This week on The House, Champagne joins us to discuss the China question, infrastructure and city planning expert Nadine Ibrahim talks about high-speed rail and Chris Hall talks with former political strategists David Herle, Jenni Byrne and Scott Reid of the Herle Burly podcast.

How did Oedipus become such a naughty little boy? Is it all the fault of his mother? Perth Theatre Company's latest show is an imaginative take on the Greek myth, says ABC 720's cultural correspondent Victoria Laurie

Australia is blessed with a vast number of stunning swimming holes, lakes, creeks, rivers and beaches. We thought we'd take one for the team and find a few excellent spots for you to cool down.

As we assess the damage from Wagga Wagga City Council's tensions with China over a sister-city relationship, there's a lesson for our broader relationship with one of our biggest trading partners, writes Jieh-Yung Lo.

The Television Academy has ruled: No more double dipping. After several years of documentary projects walking the line between the Oscars and Emmys — and finding the loophole to submit for both — the org has ruled that programs won't be eligible for an Emmy if they've been nominated for an Oscar. The TV Academy […]

(Court of Appeals of New York) - Conviction for felony murder and rape is reversed where the trial court abused its discretion by precluding the defendant from introducing evidence of third-party culpability and such error was not harmless under the circumstances.

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Facioscapulohumeral muscular dystrophy (FSHD) results from expression of the full-length double homeobox 4 (DUX4-FL) retrogene in skeletal muscle. However, even in cases of severe FSHD the presence of DUX4 is barely detectable. In this issue of the JCI, Bosnakovski et al. used an inducible, muscle-specific human DUX4 to reproduce the low-level, sporadic DUX4 expression of human FSHD muscle as well the myopathology seen in human FSHD disease. Notably, dysregulated fibroadipogenic progenitors accumulated in affected muscles, thus providing a mechanism for the replacement of muscle by fibrosis and fat.

Our warm cheesy bacon dip is the perfect appetizer recipe for holiday parties, family gatherings, or even game day! It’s loaded with delicious hickory-smoked bacon and cheese, making every bite beyond scrumptious! Warm Cheesy Bacon Dip Recipe Have you ever noticed that when you think about appetizer recipes, one word always magically pops into your mind? […]

The post Warm Cheesy Bacon Dip appeared first on Dear Crissy.

Yesterday was Day 45 Our five o'clock briefing was delivered by the less than charismatic Mr Gove who told us more of the same . He spelled out the numbers of deaths the numbers of tests that had been undertaken. The numbers rolled off his tongue . Traf

The award shows are changing up the script when it comes to documentary eligibility.

China has gone on a "charm offensive" to try to make the world overlook Beijing's culpability in the coronavirus crisis and the country's aggressive moves against its neighbors.

'People entering French territory from European countries (EU/Schengen and United Kingdom) will not be affected by the quarantine measure,' says French consulate

Trung tâm Lưu trữ Quốc gia tại TPHCM vừa khai mạc triển lãm ngày 'Thống nhất non sông' kỷ niệm 45 năm ngày 30/04/1975-2020. Ảnh từ trang Facebook của ông Trần Hữu Phúc Tiến.

Orta Doğu'da barış sürecini canlandırmak için diplomasi atağı başlatan ABD son olarak da Başkan Barack Obama'nın ulusal güvenlik danışmanı James Jones'u bölgeye gönderdi.

Boston dominated for most of four quarters but Indiana briefly took the lead in the final minutes behind Victor Oladipo and inspired defensive play.

Victor Oladipo was rocking and the Pacers were rolling before NBA shutdown, leaving President Kevin Pritchard, team hopeful about possible resumption.

Oladipo: 'I can look at it like I was just getting my rhythm back or as an opportunity to rest and ... continue building strength in my tendon.'

Do you know that feeling when you are hyped and ready to take on a new challenge? You are taken over by a surge of motivation and excitement and you’ve made a commitment you fully intend to stick to. It sounds familiar, right? Perhaps you declared your intention to dedicate more time to self-care, or […]

The post 7 Must-Do Hacks for When Your Motivation Dips appeared first on Dumb Little Man.

