pli Single-nucleus transcriptomics of the prefrontal cortex in major depressive disorder implicates oligodendrocyte precursor cells and excitatory neurons By feeds.nature.com Published On :: 2020-04-27 Full Article
pli Potential through simplicity: thymidine kinase-1 as a biomarker for CDK4/6 inhibitors By feeds.nature.com Published On :: 2020-05-08 Full Article
pli Associations between sleep bruxism and (peri-)implant complications: lessons learned from a clinical study By www.nature.com Published On :: 2020-01-30 Full Article
pli Viral contamination in biologic manufacture and implications for emerging therapies By feeds.nature.com Published On :: 2020-04-27 Full Article
pli African-American men with low-risk prostate cancer treated with radical prostatectomy in an equal-access health care system: implications for active surveillance By feeds.nature.com Published On :: 2020-04-23 Full Article
pli Fixed orthodontic appliances: a practical guide By feeds.nature.com Published On :: 2020-05-08 Full Article
pli Biallelic mutations in <i>SORD</i> cause a common and potentially treatable hereditary neuropathy with implications for diabetes By feeds.nature.com Published On :: 2020-05-04 Full Article
pli e-EMGDE, RIC, NEDA y las normas de codificación: más allá de un perfil de aplicación en archivos By eprints.rclis.org Published On :: Sat, 25 Apr 2020 19:50:53 +0200 Baños-Moreno, María-José and Valentín-Ruiz, Francisco-José and Blázquez-Martín-de-las-Mulas, Antonio e-EMGDE, RIC, NEDA y las normas de codificación: más allá de un perfil de aplicación en archivos., 2019 . In IV Congreso ISKO España-Portugal, Barcelona, 11-12 de julio de 2019. [Conference paper] Full Article
pli Educar para la transparencia y una ciudadanía informada: diseño, aplicación y evaluación del programa IRIS para alumnado de Bachillerato de la Región de Murcia (España) By eprints.rclis.org Published On :: Sat, 02 May 2020 08:44:02 +0200 Campillo-Meseguer, María-José and Galiano-Martínez, Antonio and Gómez-Hernández, José-Antonio and Hidalgo-Pérez, Antonio and López Aniorte, María-del-Carmen and Martínez-Navarro, Emilio and Molina-Molina, José and Mayor-Balsas, José-Manuel and Ros-Media, José Luis and Oliva-Palazón, Elena and Reverte-Martínez, Francisco-Manuel and Baeza-Hernández, María-José . Educar para la transparencia y una ciudadanía informada: diseño, aplicación y evaluación del programa IRIS para alumnado de Bachillerato de la Región de Murcia (España)., 2020 In: Competencias en Información y Políticas para Educación Superior: Estudios Hispano-Brasileños, volumen 1. Universidad Complutense de Madrid, pp. 123-138. [Book chapter] Full Article
pli Geopolitical and Market Implications of Renewable Hydrogen: New Dependencies in a Low-Carbon Energy World By feedproxy.google.com Published On :: Mar 4, 2020 Mar 4, 2020To accelerate the global transition to a low-carbon economy, all energy systems and sectors must be actively decarbonized. While hydrogen has been a staple in the energy and chemical industries for decades, renewable hydrogen is drawing increased attention today as a versatile and sustainable energy carrier with the potential to play an important piece in the carbon-free energy puzzle. Countries around the world are piloting new projects and policies, yet adopting hydrogen at scale will require innovating along the value chains; scaling technologies while significantly reducing costs; deploying enabling infrastructure; and defining appropriate national and international policies and market structures. What are the general principles of how renewable hydrogen may reshape the structure of global energy markets? What are the likely geopolitical consequences such changes would cause? A deeper understanding of these nascent dynamics will allow policy makers and corporate investors to better navigate the challenges and maximize the opportunities that decarbonization will bring, without falling into the inefficient behaviors of the past. Full Article
pli Implication of gut microbiota in the association between infant antibiotic exposure and childhood obesity and adiposity accumulation By feeds.nature.com Published On :: 2020-04-22 Full Article
pli Predictors of weight loss after bariatric surgery—a cross-disciplinary approach combining physiological, social, and psychological measures By feeds.nature.com Published On :: 2020-04-23 Full Article
pli Geopolitical and Market Implications of Renewable Hydrogen: New Dependencies in a Low-Carbon Energy World By feedproxy.google.com Published On :: Mar 4, 2020 Mar 4, 2020To accelerate the global transition to a low-carbon economy, all energy systems and sectors must be actively decarbonized. While hydrogen has been a staple in the energy and chemical industries for decades, renewable hydrogen is drawing increased attention today as a versatile and sustainable energy carrier with the potential to play an important piece in the carbon-free energy puzzle. Countries around the world are piloting new projects and policies, yet adopting hydrogen at scale will require innovating along the value chains; scaling technologies while significantly reducing costs; deploying enabling infrastructure; and defining appropriate national and international policies and market structures. What are the general principles of how renewable hydrogen may reshape the structure of global energy markets? What are the likely geopolitical consequences such changes would cause? A deeper understanding of these nascent dynamics will allow policy makers and corporate investors to better navigate the challenges and maximize the opportunities that decarbonization will bring, without falling into the inefficient behaviors of the past. Full Article
pli Geopolitical and Market Implications of Renewable Hydrogen: New Dependencies in a Low-Carbon Energy World By feedproxy.google.com Published On :: Mar 4, 2020 Mar 4, 2020To accelerate the global transition to a low-carbon economy, all energy systems and sectors must be actively decarbonized. While hydrogen has been a staple in the energy and chemical industries for decades, renewable hydrogen is drawing increased attention today as a versatile and sustainable energy carrier with the potential to play an important piece in the carbon-free energy puzzle. Countries around the world are piloting new projects and policies, yet adopting hydrogen at scale will require innovating along the value chains; scaling technologies while significantly reducing costs; deploying enabling infrastructure; and defining appropriate national and international policies and market structures. What are the general principles of how renewable hydrogen may reshape the structure of global energy markets? What are the likely geopolitical consequences such changes would cause? A deeper understanding of these nascent dynamics will allow policy makers and corporate investors to better navigate the challenges and maximize the opportunities that decarbonization will bring, without falling into the inefficient behaviors of the past. Full Article
