fyi MOBILE PURIFICATION DEVICE AND METHOD FOR PURIFYING INDOOR AIR AND/OR FRESH AIR By www.freepatentsonline.com Published On :: Thu, 11 May 2017 08:00:00 EDT A mobile purification device for purifying indoor air and/or fresh air, has a holder and a filter element having a particle-filtering and a gas-adsorbing region, the particle-filtering region having a filter medium and the filter element being received in the holder to purify indoor air and/or fresh air containing smoke and/or particles and is useful as a mobile purification device, filtering particle-polluted and/or smoke-polluted indoor air and/or fresh air as effectively as possible, with particulate, emitted contaminants being prevented as far as possible from being discharged from the gas-adsorbing region into a space, wherein the particle-filtering region faces a downstream side of the holder and in that the gas-adsorbing region faces an upstream side, which can be supplied with indoor air and/or fresh air polluted with smoke and/or particles. Full Article
fyi Process for purifying solid carboniferous fuels prior to combustion, liquefaction or gasification using a rotary chamber By www.freepatentsonline.com Published On :: Tue, 31 Mar 2015 08:00:00 EDT Solid carboniferous fuels contain varying quantities of moisture, mercury, chlorine, nitrogen, sulfur, heavy metals and other materials that attain vapor pressure at elevated temperatures. The cost effective removal of these degrading and sometimes hazardous materials is important to the further use of the fuel for combustion as a solid, liquid, or gas. The solid fuel is cut, shredded, ground or sieved to appropriate size, and heated in a chamber that can exclude oxygen and air thus preventing ignition. The unwanted materials are driven in the gaseous state and extracted for disposal. The solid fuel cleaned of pollutants exits the chamber and is cooled below ignition temperature prior to contact with oxygen. The solid fuel thus purified is more appropriate for combustion, liquefaction or gasification due to the reduced costs in use as a fuel or in the post combustion clean up. Full Article
fyi APPARATUS FOR IDENTIFYING LOCATION OF USER By www.freepatentsonline.com Published On :: Thu, 22 Jun 2017 08:00:00 EDT A terminal for identifying a location of a user includes a transmitter configured to transmit data, a receiver configured to receive the data, a sensor configured to sense at least one piece of context information, and a controller configured to determine a priority order of area information, service set identifier (SSID) information, global positioning system (GPS) signal information, and the context information corresponding to each location, identify the location based on the priority order, and determine the priority order of the SSID information and the GPS signal information in response to retrieving a number of SSIDs. Full Article
fyi Kronos Once Again Conveys the Unifying Power of Music By www.eastbayexpress.com Published On :: Wed, 19 Feb 2020 01:00:00 -0800 Quartet's formidable live performance at Zellerbach was nonetheless upstaged by the work of its collaborators. That's probably how the members wanted it. Without disrespecting the formidable prowess of the Kronos Quartet, the contemporary string quartet was upstaged in its live performance last Thursday at Zellerbach Hall by a guy at a piano and the filmed performance of an Inuk throat singer and a pipa player. The ambitious two-part program An Evening With Kronos Quartet began with celebrated minimalist composer and keyboard player Terry Riley performing a solo piano set.… Full Article Music
fyi NON-INVASIVE SYSTEMS AND METHODS FOR IDENTIFYING RESPIRATORY DISTURBANCES EXPERIENCED BY A SUBJECT By www.freepatentsonline.com Published On :: Thu, 29 Jun 2017 08:00:00 EDT An example method for detecting respiratory disturbances experienced by a subject can include receiving an airflow signal and at least one of an acoustic or vibration signal, where the airflow, acoustic, and/or vibration signals are associated with the subjects breathing. At least one feature can be extracted from the airflow signal and at least one feature can be extracted from at least one of the acoustic or vibration signal. Based on the extracted features, at least one respiratory disturbance can be detected. The respiratory disturbance can be flow limited breath or inspiratory flow limitation (“IFL”). Full Article
