has no relief with corticosteroids and bronchodilators. His pulse is 140 per min, respiratory rate is 40 per min, blood pressure is 90/60 mmHg and room air oxygen saturation is 80%. Arterial blood gas (ABG) analysis shows hypercapnic respiratory failure. In view this respiratory failure, the patient is intubated and mechanical ventilation initiated. A chest radiograph is shown in figure 1. The therapy initiated includes bronchodilators, a systemic steroid, antibiotics and supportive care. Full Article
hype Worldwide Increase in Diagnosis of Hypertension in Children By aapgrandrounds.aappublications.org Published On :: 2020-05-01T00:59:36-07:00 Full Article
hype Hypermutator Pseudomonas aeruginosa Exploits Multiple Genetic Pathways To Develop Multidrug Resistance during Long-Term Infections in the Airways of Cystic Fibrosis Patients [Mechanisms of Resistance] By aac.asm.org Published On :: 2020-04-21T08:01:09-07:00 Pseudomonas aeruginosa exploits intrinsic and acquired resistance mechanisms to resist almost every antibiotic used in chemotherapy. Antimicrobial resistance in P. aeruginosa isolates recovered from cystic fibrosis (CF) patients is further enhanced by the occurrence of hypermutator strains, a hallmark of chronic infections in CF patients. However, the within-patient genetic diversity of P. aeruginosa populations related to antibiotic resistance remains unexplored. Here, we show the evolution of the mutational resistome profile of a P. aeruginosa hypermutator lineage by performing longitudinal and transversal analyses of isolates collected from a CF patient throughout 20 years of chronic infection. Our results show the accumulation of thousands of mutations, with an overall evolutionary history characterized by purifying selection. However, mutations in antibiotic resistance genes appear to have been positively selected, driven by antibiotic treatment. Antibiotic resistance increased as infection progressed toward the establishment of a population constituted by genotypically diversified coexisting sublineages, all of which converged to multidrug resistance. These sublineages emerged by parallel evolution through distinct evolutionary pathways, which affected genes of the same functional categories. Interestingly, ampC and ftsI, encoding the β-lactamase and penicillin-binding protein 3, respectively, were found to be among the most frequently mutated genes. In fact, both genes were targeted by multiple independent mutational events, which led to a wide diversity of coexisting alleles underlying β-lactam resistance. Our findings indicate that hypermutators, apart from boosting antibiotic resistance evolution by simultaneously targeting several genes, favor the emergence of adaptive innovative alleles by clustering beneficial/compensatory mutations in the same gene, hence expanding P. aeruginosa strategies for persistence. Full Article
hype Molecular and Clinical Characterization of Multidrug-Resistant and Hypervirulent Klebsiella pneumoniae Strains from Liver Abscess in Taiwan [Epidemiology and Surveillance] By aac.asm.org Published On :: 2020-04-21T08:01:09-07:00 Hypervirulent Klebsiella pneumoniae strains are the major cause of liver abscesses throughout East Asia, and these strains are usually antibiotic susceptible. Recently, multidrug-resistant and hypervirulent (MDR-HV) K. pneumoniae strains have emerged due to hypervirulent strains acquiring antimicrobial resistance determinants or the transfer of a virulence plasmid into a classic MDR strain. In this study, we characterized the clinical and microbiological properties of K. pneumoniae liver abscess (KPLA) caused by MDR-HV strains in Taiwan. Patients with community onset KPLA were retrospectively identified at Taipei Veterans General Hospital during January 2013 to May 2018. Antimicrobial resistance mechanisms, capsular types, and sequence types were determined. MDR-HV strains and their parental antimicrobial-susceptible strains further underwent whole-genome sequencing (WGS) and in vivo mice lethality tests. Thirteen MDR-HV strains were identified from a total of 218 KPLA episodes. MDR-HV strains resulted in similar outcomes to antimicrobial-susceptible strains. All MDR-HV strains were traditional hypervirulent clones carrying virulence capsular types. The major resistance mechanisms were the overexpression of efflux pumps and/or the acquisition of ESBL or AmpC β-lactamase genes. WGS revealed that two hypervirulent strains had evolved to an MDR phenotype due to mutation in the ramR gene and the acquisition of an SHV-12-bearing plasmid, respectively. Both these MDR-HV strains retained high virulence compared to their parental strains. The spread of MDR-HV K. pneumoniae strains in the community raises significant public concerns, and measures should be taken to prevent the further acquisition of carbapenemase and other resistance genes among these strains in order to avoid the occurrence of untreatable KPLA. Full Article
