Archives, Room Use Only - V285.G7 S54 1937

Archives, Room Use Only - VK381.B76 1917

Archives, Room Use Only - UG573.U56 1916

Archives, Room Use Only - TK5262.B79 1876

Archives, Room Use Only - HE7673.W47 1913

Words to tattoo on your knuckles:

Over the past couple of years, my blog hasn’t felt my own, to a degree. It’s felt like I’ve been writ­ing for an audi­ence, post­ing stuff for oth­ers rather than myself. That’s arse-backwards. A blog should be about per­sonal expres­sion. The moment you start think­ing, and writ­ing, to please oth­ers then it’s a bind; it feels less like a per­sonal exer­cise and more of a job.

A beautiful, thoughtful redesign from Mark Boulton (and a responsive one at that). Go go, read read.

The Congress requested the President to remind the central government of its 'raj dharma', Singh said.

Nearly 7,000 paramilitary forces have been deployed in the affected areas of the northeast district since Monday.

The Congress and other opposition parties have accused the police of bias and inaction in the Delhi violence.

Startup designs foldable japi

September 23, 2015

As an industry, we’ve worked to established many new practices and tools for nimble design teams, from A/B testing to measuring bounce rates and CTR performance. But a lot of these methods require engineers or some amount of technical know-how to execute, and they take place only after something has been launched.

The judicious application of “dumb data” can streamline your workflow and improve your designs

What many people don’t know is that there are some unexpected applications of data to consider earlier in the design process, which you, the designer, can do yourself. They’re not fancy, and you don’t need to know how to write SQL queries. The judicious application of just-enough “dumb data” can streamline your workflow and improve your designs in surprisingly useful ways.

Here are...read more
By Jocelyn Lin

September 28, 2015

Good design in any discipline usually carries a structure of order and harmony. Since the Renaissance, artists and architects have used a strong understanding of proportions to create aesthetically pleasing architecture. Many of these classical design principles have followed us into modern times and can be found today in effective web design.

Take an A4 piece of paper for example. If you take it and halve it, the resulting size is A5 with the same exact proportions. No other proportion has the same properties. 16th century architect, Andrea Palladio knew this well. It is believed that because, fundamentally, most architects—like Palladio—use a similar system of proportions to plan and design spaces, buildings can look very different while remaining similar at their cores.

Structure and Beauty

It’s in human nature to...read more
By Ling Lim

September 30, 2015

By their very nature, heuristics offer a hands-on approach to discovery, where knowledge is culled through trial and error. They are rules of thumb that give us a framework as we move through the research and design process.

In service design, this kind of framework is also valuable for assessing completed projects to find the weak links. A heuristic can apply to a single interaction as well as to the overall service eco-system. Heuristics can be applied to a single moment in time or to a user’s entire long-term relationship with a service.

This conceptual approach to design recognizes that experiences are coproduced, and that human interaction is a key component of many, if not all, services. As systems grow ever more sophisticated and interconnected, designers will continue to face new challenges. Service design heuristics can help us to frame and think about...read more
By Usability Matters

October 5, 2015

You may have recently seen an abundance of bug-eyed people puking rainbows on Snapchat. Thank Looksery for that. Launched last year as an entertainment app based on face recognition technology and special effects, Looksery was acquired by Snapchat last month.

Looksery technology propels Snapchat’s new special effects

Founded in 2013, Looksery launched in October 2014 after...read more
By Jordan Crone

October 6, 2015

Many important considerations impact software design. Business goals, user goals, user context, cultural considerations, platform paradigms, branding requirements, devices … the list goes on and on. While a primary focus for any software design effort should be the data or other content that’s being displayed, this keystone element is often given short shrift. This is unfortunate and shortsighted. Given the focus it your content will receive, it should be a primary consideration during the design process.

It is a common practice to represent data and content as “Lorem ipsum,” repeating data, or simply using “best case scenario” data. In reality, this isn’t what will be experienced in the final product. The data you have to work with can drastically affect the final design, and the design will influence the type, format, and presentation of data.

Infusing Real Content into Your Designs

Whether you’re using...read more
By Juan Sanchez

No-touch systems, infrastructure to work from home are some of the changes

Communication gap hindering their bail application process

If you are wondering when to apply which design methods, this mind map may help you.

O’REILLY DESIGN CONFERENCE - get the skills and insights you need to design the products of the future. Save 20% with code ALIST

'I'm excited to get back in, I really do miss it. This has been almost a blessing on one side because it gives you more appreciation for the things that you love and do.'

True North to align with Magnetic North at Greenwich for first time in 360 years  Telegraph.co.uk

Fracking: UK shale gas reserves 'significantly lower than previous estimates'  Energy Live News - Energy Made Easy

Fracking firm Cuadrilla signs secret deal with geological agency to 'destroy confidential documents'  iNews

The present work reports on the charge and spin density modelling of YTiO3 in its ferromagnetic state (TC = 27 K). Accurate polarized neutron diffraction and high-resolution X-ray diffraction (XRD) experiments were carried out on a single crystal at the ORPHÉE reactor (LLB) and SPRING8 synchrotron source. The experimental data are modelled by the spin resolved pseudo-atomic multipolar model (Deutsch et al., 2012). The refinement strategy is discussed and the result of this electron density modelling is compared with that from XRD measured at 100 K and with density functional theory calculations. The results show that the spin and charge densities around the Ti atom have lobes directed away from the O atoms, confirming the filling of the t2g orbitals of the Ti atom. The dxy orbital is less populated than dxz and dyz, which is a sign of a partial lift of degeneracy of the t2g orbitals. This study confirms the orbital ordering at low temperature (20 K), which is already present in the paramagnetic state above the ferromagnetic transition (100 K).

Rational structure-based drug design (SBDD) relies on the availability of a large number of co-crystal structures to map the ligand-binding pocket of the target protein and use this information for lead-compound optimization via an iterative process. While SBDD has proven successful for many drug-discovery projects, its application to G protein-coupled receptors (GPCRs) has been limited owing to extreme difficulties with their crystallization. Here, a method is presented for the rapid determination of multiple co-crystal structures for a target GPCR in complex with various ligands, taking advantage of the serial femtosecond crystallography approach, which obviates the need for large crystals and requires only submilligram quantities of purified protein. The method was applied to the human β2-adrenergic receptor, resulting in eight room-temperature co-crystal structures with six different ligands, including previously unreported structures with carvedilol and propranolol. The generality of the proposed method was tested with three other receptors. This approach has the potential to enable SBDD for GPCRs and other difficult-to-crystallize membrane proteins.

The performance of automated model building in crystal structure determination usually decreases with the resolution of the experimental data, and may result in fragmented models and incorrect side-chain assignment. Presented here are new methods for machine-learning-based docking of main-chain fragments to the sequence and for their sequence-independent connection using a dedicated library of protein fragments. The combined use of these new methods noticeably increases sequence coverage and reduces fragmentation of the protein models automatically built with ARP/wARP.