Hallucinations linked to differences in brain structure
The effect was observed regardless of whether hallucinations were auditory or visual in nature, consistent with a reality monitoring explanation.
The effect was observed regardless of whether hallucinations were auditory or visual in nature, consistent with a reality monitoring explanation.
Rakshitha, a native of Somanahalli in Kadur taluk, suffered a head injury on September 18 after a fall while getting off a bus in Chikkamagaluru
The centre is an outcome of a ₹100 crore grant to NCBS and NIMHANS for long-term research, and to build capacity for both research and practice in the mental health field
The Sudha Gopalakrishnan Brain Centre powers an ambitious Global Project to image the human brain at the cellular level by generating unprecedented human brain data, scientific output and technology tools
Dave's got an idea for a second brain app that's customized to his brain, where we're at with Notion and other notes apps, and accessibility on LLM's in browsers.
We need to start brainstorming for ideas and features that we want on the new science portal so we'll be prepared for when we locate a web designer.
Here are a list of some other science library websites. Not all are great but I'd like for us to discuss what elements we like and which features we don't like (just as important). Please feel free to post links to other libraries you think are worthy of critique. Also, if there are general guidelines and features that you'd like to include please post about those too.
My first impression looking at these sites is how busy they all are. Lots of links and it seems overwhelming at first glance. Its a decision that we'll have to make about how much information should be quickly accessible on the main page but yet still easily usable. Caltech's library page is the most easily navigated, IMO. I like the quick drop down boxes and the selection of links. I especially like the menu for authors - as the issue of open access and author rights becomes more important on campus, we'll need to take an active role in helping the faculty understand their rights and options for publishing.
Berkeley: Chemistry: http://www.lib.berkeley.edu/CHEM/
Engineering: http://www.lib.berkeley.edu/ENGI/
Physics/Ay: http://www.lib.berkeley.edu/PHYS/
Caltech: http://library.caltech.edu/
Chicago : http://www1.lib.uchicago.edu/e/crerar/index.php3
Irvine: http://www.lib.uci.edu/libraries/science.html
Michigan: http://www.lib.umich.edu/science/
MIT Science Library: http://libraries.mit.edu/science/
Oregon Science Library: http://libweb.uoregon.edu/scilib/
Santa Cruz: http://libweb.uoregon.edu/scilib/
The first scientist from a developing country to be appointed to the top position of IBRO, Shubha Tole is currently the dean of graduate studies at Tata Institute of Fundamental Research, Mumbai
β-Glucocerebrosidase (GBA) hydrolyzes glucosylceramide (GlcCer) to generate ceramide. Previously, we demonstrated that lysosomal GBA1 and nonlysosomal GBA2 possess not only GlcCer hydrolase activity, but also transglucosylation activity to transfer the glucose residue from GlcCer to cholesterol to form β-cholesterylglucoside (β-GlcChol) in vitro. β-GlcChol is a member of sterylglycosides present in diverse species. How GBA1 and GBA2 mediate β-GlcChol metabolism in the brain is unknown. Here, we purified and characterized sterylglycosides from rodent and fish brains. Although glucose is thought to be the sole carbohydrate component of sterylglycosides in vertebrates, structural analysis of rat brain sterylglycosides revealed the presence of galactosylated cholesterol (β-GalChol), in addition to β-GlcChol. Analyses of brain tissues from GBA2-deficient mice and GBA1- and/or GBA2-deficient Japanese rice fish (Oryzias latipes) revealed that GBA1 and GBA2 are responsible for β-GlcChol degradation and formation, respectively, and that both GBA1 and GBA2 are responsible for β-GalChol formation. Liquid chromatography–tandem MS revealed that β-GlcChol and β-GalChol are present throughout development from embryo to adult in the mouse brain. We found that β-GalChol expression depends on galactosylceramide (GalCer), and developmental onset of β-GalChol biosynthesis appeared to be during myelination. We also found that β-GlcChol and β-GalChol are secreted from neurons and glial cells in association with exosomes. In vitro enzyme assays confirmed that GBA1 and GBA2 have transgalactosylation activity to transfer the galactose residue from GalCer to cholesterol to form β-GalChol. This is the first report of the existence of β-GalChol in vertebrates and how β-GlcChol and β-GalChol are formed in the brain.
