len Qiming partner Helen Wong eyes capturing ‘rare gems’ in market downturn By www.dealstreetasia.com Published On :: Sun, 19 Apr 2020 23:24:18 +0000 Qiming, which closed a $1.1 billion fund recently, will look for startups with "good fundamentals." The post Qiming partner Helen Wong eyes capturing ‘rare gems’ in market downturn appeared first on DealStreetAsia. Full Article Asia-Pacific COVID-19 Helen Wong Qiming Venture Partners
len China’s Trip.com CEO says primary challenge is to ensure cash flows this year By www.dealstreetasia.com Published On :: Mon, 27 Apr 2020 00:30:24 +0000 The industry in China has begun to show signs of a pickup with a rise in bookings, Trip.com CEO Jane Jie Sun added. The post China’s Trip.com CEO says primary challenge is to ensure cash flows this year appeared first on DealStreetAsia. Full Article Trip.com Group Tripadvisor
len SBI Cards betting on millennial-driven growth story in upcoming share sale By www.dealstreetasia.com Published On :: Sun, 01 Dec 2019 15:56:41 +0000 Is India’s first IPO of a credit card issuer an opportunity with boundless prospects or a victim of arrested development? The post SBI Cards betting on millennial-driven growth story in upcoming share sale appeared first on DealStreetAsia. Full Article SBI Cards
len Current challenges in Indonesian logistics sector throw up opportunities By www.dealstreetasia.com Published On :: Tue, 21 Jan 2020 23:11:39 +0000 At 24 per cent of Indonesia’s GDP, the country’s logistics costs are among the highest in Southeast Asia. The post Current challenges in Indonesian logistics sector throw up opportunities appeared first on DealStreetAsia. Full Article KarGo Kejora Ventures Ninja Xpress Indonesia
len China’s Starbucks challenger Luckin Coffee isn’t all out of luck By www.dealstreetasia.com Published On :: Mon, 03 Feb 2020 13:41:02 +0000 The opportunely timed sale gives Luckin a war chest to survive the hit to consumption from the epidemic. The post China’s Starbucks challenger Luckin Coffee isn’t all out of luck appeared first on DealStreetAsia. Full Article Luckin Coffee Starbucks
len Bangkok Bank plans to acquire another Indonesian lender By www.dealstreetasia.com Published On :: Thu, 05 Mar 2020 14:00:38 +0000 Bangkok Bank plans to acquire another Indonesian lender after buying a controlling stake in Indonesian Bank Permata. The post Bangkok Bank plans to acquire another Indonesian lender appeared first on DealStreetAsia. Full Article Bangkok Bank
len Thailand’s Kasikornbank gets approval for $40m stake in Myanmar lender By www.dealstreetasia.com Published On :: Sun, 12 Apr 2020 17:38:25 +0000 The investment will be done through its unit Kasikorn Vision. The post Thailand’s Kasikornbank gets approval for $40m stake in Myanmar lender appeared first on DealStreetAsia. Full Article Kasikornbank Pcl
len No ‘Silence, s’il vous plaît’? French Open could take place without fans By www.france24.com Published On :: Sun, 10 May 2020 13:05:48 GMT The French Open tennis tournament at Roland Garros could be held without fans later this year, the president of the French Tennis Federation (FTF) said on Sunday. Full Article Europe
len Race relations in 2016: much to deplore but plenty to applaud By www.theguardian.com Published On :: 2016-08-18T12:15:01Z No one should be complacent about racism but the story is rarely as straightforward as some commentators routinely assertIn my city neighbourhood this summer a man on the run from police custody hit a black woman in the face. Understandably, she reported it as a racial attack. Except it probably wasn’t. The runaway also hit a boy when his mother opened the door and tried to spray another woman’s hair red at a bus stop. He had mental health problems.Not much harm done in this instance. But it’s one reason why I don’t often write about race relations in modern Britain, though I first did so 50 years ago when many aspects of them were pretty grim. Continue reading... Full Article Race Equality and Human Rights Commission (EHRC) Politics UK news Society
len Ghost Lode - Lenten Distance [2020] By funkysouls.org Published On :: Sat, 09 May 2020 15:39:12 GMT AmbientDroneGuitarInstrumental Дата релиза: 08.05.2020 Качество: Lossless uploaded by loathsome & DystopianBy Список треков:01. Week One02. Week Two03. Week Three04. Week Four05. Week Five06. Week Six Скачать и обсудить альбом здесь Full Article