fyi ELECTROLYTIC LIQUID GENERATING DEVICE, LIQUID MODIFYING DEVICE PROVIDED WITH ELECTROLYTIC LIQUID GENERATING DEVICE, AND ELECTRIC APPARATUS USING ELECTROLYTIC LIQUID GENERATED BY MEANS OF ELECTROLYTIC LIQUID GENERATING DEVICE By www.freepatentsonline.com Published On :: Thu, 22 Jun 2017 08:00:00 EDT Electrolytic liquid generating device (1) includes laminated body (41) in which conductive film (46) is laminated to be interposed between mutually adjacent electrodes (44, 45), and electrolytic part (40) which electrolyzes liquid. Furthermore, electrolytic liquid generating device (1) includes a passage having inflow port (71) in which liquid to be provided to electrolytic part (40) flows and outflow port (72) from which electrolytic liquid generated in electrolytic part (40) flows out. The passage is formed such that liquid flowing direction (X) crosses laminated direction (Z) of laminated body (41). Full Article
fyi DEVICES AND METHODS FOR IDENTIFYING A BIOLOGICAL OR CHEMICAL RESIDUE IN AN LIQUID SAMPLE By www.freepatentsonline.com Published On :: Thu, 29 Jun 2017 08:00:00 EDT The invention discloses methods and devices for rapidly detecting a biological and/or chemical residue in a liquid sample. In some embodiments of the instant invention, a single antenna is generally employed in proximity to an aqueous solution in a disposable cup, with electrical outputs being recorded by an electrical metering device in communication with the single antenna. Commercial plastic cups may be used for detection of electric fields related to cleanliness of water samples. General and specific target detection may be performed with various embodiments of the instant invention. Full Article
fyi AMPLIFYING ELECTRONIC CIRCUIT WITH REDUCED START-UP TIME FOR A SIGNAL INCLUDING QUADRATURE COMPONENTS By www.freepatentsonline.com Published On :: Thu, 29 Jun 2017 08:00:00 EDT An electronic circuit for amplifying signals with two components in phase quadrature, which includes: a feedback amplifier with a feedback capacitor; a switch that drives charging and discharging of the feedback capacitor; an additional capacitor; and a coupling circuit, which alternatively connects the additional capacitor in parallel to the feedback capacitor or else decouples the additional capacitor from the feedback capacitor. The switch opens at a first instant, where a first one of the two components assumes a first zero value; the coupling circuit decouples the additional capacitor from the feedback capacitor in a way synchronous with a second instant, where the first component assumes a second zero value. Full Article
fyi METHODS OF LINEARLY AMPLIFYING WHOLE GENOME OF A SINGLE CELL By www.freepatentsonline.com Published On :: Thu, 29 Jun 2017 08:00:00 EDT Embodiments of the disclosure encompass methods of amplifying nucleic acid from one or more cells using MALBAC (multiple annealing and looping-based amplification cycles) primers. In particular embodiments, the nucleic acid is amplified as amplicons in a linear manner. Specific embodiments include the removal or effective destruction of nonlinearly produced amplicons. Full Article
fyi SEPARATING AND QUANTIFYING THIAMINE PYROPHOSPHATE AND PYRIDOXAL 5-PHOSPHATE IN HUMAN WHOLE BLOOD By www.freepatentsonline.com Published On :: Thu, 29 Jun 2017 08:00:00 EDT The present disclosure provides robust, high-throughput, and clinically applicable methods for simultaneously separating and quantifying the biologically active forms of Vitamin B1 (TPP) and Vitamin B6 (PLP) from human whole blood. Full Article
