Lipid rafts are highly ordered regions of the plasma membrane that are enriched in cholesterol and sphingolipids and play important roles in many cells. In hematopoietic stem and progenitor cells (HSPCs), lipid rafts house receptors critical for normal hematopoiesis. Lipid rafts also can bind and sequester kinases that induce negative feedback pathways to limit proliferative cytokine receptor cycling back to the cell membrane. Modulation of lipid rafts occurs through an array of mechanisms, with optimal cholesterol efflux one of the major regulators. As such, cholesterol homeostasis also regulates hematopoiesis. Increased lipid raft content, which occurs in response to changes in cholesterol efflux in the membrane, can result in prolonged receptor occupancy in the cell membrane and enhanced signaling. In addition, certain diseases, like diabetes, may contribute to lipid raft formation and affect cholesterol retention in rafts. In this review, we explore the role of lipid raft-related mechanisms in hematopoiesis and CVD (specifically, atherosclerosis) and discuss how defective cholesterol efflux pathways in HSPCs contribute to expansion of lipid rafts, thereby promoting myelopoiesis and thrombopoiesis. We also discuss the utility of cholesterol acceptors in contributing to lipid raft regulation and disruption, and highlight the potential to manipulate these pathways for therapeutic gain in CVD as well as other disorders with aberrant hematopoiesis.

Publication Date: Apr 10 2020 New Fund Launches In addition to completing the Listing Application, new funds are required to complete a certification prior to receiving approval of an initial listing application. The certification can be found here. Listing Transfers In addition to completing the Listing Application, funds switching from another market to Nasdaq are required to complete a certification regarding compliance with SEC Rule 6c-11. The certification must be completed prior to...

A man has been arrested in connection with the “vile and brutal” murders of 8-year-old Toya Brown and 15-year-old Nyron Taylor, who were shot and killed last evening, revealed Minister of National Security, Dr. Horace Chang. Chang says...

Bile acids (BAs) serve multiple biological functions, ranging from the absorption of lipids and fat-soluble vitamins to serving as signaling molecules through the direct activation of dedicated cellular receptors. Synthesized by both host and microbial pathways, BAs are increasingly understood as participating in the regulation of numerous pathways relevant to metabolic diseases, including lipid and glucose metabolism, energy expenditure, and inflammation. Quantitative analyses of BAs in biological matrices can be problematic due to their unusual and diverse physicochemical properties, making optimization of a method that shows good accuracy, precision, efficiency of extraction, and minimized matrix effects across structurally distinct human and murine BAs challenging. Herein we develop and clinically validate a stable-isotope-dilution LC/MS/MS method for the quantitative analysis of numerous primary and secondary BAs in both human and mouse biological matrices. We also utilize this tool to investigate gut microbiota participation in the generation of structurally specific BAs in both humans and mice. We examine circulating levels of specific BAs and in a clinical case-control study of age- and gender-matched type 2 diabetes mellitus (T2DM) versus nondiabetics. BAs whose circulating levels are associated with T2DM include numerous 12α-hydroxyl BAs (taurocholic acid, taurodeoxycholic acid, glycodeoxycholic acid, deoxycholic acid, and 3-ketodeoxycholic acid), while taurohyodeoxycholic acid was negatively associated with diabetes. The LC/MS/MS-based platform described should serve as a robust, high-throughput investigative tool for studying the potential involvement of structurally specific BAs and the gut microbiome on both physiological and disease processes.

Lipid rafts are highly ordered regions of the plasma membrane that are enriched in cholesterol and sphingolipids and play important roles in many cells. In hematopoietic stem and progenitor cells (HSPCs), lipid rafts house receptors critical for normal hematopoiesis. Lipid rafts also can bind and sequester kinases that induce negative feedback pathways to limit proliferative cytokine receptor cycling back to the cell membrane. Modulation of lipid rafts occurs through an array of mechanisms, with optimal cholesterol efflux one of the major regulators. As such, cholesterol homeostasis also regulates hematopoiesis. Increased lipid raft content, which occurs in response to changes in cholesterol efflux in the membrane, can result in prolonged receptor occupancy in the cell membrane and enhanced signaling. In addition, certain diseases, like diabetes, may contribute to lipid raft formation and affect cholesterol retention in rafts. In this review, we explore the role of lipid raft-related mechanisms in hematopoiesis and CVD (specifically, atherosclerosis) and discuss how defective cholesterol efflux pathways in HSPCs contribute to expansion of lipid rafts, thereby promoting myelopoiesis and thrombopoiesis. We also discuss the utility of cholesterol acceptors in contributing to lipid raft regulation and disruption, and highlight the potential to manipulate these pathways for therapeutic gain in CVD as well as other disorders with aberrant hematopoiesis.