len - Furnished Accommodation - Free Medical and Transportation - Excellent Recreational facilities - Annual leave with ticket - Tax free Income, save all that you earn, no deductions - All facilities within the medical complex such as Salon, Laundry, Grocery By jobs.monsterindia.com Published On :: 2020-05-10 08:06:44 Company: Jesseena Marine Services Private LimitedExperience: 4 to 7location: Saudi ArabiaRef: 24828815Summary: Job Description : Vacancy for one of the Reputed Ministry of Defense -Military Hospital in Saudi Arabia. Criteria: - BSc / Post BSc Nursing from Govt. approved college through regular medium - 4 years experience.... Full Article
len - Furnished Accommodation - Free Medical and Transportation - Excellent Recreational facilities - Annual leave with ticket - Tax free Income, save all that you earn, no deductions - All facilities within the medical complex such as Salon, Laundry, Grocery By jobs.monsterindia.com Published On :: 2020-05-09 20:06:55 Company: Jesseena Marine Services Private LimitedExperience: 3 to 5location: Saudi ArabiaRef: 24828613Summary: Job Description : Vacancy for one of the Reputed Ministry of Defense -Military Hospital in Saudi Arabia. Criteria: - BSc / Post BSc Nursing from Govt. approved college through regular medium - minimum 3-5 years of .... Full Article
len - Furnished Accommodation - Free Medical and Transportation - Excellent Recreational facilities - Annual leave with ticket - Tax free Income, save all that you earn, no deductions - All facilities within the medical complex such as Salon, Laundry, Grocery By jobs.monsterindia.com Published On :: 2020-05-09 20:06:54 Company: Jesseena Marine Services Private LimitedExperience: 4 to 5location: Saudi ArabiaRef: 24828612Summary: Job Description : Vacancy for one of the Reputed Ministry of Defense -Military Hospital in Saudi Arabia. Criteria: - BSc / Post BSc Nursing from Govt. approved college through regular medium - minimum 3-5 years of .... Full Article
len Egon Zehnder’s Jill Ader: challenging tradition By www.ft.com Published On :: Sun, 09 Jun 2019 04:00:28 GMT The leader of the executive search firm won her post after an unprecedented election Full Article
len Powell’s challenge at the Fed By www.ft.com Published On :: Sun, 04 Feb 2018 13:20:28 GMT He must work out how to achieve growth that is adequate and financially sustainable Full Article
len Young Turk Dan Mannix on poaching talent during lockdown By www.ft.com Published On :: Sun, 10 May 2020 10:00:08 GMT Chief of British boutique RWC lures prized managers with offer of much greater autonomy Full Article
len Mexico’s leftist ‘Amlo’ weighs up Trump challenge By www.ft.com Published On :: Mon, 25 Jun 2018 07:01:41 GMT Would-be president and foreign policy neophyte faces test north of the border Full Article
len COVID-19: Is It Safe To Wear Contact Lenses During The Pandemic? By www.boldsky.com Published On :: Sat, 09 May 2020 17:30:43 +0530 As of today, the total number of confirmed COVID-19 cases in India is 59662, with 17847 recovered cases and 1981 deaths. The concerns related to COVID-19 pandemic is increasing day by day. The WHO and CDC along with many healthcare institutions Full Article
len Ongoing first quarter is challenging, says SBI Card CEO Hardayal Prasad By www.thehindubusinessline.com Published On :: Sun, 10 May 2020 18:42:17 +0530 Expect ‘business as usual’ scenario returning from October; current operations at 60 per cent of pre-Covid levels Full Article Premium
len The Covid challenge to Indian school education: Reform or perish By www.thehindubusinessline.com Published On :: Sun, 10 May 2020 22:14:46 +0530 Reluctant schools and teachers have been forced to adapt to e-learning Full Article Education
len Brighton Covid-19 case highlights challenges of resuming EPL By indianexpress.com Published On :: Sun, 10 May 2020 13:47:12 +0000 Full Article Football Sports
len KVÍZ: Znáte specifika bydlení v družstevním bytě? By www.idnes.cz Published On :: Sat, 09 May 2020 22:00:00 GMT V družstevních bytech žije přibližně 10 procent českých domácností. Vzhledem k rostoucím cenám nemovitostí je tento typ bydlení oproti osobnímu vlastnictví dostupnější, a zažívá tak další vlnu rozvoje. Družstevní vlastnictví má ale svá specifika. Pokud o koupi družstevního bytu uvažujete, ověřte si své znalosti v dnešním kvízu. Full Article Finance - Finanční rádce
