Title: The Cold Truth About Migraine Headaches
Category: Health News
Created: 5/3/2018 12:00:00 AM
Last Editorial Review: 5/4/2018 12:00:00 AM

Title: An Expert's Guide to a Safe Run in Cold Weather
Category: Health News
Created: 3/14/2020 12:00:00 AM
Last Editorial Review: 3/16/2020 12:00:00 AM

Title: Potato & Sausages, Cold Cuts a Bad Combo for Your Brain
Category: Health News
Created: 4/22/2020 12:00:00 AM
Last Editorial Review: 4/23/2020 12:00:00 AM

Ana Gabriela Jimenez, Emily Cornelius Ruhs, Kailey J. Tobin, Katie N. Anderson, Audrey Le Pogam, Lyette Regimbald, and Francois Vezina

Seasonal changes in maximal thermogenic capacity (M_sum) in wild black-capped chickadees suggests that adjustments in metabolic performance are slow and begin to take place before winter peaks. However, when mean minimal ambient temperature (T_a) reaches –10°C, the chickadee phenotype appears to provide enough spare capacity to endure days with colder T_a, down to –20°C or below. This suggests that birds could also maintain a higher antioxidant capacity as part of their cold-acclimated phenotype to deal with sudden decreases in temperature. Here, we tested how environmental mismatch affected oxidative stress by comparing cold-acclimated (–5°C) and transition (20°C) phenotypes in chickadees exposed to an acute 15°C drop in temperature with that of control individuals. We measured superoxide dismutase, catalase and glutathione peroxidase activities, as well as lipid peroxidation damage and antioxidant scavenging capacity in pectoralis muscle, brain, intestine and liver. We generally found differences between seasonal phenotypes and across tissues, but no differences with respect to an acute cold drop treatment. Our data suggest oxidative stress is closely matched to whole-animal physiology in cold-acclimated birds compared with transition birds, implying that changes to the oxidative stress system happen slowly.

Background

Kidney injury associated with cold storage is a determinant of delayed graft function and the long-term outcome of transplanted kidneys, but the underlying mechanism remains elusive. We previously reported a role of protein kinase C- (PKC) in renal tubular injury during cisplatin nephrotoxicity and albumin-associated kidney injury, but whether PKC is involved in ischemic or transplantation-associated kidney injury is unknown.

⁶⁸Ga-labeled urea-based inhibitors of the prostate-specific membrane antigen (PSMA), such as ⁶⁸Ga-PSMA-11, are promising small molecules for targeting prostate cancer (PCa). Although this radiopharmaceutical was produced mostly by means of manual synthesis and automated synthesis modules, a sterile cold kit was recently introduced. The aim of our study was to evaluate the image quality of ⁶⁸Ga-PSMA-11 PET/CT (PSMA-PET) in a population of PCa patients after the injection of comparable activities of ⁶⁸Ga-PSMA-11 obtained with the 2 different synthetic procedures. A secondary aim was to identify secondary factors that may have an impact on image quality and, thus, final interpretation. Methods: Two different groups of 100 consecutive PCa patients who underwent PSMA-PET were included in the study. The first group of patients was imaged with ⁶⁸Ga-PSMA-11 obtained using synthesis modules, whereas the second group’s tracer activity was synthesized using a sterile cold kit. All PET images were independently reviewed by 2 nuclear medicine diagnosticians with at least 2 y of experience in PSMA-based imaging and unaware of the patients’ clinical history. The 2 reviewers independently rated the quality of each PSMA-PET scan using a 3-point Likert-type scale. In cases of discordance, the operators together reviewed the images and reached a consensus. Performance was evaluated on the basis of the expected biodistribution, lesion detection rate, and physiologic background uptake. Results: Overall, 104 of 200 (52%) PSMA-PET scans were positive for PCa-related findings. No significant differences in image quality between cold kits and synthesis modules were found (P = 0.13), although a higher proportion of images was rated as excellent by the observers for kits than for modules (45% vs. 34%). Furthermore, after image quality had been dichotomized as excellent or not excellent, multivariate regression analysis found several factors to be significantly associated with a not-excellent quality: an increase in patient age (+5 y: odds ratio [OR], 1.40; 95% confidence interval [CI], 1.12–1.75), an increase in patient weight (+5 kg: OR, 1.89; 95% CI, 1.53–2.32), an increase in ⁶⁸Ga-PSMA-11 uptake time (+10 min: OR, 1.45; 95% CI, 1.08–1.96), and a decrease in injected activity (–10 MBq: OR, 1.28; 95% CI, 1.07–1.52). Conclusion: No significant differences were identified between the 2 groups of patients undergoing PSMA-PET; therefore, we were not able to ascertain any significant influences of tracer production methodology on final scan quality. However, increased patient age, increased patient weight, decreased injected activity, and increased ⁶⁸Ga-PSMA-11 uptake time were significantly associated with an overall poorer image quality.

The interstellar comet Borisov, which flew past Earth in December, is full of carbon monoxide ice that implies its home star is smaller and colder than our sun

British singer previously performed during a Drag Race tour of Australia

He claimed only approved celebrities were permitted to talk to host at awards after party

Warm sunny spells for many today, Sunday colder and windier.