“Badass” new method uses a magnetised protein to activate brain cells rapidly, reversibly, and non-invasively
Researchers in the United States have developed a new method for controlling the brain circuits associated with complex animal behaviours, using genetic engineering to create a magnetised protein that activates specific groups of nerve cells from a distance.
Understanding how the brain generates behaviour is one of the ultimate goals of neuroscience – and one of its most difficult questions. In recent years, researchers have developed a number of methods that enable them to remotely control specified groups of neurons and to probe the workings of neuronal circuits.
Related: Remote control of brain activity with heated nanoparticles
Related: Researchers read and write brain activity with light
Continue reading...State-of-the-art electron microscopy reveals the large-scale organization of the proteins that regulate neurotransmitter release
This spectacular image – which took the best part of a year to create – shows the fine structure of a nerve terminal at high resolution, revealing, for the very first time, an intricate network of fine filaments that controls the movements of synaptic vesicles.
The brain is soft and wet, with the consistency of a lump of jelly. Yet, it is the most complex and highly organized structure that we know of, containing hundreds of billions of neurons and glial cells, and something on the order of one quadrillion synaptic connections, all of which are arranged in a very specific manner.
Related: 3D model of a nerve terminal in atomic detail | Mo Costandi
Related: Blowing up the brain to reveal its finer details
Continue reading...New research reveals the secret behind the remarkable intelligence of some bird species
Related: Blind cave fish evolved a shrunken brain to save energy
Calling someone “bird brain” used to be considered as an insult. Birds’ brains are very small compared to those of mammals, and what’s more, they lack the heavily wrinkled cerebral cortex, which is characteristic of the human brain, and widely believed to the seat of intelligence. It was, therefore, widely assumed that birds aren’t very clever creatures, but recently this has started to change.
Related: Ravens cooperate with friends not foes
Continue reading...A new imaging technique may give researchers fresh insights into brain development, function, and disease
The human brain is often said to be the most complex object in the known universe, and there’s good reason to believe that it is. That lump of jelly inside your head contains at least 80 billion nerve cells, or neurons, and even more of the non-neuronal cells called glia. Between them, they form hundreds of trillions of precise synaptic connections; but they all have moveable parts, and these connections can change. Neurons can extend and retract their delicate fibres; some types of glial cells can crawl through the brain; and neurons and glia routinely work together to create new connections and eliminate old ones.
These processes begin before we are born, and occur until we die, making the brain a highly dynamic organ that undergoes continuous change throughout life. At any given moment, many millions of them are being modified in one way or another, to reshape the brain’s circuitry in response to our daily experiences. Researchers at Yale University have now developed an imaging technique that enables them to visualise the density of synapses in the living human brain, and offers a promising new way of studying how the organ develops and functions, and also how it deteriorates in various neurological and psychiatric conditions.
Related: Brain’s immune cells hyperactive in schizophrenia
Related: 3D model of a nerve terminal in atomic detail | Mo Costandi
Continue reading...It’s not just your waistline that suffers as you put on weight. Researchers are beginning to find puzzling new links between obesity, memory loss and dementia
Lucy Cheke and her colleagues at the University of Cambridge recently invited a few participants into her lab for a kind of ‘treasure hunt’.
The participants navigated a virtual environment on a computer screen, dropping off various objects along their way. They then answered a series of questions to test their memory of the task, such as where they had hidden a particular object.
Related: How your eyes betray your thoughts
Related: How to optimise your brain's waste disposal system
Related: Gut bacteria regulate nerve fibre insulation
Related: Obesity linked to memory deficits
Continue reading...New research shows that the rhythm of breathing directly impacts neural activity in a network of brain areas involved in smell, memory and emotions
The rhythm of breathing co-ordinates electrical activity across a network of brain regions associated with smell, memory, and emotions, and can enhance their functioning, according to a new study by researchers at Northwestern University. The findings, published in the Journal of Neuroscience, suggest that breathing does not merely supply oxygen to the brain and body, but may also organise the activity of populations of cells within multiple brain regions to help orchestrate complex behaviours.