len DFL-preses na coronagevallen bij Dresden: "Geen reden om te twijfelen" - sporza.be By news.google.com Published On :: Sun, 10 May 2020 07:57:08 GMT DFL-preses na coronagevallen bij Dresden: "Geen reden om te twijfelen" sporza.beVolledige ploeg Dynamo Dresden moet één week voor herstart Duitse competitie in quarantaine: “Kunnen 14 dagen niet spelen” Het Laatste NieuwsAl 3 spelers besmet: "Niet twijfelen aan de voortzetting 2. Bundesliga" VoetbalNieuws.be2 extra besmettingen bij Dresden: team in quarantaine en duel met Hannover uitgesteld sporza.beGeen twijfels over hervatting Duits voetbal na nieuwe besmettingen: “Vanaf het begin gezegd dat we hierop voorbereid zijn” Het Laatste NieuwsHele verhaal bekijken via Google Nieuws Full Article
len Voormalige TVL-kok 'Chef Moke' overleden (Wellen) - Het Belang van Limburg Mobile - Het Belang van Limburg By news.google.com Published On :: Sun, 10 May 2020 09:56:00 GMT Voormalige TVL-kok 'Chef Moke' overleden (Wellen) - Het Belang van Limburg Mobile Het Belang van LimburgWellense chef Moke Karmaoui overleden: “Je blijft ons grote voorbeeld en onze held” Het Laatste NieuwsLimburgse chef Moke Karmaoui (50) overleden: “Je blijft ons grote voorbeeld en onze held” Het Laatste NieuwsHele verhaal bekijken via Google Nieuws Full Article
len Als de viroloog “nee” zegt en de handelaar “ja”: moet je maandag al meteen gaan winkelen? - Het Nieuwsblad By news.google.com Published On :: Sun, 10 May 2020 07:43:16 GMT Als de viroloog “nee” zegt en de handelaar “ja”: moet je maandag al meteen gaan winkelen? Het NieuwsbladHet dilemma: moet ik maandag gaan winkelen? De StandaardHele verhaal bekijken via Google Nieuws Full Article
len Will Kansas City's challenging regular season schedule affect its chances to repeat as Super Bowl champions? By Published On :: Sat, 09 May 2020 22:06:53 +0000 The Kansas City Chiefs will look to repeat as Super Bowl champions in 2020, but their regular season schedule won't offer any concessions. Full Article nfl
len Princeton joins court challenge to federal immigration executive order By www.princeton.edu Published On :: Mon, 13 Feb 2017 11:50:00 -0500 Princeton University and 16 other universities filed a friend-of-the-court brief Monday supporting a legal challenge to the Trump administration's Jan. 27 executive order on immigration. Full Article
len Capital High School students in Helena, Montana, recognized during online ceremony as Grand Prize winner of EPA ‘See a Bloom, Give it Room’ high school video challenge By www.epa.gov Published On :: Tue, 28 Apr 2020 00:00:00 -0400 HELENA (April 23, 2020) – Today, U.S. Environmental Protection Agency (EPA) Region 8 Deputy Regional Administrator Deb Thomas recognized students and staff from Capital High School in Helena for winning the ‘See a Bloom, Give It Room’ High School Video Challenge. Full Article
len EPA Recognizes University of Arizona and Arizona State University, Winners of Annual Campus RainWorks Challenge By www.epa.gov Published On :: Wed, 29 Apr 2020 00:00:00 -0400 PHOENIX – Today, the U.S. Full Article
len EPA Announces Winners of its Annual Campus RainWorks Challenge By www.epa.gov Published On :: Wed, 29 Apr 2020 00:00:00 -0400 WASHINGTON (April 29, 2020) — Today, the U.S. Full Article
len EPA Recognizes Food Recovery Challenge Award Winners By www.epa.gov Published On :: Thu, 23 Apr 2020 00:00:00 -0400 (WASHINGTON) - Today, the U.S. Environmental Protection Agency (EPA) nationally recognizes the exceptional accomplishments of 15 businesses and organizations participating in EPA’s Food Recovery Challenge. Full Article
len Joe Biden - Vorwurf der sexuellen Nötigung: Nach seinen Standards müsste er zurückziehen By www.spiegel.de Published On :: Fri, 8 May 2020 18:00:00 +0200 Ein Missbrauchsvorwurf gegen Joe Biden stürzt die US-Demokraten ins Dilemma. Seine Kritiker sagen: Würde er an den Standards gemessen, die er selbst aufgestellt hat, müsste er seine Kandidatur zurückziehen. Full Article Politik
len Waldkraiburg in Bayern: Staatsanwaltschaft wirft Mann versuchten Mord in 27 Fällen vor By www.spiegel.de Published On :: Sun, 10 May 2020 11:53:00 +0200 Ein 25-jähriger Mann hat die Anschläge auf Geschäfte türkischstämmiger Inhaber in Waldkraiburg gestanden. Der Tatverdächtige habe sich dem IS anschließen wollen, gab die Staatsanwaltschaft bekannt. Full Article Panorama
len Corona-Diskussionskultur: "Empörungswellen treiben die Gesellschaft auseinander" By www.spiegel.de Published On :: Sun, 10 May 2020 10:48:00 +0200 Die einen befürworten Schutzmaßnahmen, die anderen protestieren vehement: Rhetoriker Olaf Kramer erklärt, warum die Coronakrise für heftige gesellschaftliche Spannungen sorgt - und wie wir miteinander reden sollten. Full Article Wissenschaft