Invitation Only Research Event

Invitation Only Research Event

Greater compliance with dietary guidelines may reduce the chance of untreated caries in adults, according to a study published in the February issue of The Journal of the American Dental Association.

The Dental Quality Alliance will help dentists learn more about how quality measure domains can be best used to drive quality improvement at the practice level through a free webinar in March.

Janet H. Southerland
Oct 1, 2005; 23:171-178
Feature Articles

Author Priya Parker shares tools for creating meaningful connections with friends, family and coworkers during the coronavirus pandemic -- and shows how we can take advantage of gatherings that are unique to this moment of social distancing. "We don't necessarily need to gather more," she says. "We need to gather better." (This virtual conversation is part of the TED Connects series, hosted by head of TED Chris Anderson and current affairs curator Whitney Pennington Rodgers. Recorded March 27, 2020)

A statewide survey of educators in Tennessee provides critical insights into connections that exist between standards, curriculum, professional development, and ultimately student success.

London : J. & A. Churchill, 1887.

[Manchester] : School of Nursing Studies, University of Manchester, [1995?]

This paper revisits the problem of computing empirical cumulative distribution functions (ECDF) efficiently on large, multivariate datasets. Computing an ECDF at one evaluation point requires $mathcal{O}(N)$ operations on a dataset composed of $N$ data points. Therefore, a direct evaluation of ECDFs at $N$ evaluation points requires a quadratic $mathcal{O}(N^2)$ operations, which is prohibitive for large-scale problems. Two fast and exact methods are proposed and compared. The first one is based on fast summation in lexicographical order, with a $mathcal{O}(N{log}N)$ complexity and requires the evaluation points to lie on a regular grid. The second one is based on the divide-and-conquer principle, with a $mathcal{O}(Nlog(N)^{(d-1){vee}1})$ complexity and requires the evaluation points to coincide with the input points. The two fast algorithms are described and detailed in the general $d$-dimensional case, and numerical experiments validate their speed and accuracy. Secondly, the paper establishes a direct connection between cumulative distribution functions and kernel density estimation (KDE) for a large class of kernels. This connection paves the way for fast exact algorithms for multivariate kernel density estimation and kernel regression. Numerical tests with the Laplacian kernel validate the speed and accuracy of the proposed algorithms. A broad range of large-scale multivariate density estimation, cumulative distribution estimation, survival function estimation and regression problems can benefit from the proposed numerical methods.

The CEO of Move This World isn't big on screen time, but in the midst of the coronavirus pandemic, technology--when used with care--can help strengthen relationships.

The post 4 Ways to Help Students Cultivate Meaningful Connections Through Tech appeared first on Market Brief.

More with less. This is the challenge and the mantra for our future. There will be many more of us in the years to come. We will go from a population of 7.6 billion today to 9.8 billion in 2050; yet, with our current rate of usage, there will be less fresh water, less arable soil, less available land for [...]

One person has curly hair; one person has straight hair. One person tans, another burns. One person can curl her lip, another can’t. This is all because of our genes and the differences in them. Diversity. It is the spice of life.  

Yellowknife RCMP confirmed the death of the missing 22-year-old woman on Friday and charged 27-year-old Devon Larabie in connection with her death.

A 40-year-old man has been arrested and charged in connection with two break-ins at the Thunder Bay District Health unit offices, the Thunder Bay Police Service announced in a written release Friday.

Award-winning children's book explores big questions about colonization and identity.

The post SOLIDWORKS Electrical Formula SAE Tutorial: Creating Electrical Connection Points inside a SOLIDWORKS part appeared first on SOLIDWORKS Education Blog.

An incorrect GPS coordinate leads a worship team to the end of the road, yet God has another route planned.

