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Zoho building 250-bed hospital in Kattankulathur near Chennai

₹70-crore facility to use a variety of tech tools for modern healthcare provision




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Hitting the right notes in her path

Soprano Ashwati Parameshwar traces her journey in music




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A facile self-saturation process enabling the stable cycling of a small molecule menaquinone cathode in aqueous zinc batteries

Chem. Sci., 2024, 15,17971-17978
DOI: 10.1039/D4SC04685D, Edge Article
Open Access
Shuo Li, Guoli Zhang, Qianrui Li, Tianshun He, Xiaoqi Sun
A facile self-saturation strategy, realized by the introduction of a hydrophobic methyl group on naphthoquinone, is demonstrated to suppress the dissolution of small molecule cathode materials and achieve stable cycling in aqueous zinc cells.
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On-demand controlled bidirectional DNAzyme path for ultra-sensitive heavy metal ion detection

Chem. Sci., 2024, 15,18170-18178
DOI: 10.1039/D4SC04404E, Edge Article
Open Access
Jing Xu, Yujin Li, Futing Wang, Xinqi Luo, Wei Zhang, Yifan Lyu, Hongfen Yang, Ren Cai, Weihong Tan
A bidirectional self-powered biosensor is constructed for the quasi-simultaneous detection of Pb2+ and Hg2+ based on MoS2@CuS heterostructures as an accelerator and hybridization chain reaction as a signal amplification strategy.
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Tailoring Hierarchical MnO2 Nanostructures on Self-Supporting Cathodes for High-Mass-Loading Zinc-Ion Batteries

Chem. Sci., 2024, Accepted Manuscript
DOI: 10.1039/D4SC06182A, Edge Article
Open Access
Weijie Zheng, Zhibiao Cui, Cong Liu, Libei Yuan, Shengsong Li, Lilin Lin, Tao Meng, Liangui Yang, Yexiang Tong, Dong Shu
Aqueous zinc-ion batteries (AZIBs) with MnO2 cathodes have promising application prospects, however, their performance is hindered by their low efficiency and insufficient life. By leveraging the nanomicellar properties of cetyltrimethylammonium...
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Differentiating carrier protein interactions in biosynthetic pathways using dapoxyl solvatochromism

Chem. Sci., 2024, Advance Article
DOI: 10.1039/D4SC05499G, Edge Article
Open Access
Matthew G. Miyada, Yuran Choi, Kyle Rich, James J. La Clair, Michael D. Burkart
A highly sensitive solvatochromic system was developed to monitor the loading and interactivity of carrier proteins associated with fatty acid, polyketide and non-ribosomal peptide biosynthesis.
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Pathway control in metallosupramolecular polymerization of a monoalkynylplatinum(II) terpyridine complex through competitive complex formation

Chem. Sci., 2024, Advance Article
DOI: 10.1039/D4SC06083K, Edge Article
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Minhye Kim, Heekyoung Choi, Minjoo Kim, Seonghan Kim, Seohyeon Yun, Eunji Lee, Jaeheung Cho, Sung Ho Jung, Jong Hwa Jung
The modification of metalloligands based on bis-type amideterpyridine platinum(II) complexes not only induces the formation of helical supramolecular polymers but also introduces a kinetic trapping strategy in competitive conditions.
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Finding her own path

Kathak exponent Rachana Yadav draws parallels between the universe and human life in her latest productionSwaraah




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From text to speech : the MITalk system / Jonathan Allen, M. Sharon Hunnicutt, Dennis Klatt, with Robert C. Armstrong and David Pisoni

Cambridge [Cambridgeshire] ; New York : Cambridge University Press, 1987




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Applying Low Levels of Strain to Model Nascent Phenomenon of Retinal Pathologies

Lab Chip, 2024, Accepted Manuscript
DOI: 10.1039/D4LC00205A, Paper
Chase Paterson, Elizabeth Vargis
Age-related macular degeneration (AMD) is a leading cause of vision loss in the elderly. A better understanding of the mechanisms of the disease, especially at early stages, could elucidate new...
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Integrated device for plasma separation and nucleic acid extraction from whole blood toward point-of-care detection of bloodborne pathogens

Lab Chip, 2024, 24,5124-5136
DOI: 10.1039/D4LC00571F, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Abigail G. Ayers, Christia M. Victoriano, Samuel K. Sia
This work presents PRECISE, a device that integrates plasma separation and nucleic acid extraction, enabling streamlined sample preparation of whole blood for point-of-care diagnostics without external equipment or electricity.
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Observing root growth and signalling responses to stress gradients and pathogens using the bi-directional dual-flow RootChip