len Brooklyn man triumphs in lengthy Airbnb battle with city as judge orders city to ‘leave the poor guy alone’ By www.nydailynews.com Published On :: Sat, 09 May 2020 19:56:31 +0000 A disabled Brooklynite who ran afoul of Department of Buildings officials by renting out his home to Airbnb users triumphed last week when a Manhattan judge ordered the city to repay his $4,375 fine and cover any additional costs and payouts in his battle with the de Blasio administration. The decision ended a legal battle pitting Stanley “Skip” Karol against the city that began with an anonymous phone call back in July 2018. Full Article
len Clones lies silent today as sound of summer must wait By www.rte.ie Published On :: Fri, 08 May 2020 12:59:36 +0000 Damian Lawlor celebrates the special place Clones has in the GAA and how Cavan-Monaghan this afternoon would have heralded the start of an Irish summer Full Article GAA
len John Lennon’s former Florida estate on market for eye-popping $47.5M By www.nydailynews.com Published On :: Sun, 10 May 2020 01:17:46 +0000 The former Palm Beach, Fla., home of John Lennon and Yoko Ono is for sale at $47.5 million. Full Article
len Brooklyn man triumphs in lengthy Airbnb battle with city as judge orders city to ‘leave the poor guy alone’ By www.nydailynews.com Published On :: Sat, 09 May 2020 19:56:31 +0000 A disabled Brooklynite who ran afoul of Department of Buildings officials by renting out his home to Airbnb users triumphed last week when a Manhattan judge ordered the city to repay his $4,375 fine and cover any additional costs and payouts in his battle with the de Blasio administration. The decision ended a legal battle pitting Stanley “Skip” Karol against the city that began with an anonymous phone call back in July 2018. Full Article
len Coronavirus: TikTok challenge lifting zookeepers' spirits By www.bbc.co.uk Published On :: Sun, 10 May 2020 07:56:20 GMT Zookeepers are sharing a new challenge to help lift their spirits during the coronavirus lockdown. Full Article
len Apple India Website Puts Siri in Silent Mode By labnol.tumblr.com Published On :: Sat, 26 Nov 2011 15:33:09 +0530 Apple India Website Puts Siri in Silent Mode Full Article
len News24.com | Pieter du Toit: Beyond Covid-19 lies turbulence, change and opportunity By www.news24.com Published On :: Sat, 09 May 2020 21:43:51 +0200 South Africans must insist on innovative solutions and new policies to ensure that when the country emerges from this governance and economic crisis, it does so not only aware of the country’s weaknesses but also primed to effect the necessary changes, writes Pieter du Toit. Full Article
len Army and Navy closing for good due to challenges from pandemic By edmonton.ctvnews.ca Published On :: Sat, 9 May 2020 15:21:00 -0600 A Canadian department store chain is calling it quits after more than a century in business. Full Article
len 'Pretty happy': Stolen wood carving returned to Edmonton artist By edmonton.ctvnews.ca Published On :: Sat, 9 May 2020 18:53:19 -0600 Soon after CTV News Edmonton aired a story about a local wood carver who had one of his carvings stolen, he got a knock on his door. Full Article
len Dog stolen from foster home in Chestermere, Alta. found safe By calgary.ctvnews.ca Published On :: Sat, 9 May 2020 15:46:00 -0600 Wera, a four-year-old terrier cross, has found her way home to a Calgary-care organization after fraudsters tricked the dog's foster family. Full Article
len Kiwanis and Soap for Hope lend a (clean) helping hand By calgary.ctvnews.ca Published On :: Sat, 9 May 2020 18:18:00 -0600 A new, squeaky clean business venture is helping Calgary’s most vulnerable during the COVID-19 pandemic. Full Article
len China's Third Plenum: Policy Changes and Their Impact By feedproxy.google.com Published On :: Mon, 04 Nov 2013 10:15:41 +0000 Research Event 13 November 2013 - 12:00pm to 1:00pm Chatham House, London Meeting Summary - China’s Third Plenum: Policy Changes and their Impactpdf | 39.94 KB Event participants Dr Tim Summers, Senior Consulting Fellow, Asia Programme, Chatham House One year after a transition at the top of China's Communist Party, a major party gathering − the third plenum − was held on 9-12 November, with Chinese officials preparing a 'comprehensive plan for reform' in the context of apparently slowing growth in China as well as social and environmental challenges.The speaker will comment on the outcomes of the plenum and the debates which led up to it, and examine likely policy changes and their impact on developments in China. Department/project Asia-Pacific Programme Full Article
