There have been calls for greater transparency on remote cattle stations after a FOI request revealed a push to keep the mass death of a critically endangered species under wraps.

A finishing school for western ringtail possums is not about airs and graces it's about helping orphaned possums get used to fending for themselves.

Usually, federal elections are decided outside Victoria. This one could be different, with Bill Shorten hoping to pick up a number of seats in his home state that were once considered Liberal bastions.

Residents have been left vulnerable and fearing for their future water security as underground aquifers run critically low in rural Darwin and communities fear what a second poor wet season could mean for their future.

Last year, Nigel Shedden got married to wife Belinda and together they moved into their dream home. Today, the couple are living with Mr Shedden's mother, and the home they spent 18 months building has been sold.

Two men are critically injured after a crane overturns near Mareeba in Far North Queensland this morning. The crash follows the death of a man in a separate crane incident on Sunday.

LIVExchange 2019, an annual live exporters conference and themed 'welfare beyond borders', acknowledges of the public relations problems the trade faces.

Facets Of Folk Hit #1 On The Folk Alliance International Folk DJ Charts And Is Now On The List For Consideration For The Grammy® For Best Folk Album

Facets Of Folk Hit #1 On The Folk Alliance International Folk DJ Charts And Is Now On The List For Consideration For The Grammy® For Best Folk Album

Erica Barrier, 28, suffered serious neck and spine injuries.

Treating neuropathic pain is challenging and novel non–opioid-based medicines are needed. Using unbiased receptomics, transcriptomic analyses, immunofluorescence, and in situ hybridization, we found that the expression of the orphan GPCR Gpr160 and GPR160 increased in the rodent dorsal horn of the spinal cord following traumatic nerve injury. Genetic and immunopharmacological approaches demonstrated that GPR160 inhibition in the spinal cord prevented and reversed neuropathic pain in male and female rodents without altering normal pain response. GPR160 inhibition in the spinal cord attenuated sensory processing in the thalamus, a key relay in the sensory discriminative pathways of pain. We also identified cocaine- and amphetamine-regulated transcript peptide (CARTp) as a GPR160 ligand. Inhibiting endogenous CARTp signaling in spinal cord attenuated neuropathic pain, whereas exogenous intrathecal CARTp evoked painful hypersensitivity through GPR160-dependent ERK and cAMP response element–binding protein (CREB). Our findings de-orphanize GPR160, identify it as a determinant of neuropathic pain and potential therapeutic target, and provide insights into its signaling pathways. CARTp is involved in many diseases including depression and reward and addiction; de-orphanization of GPR160 is a major step forward understanding the role of CARTp signaling in health and disease.

INPEX selects IBM to manage operation critical apps in Australia

Knowing that today’s homes burn faster than ever, the National Fire Protection Association (NFPA) announced “Every Second Counts: Plan Two Ways Out” as the official theme for this year’s Fire Prevention Week campaign, October 8-14, 2017. Experts say you may have as little as two minutes (or even less) to safely escape a typical home fire from the time the smoke alarm sounds.

A newly discovered unpatchable hardware vulnerability in Xilinx programmable logic products could allow an attacker to break bitstream encryption, and clone intellectual property, change the functionality, and even implant hardware Trojans. The details of the attacks against Xilinx 7-Series and Virtex-6 Field Programmable Gate Arrays (FPGAs) have been covered in a paper titled "The

It's not 'Patch Tuesday,' but software giant Adobe today released emergency updates for three of its widely used products that patch dozens of newly discovered critical vulnerabilities. The list of affected software includes Adobe Illustrator, Adobe Bridge, and Magento e-commerce platform, containing a total of 35 vulnerabilities where each one of them is affected with multiple critical

Security researchers are sounding the alarm over newly discovered vulnerabilities in some popular online learning management system (LMS) plugins that various organizations and universities use to offer online training courses through their WordPress-based websites. According to the Check Point Research Team, the three WordPress plugins in question — LearnPress, LearnDash, and LifterLMS —

Two severe security flaws have been discovered in the open-source SaltStack Salt configuration framework that could allow an adversary to execute arbitrary code on remote servers deployed in data centers and cloud environments. The vulnerabilities were identified by F-Secure researchers earlier this March and disclosed on Thursday, a day after SaltStack released a patch (version 3000.2)

The COVID-19 crisis is laying bare our city’s extreme racial and economic inequality. Not only have communities of color borne the brunt of the pandemic, but workers of color make up 75% of New York’s essential workers, the people who are risking their health to provide the services on which we all rely.