pli Building PhoneGap applications powered by Database.com By www.adobe.com Published On :: Wed Jun 13 22:57:00 UTC 2012 Learn how to create mobile apps built using PhoneGap, with data served and persisted using Database.com. Full Article
pli PhoneGap advice on dealing with Apple application rejections By www.adobe.com Published On :: Mon Oct 29 22:57:00 UTC 2012 Learn about Apple App Store rejections and how to address common omissions in your app designs when converting your web app to an iOS app. Full Article
pli Geopolitical and Market Implications of Renewable Hydrogen: New Dependencies in a Low-Carbon Energy World By feedproxy.google.com Published On :: Mar 4, 2020 Mar 4, 2020To accelerate the global transition to a low-carbon economy, all energy systems and sectors must be actively decarbonized. While hydrogen has been a staple in the energy and chemical industries for decades, renewable hydrogen is drawing increased attention today as a versatile and sustainable energy carrier with the potential to play an important piece in the carbon-free energy puzzle. Countries around the world are piloting new projects and policies, yet adopting hydrogen at scale will require innovating along the value chains; scaling technologies while significantly reducing costs; deploying enabling infrastructure; and defining appropriate national and international policies and market structures. What are the general principles of how renewable hydrogen may reshape the structure of global energy markets? What are the likely geopolitical consequences such changes would cause? A deeper understanding of these nascent dynamics will allow policy makers and corporate investors to better navigate the challenges and maximize the opportunities that decarbonization will bring, without falling into the inefficient behaviors of the past. Full Article
pli Building Solidarity: Challenges, Options, and Implications for COVID-19 Responses By www.belfercenter.org Published On :: Mar 30, 2020 Mar 30, 2020In this white paper, authors Melani Cammett and Evan Lieberman try to shed light on what social solidarity is, how it might affect attitudinal and behavioral change; and given its desirable properties, what strategies impede and which facilitate the building of solidarity, particularly given the unique circumstances of the COVID-19 pandemic. Full Article
pli Trump's Iran Deal Move Splits America From its European Allies - That's a Problem By www.belfercenter.org Published On :: May 9, 2018 May 9, 2018President Trump’s unilateral withdrawal from the Iranian nuclear deal has driven yet another wedge between Washington and its closest European allies – a longstanding goal of Iranian policy and a major gift to Russia. Full Article
pli Geopolitical and Market Implications of Renewable Hydrogen: New Dependencies in a Low-Carbon Energy World By feedproxy.google.com Published On :: Mar 4, 2020 Mar 4, 2020To accelerate the global transition to a low-carbon economy, all energy systems and sectors must be actively decarbonized. While hydrogen has been a staple in the energy and chemical industries for decades, renewable hydrogen is drawing increased attention today as a versatile and sustainable energy carrier with the potential to play an important piece in the carbon-free energy puzzle. Countries around the world are piloting new projects and policies, yet adopting hydrogen at scale will require innovating along the value chains; scaling technologies while significantly reducing costs; deploying enabling infrastructure; and defining appropriate national and international policies and market structures. What are the general principles of how renewable hydrogen may reshape the structure of global energy markets? What are the likely geopolitical consequences such changes would cause? A deeper understanding of these nascent dynamics will allow policy makers and corporate investors to better navigate the challenges and maximize the opportunities that decarbonization will bring, without falling into the inefficient behaviors of the past. Full Article
pli Mission accomplished, says Button By en.espnf1.com Published On :: Sun, 14 Nov 2010 19:14:52 GMT Jenson Button says McLaren accomplished their main aim of finishing second in the constructors' standings after he finished third behind team-mate Lewis Hamilton in the Abu Dhabi Grand Prix Full Article
pli Geopolitical and Market Implications of Renewable Hydrogen: New Dependencies in a Low-Carbon Energy World By feedproxy.google.com Published On :: Mar 4, 2020 Mar 4, 2020To accelerate the global transition to a low-carbon economy, all energy systems and sectors must be actively decarbonized. While hydrogen has been a staple in the energy and chemical industries for decades, renewable hydrogen is drawing increased attention today as a versatile and sustainable energy carrier with the potential to play an important piece in the carbon-free energy puzzle. Countries around the world are piloting new projects and policies, yet adopting hydrogen at scale will require innovating along the value chains; scaling technologies while significantly reducing costs; deploying enabling infrastructure; and defining appropriate national and international policies and market structures. What are the general principles of how renewable hydrogen may reshape the structure of global energy markets? What are the likely geopolitical consequences such changes would cause? A deeper understanding of these nascent dynamics will allow policy makers and corporate investors to better navigate the challenges and maximize the opportunities that decarbonization will bring, without falling into the inefficient behaviors of the past. Full Article
pli Geopolitical and Market Implications of Renewable Hydrogen: New Dependencies in a Low-Carbon Energy World By feedproxy.google.com Published On :: Mar 4, 2020 Mar 4, 2020To accelerate the global transition to a low-carbon economy, all energy systems and sectors must be actively decarbonized. While hydrogen has been a staple in the energy and chemical industries for decades, renewable hydrogen is drawing increased attention today as a versatile and sustainable energy carrier with the potential to play an important piece in the carbon-free energy puzzle. Countries around the world are piloting new projects and policies, yet adopting hydrogen at scale will require innovating along the value chains; scaling technologies while significantly reducing costs; deploying enabling infrastructure; and defining appropriate national and international policies and market structures. What are the general principles of how renewable hydrogen may reshape the structure of global energy markets? What are the likely geopolitical consequences such changes would cause? A deeper understanding of these nascent dynamics will allow policy makers and corporate investors to better navigate the challenges and maximize the opportunities that decarbonization will bring, without falling into the inefficient behaviors of the past. Full Article