hype Digital storytelling: Selling properties with ease in a hyper-connected world By batdongsan.com.vn Published On :: 17:34 04/03/2020 Three marketing experts share their unconventional means of capturing the attention of potential homeowners of today. Full Article
hype More than 40 children treated in London for 'hyper inflammatory new disease after seemingly contracting coronavirus' By www.standard.co.uk Published On :: 2020-05-07T09:20:00Z More than 40 children have been treated in a specialist London hospital for a "hyper inflammatory" new disease after apparently contracting coronavirus, the Standard has been told. Full Article
hype Bug experts dismiss worry about U.S. 'murder hornets' as hype By www.ctvnews.ca Published On :: Thu, 7 May 2020 15:47:57 -0400 Insect experts say people should calm down about the big bug with the nickname "murder hornet" -- unless you are a beekeeper or a honeybee. Full Article
hype Salman Khan's Car Collection Worth Rs 14 Crores Is As Hypercool As His Movies & Swag By www.mensxp.com Published On :: Fri, 08 May 2020 12:40:41 +0530 Full Article Road Warriors
hype Peter V'landys's hyper-aggressive approach to restarting the NRL could end in boom or bust By www.abc.net.au Published On :: Tue, 28 Apr 2020 04:40:19 +1000 Flattering comparisons with other leading sports officials have also helped elevate the ARL chairman's current status as the can-do man of Australian sport, but as Richard Hinds asks, is he about to make a huge mistake? Full Article NRL Rugby League Sport COVID-19 Diseases and Disorders Health
hype Mallinckrodt’s INOmax successful in trial of neonates with pulmonary hypertension By www.thepharmaletter.com Published On :: Mon, 04 May 2020 17:20:00 +0100 UK-based Mallinckrodt Pharmaceuticals has ended a trial of INOmax (nitric oxide) gas early due to positive… Full Article Drug Trial/Inomax/Mallinckrodt/Nitric Oxide/Pharmaceutical/Research/Respiratory and Pulmonary/UK
hype Justice Department Files Antitrust Lawsuit to Stop VeriFone from Buying Hypercom and Entering into Anticompetitive Divestiture Agreement with Ingenico By www.justice.gov Published On :: Thu, 12 May 2011 14:55:33 EDT The Department of Justice filed a civil antitrust lawsuit today to block the proposed acquisition by VeriFone Systems Inc. of Hypercom Corp. Full Article OPA Press Releases
hype VeriFone, Hypercom and Ingenico Abandon Plans to Divest Point of Sale Business to Ingenico Following Justice Department Lawsuit By www.justice.gov Published On :: Fri, 20 May 2011 15:36:21 EDT VeriFone Systems Inc., Hypercom Corp. and Ingenico S.A. have abandoned plans for Hypercom to divest its U.S. point-of-sale business to Ingenico. Full Article OPA Press Releases
hype Justice Department Reaches Settlement with VeriFone and Hypercom After Gores Group is Determined to be Acceptable Buyer for Point-of-Sale Terminals Business By www.justice.gov Published On :: Thu, 4 Aug 2011 09:53:20 EDT The Department of Justice announced today that, in order for VeriFone Systems Inc. to complete its acquisition of Hypercom Corp., it must divest Hypercom’s U.S. point-of-sale terminals business to an entity sponsored by Gores Group LLC, a private equity fund. Full Article OPA Press Releases
hype The transient receptor potential vanilloid 4 (TRPV4) ion channel mediates protease activated receptor 1 (PAR1)-induced vascular hyperpermeability By feeds.nature.com Published On :: 2020-04-27 Full Article
hype A pentaploid-based linkage map of the ancestral octoploid strawberry <i>Fragaria virginiana</i> reveals instances of sporadic hyper-recombination By feeds.nature.com Published On :: 2020-05-07 Full Article
hype Endostatin and ST2 are predictors of pulmonary hypertension disease course in infants By feeds.nature.com Published On :: 2020-05-04 Full Article
hype The fat and the furious: fatty acids fuel hyperproliferative germinal center B cells By feeds.nature.com Published On :: 2020-05-07 Full Article
hype Natural genetic variation in Stim1 creates stroke in the spontaneously hypertensive rat By feeds.nature.com Published On :: 2020-04-17 Full Article
