(California Court of Appeal) - Affirmed. Plaintiff sought to prevent the rebuilding of an equestrian facility following a fire by filing a petition to have the Coastal Commission to revoke the required coastal development permit on the grounds that the regulation used to make the decision was not interpreted correctly. The appeals court disagreed.

(United States First Circuit) - In a suit brought by a solo law practitioner alleging that defendant violated the Computer Fraud and Abuse Act (CFAA) when it issued a software license key that expired on May 31, 2011, despite the fact that he owned a permanent license to the software at issue, the district court's order adopting the magistrate judge's report and recommendation, denying plaintiff's motion to strike, and granting HSI's motion for summary judgment are affirmed where plaintiff failed to establish the necessary $75,000 amount in controversy.

(California Court of Appeal) - Held that the trial court lacked subject matter jurisdiction to hear the People's claim alleging that the owner of a tobacco smoke shop on Indian lands was liable under California's Unfair Competition Law for violating various laws applicable to cigarette sales and marketing. Reverse an order granting summary adjudication to the People on this claim.

A compelling addition to repo house – but is the Redmond flavour too strong?

GitHub had a lot to say about its plans at its virtual Satellite event yesterday, but the most far-reaching was the advent of Codespaces, the ability to edit code online, integrated into the GitHub user interface.…

Revisit what it’s like to run a PDP-10 and be eaten by a grue

Source code for seminal adventure game Zork, dating back to 1977 and recovered from MIT tapes, was published this week on GitHub.…

IBM es y ha sido un jugador clave en el progreso de México, liderando en el transcurso de 90 años a diferentes generaciones a través de la transformación de industrias y profesiones, e impactando el panorama económico, académico y social del país gracias a la estrecha colaboración con todos los actores de la sociedad.

MineHub Technologies e IBM anunciaron hoy una colaboración para utilizar la tecnología blockchain con el objetivo de mejorar la eficiencia operativa, logística, financiamiento y reducir los costos en la cadena de suministro de concentrados minerales de alto valor, desde la mina hasta el comprador final.

IBM Q Network to explore practical applications of quantum computing for business and science with University of Melbourne, JPMorgan Chase, Daimler AG, Samsung, JSR Corporation, Barclays, Hitachi Metals, Honda, Nagase, Keio University, Oak Ridge National Lab, and Oxford University.

When it comes to getting traffic to your website, one of the ways that is commonly talked about is writing and submitting articles to sites such as Ezine Articles, or Article Base. These types of sites provide one way back links related your topic with the objective of driving targeted traffic to your website.

Ambient pollution is a byproduct of economic activity. It has been widely reported that COVID-19 and associated lockdowns have generated large improvements in air quality worldwide, including to China's notoriously-poor air quality. We analyze China's official pollution monitor data and account for the large, recurrent improvement in air quality following Lunar New Year (LNY), which essentially coincided with lockdowns in 2020. With the important exception of NO2, China's air quality improvements in 2020 are smaller than we should expect near the pandemic's epicenter: Hubei province. Compared with LNY improvements experienced in 2018 and 2019 in Hubei, we see smaller improvements in SO2 while ozone concentrations increased in both relative and absolute terms (roughly doubling). Similar patterns are found for the six provinces neighboring Hubei. We conclude that whether COVID-19 actually decreased pollution in China depends on the pollutant and reference period considered.

R.D. Hubbard, who once owned part of Hollywood Park and Los Alamitos Race Course, died at his home in Palm Desert on Wednesday at age 84.

Warning memos were written. Research was funded. But what good is any of this if American leaders fail to act?

New techniques are being used to transform images from Hubble into spectacular 3D visualisations.

oscon: There's still time left to apply for #OSCON scholarships from @github + @newrelic. Deadline is 6/15 http://t.co/xQwx30jnaN

Tart rhubarb and creamy custard—sweetened with just a hint of orange zest and nestled inside a flaky crust—are a match made in rustic pie heaven. This no-fuss single crust pie takes only a few minutes to prepare.

Continue reading "Rhubarb Custard Pie" »

The One Health Poultry Hub is committed to minimise the international public health risks associated with the rapid intensification of poultry production in India, Sri Lanka, Bangladesh and Vietnam through building capacity for interdisciplinary research and supporting cross-sectorial collaborations at national and regional levels.

Cholesterol/sphingolipid-rich membrane domains, known as lipid rafts or membrane rafts, play a critical role in the compartmentalization of signaling pathways. Physical segregation of proteins in lipid rafts may modulate the accessibility of proteins to regulatory or effector molecules. Thus, lipid rafts serve as sorting platforms and hubs for signal transduction proteins. Cancer cells contain higher levels of intracellular cholesterol and lipid rafts than their normal non-tumorigenic counterparts. Many signal transduction processes involved in cancer development (insulin-like growth factor system and phosphatidylinositol 3-kinase-AKT) and metastasis [cluster of differentiation (CD)44] are dependent on or modulated by lipid rafts. Additional proteins playing an important role in several malignant cancers (e.g., transmembrane glycoprotein mucin 1) are also being detected in association with lipid rafts, suggesting a major role of lipid rafts in tumor progression. Conversely, lipid rafts also serve as scaffolds for the recruitment and clustering of Fas/CD95 death receptors and downstream signaling molecules leading to cell death-promoting raft platforms. The partition of death receptors and downstream signaling molecules in aggregated lipid rafts has led to the formation of the so-called cluster of apoptotic signaling molecule-enriched rafts, or CASMER, which leads to apoptosis amplification and can be pharmacologically modulated. These death-promoting rafts can be viewed as a linchpin from which apoptotic signals are launched. In this review, we discuss the involvement of lipid rafts in major signaling processes in cancer cells, including cell survival, cell death, and metastasis, and we consider the potential of lipid raft modulation as a promising target in cancer therapy.