pli Geopolitical and Market Implications of Renewable Hydrogen: New Dependencies in a Low-Carbon Energy World By feedproxy.google.com Published On :: Mar 4, 2020 Mar 4, 2020To accelerate the global transition to a low-carbon economy, all energy systems and sectors must be actively decarbonized. While hydrogen has been a staple in the energy and chemical industries for decades, renewable hydrogen is drawing increased attention today as a versatile and sustainable energy carrier with the potential to play an important piece in the carbon-free energy puzzle. Countries around the world are piloting new projects and policies, yet adopting hydrogen at scale will require innovating along the value chains; scaling technologies while significantly reducing costs; deploying enabling infrastructure; and defining appropriate national and international policies and market structures. What are the general principles of how renewable hydrogen may reshape the structure of global energy markets? What are the likely geopolitical consequences such changes would cause? A deeper understanding of these nascent dynamics will allow policy makers and corporate investors to better navigate the challenges and maximize the opportunities that decarbonization will bring, without falling into the inefficient behaviors of the past. Full Article
pli Geopolitical and Market Implications of Renewable Hydrogen: New Dependencies in a Low-Carbon Energy World By feedproxy.google.com Published On :: Mar 4, 2020 Mar 4, 2020To accelerate the global transition to a low-carbon economy, all energy systems and sectors must be actively decarbonized. While hydrogen has been a staple in the energy and chemical industries for decades, renewable hydrogen is drawing increased attention today as a versatile and sustainable energy carrier with the potential to play an important piece in the carbon-free energy puzzle. Countries around the world are piloting new projects and policies, yet adopting hydrogen at scale will require innovating along the value chains; scaling technologies while significantly reducing costs; deploying enabling infrastructure; and defining appropriate national and international policies and market structures. What are the general principles of how renewable hydrogen may reshape the structure of global energy markets? What are the likely geopolitical consequences such changes would cause? A deeper understanding of these nascent dynamics will allow policy makers and corporate investors to better navigate the challenges and maximize the opportunities that decarbonization will bring, without falling into the inefficient behaviors of the past. Full Article
pli Geopolitical and Market Implications of Renewable Hydrogen: New Dependencies in a Low-Carbon Energy World By feedproxy.google.com Published On :: Mar 4, 2020 Mar 4, 2020To accelerate the global transition to a low-carbon economy, all energy systems and sectors must be actively decarbonized. While hydrogen has been a staple in the energy and chemical industries for decades, renewable hydrogen is drawing increased attention today as a versatile and sustainable energy carrier with the potential to play an important piece in the carbon-free energy puzzle. Countries around the world are piloting new projects and policies, yet adopting hydrogen at scale will require innovating along the value chains; scaling technologies while significantly reducing costs; deploying enabling infrastructure; and defining appropriate national and international policies and market structures. What are the general principles of how renewable hydrogen may reshape the structure of global energy markets? What are the likely geopolitical consequences such changes would cause? A deeper understanding of these nascent dynamics will allow policy makers and corporate investors to better navigate the challenges and maximize the opportunities that decarbonization will bring, without falling into the inefficient behaviors of the past. Full Article
pli Geopolitical and Market Implications of Renewable Hydrogen: New Dependencies in a Low-Carbon Energy World By feedproxy.google.com Published On :: Mar 4, 2020 Mar 4, 2020To accelerate the global transition to a low-carbon economy, all energy systems and sectors must be actively decarbonized. While hydrogen has been a staple in the energy and chemical industries for decades, renewable hydrogen is drawing increased attention today as a versatile and sustainable energy carrier with the potential to play an important piece in the carbon-free energy puzzle. Countries around the world are piloting new projects and policies, yet adopting hydrogen at scale will require innovating along the value chains; scaling technologies while significantly reducing costs; deploying enabling infrastructure; and defining appropriate national and international policies and market structures. What are the general principles of how renewable hydrogen may reshape the structure of global energy markets? What are the likely geopolitical consequences such changes would cause? A deeper understanding of these nascent dynamics will allow policy makers and corporate investors to better navigate the challenges and maximize the opportunities that decarbonization will bring, without falling into the inefficient behaviors of the past. Full Article
pli Geopolitical and Market Implications of Renewable Hydrogen: New Dependencies in a Low-Carbon Energy World By feedproxy.google.com Published On :: Mar 4, 2020 Mar 4, 2020To accelerate the global transition to a low-carbon economy, all energy systems and sectors must be actively decarbonized. While hydrogen has been a staple in the energy and chemical industries for decades, renewable hydrogen is drawing increased attention today as a versatile and sustainable energy carrier with the potential to play an important piece in the carbon-free energy puzzle. Countries around the world are piloting new projects and policies, yet adopting hydrogen at scale will require innovating along the value chains; scaling technologies while significantly reducing costs; deploying enabling infrastructure; and defining appropriate national and international policies and market structures. What are the general principles of how renewable hydrogen may reshape the structure of global energy markets? What are the likely geopolitical consequences such changes would cause? A deeper understanding of these nascent dynamics will allow policy makers and corporate investors to better navigate the challenges and maximize the opportunities that decarbonization will bring, without falling into the inefficient behaviors of the past. Full Article