hype Blood pressure control and complex health conditions in older adults: impact of recent hypertension management guidelines By feeds.nature.com Published On :: 2020-04-28 Full Article
hype Gamma-glutamyltransferase, arterial remodeling and prehypertension in a healthy population at low cardiometabolic risk By feeds.nature.com Published On :: 2020-04-29 Full Article
hype Urate-lowering therapy exerts protective effects against hypertension development in patients with gout By feeds.nature.com Published On :: 2020-05-04 Full Article
hype Effects of chronic type 5 phosphodiesterase inhibition on penile microvascular reactivity in hypertensive patients with erectile dysfunction: a randomized crossover placebo-controlled trial By feeds.nature.com Published On :: 2020-05-04 Full Article
hype Management of hypertension in the very old: aggressive reduction of blood pressure is harmful in most patients By feeds.nature.com Published On :: 2020-05-06 Full Article
hype Hypertension in rheumatic diseases: prevalence, awareness, treatment, and control rates according to current hypertension guidelines By feeds.nature.com Published On :: 2020-05-07 Full Article
hype Dystrophic calcification and heterotopic ossification in fibrocartilaginous tissues of the spine in diffuse idiopathic skeletal hyperostosis (DISH) By feeds.nature.com Published On :: 2020-04-02 Full Article
hype Physicist's hyperrealistic origami art bridges nature, math and science (Video) By www.treehugger.com Published On :: Tue, 30 Jun 2015 07:00:00 -0400 Believe it or not, these folded works of wonder are created from a single sheet of paper -- no cuts, no glue. Full Article Living
hype New Life Science Building at University of Washington is described as "hyper-sustainable" By www.treehugger.com Published On :: Fri, 07 Dec 2018 10:25:04 -0500 Or is it a missed opportunity? Full Article Design
hype Artist sculpts hyper-real landscape out of encyclopedia set (Video) By www.treehugger.com Published On :: Fri, 31 Jul 2015 13:38:49 -0400 Books aren't just for reading -- you can carve incredible works out of them too, as this artist has done with this 24-volume set. Full Article Living
hype A Waterloop is a Hyperloop from Waterloo By www.treehugger.com Published On :: Mon, 28 Nov 2016 11:20:19 -0500 Engineering students come up with a hyperloop pod that floats on air. Full Article Transportation
hype Why such hype over Pizza Hut's new round compostable box? By www.treehugger.com Published On :: Thu, 24 Oct 2019 11:00:00 -0400 Until it can be composted in my own backyard, I'm not getting excited. Full Article Business
hype hyper atheist By www.toothpastefordinner.com Published On :: Thu, 20 Aug 2015 04:00:00 EDT Today on Toothpaste For Dinner: hyper atheistThe Worst Things For Sale is Drew's blog. It updates every day. Subscribe to the Worst Things For Sale RSS! Full Article comic
hype conventional hyper organic By www.toothpastefordinner.com Published On :: Thu, 25 Aug 2016 04:00:00 EDT Today on Toothpaste For Dinner: conventional hyper organicThe Worst Things For Sale is Drew's blog. It updates every day. Subscribe to the Worst Things For Sale RSS! Full Article comic
hype whos that hypeman By www.toothpastefordinner.com Published On :: Fri, 16 Dec 2016 04:00:00 EST Today on Toothpaste For Dinner: whos that hypemanThe Worst Things For Sale is Drew's blog. It updates every day. Subscribe to the Worst Things For Sale RSS! Full Article comic
hype hyper definition By www.toothpastefordinner.com Published On :: Wed, 18 Jul 2018 04:00:00 EDT Today on Toothpaste For Dinner: hyper definitionThe Worst Things For Sale is Drew's blog. It updates every day. Subscribe to the Worst Things For Sale RSS! Full Article comic
hype Lucky's Hyperactive Imagination By feedproxy.google.com Published On :: Wed, 14 Aug 2013 22:46:49 -0700 Full Article marshmallow lucky charms imagined
hype World Hypertension Day: Why and how you should reduce your salt intake By www.mid-day.com Published On :: 17 May 2018 06:56:21 GMT Representational Image According to WHO, about 9.8 million people die every year due to hypertension-related complications. Hypertension is considered a silent killer producing heart disease, kidney failure and strokes. About 35 percent of world population above the age of 25 suffers from hypertension. One of the important strategies to lower hypertension in the population and its complications is reducing salt intake. Developed countries like Finland, United Kingdom, Australia and Canada have been actively campaigning for the reduction of salt intake in the population. In these countries, there has