fyi METHOD OF VERIFYING REMOVAL OF A PEEL PLY MATERIAL FROM A COMPOSITE STRUCTURE AND DOPED PEEL PLY ASSEMBLY By www.freepatentsonline.com Published On :: Thu, 29 Jun 2017 08:00:00 EDT A method of verifying removal of peel ply material from a composite structure is provided. The method includes doping a layer of peel ply fabric with an identifier. The method also includes curing the composite structure with the layer of peel ply fabric disposed on a surface of the composite structure. The method further includes removing the layer of peel ply fabric from the surface. The method yet further includes scanning the surface of the composite structure for the identifier. Full Article
fyi Bangladesh garment factories reopen, defying virus lockdown By retail.economictimes.indiatimes.com Published On :: 2020-04-27T11:49:51+05:30 "We have to accept coronavirus as part of life. If we don't open factories, there will be economic crisis," said Bangladesh Knitwear Manufacturers and Exporters Association vice president Mohammad Hatem. Full Article
fyi Diversifying Your Interests (Two Guys on Your Head Live) By kutpodcasts.org Published On :: Wed, 15 May 2019 20:52:37 +0000 KUT’s Rebecca McInroy along with Dr. Art Markman and Dr. Bob Duke talk about why it’s so important to diversify your interests. What is unhealthy about a one track mind? And why is it important to step outside our brain’s comfort zone? Full Article Two Guys on Your Head Views and Brews aging brain Art Markman audio Bob Duke Cactus Cafe comedy interests podcast protecting your brain psychology Rebecca McInroy two guys on your head
fyi U.S. women’s soccer team beats Haiti 4-0 in its opening match of Olympic qualifying By www.seattletimes.com Published On :: Tue, 28 Jan 2020 23:26:48 -0800 Reign FC standout Megan Rapinoe, voted The Best FIFA Women’s Player of 2019, entered the Group A match in the 62nd minute. Five minutes later, her corner kick was headed in by Lynn Williams for a 2-0 lead. Full Article Olympics Other Sports Reign Sports
fyi U.S. wins Group A in CONCACAF Women’s Olympic Qualifying soccer tournament By www.seattletimes.com Published On :: Mon, 03 Feb 2020 21:07:32 -0800 The top-ranked U.S. team will earn a berth in this year’s Tokyo Olympics if it can win a semifinal match against either Canada or Mexico on Friday in Carson, Calif. Full Article Olympics Other Sports Reign Sports
fyi Ellen Page expresses frustration with 'absolutely horrifying' environmental racism in N.S. By www.cbc.ca Published On :: Mon, 30 Mar 2020 17:07:50 EDT In a new doc, the Canadian actress takes a searing look at injustices in her home province. Full Article Radio/Q
fyi Diversifying into a brewery By www.abc.net.au Published On :: Thu, 20 Aug 2015 12:10:00 +1000 Following the knock on effect from the mining downturn, Linda Palmer decided it was time to diversify from her family's construction business. Today Linda keeps herself busy with a different kind of construction - one that involves developing beer and cider instead. Full Article ABC Local tropic Business Economics and Finance:Industry:Mining Business Economics and Finance:Small Business:All Lifestyle and Leisure:All:All Lifestyle and Leisure:Beverages:All Rural:Agricultural Crops:Fruit Health:Drug Use:Alcohol Australia:QLD:Mackay 4740
fyi Former Exmouth shire officers face court accused of falsifying records in $1m aquarium purchase By www.abc.net.au Published On :: Wed, 14 Aug 2019 10:49:00 +1000 A trial is underway to determine if two former senior staff from the Shire of Exmouth in WA falsified records in relation to a $1 million aquarium purchase. Full Article ABC Pilbara northwestwa Government and Politics:Local Government:All Law Crime and Justice:Courts and Trials:All Australia:WA:All Australia:WA:Carnarvon 6701 Australia:WA:Exmouth 6707
fyi Tiny koala joey defying the odds after being rescued when mother hit by car By www.abc.net.au Published On :: Sat, 27 Jul 2019 10:56:00 +1000 Pixie weighed less than 200 grams when she was rescued after her mother was hit by a car. Carers thought she was too tiny to survive, but they were wrong. Full Article ABC Mid North Coast newcastle midnorthcoast Human Interest:All:All Human Interest:Animals:All Science and Technology:Animals:All Science and Technology:Animals:Animal Behaviour Australia:NSW:Newcastle 2300 Australia:NSW:Port Macquarie 2444