pli Geopolitical and Market Implications of Renewable Hydrogen: New Dependencies in a Low-Carbon Energy World By feedproxy.google.com Published On :: Mar 4, 2020 Mar 4, 2020To accelerate the global transition to a low-carbon economy, all energy systems and sectors must be actively decarbonized. While hydrogen has been a staple in the energy and chemical industries for decades, renewable hydrogen is drawing increased attention today as a versatile and sustainable energy carrier with the potential to play an important piece in the carbon-free energy puzzle. Countries around the world are piloting new projects and policies, yet adopting hydrogen at scale will require innovating along the value chains; scaling technologies while significantly reducing costs; deploying enabling infrastructure; and defining appropriate national and international policies and market structures. What are the general principles of how renewable hydrogen may reshape the structure of global energy markets? What are the likely geopolitical consequences such changes would cause? A deeper understanding of these nascent dynamics will allow policy makers and corporate investors to better navigate the challenges and maximize the opportunities that decarbonization will bring, without falling into the inefficient behaviors of the past. Full Article
pli Geopolitical and Market Implications of Renewable Hydrogen: New Dependencies in a Low-Carbon Energy World By feedproxy.google.com Published On :: Mar 4, 2020 Mar 4, 2020To accelerate the global transition to a low-carbon economy, all energy systems and sectors must be actively decarbonized. While hydrogen has been a staple in the energy and chemical industries for decades, renewable hydrogen is drawing increased attention today as a versatile and sustainable energy carrier with the potential to play an important piece in the carbon-free energy puzzle. Countries around the world are piloting new projects and policies, yet adopting hydrogen at scale will require innovating along the value chains; scaling technologies while significantly reducing costs; deploying enabling infrastructure; and defining appropriate national and international policies and market structures. What are the general principles of how renewable hydrogen may reshape the structure of global energy markets? What are the likely geopolitical consequences such changes would cause? A deeper understanding of these nascent dynamics will allow policy makers and corporate investors to better navigate the challenges and maximize the opportunities that decarbonization will bring, without falling into the inefficient behaviors of the past. Full Article
pli Geopolitical and Market Implications of Renewable Hydrogen: New Dependencies in a Low-Carbon Energy World By feedproxy.google.com Published On :: Mar 4, 2020 Mar 4, 2020To accelerate the global transition to a low-carbon economy, all energy systems and sectors must be actively decarbonized. While hydrogen has been a staple in the energy and chemical industries for decades, renewable hydrogen is drawing increased attention today as a versatile and sustainable energy carrier with the potential to play an important piece in the carbon-free energy puzzle. Countries around the world are piloting new projects and policies, yet adopting hydrogen at scale will require innovating along the value chains; scaling technologies while significantly reducing costs; deploying enabling infrastructure; and defining appropriate national and international policies and market structures. What are the general principles of how renewable hydrogen may reshape the structure of global energy markets? What are the likely geopolitical consequences such changes would cause? A deeper understanding of these nascent dynamics will allow policy makers and corporate investors to better navigate the challenges and maximize the opportunities that decarbonization will bring, without falling into the inefficient behaviors of the past. Full Article
pli HRT slammed for 'misleading information' by supplier By en.espnf1.com Published On :: Tue, 11 Dec 2012 09:44:30 GMT One of HRT's suppliers has accused the team of providing "misleading information" and claims the team went in to liquidation in early November Full Article
pli Geopolitical and Market Implications of Renewable Hydrogen: New Dependencies in a Low-Carbon Energy World By feedproxy.google.com Published On :: Mar 4, 2020 Mar 4, 2020To accelerate the global transition to a low-carbon economy, all energy systems and sectors must be actively decarbonized. While hydrogen has been a staple in the energy and chemical industries for decades, renewable hydrogen is drawing increased attention today as a versatile and sustainable energy carrier with the potential to play an important piece in the carbon-free energy puzzle. Countries around the world are piloting new projects and policies, yet adopting hydrogen at scale will require innovating along the value chains; scaling technologies while significantly reducing costs; deploying enabling infrastructure; and defining appropriate national and international policies and market structures. What are the general principles of how renewable hydrogen may reshape the structure of global energy markets? What are the likely geopolitical consequences such changes would cause? A deeper understanding of these nascent dynamics will allow policy makers and corporate investors to better navigate the challenges and maximize the opportunities that decarbonization will bring, without falling into the inefficient behaviors of the past. Full Article
pli Stephen P. Cohen’s disciplinary contribution to political science By webfeeds.brookings.edu Published On :: Mon, 04 Nov 2019 16:47:14 +0000 There are people who influence you and there is the person who changes your life. For me, that person was Steve Cohen. From the first time I spoke with him on the phone in 1993 about a story I was writing for India Today (where I worked then), to my entry into the graduate program… Full Article
pli Taiwan’s January 2020 elections: Prospects and implications for China and the United States By webfeeds.brookings.edu Published On :: EXECutive Summary Taiwan will hold its presidential and legislative elections on January 11, 2020. The incumbent president, Tsai Ing-wen of the Democratic Progressive Party (DPP), appears increasingly likely to prevail over her main challenger, Han Kuo-yu of the Kuomintang (KMT). In the legislative campaign, the DPP now has better than even odds to retain its… Full Article
pli Impacts and implications of the 2020 Taiwan general elections By webfeeds.brookings.edu Published On :: Mon, 06 Jan 2020 19:01:50 +0000 Taiwan held elections for the president and all the members of the Legislative Yuan on January 11. Although President Tsai Ing-wen had maintained a strong lead in the polls, there were questions about the reliability of some polls. Moreover, the outcome of the legislative elections was very uncertain. China, which has long made clear its… Full Article