been a close association between government and NGO’s for this purpose. Finland was the first country to show an enormous health benefit by reducing salt in the diet. Not only the population’s health improves, there is also a great benefit in saving health expenditure related to heart revascularization and dialysis. How does eating salt lead to or cause hypertension? Eating salt increases the amount of salt in your blood, which ruins the balance of electrolytes and other vitamins and minerals in your body. This imbalance reduces your kidney's ability to filter out toxins from your body. It also reduces your kidney's ability to get rid of excess fluid from your body. This results in high blood pressure due to excess fluid in your body that exerts pressure on the blood vessels leading to the kidneys. How much is too much? Dr Umesh Khanna, Senior Nephrologist and Secretary of Amar Gandhi Foundation said, “The WHO’s recommendation of salt intake from all sources is less than 5 grams per day. Salt or sodium is present in natural food, it is added while cooking and also used as a preservative for processed food. Considering the rapid economic growth that is happening in our country with urbanization and increased demand for processed food, it is imperative that we act at the earliest to control the salt intake of the Indian population.” What happens when you reduce your salt intake? “Salt or Sodium in various forms has been used as a preservative for several thousand years. It enhances the taste, prevents the growth of harmful microorganisms and can improve the texture of food, Taste is often a habit and high salt intake can saturate the taste buds. If you lower salt intake for 2 weeks you can start appreciating low salt intake and other tastes,” says Dr Umesh Khanna What are the most common hidden sources of salt one should keep an eye out for? Dr Umesh Khanna said, “Sodium in various forms is used as a flavouring, buffering, anticaking, leavening, thickening and stabilizing agent. The biggest culprit is in baked goods especially bread and instant noodles.” How can a person start to reduce their salt intake? Here are a few tips by Dr Umesh Khanna Get used to low salt to allow the taste buds to recover: Not only does reducing your salt intake affect your blood pressure and other health parameters, it also helps you taste foods better. Eat fresh food when possible: Since processed foods are packed with high levels of salt, switching to fresh and natural foods is the best way to reduce your daily salt intake. Add less salt in cooking: With high amounts of salt added to food, your taste buds become immune to the level of salt and you will eventually need more salt in your food to bring out the taste you are looking for. Gradually reducing this amount will help you give up the high salt habit one step at a time. And since your taste buds will eventually become more sensitive to salt content in food, dishes made with low salt will start to taste as delicious as one with high salt content. Do not add extra salt while at the table: A common practice in India is to provide a little bit of salt on the side of one’s plate while eating and to provide a salt shaker for one to spice up their soups. By stopping this practice, you can reduce your salt intake. Use herbs and spices as flavouring agents: Ditch the salt and use herbs and other natural flavouring agents to your dishes that will help enhance the flavour while reducing your salt intake. Dr Umesh Khanna, MD, DNB Nephrology, Lancelot Kidney & GI Center, Karuna Hospital & Asian Heart Institute. He is the Chairman, Mumbai Kidney Foundation, Trustee, Sapiens Health Foundation, Secretary, Mumbai Nephrology Group and the Secretary, Amar Gandhi Foundation Catch up on all the latest Crime, National, International and Hatke news here. Also download the new mid-day Android and iOS apps to get latest updates Full Article