fyi Tips on identifying three different species of whales By www.abc.net.au Published On :: Mon, 05 Aug 2019 07:29:00 +1000 Full Article ABC Great Southern greatsouthern Environment:All:All Environment:Oceans and Reefs:All Science and Technology:Animals:All Science and Technology:Animals:Mammals - Whales Australia:WA:Albany 6330
fyi Socceroos beat Nepal in World Cup qualifying at Canberra Stadium By www.abc.net.au Published On :: Fri, 11 Oct 2019 16:25:00 +1100 Australia beats Nepal 5-0 in Canberra thanks to a Jamie Maclaren hat-trick and two goals from debutant Harry Souttar. Full Article ABC Radio Canberra canberra Sport:All:All Sport:Soccer:All Sport:Soccer:Socceroos Sport:Soccer:World Cup Australia:ACT:All Australia:ACT:Canberra 2600 Australia:All:All Nepal:All:All
fyi Shane van Gisbergen leaps out of car during Gold Coast 600 qualifying to help rival Scott McLaughlin after crash By www.abc.net.au Published On :: Mon, 28 Oct 2019 08:12:00 +1100 Shane van Gisbergen is desperate to make up ground on Scott McLaughlin in the race for the Supercars championship, but he forgot about that in the wake of his countryman's frightening crash on the Gold Coast. Full Article ABC Gold Coast goldcoast Sport:All:All Sport:Motor Sports:All Australia:All:All Australia:QLD:All Australia:QLD:Surfers Paradise 4217
fyi HBO's Trip to 'Lovecraft Country' Takes a Horrifying Turn in First Trailer — Watch By www.yahoo.com Published On :: Fri, 01 May 2020 13:44:44 -0400 Not even the most thorough packing list can help you prepare for a trip to Lovecraft Country. At least, that's the sense we're getting from a new trailer for HBO's series adaptation of Matt Ruff's novel, which you can view above. Lovecraft Country stars Jonathan Majors (When We Rise) as Atticus Freeman, who embarks on […] Full Article
fyi USGA cancels local qualifying, 'premature to speculate' on U.S. Open By www.thescore.com Published On :: Tue, 17 Mar 2020 20:56:34 +0000 Full Article
fyi Whitmer Admin Sics Michigan Cops on 77-Year-Old Barber Defying Shutdown By feedproxy.google.com Published On :: Sat, 09 May 2020 16:46:07 +0000 A 77-year-old Michigan barber said he won't stop working "unless he is tasered by the police or Jesus Christ himself walks in" and will continue defying Gov. Gretchen Whitmer's executive orders. Full Article Economy Health Politics coronavirus Gretchen Whitmer lockdown Michigan Owosso stay-at-home orders
fyi Important Update on FYI Inheritance Fund Scam By feedproxy.google.com Published On :: Tue, 18 Sep 2012 18:24:29 GMT Important information about this scammer came to light during our investigation. We have published a reply from the scammer in the comments section of the example to illustrate the mechanics of this specific scam. Full Article
fyi Reagan Gomez Shares Husband's Terrifying Police Encounter By feeds.bet.com Published On :: Wed, 6 May 2020 07:45:00 EDT "They were looking for a problem." Full Article Celebrities
fyi NFL Player’s Terrifying Arrest Video Shows Cop’s Gun In Bashaud Breeland’s Face By feeds.bet.com Published On :: Fri, 1 May 2020 09:11:52 EDT The Kansas City Chiefs’ CB had a gun pointed in his face. Full Article Sports News National News
fyi Bermuda Charge Launch Qualifying Criteria By bernews.com Published On :: Sun, 08 Mar 2020 22:00:42 +0000 Organisers of the Bermuda Charge motorcycle road race have launched qualifying criteria for local riders, which contain initiatives to encourage local road safety. Bermuda Charge committee member and former professional motorcycle racer Antoine Richards said, “The requirements are designed not only to ensure that participants hold the necessary riding skills, but also to quantifiably assist […](Click to read the full article) Full Article All Sports #MotorcycleRacing
fyi Identifying Unintended Harms of Cybersecurity Countermeasures By www.lightbluetouchpaper.org Published On :: Wed, 29 Jan 2020 13:31:43 +0000 In this paper (winner of the eCrime 2019 Best Paper award), we consider the types of things that can go wrong when you intend to make things better and more secure. Consider this scenario. You are browsing through Internet and see a news headline on one of the presidential candidates. You are unsure if the … Continue reading Identifying Unintended Harms of Cybersecurity Countermeasures → Full Article Academic papers Awards Cybercrime