pli A controversial new demonstration in Medicare: Potential implications for physician-administered drugs By webfeeds.brookings.edu Published On :: Tue, 03 May 2016 12:56:00 -0400 According to an August 2015 survey, 72 percent of Americans find drug costs unreasonable, with 83 percent believing that the federal government should be able to negotiate prices for Medicare. Recently, Acting Administrator of the Centers for Medicare and Medicaid Services (CMS) Andy Slavitt commented that spending on medicines increased 13 percent in 2014 while health care spending growth overall was only 5 percent, the highest rate of drug spending growth since 2001. Some of the most expensive drugs are covered under Medicare’s medical benefit, Part B, because they are administered by a physician. They are often administered in hospital outpatient departments and physician offices, and most commonly used to treat conditions like cancer, rheumatoid arthritis, and macular degeneration. Between 2005 and 2014, spending on Part B drugs has increased annually by 7.7 percent, with the top 20 drugs by total amount of Medicare payments accounting for 57 percent of total Part B drug costs. While overall Part B drug spending is a small portion of Medicare drug spending, the high growth rate is a concern, especially as new expensive breakthrough cancer drugs enter the market and have a negative effect on consumers’ pockets. Unlike Part D, the prescription drug benefit, there are fewer incentives built in to Part B for providers to consider lower cost treatments for patients even if the lower cost drug may be clinically equivalent to the more expensive drug, because prior to budget sequestration, providers received 6 percent on top of the Average Sales Price (ASP) of the drug. Larger providers and hospitals often receive discounts on these drugs as well, increasing the amount they receive directly on top of the out-of-pocket cost of the drug. This leads to more out-of-pocket costs for the consumer, as patients usually pay 20 percent of Part B services. The Government Accountability Office (GAO) estimated that in 2013, among new drugs covered under Part B, nearly two-thirds had per beneficiary costs of over $9,000 per year, leading to out-of-pocket costs for consumers of amounts between $1,900 and $107,000 over the year. On top of these high costs, this can lead to problems with medication adherence, even for serious conditions such as cancer. A New Payment Model To help change these incentives and control costs, CMS has proposed a new demonstration program, which offers a few different reimbursement methods for Part B drugs. The program includes a geographically stratified design methodology to test and evaluate the different methods. One of the methods garnering a lot of attention is a proposal to lower the administration add-on payment to providers, from current 6 percent of ASP, to 2.5 percent plus a flat fee of $16.80 per administration day. Policymakers, physician organizations, and patient advocacy organizations have voiced major concerns raising the alarm that this initiative will negatively affect patient access to vital drugs and therefore produce poorer patient outcomes. The sequester will also have a significant impact on the percentage add on, reducing it to closer to an estimated .86 percent plus the flat fee. But we believe the goals of the program and its potential to reduce costs represent an important step in the right direction. We hope the details can be further shaped by the important communities of providers and patients who will deliver and receive medical care. Geographic Variation Last year, we wrote a Health Affairs Blog that highlighted some of the uses and limitations of publicly available Part B physician payment data. One major use was to show the geographic variation in practice patterns and drug administration, and we particularly looked at the difference across states in Lucentis v. Avastin usage. As seen in Exhibit 1, variation in administration is wide among states, even though both are drugs used to treat the same condition, age-related macular degeneration, and were proven to have clinically similar outcomes, but the cost of Lucentis was $2,000 per dose, while Avastin was only $50 per dose. Using the same price estimates from our previous research, which are from 2012, we found that physician reimbursement under the proposed demonstration would potentially change from $120 to $66.80 for Lucentis, and increase from $3 to $18.05 for Avastin. Under the first payment model, providers were receiving 40 times as much to administer Lucentis instead of Avastin, while under the new proposed payment model, they would only receive 3.7 times as much. While still a formidable gap, this new policy would have decreased financial reimbursement for providers to administer Lucentis, a costly, clinically similar drug to the much cheaper Avastin. As seen in Exhibit 1, a majority of physicians prescribe Avastin, thus this policy will allow for increased reimbursement in those cases, but in states where Lucentis is prescribed in higher proportions, prescribing patterns might start to change as a result of the proposed demonstration. Source: Author’s estimates using 2012 CMS Cost Data and Sequestration Estimates from DrugAbacus.org The proposed demonstration program includes much more than the ASP modifications in its second phase, including: discounting or eliminating beneficiary copays, indication-based pricing that would vary payments based on the clinical effectiveness, reference pricing for similar drugs, risk-sharing agreements with drug manufacturers based on clinical outcomes of the drug, and creating clinical decision tools for providers to help develop best practices. This is all at the same time that a new model in oncology care (OCM) is being launched, which could help to draw attention to total cost of care. It is important that CMS try to address rising drug costs, but also be sure to consider all relevant considerations during the comment period to fine-tune the proposal to avoid negative effects on beneficiaries’ care. We believe CMS should consider offering a waiver for organizations already participating in Center for Medicare & Medicaid Innovation (CMMI) models like the OCM, because financial benchmarks are based on past performance and any savings recognized in the future could be artificial, attributable to this demonstration rather than to better care coordination and some of the other practice requirements that are part of the proposed OCM. Furthermore, because this demonstration sets a new research precedent and because it is mandatory in the selected study areas rather than voluntary, CMS must try to anticipate and avoid unintended consequences related to geographic stratification. For example, it is possible to imagine organizations with multiple locations directing patients to optimal sites for their business. Also, without a control group, some findings may be unreliable. The proposed rule currently lacks much detail, and there does not seem to be enough time for organizations to evaluate the impact of the proposed rule on their operations. Having said that, it will be important for stakeholders of all types to submit comments to the proposed rule in an effort to improve the final rule prior to implementation. The critical question for the policymakers and stakeholders is whether this model can align with the multitude of other payment model reforms — unintended consequences could mitigate all the positive outcomes that a CMMI model offers to beneficiaries. Helping beneficiaries is and should be CMS’ ultimate obligation. Authors Kavita PatelCaitlin Brandt Full Article