7 May 2020 , Volume 96, Number 3

Research Event

Event participants

Research Event

Event participants

EJ Blanchette-Mackie
Jun 1, 1995; 36:1211-1226
Articles

DL Brasaemle
Nov 1, 1997; 38:2249-2263
Articles

Dawn L. Brasaemle
Dec 1, 2007; 48:2547-2559
Thematic Reviews

Saverio Cinti
Nov 1, 2005; 46:2347-2355
Research Articles

7 May 2020 , Volume 96, Number 3

Invitation Only Research Event

Event participants

HE Raffaele Trombetta, Italian Ambassador to the UK, Co-Host, COP 26
Archie Young, UK Lead Climate Negotiator, Cabinet Office 
Peter Betts, Associate Fellow, Energy, Environment and Resources Department, Chatham House
Chair: Professor Tim Benton, Research Director, Energy, Environment and Resources, Chatham House  

Research Event

Event participants

Expert

(To watch the whole media session with sign language interpretation, click here.)

Hong Kong's economy in the first quarter of 2020 contracted 8.9% over a year earlier, the largest decline on record since 1974.

The Census & Statistics Department announced the findings today as it released advance estimates on Gross Domestic Product for the first quarter.

Addressing the media today, Financial Secretary Paul Chan noted the economic recession deepened in Hong Kong in the first quarter of 2020.

“Although locally, the epidemic situation seems to be under control, but the external environment is still very challenging. Globally, the epidemic is yet to be put under complete control. That will affect our exports. That will also affect international travelling and business investments. 

“So, going forward in the second quarter, we believe that even if there is improvement, the improvement will be gradual and small.”

According to those estimates, private consumption expenditure decreased 10.2% in real terms in the first quarter from a year earlier, deteriorating from the 2.9% decline in the fourth quarter of 2019.

Government consumption expenditure grew 8.3% year-on-year, after the increase of 6.1% in the fourth quarter of 2019.

Gross domestic fixed capital formation dropped by 13.9%, compared with the decrease of 16.8% in the previous quarter.

Over the same period, total exports of goods declined 9.7% and imports of goods also fell 10.9%.

Exports of services dropped 37.8% and imports of services decreased 25.4%.

Mr Chan called on people to work together to promote economic development by consumption.

“If we are able to work together, if we can unite together - not just to fight the virus, but to stimulate consumption to promote economic development - I think the economic situation will be able to stabilise somewhat in the second quarter. 

“If the global epidemic situation improves, we will be able to come out of recession gradually towards the end of this year. 

“I will appeal to our people's support for us to roll out various measures in the Anti-epidemic Fund - round one and round two - as well as the relief packages in the 2020-21 Budget as soon as possible.

“Many of those initiatives are still yet to be implemented. Upon full implementation of those measures, I think the positive impact on the economy would be better felt by the community. We will be monitoring the situation carefully.”

The Government stands ready to roll out additional measures to support Hong Kong people and the businesses, Mr Chan added.

Accumulating evidence suggests that brown adipose tissue (BAT) is a potential therapeutic target for managing obesity and related diseases. PGAM family member 5, mitochondrial serine/threonine protein phosphatase (PGAM5), is a protein phosphatase that resides in the mitochondria and regulates many biological processes, including cell death, mitophagy, and immune responses. Because BAT is a mitochondria-rich tissue, we have hypothesized that PGAM5 has a physiological function in BAT. We previously reported that PGAM5-knockout (KO) mice are resistant to severe metabolic stress. Importantly, lipid accumulation is suppressed in PGAM5-KO BAT, even under unstressed conditions, raising the possibility that PGAM5 deficiency stimulates lipid consumption. However, the mechanism underlying this observation is undetermined. Here, using an array of biochemical approaches, including quantitative RT-PCR, immunoblotting, and oxygen consumption assays, we show that PGAM5 negatively regulates energy expenditure in brown adipocytes. We found that PGAM5-KO brown adipocytes have an enhanced oxygen consumption rate and increased expression of uncoupling protein 1 (UCP1), a protein that increases energy consumption in the mitochondria. Mechanistically, we found that PGAM5 phosphatase activity and intramembrane cleavage are required for suppression of UCP1 activity. Furthermore, utilizing a genome-wide siRNA screen in HeLa cells to search for regulators of PGAM5 cleavage, we identified a set of candidate genes, including phosphatidylserine decarboxylase (PISD), which catalyzes the formation of phosphatidylethanolamine at the mitochondrial membrane. Taken together, these results indicate that PGAM5 suppresses mitochondrial energy expenditure by down-regulating UCP1 expression in brown adipocytes and that its phosphatase activity and intramembrane cleavage are required for UCP1 suppression.