The mayhem began when the assailant went berzerk inside an apartment building on Dorchester Road and East 21 St. in Flatbush about 10:50 p.m. Saturday, punching and kicking two men before stabbing one multiple times, police said.

The small businesses, many of which already run on razor-thin margins, are struggling to make end meet amid the crisis.

HYPOCRISY is one of the aggravating sins of the progressive elite. There is nothing more sickening than the failure of prominent figures to abide by the standards they seek to impose on others. Such double standards can be found in socialists who rage against private education but send their children to fee-paying schools, or in eco warriors who wail about carbon footprints while globe-trotting in luxury jets.

HYPOCRISY is one of the aggravating sins of the progressive elite. There is nothing more sickening than the failure of prominent figures to abide by the standards they seek to impose on others. Such double standards can be found in socialists who rage against private education but send their children to fee-paying schools, or in eco warriors who wail about carbon footprints while globe-trotting in luxury jets.

Archaic computer technology is hampering the effort to combat the effects of covid-19 in the United States.

All the latest Covid-19 updates from around the world.

Barttin is the accessory subunit of the human ClC-K chloride channels, which are expressed in both the kidney and inner ear. Barttin promotes trafficking of the complex it forms with ClC-K to the plasma membrane and is involved in activating this channel. Barttin undergoes post-translational palmitoylation that is essential for its functions, but the enzyme(s) catalyzing this post-translational modification is unknown. Here, we identified zinc finger DHHC-type containing 7 (DHHC7) protein as an important barttin palmitoyl acyltransferase, whose depletion affected barttin palmitoylation and ClC-K-barttin channel activation. We investigated the functional role of barttin palmitoylation in vivo in Zdhhc7−/− mice. Although palmitoylation of barttin in kidneys of Zdhhc7−/− animals was significantly decreased, it did not pathologically alter kidney structure and functions under physiological conditions. However, when Zdhhc7−/− mice were fed a low-salt diet, they developed hyponatremia and mild metabolic alkalosis, symptoms characteristic of human Bartter syndrome (BS) type IV. Of note, we also observed decreased palmitoylation of the disease-causing R8L barttin variant associated with human BS type IV. Our results indicate that dysregulated DHHC7-mediated barttin palmitoylation appears to play an important role in chloride channel dysfunction in certain BS variants, suggesting that targeting DHHC7 activity may offer a potential therapeutic strategy for reducing hypertension.

WS Harris
Jun 1, 1989; 30:785-807
Reviews

7 May 2020 , Volume 96, Number 3

K. D. Cherednichenko, Yu. Yu. Ershova, A. V. Kiselev and S. N. Naboko
Trans. Moscow Math. Soc. 80 (2020), 251-294.
Abstract, references and article information

Firefox's latest version is out, with new password management features and a raft of security fixes.

Mohamed Jleli, Bessem Samet and Philippe Souplet
Proc. Amer. Math. Soc. 148 (2020), 2579-2593.
Abstract, references and article information