pli Thoughts on the Hagel Filibuster and its Political Implications By webfeeds.brookings.edu Published On :: Thu, 14 Feb 2013 00:00:00 -0500 I’m late to the conversation about whether or not Republican efforts to insist on sixty votes for cloture on Chuck Hagel’s nomination as Secretary of Defense constitutes a filibuster. Bernstein’s earlier piece ("This is what a filibuster looks like") and Fallows’ recent contribution provide good, nuanced accounts of why Republican tactics amount to a filibuster, even if some GOP senators insist otherwise. In short, the duck test applies: If it looks like a duck, swims like a duck and quacks like a duck, then …. it’s a filibuster! Still, I think there’s more to be said about the politics and implications of the Hagel nomination. A few brief thoughts: First, let’s put to rest the debate about whether insisting on sixty votes to cut off debate on a nomination is a filibuster or, at a minimum, a threatened filibuster. It is. Even if both parties have moved over the past decade(s) to more regularly insist on sixty votes to secure passage of major (and often minor) legislative measures and confirmation of Courts of Appeals nominees, we shouldn’t be fooled by the institutionalization—and the apparent normalization—of the 60-vote Senate. Refusing to consent to a majority’s effort to take a vote means (by definition) that a minority of the Senate has flexed its parliamentary muscles to block Senate action. I think it’s fair to characterize such behavior as evidence of at least a threatened filibuster—even if senators insist that they are holding up a nomination only until their informational demands are met. Second, there’s been a bit of confusion in the reporting about whether filibusters of Cabinet appointees are unprecedented. There appears to have been no successful filibusters of Cabinet appointees, even if there have been at least two unsuccessful filibusters against such nominees. (On two occasions, Cabinet appointees faced cloture votes when minority party senators placed holds on their nominations—William Verity in 1987 and Kempthorne in 2006. An EPA appointee has also faced cloture, but EPA is not technically cabinet-level, even if it is now Cabinet-status). Of course, there have been other Cabinet nominees who have withdrawn; presumably they withdrew, though, because they lacked even majority support for confirmation. Hagel’s situation will be unprecedented only if the filibuster succeeds in keeping him from securing a confirmation vote. Third, using cloture votes as an indicator of a filibuster underestimates the Senate’s seeping super-majoritarianism. (Seeping super-majoritarianism?! Egads.) At least two other recent Cabinet nominations have been subjected to 60-vote requirements: Kathleen Sebelius in 2009 (HHS) and John Bryson (Commerce) in 2011. Both nominees faced threatened filibusters by Republican senators, preventing majority leader Reid from securing the chamber’s consent to schedule a confirmation vote—until Reid agreed to require sixty votes for confirmation. The Bryson unanimous consent agreement (UCA) appears on the right, an agreement that circumvented the need for cloture. Embedding a 60-vote requirement in a UCA counts as evidence of an attempted filibuster, albeit an unsuccessful one. After all, other Obama nominees (such as Tim Geithner) were confirmed after Reid negotiated UCAs that required only 51 votes for confirmation, an agreement secured because no Republicans were threatening to filibuster. Finally, what are the implications for the Hagel nomination? If Republicans were insisting on sixty votes on Senator Cornyn’s grounds that “There is a 60-vote threshold for every nomination,” then I bet Reid would have been able to negotiate a UCA similar to Sebelius’s and Bryson’s. But Hagel’s opponents see the time delay imposed by cloture as instrumental to their efforts to sow colleagues’ doubts about whether Hagel can be confirmed (or at a minimum to turn this afternoon’s cloture vote into a party stand to make their point about Benghazi). Of course, it’s possible that the time delay will work to Democrats’ benefit if they can make headlines that GOP obstruction puts national security at risk. (Maybe Leon Panetta should have jetted to his walnut farm to make the point before the cloture vote.) Whatever the outcome, the Hagel case reminds us that little of the Senate’s business is protected from the intense ideological and partisan polarization that permeates the chamber and is amplified by the chamber’s lax rules of debate and senators’ lack of restraint. Filibustering of controversial Cabinet nominees seems to be on the road to normalization—even if Hagel is ultimately confirmed. Authors Sarah A. Binder Publication: The Monkey Cage Image Source: © Kevin Lamarque / Reuters Full Article
pli Africa in the news: South Africa looks to open up; COVID-19 complicates food security, malaria response By webfeeds.brookings.edu Published On :: Sat, 25 Apr 2020 11:30:28 +0000 South Africa announces stimulus plan and a pathway for opening up As of this writing, the African continent has registered over 27,800 COVID-19 cases, with over 1,300 confirmed deaths, according to the Africa Centers for Disease Control and Prevention. Countries around the continent continue to instate various forms of social distancing restrictions: For example, in… Full Article