fyi FYI: Your browser can pick up ultrasonic signals you can't hear, and that sounds like a privacy nightmare to some By go.theregister.co.uk Published On :: Thu, 07 May 2020 21:24:21 GMT High-frequency audio could be used to stealthily track netizens Technical folks looking to improve web privacy haven't been able to decide whether sound beyond the range of human hearing poses enough of a privacy risk to merit restriction.… Full Article
fyi Classifying Books: Some Early Lessons Learned By floggingbabel.blogspot.com Published On :: Mon, 13 Apr 2020 22:06:00 +0000 .Flushed with the feeling of success that comes from having cleaned my office to such a degree that the rugs are now visible, I thought today that I would take on the problem of excess books. Surely there are some I don't actually need. So I chose a shelf at near-random (it was one of those actually accessible without moving the boxes of books stacked before it to another location), and started going through both rows (the shelves are double-stacked, of course) to see what they contained.Only to discover that the shelf was stocked with books placed there at seeming random. Mr. Evelyn's diary lies cheek-to-jowl with Gertrude Stein's Picasso. Jeff Danziger's Teed Tales abuts, appropriately enough, a history of Vermont. There is a collection of stories by T. Corgahesson Boyle, Zora Neale Hurston's autobiography, a novel by Sean Stewart, and a collection of essays by Ursula K. Le Guin. These last two, by the way, are misfiled since I have a science fiction section arranged almost alphabetically by author and a designated place for stacks of SF criticism and related essays. Which is where Gwyneth Jones' Joanna Russ should be as well.Here's T. H. White's wonderful collection of mythical animals from medieval bestiaries, The Book of Beasts. The Return of Fursey! Mosses from an Old Manse. Flann O'Brien's The Best of Myles reappears from hiding; after I've obsessively reread it a few times, I'll have to hide it somewhere else among my books, if I'm ever to read anything else. Oh, but there's also John McPhee's The Pine Barrens, which some of us persist in thinking his best book. Though it has competition. And here is a battered but charming old hardcover of Charles Fort's The Book of the Damned. I have a biography of Fort around here somewhere, though I doubt I'll find it today. Some few of these I haven't read--Fishing from Earliest Times is one example, though I'm sure I'll get to it soon. But I've read every story in The Corrector of Destinies, Melville Davidson Post's extremely odd collection of detective fiction (sort of), and I'll have to blog about it here someday.There are thirty shelves of books on one wall of my office and my first attack upon the one provided me with nothing to cull, And I've put aside a short stack of books to read or reacquaint myself with. Not have I done much to organize it--but wait! Here, just one shelf below is Damon Knight's Charles Fort. Up it goes, alongside The Book of the Damned, so nobody could say the last hour was wasted. Though it came close.Nor was I able to impose a theme upon the shelf, other than Books I Am Delighted to Possess. But maybe that's enough.In any case, it will have to do.Above: For technical reasons, I'm having difficulty uploading a picture of the wall of books in my office. So here's a pic of part of the wall of books in my bedroom. * Full Article
fyi SEE IT: NYPD roughly arrests men defying social distancing in Brooklyn By www.nydailynews.com Published On :: Tue, 05 May 2020 21:42:47 +0000 Antonio Rivera, accused of getting high in East New York amidst a group of people ignoring the city’s pandemic policies, was sent tumbling to the street when he came at one of the NYPD cops making arrests. The video shows police placing Rivera in handcuffs as he was lying on the ground behind their car. Full Article