hype World Hypertension Day: Regulating salt intake is key to prevent hypertension By www.mid-day.com Published On :: 17 May 2018 11:12:40 GMT Regulating salt consumption is key to prevent hypertension, which is associated with an increased risk of heart disease, heart attack, stroke and heart failure, say experts. According to World Health Organization (WHO), adults should reduce consumption of sodium to less than 2 grams a day, or the equivalent of about one teaspoon of table salt to reduce the risk of heart disease. Hypertension is a condition in which the blood vessels have persistently raised pressure. Hypertension is also referred to as high or raised blood pressure. Hypertension can also affect fertility in both males and females, says Rajalaxmi Walavalkar of Cocoon Fertility. Hypertension not only affects fertility but also is also known to cause trouble sleeping. Trouble sleeping leads to signs of premature ageing, like fine lines, uneven pigmentation and reduced elasticity. "Hypertension can lead to cardiovascular diseases. The rise in blood pressure caused by eating too much salt may damage the arteries leading to the heart," Vijay D'Silva, Director at the Asian Heart Institute, said in statement. According to a recent study, published in the journal Hypertension, about half of adults living in Asia are suffering from the high blood pressure. While lifestyle factors, including diet and stress, are behind the high hypertension rates in Asia, one common problem is high salt intake, the study showed. Asians not only tend to have diets high in sodium, but they are genetically more sensitive to sodium, the researchers said. "Raised blood pressure due to high salt consumption is the biggest single contributing risk factor for non-communicable diseases and damage to your kidney," explained Bhupendra Gandhi of the NGO Amar Gandhi Foundation. Previously, it was believed that eating high amounts of fruit and vegetables might help counteract the effect of high salt on blood pressure. However, another study led by researchers from the Imperial College London and Northwestern University, showed that people eating higher amounts of salt had higher blood pressure -- no matter how healthy a person's overall diet. "Anyone with hypertension is at an increased risk of infertility. A high salt diet leading to high blood pressure can result in delayed puberty and even impact reproductive health," Walavalkar noted. Besides affecting the heart and fertility, hypertension can affect the skin too, the health experts said. "High blood pressure can harden your arteries, which decreases the flow of blood and oxygen. An impairment of the flow of oxygen, to an organ such as your face, can cause your skin to dry and wrinkles faster which can make one look less youthful," said Amit Karkhanis - Medical Cosmetologist and founder of Dr Tvacha clinic. Reducing salt consumption in everyday life, cutting down on fried foods and processed foods, can not only curb the problem of hypertension but also save multiple organs from damage and pave way for a healthy life. Also read: Mumbai Health: These 7 Lifestyle Changes May Help Lower Heart Disease Risk (Edited by mid-day online desk, with inputs from IANS) Catch up on all the latest Mumbai news, crime news, current affairs, and also a complete guide on Mumbai from food to things to do and events across the city here. Also download the new mid-day Android and iOS apps to get latest updates Full Article
hype World Hypertension Day: Expert tips on dealing with hypertension effectively By www.mid-day.com Published On :: 17 May 2018 12:04:16 GMT Representational Image 50 percent of people between the age of 60 to 69 years suffer from hypertension. This statistic only worsens as a person grows older reaching about 75 percent in those over the age of 70. In fact, the lifetime risk of developing hypertension is approximately 90 percent for men and women who were non-hypertensive at 55 or 65 years respectively – making hypertension a condition that requires our immediate attention. While the condition affects one’s whole body, your heart is one organ that takes the worst beating. Dr Santosh Kumar Dora, Senior Cardiologist, Asian Heart Institute tells you how hypertension affects your heart and what you can do to deal with the condition. How does hypertension affect your heart? It can result in hardening and thickening of the heart arteries, leading to their narrowing and causing the heart to receive less blood supply. It can also cause a heart attack. In fact, persons who present with an acute heart attack often have preexisting hypertension that evaded detection and treatment. It can cause abnormal thickening of heart muscle, the presence of which is a strong predictor of future cardiovascular death. High blood pressure puts more load on the heart and increases the amount of work that the heart has to do. Eating right Eating a heart-healthy diet is important for managing your blood pressure and reducing your risk of heart attack, heart disease, stroke and other diseases. Aim to eat a diet that's rich in fruits, vegetables, whole grain and high fibre foods, fat-free and low fat or 1 % dairy products etc. Avoid saturated