Lab Chip, 2024, Advance Article
DOI: 10.1039/D4LC00659C, Paper
Open Access
Claudia Allan, Yiling Sun, Stephen C. Whisson, Michael Porter, Petra C. Boevink, Volker Nock, Claudia-Nicole Meisrimler
Using a bi-directional dual-flow RootChip with integrated force sensing micropillars, root growth and signalling responses to stress gradients and pathogens were studied in Arabidopsis thaliana, Nicotiana benthamiana and Solanum lycopersicum.
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Kerala School Sports & Games 2024: Athletics events to start on Thursday




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Not afraid of any probe, says Mamkootathil




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All set for Tazhathangadi Boat race on November 16




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Catholic Church to intensify Munambam protests

Protest gatherings were held in over 1,500 parishes of the Syro-Malabar Church across the State




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Ather

A start-up or an upstart? We take a look at Ather’s journey




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Weather Dept issues yellow alert in TN for next 24 hours




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Weather Dept issues yellow alert in TN from Nov 13




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Shah Rukh Khan feels breathless after quitting smoking: Know withdrawal symptoms, how to manage them

Quitting smoking is a major accomplishment, but it can come with withdrawal symptoms that vary in intensity and duration based on the individual and how long they smoked.




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For healthy adults, taking multivitamins daily is not associated with a lower risk of death

A large analysis of data from nearly 400,000 healthy U.S. adults followed for more than 20 years has found no association between regular multivitamin use and lower risk of death.




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ED action on T.N. Minister Senthilbalaji as per Supreme Court direction: BJP MLA Vanathi

BJP spokesperson Syed Zafar Islam also reiterated that the arrest was based on evidence and following the Supreme Court’s critical observation about the case involving the former AIADMK leader, now in the ruling DMK.




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Real development of Vizianagaram, Parvathipuram districts all thanks to YSRCP regime: Andhra Pradesh Deputy Chief Minister

The Central Tribal University of Andhra Pradesh will soon become a reality, as Chief Minister Y.S. Jaganmohan Reddy is scheduled to lay its foundation stone on August 25, said Peedika Rajanna Dora




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Watch | Maratha reservation stir | What are its implications of the OBC backlash?

In this episode of Talking Politics, we discuss the implications of the OBC backlash over the Maratha reservation stir and its impact on the domestic politics of the state.




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Cyclone Michaung | Death toll rises to seven in Chennai and neighbouring districts; over 61,600 moved to relief camps

Additional workforce is being sourced from neighbouring districts to undertake relief operations in Chennai and three neighbouring districts on war footing




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Panel to inventory jewellery, precious stones in the Ratna Bhandar of the Shree Jagannath Temple in Puri

Arijit Pasayat, former Supreme Court judge, will head the 12-member committee 




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Yogi Adityanath meets U.P. Governor after Delhi visit, adds fuel to buzz over Cabinet expansion before Lok Sabha polls

The Uttar Pradesh CM’s visit to the Governor’s house assumes significance as he attended the crucial BJP meeting in New Delhi for the general election only a few hours earlier




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Will scrap Agnipath scheme when we come to power: Akhilesh Yadav

Akhilesh Yadav repeatedly promised to scrap the short-term military recruitment scheme if the INDIA bloc, came to power




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Delhi coaching centre deaths: High Court to hear plea seeking setting up of panel to probe incident

The plea was mentioned for urgent hearing on July 30 before a bench of Acting Chief Justice Manmohan and Justice Tushar Rao Gedela which said the matter be listed on Wednesday




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Rajasthan rains: Death toll rises to 22, CM visits affected areas in Jaipur

Chief Minister Bhajanlal Sharma conducted a field visit in various parts of the city following incessant rains




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‘Father of Indian chess boom’: The Anand effect that’s shaping a ‘golden generation’

The country swept both the men's and women's gold at the 45th Olympiad in Budapest, Hungary




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Heroes’ Homecoming: Gukesh, Praggnanandhaa, Vaishali, and Srinath’s touchdown amid fanfare

Both the Indian men's and women's teams scripted history on Sunday (September 22, 2024), winning their maiden gold medals in the Chess Olympiad in Hungary.




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Chess happened by accident but it was a happy accident: Vidit Gujrathi

It has not sunk in yet but I do know this achievement is going to stay with us for a long time, says Grandmaster Vidit Gujrathi




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Weight management is athlete’s responsibility, says Mary Kom on Vinesh Phogat’s Olympic disqualification

Vinesh Phogat, who was being seen as gold medal contender in Paris Olympics, was disqualified from competing in the final of the 50kg weight class for being 100 grams over the permissible limit




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A hands-on shopping experience of athleisure wear in Coimbatore

TechnoSport offers a premium hands-on shopping experience of performance and athleisure wear with the launch of its first flagship store in Coimbatore



  • Life & Style

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Shooter Yukun Liu and Yang Jiin are athletes of the year




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Raveendran Sankaran Interview | We will ensure that more athletes from Bihar get into the Indian team in the 2028 Olympics