"How can we honour these 'mothers and fathers' [of OM]," asks David Greenlee. "Inclusion is one way, encouraging their ongoing participation, not forgetting them in our concern."

Celtic Connections

Celtic Connections

Celtic Connections

Celtic Connections

Celtic Connections

The Celtic Connections roots and traditional music festival recorded 100,000 visits this January.

WHEN Malian quartet Songhoy Blues performed at last year's Celtic Connections, audiences were treated to a form of music appealingly dubbed “desert blues”. A user-friendly term, it sounds like it could have been dreamed up by a marketing agency and applied equally well to a perfume, a brand of jeans or a chain of upmarket Tex-Mex restaurants.

Celtic Connections

From Thursday 16 January to Sunday 2 February 2020, musicians from across the world will take part in over 300 events in venues throughout Glasgow for the UK's premier celebration of celtic music.

THE Celtic Connections music festival last night lifted the curtain on next year’s line up – and revealed it will be kicking off the 700th celebrations of the Declaration of Arbroath.

IT’S been an up and down sort of day for Imran Akhtar. And in a much too literal sense, as far as he’s concerned. First, he had to clamber on top of the roof of the Ottoman Coffee House on Glasgow’s Berkeley Street, to make sure the temporary tarpaulin was still in place and keeping out the wind, rain, hail and snow. (It’s been one of those typical Scottish afternoons, with the weather behaving like a plump maiden aunt’s two-layered chocolate box. In other words, way too many delights

Students with dyslexia often struggle with math fluency as well, and scholars at a recent conference put a spotlight on some of the possible connections.

MASC has successfully designed and delivered critical equipment and supplies needed to protect health care workers and patients during the COVID-19 pandemic.

Penn State Greater Allegheny student Katarina Shields wanted to help her fellow students seek creative ways to stay connected, make new friends and reduce stress during the remote learning period. The junior IST major developed “Virtual Game Night," a place to game for students attending all Penn State campuses, through the local gamer app Discord. The first event will be held April 18.

To prepare to view the University's virtual commencement ceremony on May 9, graduates and guests may on Thursday and Friday test the livestream and confirm that browser settings are adjusted to view the livestream.

A broker-dealer operating in Delaware, Horace Mann Investors, Inc., has agreed to provide settlement payments to numerous customers with IRA accounts opened by one of its registered representatives, Dieter Hofmann.

On view from September 6-27, 2019 Free opening reception on Friday, September 6, at 5 p.m. Wilmington, Del. (August 27, 2019) – “Human Connection,” an exhibition of sculptures, pastels, and drawings by Olga Nielsen, will be on view in the Delaware Division of the Arts’ Mezzanine Gallery from September 6-27, 2019. The artist will host […]

Welcome to the first post for the Getting Started with Python Integration to SAS Viya series! With the popularity of the Python programming language for data analysis and SAS Viya's ability to integrate with Python, I thought, why not create tutorials for users integrating the two? To begin the series [...]

Getting Started with Python Integration to SAS® Viya® - Part 1 - Making a Connection was published on SAS Users.

Welcome to the first post for the Getting Started with Python Integration to SAS Viya series! With the popularity of the Python programming language for data analysis and SAS Viya's ability to integrate with Python, I thought, why not create tutorials for users integrating the two? To begin the series [...]

Getting Started with Python Integration to SAS® Viya® - Part 1 - Making a Connection was published on SAS Users.

"The first batch of staff were trained at French labs," she said, adding that its equipment is tested every year by internationally recognised third parties.

  Introduction Android* applications may require a peer-to-peer connection between two or more Android* devices without a Wi-Fi access point or Internet access. Two examples of this are file sharing...

While governments grow more protectionist over trade and physical borders, companies such as Microsoft are bridging the gap by funding international collaborative enterprises.

2020 Hyundai Elantra vs. 2020 Toyota Corolla: Compare Cars The 2020 Toyota Corolla and 2020 Hyundai Elantra are two compact cars—and hatchbacks—that are great values with thrifty hybrids. Mailbag: What's the difference between car, crossover, and SUV anyway? "Why isn't an SUV a station wagon or a crossover?" a perplexed reader wrote...