Georgia authorities arrested a white father and son on Thursday (US time) and charged them with murder in the February shooting death of a black man they had pursued in a truck after spotting him running in their neighbourhood.The...

Chicago's final frost date usually arrives in mid-May, meaning gardeners can start planting some of their hardier vegetables and seedlings.

The coronavirus outbreak has put science on hold. Now there are discoveries that may never be made and patients who will miss the chance at a breakthrough cure.

The coronavirus is pitching the U.S. and China into a new Cold War -- a confrontation over ideology as well as trade and security. It's happening partly because President Trump needs an issue to run on -- and it's dangerous

May 3, 2020

Rachel Esplin Odell argues for a wiser and more conservative strategy that resists the temptation to exaggerate the challenge posed by China.

May 5, 2020

Stephen Walt writes that arguments against U.S. offshore balancing misunderstand history. The strategy that worked against the Soviet Union can work against China.

May 6, 2020

Nathaniel Moir reviews Maxwell Taylor's Cold War: From Berlin to Vietnam by Ingo Trauschweizer.

May 6, 2020

Nathaniel Moir reviews Maxwell Taylor's Cold War: From Berlin to Vietnam by Ingo Trauschweizer.

May 5, 2020

Stephen Walt writes that arguments against U.S. offshore balancing misunderstand history. The strategy that worked against the Soviet Union can work against China.

May 5, 2020

Stephen Walt writes that arguments against U.S. offshore balancing misunderstand history. The strategy that worked against the Soviet Union can work against China.

May 3, 2020

Rachel Esplin Odell argues for a wiser and more conservative strategy that resists the temptation to exaggerate the challenge posed by China.

May 5, 2020

Stephen Walt writes that arguments against U.S. offshore balancing misunderstand history. The strategy that worked against the Soviet Union can work against China.

May 6, 2020

Nathaniel Moir reviews Maxwell Taylor's Cold War: From Berlin to Vietnam by Ingo Trauschweizer.

May 3, 2020

Rachel Esplin Odell argues for a wiser and more conservative strategy that resists the temptation to exaggerate the challenge posed by China.

May 5, 2020

Stephen Walt writes that arguments against U.S. offshore balancing misunderstand history. The strategy that worked against the Soviet Union can work against China.

May 6, 2020

Nathaniel Moir reviews Maxwell Taylor's Cold War: From Berlin to Vietnam by Ingo Trauschweizer.

May 3, 2020

Rachel Esplin Odell argues for a wiser and more conservative strategy that resists the temptation to exaggerate the challenge posed by China.

May 5, 2020

Stephen Walt writes that arguments against U.S. offshore balancing misunderstand history. The strategy that worked against the Soviet Union can work against China.

May 6, 2020

Nathaniel Moir reviews Maxwell Taylor's Cold War: From Berlin to Vietnam by Ingo Trauschweizer.

May 3, 2020

Rachel Esplin Odell argues for a wiser and more conservative strategy that resists the temptation to exaggerate the challenge posed by China.

May 5, 2020

Stephen Walt writes that arguments against U.S. offshore balancing misunderstand history. The strategy that worked against the Soviet Union can work against China.

May 6, 2020

Nathaniel Moir reviews Maxwell Taylor's Cold War: From Berlin to Vietnam by Ingo Trauschweizer.

May 3, 2020

Rachel Esplin Odell argues for a wiser and more conservative strategy that resists the temptation to exaggerate the challenge posed by China.

May 5, 2020

Stephen Walt writes that arguments against U.S. offshore balancing misunderstand history. The strategy that worked against the Soviet Union can work against China.

May 6, 2020

Nathaniel Moir reviews Maxwell Taylor's Cold War: From Berlin to Vietnam by Ingo Trauschweizer.

May 3, 2020

Rachel Esplin Odell argues for a wiser and more conservative strategy that resists the temptation to exaggerate the challenge posed by China.

May 5, 2020

Stephen Walt writes that arguments against U.S. offshore balancing misunderstand history. The strategy that worked against the Soviet Union can work against China.

May 6, 2020

Nathaniel Moir reviews Maxwell Taylor's Cold War: From Berlin to Vietnam by Ingo Trauschweizer.

May 5, 2020

Stephen Walt writes that arguments against U.S. offshore balancing misunderstand history. The strategy that worked against the Soviet Union can work against China.

May 3, 2020

Rachel Esplin Odell argues for a wiser and more conservative strategy that resists the temptation to exaggerate the challenge posed by China.

May 5, 2020

Stephen Walt writes that arguments against U.S. offshore balancing misunderstand history. The strategy that worked against the Soviet Union can work against China.

May 6, 2020

Nathaniel Moir reviews Maxwell Taylor's Cold War: From Berlin to Vietnam by Ingo Trauschweizer.

May 3, 2020

Rachel Esplin Odell argues for a wiser and more conservative strategy that resists the temptation to exaggerate the challenge posed by China.

May 5, 2020

Stephen Walt writes that arguments against U.S. offshore balancing misunderstand history. The strategy that worked against the Soviet Union can work against China.

May 6, 2020

Nathaniel Moir reviews Maxwell Taylor's Cold War: From Berlin to Vietnam by Ingo Trauschweizer.