and trans fats, excess salt and added sugar in your diet. DASH (Dietary approach to stop hypertension) diet pattern which contains low sodium, high potassium and rich in fruits and vegetables reduces by an average of 5.5 mm Hg for systolic and 3 mm Hg for diastolic blood pressure. For hypertensive patients, the reduction is 11.4 mm Hg for systolic and 5.5 for diastolic blood pressure. Low salt (< 1500 mg/day) further potentiates the reduction of blood pressure. Maintain a healthy weight: As your body weight increases, your blood pressure can rise. In fact, being overweight can make you more likely to develop high blood pressure than if you are at your desirable weight. You can reduce your risk of high blood pressure by losing weight. Even small amounts of weight loss can make a big difference in helping to prevent and treat high blood pressure. Studies conducted in obese hypertensive patients show a decrease in body weight by 1 kg resulted in a reduction of systolic and diastolic pressure by 1.2 and 1.0 mmHg, respectively. Be physically active: Physical activity not only helps control your blood pressure, it also helps you manage your weight, strengthen your heart and manage your stress level. Even moderately intense physical activity, such as brisk walking, is beneficial when done regularly for a total of 30 minutes or longer at least 5 days a week. Hiking or stair-climbing, jogging, running, bicycling, swimming, fitness classes, team sports, dance classes are some of the activities which can help you stay fit. Studies say that regular dynamic physical exercise for at least 30 minutes daily for most days of a week leads to 5 to 9 mm Hg reduction of systolic blood pressure. Say no to tobacco: While smoking has not been conclusively proven to cause high blood pressure, each cigarette you smoke temporarily increases your blood pressure for many minutes after you finish. For your overall health and to reduce your risk of heart attack and stroke, avoid all forms of tobacco as well as secondhand smoke. A study has shown that smoking cessation leads to a reduction of systolic blood pressure by 3.5 mm Hg and diastolic blood pressure by 1.9 mm Hg. Avoid drinking: Drinking too much alcohol can raise blood pressure to unhealthy levels. Having more than three drinks in one sitting temporarily increases your blood pressure, but repeated binge drinking can lead to long-term increases. If you have high blood pressure, avoid alcohol or drink alcohol only in moderation. Also read: World Hypertension Day: Why And How You Should Reduce Your Salt Intake Catch up on all the latest Crime, National, International and Hatke news here. Also download the new mid-day Android and iOS apps to get latest updates Full Article
hype Avengers: Endgame Movie Review: Equals the hype; that's saying a lot! By www.mid-day.com Published On :: 26 Apr 2019 04:39:29 GMT Avengers: EndgameU/A: Action, Adventure, FantasyDirector: Anthony Russo, Joe RussoCast: Robert Downey Jr, Chris Evans, Mark Ruffalo, Chris Hemsworth, Scarlett JohanssonRating: How does one put together words about a film that, for all practical purposes, anything and everything you write, is likely to be misconstrued/diagnosed as a spoiler? Suffice it to know that this expectedly dramatic conclusion of Marvel's three-part Infinity Saga is a relatively internalised, deep and sober film, concerned more with the motivations of super-heroes, the choices before them, and what they should pick, in order to take on super-villain Thanos—of course. For one, the earth is a much quieter place, since as you're aware, its species have been annihilated, decimated by Devil Thanos, ever since he got his hands on the infinity stones, and went on to execute the bizarre plan of supposedly ethical ethnic cleansing—randomly ridding planets of half its populations, to make them more sustainable, by restoring balance of sorts, as it were. Of course, there will be survivors. And Iron Man or Tony Stark (Robert Downey Jr), to start with, is thankfully rescued or reunited with the human family back home. So is Hawkeye (Jeremy Renner). Both of them, like all the others, seem to be somberly dealing with the aftermath of a universal tragedy. Surely, you have your own favourites from this cinematic universe (and how can Iron Man not top that list?). But there's something about the inherent cuteness of Hulk (Mark Ruffalo) that saves this franchise's final installment from turning into a complete depresso—left to be downed over rounds of espresso, what with the screen-time running three hours