(George Mason University) Nathan Sleeter, Research Assistant Professor, Roy Rosenzweig Center for History and New Media (RRCHNM), is directing a project in which RRCHNM will create three classroom simulations based on events from the history of diplomacy for secondary education instructors.

Mona Radwan
Apr 1, 2020; 19:640-654
Research

Samuel W Entwisle
Apr 6, 2020; 0:RA120.001946v2-mcp.RA120.001946
Research

6 November 2019 , Volume 95, Number 6

C9ORF72-associated Motor Neuron Disease patients feature abnormal expression of 5 dipeptide repeat (DPR) polymers. Here we used quantitative proteomics in a mouse neuronal-like cell line (Neuro2a) to demonstrate that the Arg residues in the most toxic DPRS, PR and GR, leads to a promiscuous binding to the proteome compared with a relative sparse binding of the more inert AP and GA. Notable targets included ribosomal proteins, translation initiation factors and translation elongation factors. PR and GR comprising more than 10 repeats appeared to robustly stall on ribosomes during translation suggesting Arg-rich peptide domains can electrostatically jam the ribosome exit tunnel during synthesis. Poly-GR also recruited arginine methylases, induced hypomethylation of endogenous proteins, and induced a profound destabilization of the actin cytoskeleton. Our findings point to arginine in GR and PR polymers as multivalent toxins to translation as well as arginine methylation that may explain the dysfunction of biological processes including ribosome biogenesis, mRNA splicing and cytoskeleton assembly.

Accumulating evidence suggests that brown adipose tissue (BAT) is a potential therapeutic target for managing obesity and related diseases. PGAM family member 5, mitochondrial serine/threonine protein phosphatase (PGAM5), is a protein phosphatase that resides in the mitochondria and regulates many biological processes, including cell death, mitophagy, and immune responses. Because BAT is a mitochondria-rich tissue, we have hypothesized that PGAM5 has a physiological function in BAT. We previously reported that PGAM5-knockout (KO) mice are resistant to severe metabolic stress. Importantly, lipid accumulation is suppressed in PGAM5-KO BAT, even under unstressed conditions, raising the possibility that PGAM5 deficiency stimulates lipid consumption. However, the mechanism underlying this observation is undetermined. Here, using an array of biochemical approaches, including quantitative RT-PCR, immunoblotting, and oxygen consumption assays, we show that PGAM5 negatively regulates energy expenditure in brown adipocytes. We found that PGAM5-KO brown adipocytes have an enhanced oxygen consumption rate and increased expression of uncoupling protein 1 (UCP1), a protein that increases energy consumption in the mitochondria. Mechanistically, we found that PGAM5 phosphatase activity and intramembrane cleavage are required for suppression of UCP1 activity. Furthermore, utilizing a genome-wide siRNA screen in HeLa cells to search for regulators of PGAM5 cleavage, we identified a set of candidate genes, including phosphatidylserine decarboxylase (PISD), which catalyzes the formation of phosphatidylethanolamine at the mitochondrial membrane. Taken together, these results indicate that PGAM5 suppresses mitochondrial energy expenditure by down-regulating UCP1 expression in brown adipocytes and that its phosphatase activity and intramembrane cleavage are required for UCP1 suppression.