pli Forecasting 2016: It’s complicated By webfeeds.brookings.edu Published On :: Thu, 07 Jan 2016 09:04:00 -0500 Keeping with tradition, we start the year with a compendium of forecasts for 2016 from our guest bloggers and ourselves. At the end of the year, we will assess how we did (for last year’s forecasting performance, click here). The prevailing sentiment about economic developments during 2016 is decidedly mixed. There are positive and negative views, sometimes from the same source. Here is a sampling: On the negative side, “emerging economies will continue to disappoint;” “ODA will be squeezed by refugee costs (and climate change financing commitments);” “geopolitical tensions will remain;” “the dollar will be stronger with a severe impact on emerging economies;” and a range of idiosyncratic, political risks: weak governance and terrorist threats in Kenya; declining investor confidence and rising social strife in South Africa; corruption scandals in Brazil; and low oil prices coupled with domestic and geopolitical tensions in Russia. On the positive side, “oil prices will remain low;” “the Islamic State will be defeated;” “the effect of monetary policy normalization will be very limited;” “food prices will remain low or fall, helping reduce global hunger;” “African countries will improve cereal yields;” “OECD countries will accept a record number of refugees and migrants;” “oil exporters will reform their economies;” and “peace agreements to end the wars in Syria, Libya and Yemen will be signed.” An emerging theme is whether the disappointments in developing country growth in 2015 stem from idiosyncratic factors in specific countries—especially the BRICS, Turkey, and Indonesia—or whether those idiosyncratic factors, often associated with domestic political developments, are symptomatic of a broader issue of a slowing down of global convergence. Indeed, this theme of whether convergence remains a strong force that will continue to dominate developing country prospects, or a weak force that is all too easily offset by other factors, will likely remain one of the critical unknowns of 2016. In summary, it is fair to say that with views as diverse as those we received, the picture for 2016 is complicated to say the least. There is no analytical clarity in the global economy, despite forecasts from most major organizations (e.g., the IMF) that growth will be better in 2016 than in 2015 in every region except perhaps East Asia (although Asia will still probably record higher growth than anywhere else). The fears generated by a slowing of one of the main engines of the global economy over the past decade, namely China, are palpable. The big story of 2016 is perhaps that it is an emerging economy, China, which is the major source of uncertainty over this year’s global outlook. While prospects for the major advanced economies—the USA, Europe, and Japan—are relatively stable, it is the developing world where there is the least clarity over the short- term outlook. Certainly, the volatility in global stock markets in the first days of the year suggests that volatility, risk aversion, and differences of views over short-term developments are all high as 2016 begins. But there is at least one bright note. Almost certainly, prospects will improve for almost 200 million people who were living in countries that last year remained outside the scope of a normally functioning global economy. In Myanmar, Argentina, Venezuela, Cuba, and Iran, economic conditions will improve as a result of recent political developments. In addition, in 2016 there will probably be at least 100 million more people joining the global middle class—those living in households with incomes of $10-100 a day (2005 PPP). Good news for them but a reminder that the task of moving towards a world with sustainable consumption and production patterns remains huge. There was one consensus thread among our bloggers—all the Europeans appear consumed by the Euro 2016 soccer event (“Spain, France, or Germany will win”), while only one blogger dared to comment on the Olympics (that Brazil would do twice as well as in 2012). It seems that sports will be less complicated than economics in 2016. Authors Shanta DevarajanWolfgang FenglerHomi Kharas Full Article
pli On December 10, 2019, Tanvi Madan discussed the policy implications of the Silk Road Diplomacy with AIDDATA in New Delhi, India. By webfeeds.brookings.edu Published On :: Tue, 10 Dec 2019 20:37:05 +0000 On December 10, 2019, Tanvi Madan discussed the policy implications of the Silk Road Diplomacy with AIDDATA in New Delhi, India. Full Article
pli The political implications of transforming Saudi and Iranian oil economies By webfeeds.brookings.edu Published On :: Mon, 30 Nov -0001 00:00:00 +0000 Both Saudi Arabia and Iran are conspicuously planning for a post-oil future. The centrality of oil to the legitimacy and autonomy of both regimes means that these plans are little more than publicity stunts. Still, just imagine for a moment what it would mean for Iran, Saudi Arabia, and the Middle East if these grandiose agendas were adopted. Full Article Uncategorized
pli Technological Scarcity, Compliance Flexibility and the Optimal Time Path of Emissions Abatement By webfeeds.brookings.edu Published On :: Tue, 25 Nov 2008 00:00:00 -0500 ABSTRACT The overall economic efficiency of a quantity-based approach to greenhouse gas mitigation depends strongly on the extent to which such a program provides opportunities for compliance flexibility, particularly with regard to the timing of emissions abatement. Here I consider a program in which annual targets are determined by choosing the optimal time path of reductions consistent with an exogenously prescribed cumulative reduction target and fixed technology set. I then show that if the availability of low-carbon technology is initially more constrained than anticipated, the optimal reduction path shifts abatement toward later compliance periods. For this reason, a rigid policy in which fixed annual targets are strictly enforced in every year yields a cumulative environmental outcome identical to the optimal policy but an economic outcome worse than the optimal policy. On the other hand, a policy that aligns actual prices (or equivalently, costs) with expected prices by simply imposing an explicit price ceiling (often referred to as a "safety valve") yields the opposite result. Comparison among these multiple scenarios implies that there are significant gains to realizing the optimal path but that further refinement of the actual regulatory instrument will be necessary to achieve that goal in a real cap-and-trade system. Downloads Download Authors Bryan K. Mignone Full Article
pli The political implications of transforming Saudi and Iranian oil economies By webfeeds.brookings.edu Published On :: Mon, 30 Nov -0001 00:00:00 +0000 Both Saudi Arabia and Iran are conspicuously planning for a post-oil future. The centrality of oil to the legitimacy and autonomy of both regimes means that these plans are little more than publicity stunts. Still, just imagine for a moment what it would mean for Iran, Saudi Arabia, and the Middle East if these grandiose agendas were adopted. Full Article Uncategorized