plus. Also Read: Box Office report: Avengers: Endgame sells 1 million advance tickets in India Indians might thank their theatres for the usually hated interval. I caught it without one, but didn't miss it either. There's enough material here to keep you engaged, even if to wonder, on occasion, if some of it makes any sense. You may or may not be impressed with the long drawn explanations, but you're only too happy to go with it. Frankly, I'm no Marvel fanboy/fanatic—if the movie-world is indeed divided into two types, then more the DC demographic. That said, there is an infectious verve and energy that multiple super-heroes bring to this cinematic universe that is hard to not be swayed by, even if an individual or sub-set, Guardians Of Galaxy in particular, may be difficult to appreciate on their own. Check out the Avengers: Endgame trailer here: Avengers: Endgame does a fine job of navigating a reasonably cogent script without over-populating the screen. Avengers: Infinity War seemed more overwrought in comparison. I re-watched portions of the 2018 prequel on my phone (for quick revision), which of course means I didn't watch it at all. For, at the end of the day, battle sequences and pyrotechnics is the point of it all, isn't it? Endgame, despite all the philosophy, is not an exception. It shines gloriously as 3D spectacle on the IMAX screen, ideally viewed from the third-row, from the back—and if you're not on IMAX, then the third row from the front—for a stunningly immersive experience, with such depth of field that the points where the camera focuses on a river, the ripples flowing towards you, you almost feel like you can wade through the frickin' water! I know, don't need to put in a word (spoilers be damned). Suffice it to know that seldom has the excitement of audiences entering a theatre, matched by those exiting, after a hugely hyped pic. Endgame equals its astounding anticipation. And that's saying a whole lot! Also read: Avengers: Endgame Box Office Prediction: Will the film open at Rs 50 crore in India? Catch up on all the latest entertainment news and gossip here. Also download the new mid-day Android and iOS apps to get latest updates Full Article
hype HyperSurfaces control electromagnetic energy with an app By ec.europa.eu Published On :: Mon, 30 Mar 2020 00:00:00 GMT Metasurfaces can manipulate electromagnetic energy far beyond the limits of natural materials. An EU-funded project has developed a multifunctional and more accessible version that could enable easily programmable, smarter environments. Full Article
hype Air Pollution Boosts Pregnancy Hypertension Risk By www.medindia.net Published On :: Traffic-related air pollution was found to increase a pregnant woman's risk for hypertension, stated new report from the National Toxicology Program (NTP). Full Article
hype New Guidelines Improve Treatment of Hyperthyroid Patients By feedproxy.google.com Published On :: Radioactive iodine is the recommended frontline treatment for patients with hyperthyroidism seen in Graves' disease, according to an evidence review led by University of Birmingham researchers. Full Article
hype Seasonal Variations in Hypertensive Disorders During Pregnancy Identified By www.medindia.net Published On :: Seasonal variations have been observed in the risk of the hypertensive disorders of pregnancy--including gestational hypertension and preeclampsia, said new study. Full Article
hype Hypertensive Disorders During Pregnancy By www.medindia.net Published On :: Women who have experienced hypertensive disorder during their pregnancies were found to be at an increased risk of developing cardiovascular or kidney Full Article
hype Hypertension Poorly Managed in Low- and Middle-income Countries: Study By www.medindia.net Published On :: Two-thirds of people with high blood pressure in low- and middle-income countries (LMICs) are affected going without treatment, according to a new study led by researchers at Harvard T. Full Article
hype Less Than One-third of Hypertensive Patients are Treated in the Global South By www.medindia.net Published On :: More than two-thirds of all people affected with high blood pressure in low- and middle-income countries go without treatment, claim researchers. Based Full Article
hype Midlife Hypertension Linked to Dementia Risk By www.medindia.net Published On :: High blood pressure patterns in middle age followed by low blood pressure later in life was linked to higher risk for dementia compared to having normal blood pressure, revealed new study findings. Full Article