The Bihar Sports University is the first of its kind; the State Sports Academy, Rajgir, acting as a State Centre for Excellence, will cater to 23 disciplines; Sports academics have to go hand in hand with training and that’s the philosophy behind it




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Argument over ‘extramarital’ relationship leads to death of three men in family in Kakinada

The police registered a case and the investigation is on




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Lakshmi Parvathi flays coalition government for arrest of social media activists




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Construction of one lakh houses under PMAY 1.0 scheme to be completed by December: Kolusu Parthasarathy

During a review of the Housing Department in Chittoor and Tirupati districts, he says that construction work was not completed in certain places due to lack of sand supply or heavy rains




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Games, gambling, and probability [electronic resource] : an introduction to mathematics / David G. Taylor, Roanoke College, Salem, VA

Boca Raton : Chapman & Hall/CRC Press, 2021




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Your death would be mine [electronic resource] : Paul and Marie Pireaud in the Great War / Martha Hanna.

Cambridge, Mass. : Harvard University Press , 2006.




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Subtle adjustment of the cyclic potential on electro-activated glassy carbon electrodes for sensitive sensing of methyl parathion

Anal. Methods, 2024, Advance Article
DOI: 10.1039/D4AY00079J, Paper
Yunyin Yang, Sian Chen, Changqiu Zhang, Yanqing Li, Xinrong Zong, Yitao Lv, Min Zhang
Upon experiencing a negligible change of 0.5 V which only takes 5 more seconds, the signal value of an e-GCE was efficiently enhanced from 2-fold to 30-fold compared with a bare GCE.
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The content of this RSS Feed (c) The Royal Society of Chemistry




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​Weather gods: On ‘Mission Mausam’

Attempts at controlling the weather are still in the realm of uncertainty




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Pathogenesis of Alzheimer's disease and therapeutic strategies involving traditional Chinese medicine

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00660G, Review Article
Shutang Li, Jinfei Yang
As research on AD has progressed, TCM and its active ingredients have increasingly played a crucial role in clinical treatment. This article summarizes extracts from TCM and briefly elucidates their pharmacological mechanisms against AD.
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Synthesis of a celastrol derivative as a cancer stem cell inhibitor through regulation of the STAT3 pathway for treatment of ovarian cancer

RSC Med. Chem., 2024, 15,3433-3443
DOI: 10.1039/D4MD00468J, Research Article
Meijuan Liu, Na Li, Zhaoxue Wang, Shuo Wang, Shaoda Ren, Xiaojing Li
A synthetic celastrol derivative (Cel-N) attenuates cancer cell stemness, inhibits the STAT3 pathway, and exerts anti-ovarian cancer effects in cell and mouse models.
The content of this RSS Feed (c) The Royal Society of Chemistry




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SLL-1A-16 suppresses proliferation and induces autophagy in non-small-cell lung cancer cells via the AKT/mTOR signaling pathway

RSC Med. Chem., 2024, 15,3460-3468
DOI: 10.1039/D4MD00405A, Research Article
Xiaoqin Luo, Jin Wang, Ruichang Wang, Jiabing Lian, Mengnan Guo, Hongrui Zhou, Mengxue Zhang, Zhe Yang, Xiaolong Li, Xianran He, Xiuli Bi
Schematic of proposed mechanism for the treatment of the SLL-1A-16 inhibiting the proliferation in NSCLC.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Rational design and in vitro testing of new urease inhibitors to prevent urinary catheter blockage

RSC Med. Chem., 2024, 15,3597-3608
DOI: 10.1039/D4MD00378K, Research Article
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Rachel A. Heylen, Nicola Cusick, Tom White, Emily J. Owen, Bethany L. Patenall, Martin Alm, Peter Thomsen, Maisem Laabei, A. Toby A. Jenkins
In silico identification of urease inhibitors based on thiourea, tested to determine IC50 and tested on a catheterised in vitro bladder model, showing efficacy in reducing catheter blockage.
The content of this RSS Feed (c) The Royal Society of Chemistry




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A novel, glutathione-activated prodrug of pimasertib loaded in liposomes for targeted cancer therapy

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00517A, Research Article
Open Access
Arianna Amenta, Susanna Comi, Marcelo Kravicz, Silvia Sesana, Antonia Antoniou, Daniele Passarella, Pierfausto Seneci, Sara Pellegrino, Francesca Re
A novel, glutathione-activated prodrug of pimasertib (PROPIMA) has been developed. PROPIMA showed ability to inhibit tumour cell migration and proliferation controlled over time, while also achieving a high incorporation rate into liposomes.
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Therapeutic upregulation of DNA repair pathways: strategies and small molecule activators

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00673A, Review Article
Juhyung Song, Cheoljun Park, Francis E. B. Cabanting, Yong Woong Jun
Potential therapeutic target proteins for upregulating DNA repair system are reviewed, along with reported small-molecule activators.
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The content of this RSS Feed (c) The Royal Society of Chemistry