len Communist Party’s Plenum Will Be Important, Not Transformative, for China By feedproxy.google.com Published On :: Fri, 08 Nov 2013 09:28:50 +0000 8 November 2013 Professor Kerry Brown Associate Fellow, Asia-Pacific Programme @Bkerrychina LinkedIn Google Scholar 20131108PudongChina.jpg View of the Pudong financial district skyline from the historic Bund, Shanghai 29 October 2013. Photo by Getty Images. Despite the hype surrounding it, the gathering of the country’s ruling elite in Beijing is likely to prize measured change over dramatic reform.If there was a clearer idea of what makes China’s new elite leadership tick, then the Plenum of the Central Committee of the Communist Party that is about to be held in Beijing would not be such a big deal. But in a polity which privileges concealment over overt statement, it is viewed widely as the one chance for outsiders to see more clearly what the leadership aims to achieve. Expectations were raised by the October statement by one of the most staid members of the current Standing Committee of the Politburo, Yu Zhengsheng, that the plenum would presage a new era of reform.In Chinese politics reform is a word that has a wholesome, positive air about it. But the question is where and when reform will happen and who will gain from it. The plenum is not like a party convention in the Western sense. It is not an eye-grabbing, media-dominating event that produces surprises. Comparing this year’s installment with the great Third Plenum of 1978 that heralded the repudiation of late Maoism and the embracing of the market, the non-state sector and foreign capital – all anathema before then – is misleading. The significance of the 1978 meeting was only obvious in hindsight. It took years for the scale of the radical transformation of the whole strategic direction of the Communist Party to be appreciated. That 2013 will prove a similar historic moment is unlikely, perhaps even impossible.What is much more likely is that the highly tactical leadership now in charge will reaffirm its commitment to incremental reform. It will make some statements about the radical urbanization that China is about to undergo and say something about social welfare reform. China’s leaders will do what they have always done in plenums over the last three decades, namely set the broad parameters of politically permissible activity that provinces, ministries and other stakeholders will then need to implement.This plenum will also have to produce something about the need to achieve greater egality and balance in the economy. It needs to answer some of the questions about how Premier Li Keqiang, in particular, intends to meet the goal of 'fast, sustainable growth' when a falling overall GDP figure looks likely. It needs to communicate to as broad a constituency as possible the arch-narrative of a world where the raw statement of growth on its own is no longer the be all and end all of government policy. It needs to say something about how the party is going to fulfill the increasingly complex aspirations of the Chinese people, aspirations that exceed purely having a materially good level of life and concern broader questions of well-being that vex the politics of all developed economies.Observers will want to see some signs too of addressing the most sensitive issues. Yu Zhengsheng talked of economic reform. Reforming the economy is now a wholly uncontroversial mantra in China. However, it impacts on one enormously important issue that reaches beyond economics: whether wealth, prosperity and development benefit the few or are accessible to the many – in other words, good, old-fashioned questions of economic and social justice. At the heart of this lies the question of how state-owned enterprises have become vehicles of profit not just for the party state, but also for tightly knit networks of vested interests. Reforms that lap at the doors of these entities also creep into the space of powerful political players, who will resist any attempt to cut down their wealth, and who have the power to resist.China’s new leadership is proving more confident than was expected and displays a high sense of historic mission. President Xi Jinping speaks increasingly like a politician who believes it is almost his historic destiny to sit at the centre of the leadership of a renascent 'rich, strong country'. The ultimate question for the plenum is not what outside observers make of it but what the vastly complex