Related: Your nose knows death is imminent | Mo Costandi
Related: A cooler way to evaluate brain surgery patients
Continue reading...New findings challenge our understanding of how the brain matures
Faces are important to us. From the moment we are are born, we prefer to look at faces than at other, inanimate objects, and, being social animals, we encounter faces every day of our lives. The face is the first thing we look to when identifying other people; faces also convey emotions, informing us of peoples’ mood, and from them we can usually determine a person’s sex and, sometimes, roughly how old they are. Eye movements can also reveal to us something about another person’s intentions.
Related: How your eyes betray your thoughts
Related: Live imaging of synapse density in the human brain
Continue reading...New research provides evidence for the idea that sleep restores cellular homeostasis in the brain and helps us to forget irrelevant information
We spend one third of our lives sleeping, but we still do not know exactly why we sleep. Recent research shows that that the brain does its housekeeping while we sleep, and clears away its waste. According to another hypothesis, sleep plays the vital role of restoring the right balance of brain synapses to enhance learning, and two studies published in today’s issue of Science now provide the most direct evidence yet for this idea.
We do know that sleep is important for consolidating newly formed memories. During waking hours, we learn all kinds of new information, both consciously and unconsciously. To store it, the brain modifies large numbers of synaptic connections, making some of them stronger and larger, and it’s now thought that as we sleep other synapses are weakened or destroyed, so that the important new information is stored for later use, while irrelevant material, which could interfere with learning, is not.
Related: The Homer Simpson effect: forgetting to remember
Related: How to optimise your brain's waste disposal system
Continue reading...New research shows that we can train our brains to become memory champions
To many of us, having to memorize a long list of items feels like a chore. But for others, it is more like a sport. Every year, hundreds of these ‘memory athletes’ compete with one another in the World Memory Championships, memorising hundreds of words, numbers, or other pieces of information within minutes. The current world champion is Alex Mullen, who beat his competitors by memorizing a string of more than 550 digits in under 5 minutes.
You may think that such prodigious mental feats are linked to having an unusual brain, or to being extraordinarily clever. But they are not. New research published in the journal Neuron shows that you, too, can be a super memorizer with just six weeks of intensive mnemonic training, and also reveals the long-lasting changes to brain structure and function that occur as a result of such training.
Related: The Homer Simpson effect: forgetting to remember
Related: A neural pathway that erases memories
Continue reading...Researchers at MIT have developed a new method of electrically stimulating deep brain tissues without opening the skull
Since 1997, more than 100,000 Parkinson’s Disease patients have been treated with deep brain stimulation (DBS), a surgical technique that involves the implantation of ultra-thin wire electrodes. The implanted device, sometimes referred to as a ‘brain pacemaker’, delivers electrical pulses to a structure called the subthalamic nucleus, located near the centre of the brain, and effectively alleviates many of the physical symptoms of the disease, such as tremor, muscle rigidity, and slowed movements.
DBS is generally safe but, like any surgical procedure, comes with some risks. First and foremost, it is highly invasive, requiring small holes to be drilled in the patient’s skull, through which the electrodes are inserted. Potential complications of this include infection, stroke, and bleeding on the brain. The electrodes, which are implanted for long periods of time, sometimes move out of place; they can also cause swelling at the implantation site; and the wire connecting them to the battery, typically placed under the skin of the chest, can erode, all of which require additional surgical procedures.
Related: Blowing up the brain to reveal its finer details
Related: Traces of memory in a dish | Mo Costandi
Continue reading...Amid massive exercises to contain the COVID-19 pandemic in Kerala, the state police on Saturday operated its rented helicopter to transport the heart of a brain dead patient from Thiruvananthapuram to...
Several government hospitals denied admission to Suresh, an auto-driver in Bengaluru, before a Twitter user highlighted his ordeal and prompted the DIPR to provide help.
Few relationships would be immune to the pressures wrought by their ordeal: the strain of caring for their desperately sick child, their brief life as fugitives, the draining legal battles.