Barttin is the accessory subunit of the human ClC-K chloride channels, which are expressed in both the kidney and inner ear. Barttin promotes trafficking of the complex it forms with ClC-K to the plasma membrane and is involved in activating this channel. Barttin undergoes post-translational palmitoylation that is essential for its functions, but the enzyme(s) catalyzing this post-translational modification is unknown. Here, we identified zinc finger DHHC-type containing 7 (DHHC7) protein as an important barttin palmitoyl acyltransferase, whose depletion affected barttin palmitoylation and ClC-K-barttin channel activation. We investigated the functional role of barttin palmitoylation in vivo in Zdhhc7−/− mice. Although palmitoylation of barttin in kidneys of Zdhhc7−/− animals was significantly decreased, it did not pathologically alter kidney structure and functions under physiological conditions. However, when Zdhhc7−/− mice were fed a low-salt diet, they developed hyponatremia and mild metabolic alkalosis, symptoms characteristic of human Bartter syndrome (BS) type IV. Of note, we also observed decreased palmitoylation of the disease-causing R8L barttin variant associated with human BS type IV. Our results indicate that dysregulated DHHC7-mediated barttin palmitoylation appears to play an important role in chloride channel dysfunction in certain BS variants, suggesting that targeting DHHC7 activity may offer a potential therapeutic strategy for reducing hypertension.

(Purdue University) New environmentally friendly technologies promise to be 'game changers' in the rare earth metals field and enable the US to create a more stable and reliable domestic source of these essential metals. Purdue University patented extraction and purifying processes using ligand-assisted chromatography are shown to remove and purify such metals from coal ash, recycled magnets and raw ore safely, efficiently and with virtually no detrimental environmental impact.

Carlos E. Mendez
Aug 1, 2014; 27:180-188
From Research to Practice

Two new regions of Microsoft's Azure cloud will open in Canberra on Tuesday.

7 May 2020 , Volume 96, Number 3

Lipid droplets (LDs) are frequently increased when excessive lipid accumulation leads to cellular dysfunction. Distinct from mouse beta cells, LDs are prominent in human beta cells, however, the regulation of LD mobilization (lipolysis) in human beta cells remains unclear. We found that glucose increases lipolysis in non-diabetic human islets, but not in type 2 diabetic (T2D) islets, indicating dysregulation of lipolysis in T2D islets. Silencing adipose triglyceride lipase (ATGL) in human pseudoislets (shATGL) increased triglycerides, and the number and size of LDs indicating that ATGL is the principal lipase in human beta cells. In shATGL pseudoislets, biphasic glucose-stimulated insulin secretion (GSIS) and insulin secretion to IBMX and KCl were all reduced without altering oxygen consumption rate compared with scramble control. Like human islets, INS1 cells showed visible LDs, glucose responsive lipolysis, and impairment of GSIS after ATGL silencing. ATGL deficient INS1 cells and human pseudoislets showed reduced Stx1a, a key SNARE component. Proteasomal degradation of Stx1a was accelerated likely through reduced palmitoylation in ATGL deficient INS1 cells. Therefore, ATGL is responsible for LD mobilization in human beta cells and supports insulin secretion by stabilizing Stx1a. The dysregulated lipolysis may contribute to LD accumulation and beta cell dysfunction in T2D islets.

Lipid droplets (LDs) are frequently increased when excessive lipid accumulation leads to cellular dysfunction. Distinct from mouse beta cells, LDs are prominent in human beta cells, however, the regulation of LD mobilization (lipolysis) in human beta cells remains unclear. We found that glucose increases lipolysis in non-diabetic human islets, but not in type 2 diabetic (T2D) islets, indicating dysregulation of lipolysis in T2D islets. Silencing adipose triglyceride lipase (ATGL) in human pseudoislets (shATGL) increased triglycerides, and the number and size of LDs indicating that ATGL is the principal lipase in human beta cells. In shATGL pseudoislets, biphasic glucose-stimulated insulin secretion (GSIS) and insulin secretion to IBMX and KCl were all reduced without altering oxygen consumption rate compared with scramble control. Like human islets, INS1 cells showed visible LDs, glucose responsive lipolysis, and impairment of GSIS after ATGL silencing. ATGL deficient INS1 cells and human pseudoislets showed reduced Stx1a, a key SNARE component. Proteasomal degradation of Stx1a was accelerated likely through reduced palmitoylation in ATGL deficient INS1 cells. Therefore, ATGL is responsible for LD mobilization in human beta cells and supports insulin secretion by stabilizing Stx1a. The dysregulated lipolysis may contribute to LD accumulation and beta cell dysfunction in T2D islets.