mixture of groups in China does. For them, a sign that the leadership is willing to take on some of the entrenched vested interests that penetrate the operations of some state-owned sectors to the core is critical.This is likely to be couched in the language of more support for the market, which is the key channel in any attack on vested interests – through widening access to wealth and economic benefits, and support for the non-state sector and entrepreneurs. It is hard to see how deeper reform can occur without these two crucial elements. And it is through these that the attitude of China’s leadership to political and legal reforms – far more complex issues that, almost certainly, will not be addressed at the plenum but will lurk in the background − will become clearer. The leadership thinks it is too early to tackle these issues directly, but this plenum will still be part of the process for it to come up with ideas for how to transform not just China’s economy, but its polity too.To comment on this article, please contact Chatham House Feedback Full Article
len China's Third Plenum: Another Turning Point? By feedproxy.google.com Published On :: Mon, 16 Dec 2013 13:59:54 +0000 Members Event 28 January 2014 - 6:00pm to 7:00pm Chatham House, London Transcript: China’s Third Plenum: Another Turning Point?pdf | 67.45 KB Q&A: China’s Third Plenum: Another Turning Point? pdf | 81.28 KB Event participants Professor Shaun Breslin, Associate Fellow, Asia Programme, Chatham House Professor Jane Duckett, Edward Caird Chair of Politics; Director, Confucius Institute; Director, The Scottish Centre for China Research, University of GlasgowProfessor Christopher Hughes, Head, International Relations Department, LSEChair: Rob Gifford, China Editor, The Economist Following the Third Plenum of the Communist Party’s 18th Central Committee in November 2013, the panel will offer their thoughts on whether the economic, political and social reforms announced, such as the relaxation of the one child policy and establishment of a national security council, signal a new era for China’s domestic and foreign policies. The speakers will consider how significant these reforms will be in comparison to those announced in 1978 by Deng Xiaoping following the Third Plenum of the 11th Central Committee. Full Article
len Glycation-mediated inter-protein cross-linking is promoted by chaperone-client complexes of {alpha}-crystallin: Implications for lens aging and presbyopia [Glycobiology and Extracellular Matrices] By feedproxy.google.com Published On :: 2020-04-24T06:08:45-07:00 Lens proteins become increasingly cross-linked through nondisulfide linkages during aging and cataract formation. One mechanism that has been implicated in this cross-linking is glycation through formation of advanced glycation end products (AGEs). Here, we found an age-associated increase in stiffness in human lenses that was directly correlated with levels of protein–cross-linking AGEs. α-Crystallin in the lens binds to other proteins and prevents their denaturation and aggregation through its chaperone-like activity. Using a FRET-based assay, we examined the stability of the αA-crystallin–γD-crystallin complex for up to 12 days and observed that this complex is stable in PBS and upon incubation with human lens–epithelial cell lysate or lens homogenate. Addition of 2 mm ATP to the lysate or homogenate did not decrease the stability of the complex. We also generated complexes of human αA-crystallin or αB-crystallin with alcohol dehydrogenase or citrate synthase by applying thermal stress. Upon glycation under physiological conditions, the chaperone–client complexes underwent greater extents of cross-linking than did uncomplexed protein mixtures. LC-MS/MS analyses revealed that the levels of cross-linking AGEs were significantly higher in the glycated chaperone–client complexes than in glycated but uncomplexed protein mixtures. Mouse lenses subjected to thermal stress followed by glycation lost resilience more extensively than lenses subjected to thermal stress or glycation alone, and this loss was accompanied by higher protein cross-linking and higher cross-linking AGE levels. These results uncover a protein cross-linking mechanism in the lens and suggest that AGE-mediated cross-linking of α-crystallin–client complexes could contribute to lens aging and presbyopia. Full Article
len Health anxiety: the silent, disabling epidemic By feeds.bmj.com Published On :: Monday, April 25, 2016 - 10:01 Full Article