fyi Moonlight turns white barn owls into terrifying ‘ghosts’ By www.pbs.org Published On :: The feathery glint startles their rodent prey, making them easier to catch. Full Article
fyi The coronavirus pandemic is terrifying — it's OK to laugh By www.latimes.com Published On :: Thu, 30 Apr 2020 08:00:58 -0400 The pandemic-related social media posts are crude. They are youthful. They mock the joys of family togetherness. Yet, they are a balm just when we need it most. Full Article
fyi Newsom chastises beachgoers, warning that defying order could delay reopening California By www.latimes.com Published On :: Mon, 27 Apr 2020 15:54:25 -0400 Gov. Newsom, saying the virus 'doesn't take the weekends off,' criticizes beachgoers and vows to increase enforcement of restrictions if necessary. Full Article
fyi North Korea nuclear alert: Satellite images reveal despot Kim's terrifying plot By feedproxy.google.com Published On :: Sat, 09 May 2020 00:11:00 +0100 KIM JONG-UN is building a massive facility outside the capital Pyongyang, satellite images have shown, suggesting he is planning to beef up his stockpile of nuclear weapons. Full Article
fyi 'It is very gratifying to see': Active COVID-19 cases dropping in Regina, southern Sask. By regina.ctvnews.ca Published On :: Fri, 8 May 2020 18:09:00 -0600 Physical distancing measures are working in southern Saskatchewan. There has been one new case in Regina in the past ten days and the South region hasn’t seen a new case since April 5. Full Article
fyi Boston Dynamics’ ‘terrifying’ robotic dogs have been put to work by at least one police agency By www.washingtonpost.com Published On :: Tue, 26 Nov 2019 22:43:41 +0000 Boston Dynamics began began leasing their robotic dogs to the public this year. One of their first customers: The Massachusetts State Police. Full Article
fyi Watch: Super short horror films that are truly terrifying By feedproxy.google.com Published On :: Fri, 08 May 2020 09:37:58 PDT Who is Patrick Mason? I just ran across a few short horror films he wrote and directed, and they're truly scary. Like edge-of-your-seat gasp-out-loud scary. Not only that, but they're beautifully made with good actors, especially Ayuda (see below). The three videos posted here are the ones I've seen so far, but there are more on his site, which I plan to watch tonight. Can't wait to see where this director takes us next. Read the rest Full Article Video horror
fyi Comparison of Label-free Methods for Quantifying Human Proteins by Shotgun Proteomics By feedproxy.google.com Published On :: 2005-10-01 William M. OldOct 1, 2005; 4:1487-1502Research Full Article
fyi Demystifying the media caricatures of Pussy Riot By feedproxy.google.com Published On :: Wed, 05 Feb 2014 12:13:19 +0000 6 February 2014 , Volume 70, Number 1 Masha Gessen, Words will Break Cement: The Passion of Pussy Riot, Granta, £8.70 Sean Guillory, author of seansrussiablog.org Guillory.jpg Maria Alyokhina and Nadazhda Tolokonnikova, two members of Pussy Riot, speak with their lawyer from a glass-walled cage in a court in Moscow. Photo: AFP/Getty Images Full Article
fyi Unifying Diverse Cities: Part 1 By www.ams.org Published On :: Mon, 9 Dec 2013 13:49:34 -0500 Despite the considerable variety among cities, researchers have identified common mathematical properties that hold around the world, regardless of a city.s population, location or even time. Full Article
fyi CBD Notification SCBD/SSSF/AS/SBG/JA/JG/88518 (2019-107): Expert Workshop to Identify Options for Modifying the Description of Ecologically or Biologically Significant Marine Areas (EBSAs) and Describing New EBSAs, 3 to 5 February 2020 - Brussels, Belgium By www.cbd.int Published On :: Wed, 27 Nov 2019 00:00:00 GMT Full Article
fyi Classifying spaces and Bredon (co)homology for transitive groupoids By www.ams.org Published On :: Thu, 02 Apr 2020 13:59 EDT Carla Farsi, Laura Scull and Jordan Watts Proc. Amer. Math. Soc. 148 (2020), 2717-2737. Abstract, references and article information Full Article