euromicron AG, a medium-sized technology group and specialist for the digital support of business processes through secure infrastructures, is pooling its digital expertise at KORAMIS GmbH, the group subsidiary that specializes in cyber security and automation. With focus on digital platforms and services KORAMIS’ portfolio will also cover the areas Smart IoT, Smart Building as well as Data Management in the future. For this step the management of KORAMIS GmbH was extended by Andreas Schmidt.

GitHub is holding its annual 'Universe' conference in San Francisco this week.

Hubbard asks: Can we design a more effective plan, in case of a next time?

Cholesterol/sphingolipid-rich membrane domains, known as lipid rafts or membrane rafts, play a critical role in the compartmentalization of signaling pathways. Physical segregation of proteins in lipid rafts may modulate the accessibility of proteins to regulatory or effector molecules. Thus, lipid rafts serve as sorting platforms and hubs for signal transduction proteins. Cancer cells contain higher levels of intracellular cholesterol and lipid rafts than their normal non-tumorigenic counterparts. Many signal transduction processes involved in cancer development (insulin-like growth factor system and phosphatidylinositol 3-kinase-AKT) and metastasis [cluster of differentiation (CD)44] are dependent on or modulated by lipid rafts. Additional proteins playing an important role in several malignant cancers (e.g., transmembrane glycoprotein mucin 1) are also being detected in association with lipid rafts, suggesting a major role of lipid rafts in tumor progression. Conversely, lipid rafts also serve as scaffolds for the recruitment and clustering of Fas/CD95 death receptors and downstream signaling molecules leading to cell death-promoting raft platforms. The partition of death receptors and downstream signaling molecules in aggregated lipid rafts has led to the formation of the so-called cluster of apoptotic signaling molecule-enriched rafts, or CASMER, which leads to apoptosis amplification and can be pharmacologically modulated. These death-promoting rafts can be viewed as a linchpin from which apoptotic signals are launched. In this review, we discuss the involvement of lipid rafts in major signaling processes in cancer cells, including cell survival, cell death, and metastasis, and we consider the potential of lipid raft modulation as a promising target in cancer therapy.

President Obama appears serenely confident as he goes about fixing the worst global financial crisis in more than half a century while simultaneously revamping the national health-care system, changing the way Americans use and produce energy, giving tax breaks to 95 percent of all households, an...

Hubbard was the AP Big 12 Offensive Player of the Year and finished eighth in the Heisman Trophy voting, the third-best finish for a Canadian player. It was the second-best single-season total in school history, trailing only Barry Sanders' 1988 Heisman season. Hubbard was the runner-up for the Cornish Trophy in 2019 after his redshirt freshman season.

Tubingen : H. Laupp, 1863.

Tubingen : H. Laupp, 1862-1869.

[Wien] : [publisher not identified], 1860.

Wien : W. Braumuller, 1895.

Wien : K.K. Hof- und Staatsdruckerei, 1861.

Rockville, Maryland : National Institute on Drug Abuse, 1986.

Rockville, Maryland : National Institute on Drug Abuse, 1985.

Rockville, Maryland : National Institute on Drug Abuse, 1985.

Rockville, Maryland : National Institute on Drug Abuse, 1985.

Hubbe (Family)

Randy L. Buckner
Feb 11, 2009; 29:1860-1873
Neurobiology of Disease

The snazzy search is part of the telescope’s 30th anniversary celebration

Hubbard's Sportive Lemurs are nocturnal. This one curiously peeked out of its hollow tree trunk bedroom when we made a bit of noise. We spotted it from a distance at Zombitse National Park in Madagascar.

The Bank for International Settlements (BIS) today announced two key appointments to the BIS Innovation Hub, a new initiative designed to support central bank collaboration on new financial technology. (Press release, 19 February 2020)

Press release "Saudi G20 Presidency and the Bank for International Settlements (BIS) Innovation Hub invite global innovators to solve RegTech and SupTech challenges", 27 April 2020

Ontario Premier Doug Ford says the Toronto Maple Leafs' parent company has been in contact with the province about the possibility of Canada's biggest city serving as a so-called "hockey pod" for teams should the NHL resume its season.

AROUND five people a day are being seen at Covid hubs across Scotland as demand for the service declines.

The cartridge was meant to upgrade the processor and GPU in the Surface Hub 2S so as to allow rotation and multiple hubs to work together.