Few relationships would be immune to the pressures wrought by their ordeal: the strain of caring for their desperately sick child, their brief life as fugitives, the draining legal battles.
The field of film and television in India has lost a number of gems in the past few days. In another setback, revered Doordarshan presenter Malvika Marathe breathed her last on May 7, 2020. The anchor and actress was 53. Malvika
The field of film and television in India has lost a number of gems in the past few days. In another setback, revered Doordarshan presenter Malvika Marathe breathed her last on May 7, 2020. The anchor and actress was 53. Malvika
Although at first a casual circle, the group became tightly organized after FDR's nomination. After the election, they were publicly christened the "Brain Trust," and became the central component of the New Deal. This exhibition will focus on the three key members of the Brain Trust—Raymond Moley, Rexford Tugwell, and Adolph Berle—and two of the New Deal cabinet members with whom they worked to bring about FDR's radical changes—Frances Perkins and Harry Hopkins. Using contemporary photographs, cartoons, broadsides, articles and newsreels, this exhibition will be supplemented by audio reminisces from the collection of the Columbia University Oral History Research Office.
Recently, scientists at the Smithsonian Tropical Research Institute in Panama discovered that the brain region responsible for learning and memory is larger in the social queens than in the solitary queens of this species. Their study is the first comparison of the brain sizes of social and non-social individuals of the same species.
The post For sweat bees, being social builds a more developed brain appeared first on Smithsonian Insider.
When it comes to brains, is bigger better? Can the tiny brain of a newly hatched spiderling handle problems as adeptly as the brain of a larger adult spider?
The post Tiny, new brains prove just as adept as large, mature brains among tropical orb-web spiders appeared first on Smithsonian Insider.
New research on tiny spiders has revealed that their brains are so large that they fill their body cavities and overflow into their legs, say a team of scientists at the Smithsonian Tropical Research Institute in Panama.
The post Brains of tiny spiders fill their body cavities and legs, Smithsonian researchers discover appeared first on Smithsonian Insider.
When it comes to brain size, Homo sapiens generally get the most credit. But to find the baby mammals with the proportionally largest brains on […]
The post Weddell seals have big-brained pups appeared first on Smithsonian Insider.
Chip a tooth and expose a nerve and the result can be a searing sensitivity to hot and cold. The hard outer layer of a […]
The post Scientists map pathway from narwhals’ sensitive tusk to brain appeared first on Smithsonian Insider.
Pop quiz! Name the first five dinosaurs that come to mind. Chances are good that one you named was Tyrannosaurs rex, a popular favorite perhaps best […]
The post New horse-sized tyrannosaur with big brain reveals how “T. rex” became top predator appeared first on Smithsonian Insider.
With its homely featherless head, undertaker’s charcoal coloring and association with death and decay, the turkey vulture (Cathartes aura) tops few lists as a favorite […]
The post Scientists in awe of huge olfactory bulb found in turkey vulture brain appeared first on Smithsonian Insider.
Javad Fahanik-babaei, Bahareh Rezaee, Maryam Nazari, Nihad Torabi, Reza Saghiri, Remy Sauve, and Afsaneh Eliassi
We have determined the electropharmacological properties of a new potassium channel from brain mitochondrial membrane by planar lipid bilayer method. Our results showed the presence of a channel with a conductance of 150 pS at potentials between 0 and –60 mV in 200 cis/50 trans mM KCl solutions.
The channel was voltage-independent, with an open probability value ~0.6 at different voltages. ATP did not affect current amplitude and Po at positive and negative voltages. Notably, adding iberiotoxin, charybdotoxin, lidocaine, and margatoxin had no effect on the channel behavior. Similarly, no changes were observed by decreasing the cis-pH to 6. Interestingly, the channel was inhibited by adding sodium in a dose dependent manner. Our results also indicated a significant increase in mitochondrial complex IV activity and membrane potential and decrease in complex I activity and mitochondrial ROS production in the presence of sodium ions.
We propose that inhibition of mitochondrial K+ transport by Na ions on K+ channel opening may be important for cell protection and ATP synthesis.