fyi PET imaging quantifying 68Ga-PSMA-11 uptake in metastatic colorectal cancer By jnm.snmjournals.org Published On :: 2020-05-01T11:16:57-07:00 At diagnosis 22% of colorectal cancer (CRC) patients have metastases and 50% later develop metastasis. Peptide receptor radionuclide therapy (PRRT) with lutetium-177 (177Lu)-PSMA-617 is employed to treat metastatic prostate cancer (PC). 177Lu-PSMA-617 targets Prostate Specific Membrane Antigen (PSMA) a cell surface protein enriched in PC and the neovasculature of other solid tumors including CRC. We performed gallium-68 (68Ga)-PSMA-11 PET-CT imaging of ten metastatic CRC patients to assess metastasis avidity. Eight patients had lesions lacking avidity and two had solitary metastases exhibiting very low avidity. Despite expression of PSMA in CRC neovasculature, none of the patients exhibited tumor avidity sufficient to be considered for 177Lu-PSMA-617 PRRT. Full Article
fyi The Challenge of Classifying Metastatic Cell Properties by Molecular Profiling Exemplified with Cutaneous Melanoma Cells and Their Cerebral Metastasis from Patient Derived Mouse Xenografts [Research] By feedproxy.google.com Published On :: 2020-03-01T00:05:26-08:00 The prediction of metastatic properties from molecular analyses still poses a major challenge. Here we aimed at the classification of metastasis-related cell properties by proteome profiling making use of cutaneous and brain-metastasizing variants from single melanomas sharing the same genetic ancestry. Previous experiments demonstrated that cultured cells derived from these xenografted variants maintain a stable phenotype associated with a differential metastatic behavior: The brain metastasizing variants produce more spontaneous micro-metastases than the corresponding cutaneous variants. Four corresponding pairs of cutaneous and metastatic cells were obtained from four individual patients, resulting in eight cell-lines presently investigated. Label free proteome profiling revealed significant differences between corresponding pairs of cutaneous and cerebellar metastases from the same patient. Indeed, each brain metastasizing variant expressed several apparently metastasis-associated proteomic alterations as compared with the corresponding cutaneous variant. Among the differentially expressed proteins we identified cell adhesion molecules, immune regulators, epithelial to mesenchymal transition markers, stem cell markers, redox regulators and cytokines. Similar results were observed regarding eicosanoids, considered relevant for metastasis, such as PGE2 and 12-HETE. Multiparametric morphological analysis of cells also revealed no characteristic alterations associated with the cutaneous and brain metastasis variants. However, no correct classification regarding metastatic potential was yet possible with the present data. We thus concluded that molecular profiling is able to classify cells according to known functional categories but is not yet able to predict relevant cell properties emerging from networks consisting of many interconnected molecules. The presently observed broad diversity of molecular patterns, irrespective of restricting to one tumor type and two main classes of metastasis, highlights the important need to develop meta-analysis strategies to predict cell properties from molecular profiling data. Such base knowledge will greatly support future individualized precision medicine approaches. Full Article
fyi Type 2 Diabetes: Demystifying the Global Epidemic By diabetes.diabetesjournals.org Published On :: 2017-06-01 Ranjit UnnikrishnanJun 1, 2017; 66:1432-1442Perspectives in Diabetes Full Article
fyi The Pathobiology of Diabetic Complications: A Unifying Mechanism By diabetes.diabetesjournals.org Published On :: 2005-06-01 Michael BrownleeJun 1, 2005; 54:1615-1625Banting Lecture 2004 Full Article
fyi Hexed - JFF finds possible World Cup Qualifying structure changes ‘disadvantageous’ By jamaica-gleaner.com Published On :: Sat, 09 May 2020 00:14:49 -0500 Jamaica Football Federation (JFF) general secretary Dalton Wint says that any potential changes to the Concacaf hexagonal round for the FIFA World Cup qualifiers could present challenges to the nation’s aim of qualifying for Qatar 2022. Wint’s... Full Article