pli Around the halls: Brookings experts discuss the implications of the US-Taliban agreement By webfeeds.brookings.edu Published On :: Thu, 05 Mar 2020 18:30:23 +0000 The agreement signed on February 29 in Doha between American and Taliban negotiators lays out a plan for ending the U.S. military presence in Afghanistan, and opens a path for direct intra-Afghan talks on the country's political future. Brookings experts on Afghanistan, the U.S. mission there, and South Asia more broadly analyze the deal and… Full Article
pli Africa in the news: South Africa looks to open up; COVID-19 complicates food security, malaria response By webfeeds.brookings.edu Published On :: Sat, 25 Apr 2020 11:30:28 +0000 South Africa announces stimulus plan and a pathway for opening up As of this writing, the African continent has registered over 27,800 COVID-19 cases, with over 1,300 confirmed deaths, according to the Africa Centers for Disease Control and Prevention. Countries around the continent continue to instate various forms of social distancing restrictions: For example, in… Full Article
pli Labor force dynamics in the Great Recession and its aftermath: Implications for older workers By webfeeds.brookings.edu Published On :: Thu, 21 Jul 2016 10:34:00 -0400 Unlike prime-age Americans, who have experienced declines in employment and labor force participation since the onset of the Great Recession, Americans past 60 have seen their employment and labor force participation rates increase. In order to understand the contrasting labor force developments among the old, on the one hand, and the prime-aged, on the other, this paper develops and analyzes a new data file containing information on monthly labor force changes of adults interviewed in the Current Population Survey (CPS). The paper documents notable differences among age groups with respect to the changes in labor force transition rates that have occurred over the past two decades. What is crucial for understanding the surprising strength of old-age labor force participation and employment are changes in labor force transition probabilities within and across age groups. The paper identifies several shifts that help account for the increase in old-age employment and labor force participation: Like workers in all age groups, workers in older groups saw a surge in monthly transitions from employment to unemployment in the Great Recession. Unlike workers in prime-age and younger groups, however, older workers also saw a sizeable decline in exits to nonparticipation during and after the recession. While the surge in exits from employment to unemployment tended to reduce the employment rates of all age groups, the drop in employment exits to nonparticipation among the aged tended to hold up labor force participation rates and employment rates among the elderly compared with the nonelderly. Among the elderly, but not the nonelderly, the exit rate from employment into nonparticipation fell more than the exit rate from employment into unemployment increased. The Great Recession and slow recovery from that recession made it harder for the unemployed to transition into employment. Exit rates from unemployment into employment fell sharply in all age groups, old and young. In contrast to unemployed workers in younger age groups, the unemployed in the oldest age groups also saw a drop in their exits to nonparticipation. Compared with the nonaged, this tended to help maintain the labor force participation rates of the old. Flows from out-of-the-labor-force status into employment have declined for most age groups, but they have declined the least or have actually increased modestly among older nonparticipants. Some of the favorable trends seen in older age groups are likely to be explained, in part, by the substantial improvement in older Americans’ educational attainment. Better educated older people tend to have lower monthly flows from employment into unemployment and nonparticipation, and they have higher monthly flows from nonparticipant status into employment compared with less educated workers. The policy implications of the paper are: A serious recession inflicts severe and immediate harm on workers and potential workers in all age groups, in the form of layoffs and depressed prospects for finding work. Unlike younger age groups, however, workers in older groups have high rates of voluntary exit from employment and the workforce, even when labor markets are strong. Consequently, reduced rates of voluntary exit from employment and the labor force can have an outsize impact on their employment and participation rates. The aged, as a whole, can therefore experience rising employment and participation rates even as a minority of aged workers suffer severe harm as a result of permanent job loss at an unexpectedly early age and exceptional difficulty finding a new job. Between 2001 and 2015, the old-age employment and participation rates rose, apparently signaling that older workers did not suffer severe harm in the Great Recession. Analysis of the gross flow data suggests, however, that the apparent improvements were the combined result of continued declines in age-specific voluntary exit rates, mostly from the ranks of the employed, and worsening reemployment rates among the unemployed. The older workers who suffered involuntary layoffs were more numerous than before the Great Recession, and they found it much harder to get reemployed than laid off workers in years before 2008. The turnover data show that it has proved much harder for these workers to recover from the loss of their late-career job loss. Download "Labor Force Dynamics in the Great Recession and its Aftermath: Implications for Older Workers" » Downloads Download "Labor Force Dynamics in the Great Recession and its Aftermath: Implications for Older Workers" Authors Gary Burtless Publication: Center for Retirement Research at Boston College Full Article
pli Africa in the news: South Africa looks to open up; COVID-19 complicates food security, malaria response By webfeeds.brookings.edu Published On :: Sat, 25 Apr 2020 11:30:28 +0000 South Africa announces stimulus plan and a pathway for opening up As of this writing, the African continent has registered over 27,800 COVID-19 cases, with over 1,300 confirmed deaths, according to the Africa Centers for Disease Control and Prevention. Countries around the continent continue to instate various forms of social distancing restrictions: For example, in… Full Article
pli Iraqi Shia leaders split over loyalty to Iran By webfeeds.brookings.edu Published On :: Sun, 05 Apr 2020 09:07:25 +0000 Full Article
pli Around the halls: Brookings experts discuss the implications of the US-Taliban agreement By webfeeds.brookings.edu Published On :: Thu, 05 Mar 2020 18:30:23 +0000 The agreement signed on February 29 in Doha between American and Taliban negotiators lays out a plan for ending the U.S. military presence in Afghanistan, and opens a path for direct intra-Afghan talks on the country's political future. Brookings experts on Afghanistan, the U.S. mission there, and South Asia more broadly analyze the deal and… Full Article
